A prospective randomised phase III study of observation versus screening MRI and pre-emptive treatment in castrate resistant prostate cancer patients with spinal metastasis.
Disease site: Prostate cancer, urological cancers
Intervention and treatment: MRI scan, followed by pre-emptive radiotherapy and/or surgery if needed
Status: In follow-up
PROMPTS is a prospective, randomised, phase III, interventional study to determine whether detection of radiological spinal cord compression (SCC) using screening MRI of the spine and pre-emptive treatment could reduce the incidence of clinical SCC in asymptomatic castrate resistant prostate cancer patients with spinal metastasis.
541 patients will be recruited from UK sites over a 2–3 year period and randomised into one of two groups. Patients in the intervention group will receive a baseline screening MRI and pre-emptive treatment to any sites of radiological SCC; following the pre-emptive treatment, patients will receive an MRI scan every 6 months. Patients in the control group will be followed up as per standard practice. All participants will be followed up for a further 3 years.
Chief Investigator: Professor David Dearnaley, The Royal Marsden NHS Foundation Trust
ICR-CTSU Scientific Lead: Dr Emma Hall
Trial management contact: [email protected]
Sponsor: The Institute of Cancer Research
Funding: Cancer Research UK (CRUK/11/053)
Further information including recruitment progress is available from the UKCRN portfolio.
Patient friendly information is available from Cancer Research UK.
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