Study and Careers

Job Details The Cancer Research UK funded Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU) seek an experienced and highly motivated Principal Statistician to join their team of over 20 statisticians. We want to hear from you if you: Enjoy the challenge of researching, developing and implementing efficient trial methodology, and designing efficient clinical trials that will make a difference in patients’ lives Seek variety in your work and opportunities to apply your statistical knowledge across multiple therapeutic areas in oncology. Thrive on being part of a multi-disciplinary research team with like-minded statisticians. Are looking to develop your career within a dynamic and supportive academic environment at a leading cancer clinical trials unit. Key Requirements The successful applicant will be an experienced and highly motivated medical statistician interested in researching new statistical methods and applying their statistical knowledge to the design and analysis of patient-centred clinical trials. They will have a post-graduate qualification in statistics. They should demonstrate a solid understanding of clinical trials and experience in applying statistical methods to real-world data. Familiarity with Bayesian statistics and early phase adaptive trials are highly desirable. Effective oral and written communication skills, as well as enthusiasm for collaborating with others from diverse disciplines, are essential. Department/Directorate Information ICR-CTSU manages an exciting portfolio of national and international phase II and III cancer clinical trials and an expanding number of phase I trials. You will contribute in shaping the development of methodological innovations and implementing efficient methods in new and ongoing trials, with a specific focus in early phase and adaptive trials. You will work as part of a multi-disciplinary team on trials methodology research and on the statistical development, oversight and analysis of a number of clinical trials within the ICR-CTSU’s Early Phase and Adaptive Trials portfolio in collaboration with external organisations and the ICR/Royal Marsden Drug Development Unit. In your supporting statement please summarise how your research/managerial experience fits with the role. We encourage all applicants to access the job pack attached for more detailed information regarding this role. This is an office-based role. Requests for hybrid working (splitting time between our Sutton site and home) may be considered following successful completion of key training and only if the role allows. Flexible working options may be considered. For informal discussion about the role, please contact Professor Christina Yap, email: [email protected] For general queries about the recruitment process, please contact ICR-CTSU, email: [email protected].

Summary of Role ICR’s Cancer Research UK Clinical Trials & Statistics Unit (ICR-CTSU) is offering a placement year training opportunity at its Sutton site in Surrey for an enthusiastic, adaptable, and quick learning individual, currently undertaking an undergraduate degree in mathematics, statistics or a related field with a strong statistical component. This an exciting opportunity for students interested in a career within clinical trials to receive training within a clinical research setting. The successful applicant will work directly with the ICR-CTSU Statisticians, Trial & Data managers and Trial administrators to support the delivery of a diverse portfolio of phase II/III clinical trials, with a special emphasis in breast, urological and head and neck cancer treatments. You will receive full training in Good Clinical Practice and experience of working in accordance with UK clinical trials legislation. This will put you ahead of the competition when you graduate if you apply for a role in clinical trials either in academic research or in industry. You should be an undergraduate student (in mathematics, statistics or a related field with a strong statistical component) in your second year of study seeking a placement year opportunity in clinical trials. This post will be office based. When applying please provide a supporting statement; together with your CV and the names and addresses of two referees. Key Requirements The successful candidate must be studying for an undergraduate degree in mathematics, statistics or a related field with a strong statistical component. You should have a high level of computer literacy, a proven ability to use MS office packages and work accurately with attention to detail as well as good written and oral communication skills. You should have the ability to adhere to written procedures, work to agreed deadlines and work as part of a team. An interest in cancer research and medical statistics, and the ability to work with confidential information is also essential. Previous experience of the use of statistical programming languages would be an advantage but is not essential. For full details of the requirements see the job description. Department/Directorate Information For information regarding the ICR-CTSU Team go to: https://www.icr.ac.uk/our-research/centres-and-collaborations/centres-at-the-icr/clinical-trials-and-statistics-unit We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact us via email at: [email protected]

Under the guidance of Professor Sebastian Guettler, we are seeking to recruit a Postdoctoral Training Fellow to to investigate the molecular mechanisms of Wnt/β-catenin signalling, using a combination of mammalian genetics, cell biology, proteomics and biochemistry. The successful candidate will apply mammalian genetics (CRISPR), cellular biochemistry, proteomics and light microscopy (including live-cell imaging) to investigate the mechanisms of Wnt/β-catenin signalling in normal physiology and cancer. The particular focus of the project will be on studying the molecular mechanisms underlying the activities and regulation of the β-catenin destruction complex and its dysregulation in APC-mutant cancers, particularly colorectal cancer. The position will offer a stimulating balance of independence and collaboration. The candidate will join a multidisciplinary, collaborative and international team with a core expertise in biochemistry, structural biology (electron microscopy, X-ray crystallography), biophysics and genetics, and established collaborations in chemistry and proteomics. About you The successful candidate must have a PhD in a biological science or any other area relevant to the proposed research, and experience in contemporary molecular biology, mammalian genetics, cell biology and biochemistry. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Department/Directorate Information Work in the Structural Biology of Cell Signalling Team, led by Professor Sebastian Guettler, in the ICR Divisions of Structural Biology and Cell and Molecular Biology, centres on the molecular mechanisms of Wnt/β-catenin signalling and telomere maintenance, both of which play key roles in stem cells and a wide range of cancers. A long-standing interest of the team is to understand how ADP-ribosylation, a complex and extremely versatile post-translational modification, controls both these systems, and how the ADP-ribosyltransferase tankyrase is regulated. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Sebastian Guettler via e-mail on [email protected].

About the Role As a Contracts Associate, you will be required to provide a professional and efficient contracts review, negotiation, and advice service to the ICR to enable a range of research and commercial activities The ICR has recently implemented a new contracts lifecycle management system. This is an exciting opportunity to work in a modern way with contracts; significantly reducing administrative workload and intelligently automating routine tasks. Key Requirements Candidates must be educated to degree level or equivalent and have an understanding and knowledge of research contractual issues. They must have experience of working in a contracts team in a higher education or research organisation setting, with well-developed analytic and problem-solving skills. Candidates must have the ability to interpret contract terms, manage workloads and prioritise tasks effectively. Excellent communication and influencing skills and good interpersonal skills will also be required. What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information The Institute of Cancer Research is one of the world’s most influential cancer research organisations. Our mission is to make the discoveries that will defeat cancer. We’re looking for a proactive and enthusiastic team member who understands the particular needs and landscape of an academic research institution. As a member of the Business and Innovation Office, you will provide a professional and efficient contracts service to academics, clinicians, and professional services colleagues across the whole of ICR, negotiating and concluding a range of simple and intermediate research agreements. We encourage all applicants to access the job pack attached for more detailed information regarding this role.