In situ analysis of the T-cell receptor repertoire in colorectal cancer

• Primary supervisor: Professor Trevor Graham
• Supervisory team: Dr Ann-Marie Baker, Professor Alan Melcher
• Primary Division and team: Molecular Pathology, Genomics and Evolutionary Dynamics
• Project area: Biological Sciences
• Studentship funded by: The Institute of Cancer Research
• Studentship start date: October 2022

• Deadline: 12 June 2022

Project proposal

Targeting RNA helicases to suppress aberrant androgen receptor expression and abrogate persistent androgen receptor signalling in lethal prostate cancer

• Primary supervisor: Dr Adam Sharp
• Supervisory team: Professor Johann de Bono, Dr Paul Clarke, Dr Juan Jimenez Vacas, Dr Jon Welti
• Primary Division and team: Clinical Studies, Translational Therapeutics
• Project area: Biological Sciences
• Studentship funded by: The Institute of Cancer Research
• Studentship start date: October 2022

• Deadline: 12 June 2022

Project proposal

Development of a patient model for real-time MRI guided radiotherapy of pancreas and liver cancer

• Primary supervisor: Professor Uwe Oelfke
• Supervisory team: Dr Jamie McClelland (UCL), Dr Alison Tree
• Primary Division and team: Radiotherapy and Imaging, Physics Modelling
• Project area: Physics; Computer science
• Studentship funded by: Cancer Research UK
• Studentship start date: October 2022

• Deadline: 12 June 2022

Project proposal

Previous projects 

Development of a patient model for real-time MRI guided radiotherapy of pancreas and liver cancer
Professor Uwe Oelfke

Charting colorectal cancer interactomes at structural resolution using chemical crosslinking and mass spectrometry
Professor Jyoti Choudhary

Development of novel dual-target agents to treat neuroblastoma that combine selective protein degradation with synergistic inhibition
Professor Hector Keun

Unravelling the role of cancer associated fibroblasts in cancer evolution and drug resistance using microfluidics
Professor Udai Banerji

An explant-in-chip platform to study immune-cancer cell interactions and enhance tumour immunogenicity ex vivo: a focus on radiotherapy
Professor Darryl Overby (Imperial)

Deciphering the metabolic determinants of bone metastasis in breast cancer
Dr George Poulogiannis

Composition and function of telomeric multi-protein complexes and their regulation by ADP-ribosylation
Dr Sebastian Guettler

Dissecting the prostate cancer-stromal interface
Prof Johann de Bono

Can artificial intelligence predict outcome in patients receiving stereotactic radiosurgery of brain metastasis?
Dr Matthew Blackledge

Single-cell transcriptomics linked to lineage tracing to interrogate the role of “plasticity first” as a positive force driving paediatric cancer evolution
Dr Alejandra Bruna

Exploring strategies for targeting oncogenic beta-catenin
Dr Paul Clarke

Examining the mechanism of chromatin replication and assembly at telomeres
Dr Max Douglas

Generation of mouse models to identify and characterize novel therapeutic targets in chemo refractory AML disease
Professor Kristian Helin

Developing innovative chemical tools to drive lytic cancer cell death
Prof Swen Hoelder

PET imaging to monitor immune cell fitness post-targeted treatment in GBM
Dr Gabriela Kramer-Marek

Understanding PolØ and ATR inhibitor sensitivity in cancer
Prof Chris Lord

Harnessing immunogenic cell death mechanisms to trigger anti tumour immunity
Prof Pascal Meier

Identifying small molecules that bind to the E3-ligase Cbl-b
Dr Gary Newton

Understanding myeloma cell – microenvironment interactions and their role in immunomodulatory drug resistance
Dr Charlotte Pawlyn

Using lattice light sheet microscopy to determine how the Spindle Assembly Checkpoint turns off
Prof Jon Pines

Advanced multiparametric MRI for the characterisation of soft tissue sarcoma and response to neoadjuvant therapy
Dr Simon Robinson