Working life and benefits

Department/Directorate Information: Division of Clinical Studies - Clinical Trials and Statistics Unit (ICR-CTSU) The ICR-CTSU is a Cancer Research UK-funded, internationally recognised methodologist led clinical trials unit, providing cancer-focused clinical trial research expertise. We lead pioneering, efficient, high-quality, and impactful trials across the phases. Our expertise ranges from experimental medicine early phase studies exploring biological efficacy to trials which may deliver widespread change to routine practice, underpinned by applied methodology to drive forward clinical trial innovation. See our clinical trials Role Summary The Group Leader will lead a component of ICR-CTSU’s portfolio of clinical trials research. The post holder will join an existing faculty and seek to further develop and grow the portfolio in line with ICR-CTSU’s overall strategy; taking responsibility for a number of ongoing trials as well as the development of new trials. There will be the opportunity to develop and grow a team including the potential for a Postdoctoral Training Fellow and/ or a Trial Manager. We seek an experienced statistician / biostatistician with a strong research interest in clinical trials methodology and a passion for direct involvement in the oversight and leadership of academic clinical trials. The successful candidate will work closely with the Director of ICR-CTSU to further enhance the Unit’s internationally recognised strength in clinical trial design, conduct and analysis. The post holder will be expected to make a substantial independent intellectual contribution to clinical trials projects and be proactive in leading and contributing to broad initiatives that enhance the overall effectiveness of ICR-CTSU. The appointee will contribute to the overall scientific life of the ICR including the newly established ICR/Royal Marsden Hospital’s Centre for Trials and Population Data Science, by providing mentorship to more junior colleagues and acting as an academic leader. We seek an individual who will work closely and collaboratively with other faculty/Group Leaders at the ICR and with international/national key opinion leaders to extend the breadth and depth of ICR-CTSU’s biologically rich clinical trials portfolio. In partnership with clinical opinion leaders, this individual will generate research funds to conduct and deliver clinical trials research at the international forefront. Presentation at national and international conferences, production of top-quality research outputs and substantial professional contribution to wider clinical trial network bodies are expected. Enthusiasm for team-based science in a collaborative interdisciplinary environment is essential. The appointment will be based on track record and the ability and willingness to engage in team science. The successful appointee will have access to ICR’s successful PhD training programme and core facilities. Key Requirements Higher degree (MSc or PhD) in medical statistics/biostatistics or an allied field (e.g. public health, epidemiology, data science) with relevant work experience Significant experience as a clinical trials, medical statistician or bio-statistician within the academic or commercial sector; a blend of both would be highly desirable A desire to apply existing and novel statistical methods to the requirements of a diverse range of statistical problems A broad understanding of cancer research Ability to lead a Clinical Trials Unit based research group As part of your online application, you will be required to upload your full CV which will pre-populate your application form, you will also be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: Lists of major publications, achievements, research grants and distinctions. A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity or a single document giving hyperlinks to these outputs. You must also complete the personal statement section of the application form in the format of a cover letter including the names and contact details of three academic referees Joining as a Group Leader, you will be given outstanding support to help you to continue to develop in your career. Along with a start-up package of funding, you will also have access to resources to establish your group, including support for recruiting key group members, such as PhD students and postdoctoral researchers. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Emma Hall ([email protected])

Under the guidance of Professor Kamil Kranc, we are seeking to recruit a Postdoctoral Training Fellow to pursue therapeutic targeting of the cellular oxygen-sensing system in order to eliminate leukaemic stem cells in acute myeloid leukaemia (AML) and develop effective treatments for this devastating disease. We have identified inhibition of hypoxia-inducible factor (HIF) hydroxylases (PHDs) as a promising non-toxic strategy to target leukaemic stem cells by modulating HIF signalling (Lawson/Holt-Martyn et al., Nature Cancer, 2024; Vukovic et al., Journal of Experimental Medicine, 2015; Vukovic et al., Blood, 2016). The postholder will investigate how inactivation of PHDs and related enzymes impacts AML biology, identify AML subtypes sensitive to these interventions, evaluate novel small-molecule inhibitors in vivo, and discover synthetic lethal vulnerabilities and resistance mechanisms to inform optimal combination strategies and overcome therapeutic resistance. About you The successful candidate must have: PhD in hypoxia biology, biochemistry, cell biology, molecular biology, stem cell biology, oncology or chemical biology. Significant experience in hypoxia biology/biochemistry, stem cell biology, and cancer research. Previous postdoctoral experience in hypoxia and/or leukaemia biology. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Department/Directorate Information: The Haemato-Oncology Group specialises in understanding and targeting leukaemic stem cells, which are responsible for AML initiation, disease progression, relapse, and resistance to conventional therapies. Our group focuses on discovering cures for acute myeloid leukaemia with an aim to identify novel therapeutic targets for selective elimination of LSCs, without disrupting normal haematopoiesis. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Kamil Kranc via email [email protected]

Under the guidance of Professor Kamil Kranc, we are seeking to recruit a Postdoctoral Training Fellow to work on therapeutic targeting of RNA modifications in acute myeloid leukaemia (AML). The successful candidate will investigate strategies to eliminate leukaemic stem cells and play a central role in developing curative treatments for this aggressive disease. Our recent work has demonstrated that inactivation of readers of the m6A mRNA modification represents a promising, non-toxic strategy for targeting leukaemic stem cells in AML (Paris et al., Cell Stem Cell, 2019; Mapperley et al., Journal of Experimental Medicine, 2021; Turner et al., eLife, 2022). Building on these findings, the postholder will explore the impact of disrupting the YTHDF family of m6A readers on AML biology, identify disease subtypes most responsive to this approach, test novel small-molecule inhibitors in vivo, and uncover synthetic lethal interactions and resistance mechanisms to guide rational combination therapies. About you The successful candidate must have: PhD in biochemistry, RNA biology, cell biology, molecular biology, stem cell biology, oncology or similar. Excellent verbal and written communication skills. Essential for communicating research, training others and drafting of reports or publications. Significant experience in RNA biology, stem cell biology, and cancer research. An excellent publication record with a track record of research excellence. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Department/Directorate Information The Haemato-Oncology Group specialises in understanding and targeting leukaemic stem cells, which are responsible for AML initiation, disease progression, relapse, and resistance to conventional therapies. Our group focuses on discovering cures for acute myeloid leukaemia with an aim to identify novel therapeutic targets for selective elimination of LSCs, without disrupting normal haematopoiesis. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Kamil Kranc via email on [email protected]

About the Role We are seeking a Senior Category Manager (IT and Professional Services) to join our Procurement Team and contribute to establishing a category approach with a focus on embedding sustainability through the procurement life cycle. . The successful candidate will play a key role in ensuring a suitable strategic approach, operational planning and delivery for the Laboratories Category. Collaborating with stakeholders to ensure compliant processes which emphasise sustainability, meet business needs, supports ICR strategy and deliver value for money. Key Responsibilities Carry out the required spend, stakeholder and supplier analysis Develop and implement detailed procurement pipeline plans Establish & maintain effective relationships with stakeholders, suppliers, technical staff and colleagues Oversee contract management and supplier relationship management Adopt and drive strategies to embed ICR Sustainable Discoveries goals into the entire procurement lifecycle Imbedding relevant ESG metrics and a collaborative approach to contract and supplier management to mitigate risk About You We are looking for an individual with excellent stakeholder management skills, an innovative and flexible attitude with an enthusiasm for process development and improvement. The role requires experience of developing and implementing a category approach What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information The ICR Procurement Team is establishing a category approach with a focus on embedding sustainability through the procurement life cycle. The role holder will be responsible for ensuring a suitable strategic approach, operational planning and delivery for their Category. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact [email protected] (Head of Procurement).