Careers at the ICR

Department/Directorate Information: Division of Clinical Studies - Clinical Trials and Statistics Unit (ICR-CTSU) The ICR-CTSU is a Cancer Research UK-funded, internationally recognised methodologist led clinical trials unit, providing cancer-focused clinical trial research expertise. We lead pioneering, efficient, high-quality, and impactful trials across the phases. Our expertise ranges from experimental medicine early phase studies exploring biological efficacy to trials which may deliver widespread change to routine practice, underpinned by applied methodology to drive forward clinical trial innovation. See our clinical trials Role Summary The Group Leader will lead a component of ICR-CTSU’s portfolio of clinical trials research. The post holder will join an existing faculty and seek to further develop and grow the portfolio in line with ICR-CTSU’s overall strategy; taking responsibility for a number of ongoing trials as well as the development of new trials. There will be the opportunity to develop and grow a team including the potential for a Postdoctoral Training Fellow and/ or a Trial Manager. We seek an experienced statistician / biostatistician with a strong research interest in clinical trials methodology and a passion for direct involvement in the oversight and leadership of academic clinical trials. The successful candidate will work closely with the Director of ICR-CTSU to further enhance the Unit’s internationally recognised strength in clinical trial design, conduct and analysis. The post holder will be expected to make a substantial independent intellectual contribution to clinical trials projects and be proactive in leading and contributing to broad initiatives that enhance the overall effectiveness of ICR-CTSU. The appointee will contribute to the overall scientific life of the ICR including the newly established ICR/Royal Marsden Hospital’s Centre for Trials and Population Data Science, by providing mentorship to more junior colleagues and acting as an academic leader. We seek an individual who will work closely and collaboratively with other faculty/Group Leaders at the ICR and with international/national key opinion leaders to extend the breadth and depth of ICR-CTSU’s biologically rich clinical trials portfolio. In partnership with clinical opinion leaders, this individual will generate research funds to conduct and deliver clinical trials research at the international forefront. Presentation at national and international conferences, production of top-quality research outputs and substantial professional contribution to wider clinical trial network bodies are expected. Enthusiasm for team-based science in a collaborative interdisciplinary environment is essential. The appointment will be based on track record and the ability and willingness to engage in team science. The successful appointee will have access to ICR’s successful PhD training programme and core facilities. Key Requirements Higher degree (MSc or PhD) in medical statistics/biostatistics or an allied field (e.g. public health, epidemiology, data science) with relevant work experience Significant experience as a clinical trials, medical statistician or bio-statistician within the academic or commercial sector; a blend of both would be highly desirable A desire to apply existing and novel statistical methods to the requirements of a diverse range of statistical problems A broad understanding of cancer research Ability to lead a Clinical Trials Unit based research group As part of your online application, you will be required to upload your full CV which will pre-populate your application form, you will also be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: Lists of major publications, achievements, research grants and distinctions. A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity or a single document giving hyperlinks to these outputs. You must also complete the personal statement section of the application form in the format of a cover letter including the names and contact details of three academic referees Joining as a Group Leader, you will be given outstanding support to help you to continue to develop in your career. Along with a start-up package of funding, you will also have access to resources to establish your group, including support for recruiting key group members, such as PhD students and postdoctoral researchers. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Emma Hall ([email protected])

About the Role We are seeking a Senior Trusts Fundraising Manager to join our Trusts & Corporate Team and contribute to our income generation plans. The successful candidate will play a key role in maximising income from Trusts and Foundations to support our mission: to make the discoveries that defeat cancer. Key Responsibilities To maximise income from Trusts and Foundations by further developing the ICR’s relationships with existing medium and large Trust donors and by personally securing the support of new ones. You will be required to focus on raising grants broadly in the range of £10k to £500k To develop a donor pipeline aligned with Trusts and Foundations that have a strong synergy with the ICR’s mission and research priorities. The postholder will help shape engagement strategies and secure multi‑year partnerships that deepen the ICR’s institutional relationships About You We are looking for a candidate able to demonstrate a substantial track record of securing support from Trusts and Foundations (including six-figure+ sums) and sustaining a portfolio of partner/donor relationships in the not-for-profit environment. An individual who can develop relationships with individuals at the highest level, both externally and internally, and including with scientists, senior volunteers and trustees. And you must be able to write well, putting together compelling proposals with detailed plans and budgets. What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information The Development and Communications directorate tells the ICR’s story and focuses on income generation. The ICR is world-renowned for its outstanding cancer research – and it deserves communication to match. We believe that communicating effectively about the ICR's work can help us build on our successes – attracting donors and supporters, the best staff and students, commercial partners and collaborators. Within the Development and Comms directorate, the Trusts & Corporate team is responsible for all philanthropic organisational relationships for the ICR. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact the Talent team via Email on [email protected]

Under the guidance of Professor Jyoti Choudhary, we are seeking to appoint a motivated Postdoctoral Training Fellow to develop innovative quantitative proteomics workflows for the characterization of protein degradation and functions. The successful candidate will play a key role in developing or optimising new proteomics methods and undertaking end-to-end analysis of a variety of samples. About you The successful candidate must have: PhD in biochemistry or chemistry with sound knowledge of biological mass spectrometry Expertise in biochemical and protein purification techniques Expertise in computational analysis of omic data-ability to perform statistics, data integration and bioinformatics Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Functional Proteomics Group The Functional Proteomics Group led by Professor Jyoti Choudhary explores the molecular phenotype of cancer studying protein-protein interactions, signalling, post-translational modifications and protein expression. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Jyoti Choudhary for further information by emailing [email protected].

About the Role We are seeking a Business Development Intern to join our Business and Innovation Office and contribute to gain experience of working in a technology transfer and knowledge exchange office. The successful candidate will gain knowledge of drafting and negotiation of contracts, knowledge of Intellectual Property protection and exploitation, the ability to distil key scientific concepts and communicate these ideas to others, knowledge of key industry areas, ability to analyse market potential and interpersonal skills Key Responsibilities You will gain; a knowledge of drafting and negotiation of contracts, knowledge of Intellectual Property protection and exploitation, the ability to distil key scientific concepts and communicate these ideas to others, knowledge of key industry areas, ability to analyse market potential and interpersonal skills We will provide formal training including the chance to attend Knowledge Exchange UK or UCL training. There will be the opportunity to shadow BIO managers on more complex projects. About You We are looking for a proactive, detail-oriented, organised, fast learner, team player individual with excellent IT skills and organisation skills. A degree in a subject relevant to the ICR or BIO is required High levels of literacy and numeracy Excellent communication skills, both written and verbal What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information Business and Innovation Office The Business and Innovation Office acts as the technology and knowledge transfer hub for The Institute of Cancer Research, providing the experience and expertise to put in place a wide range of agreements between our scientists and industry. You will be joining one of the most successful teams of its type in the UK. We are a busy team working on a wide variety of projects with many different academic and commercial partners. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Yvette Newbatt via email [email protected]

We are seeking a motivated Scientific Officer to join the Sarcoma Molecular Pathology Group under the leadership of Professor Janet Shipley. You will provide key technical support to ongoing research programmes focused on the molecular characterisation of sarcomas, contributing to projects that directly support the development of improved diagnostics and therapeutic strategies. Your work will involve screening, testing, and optimising antibodies that detect aberrant proteins in sarcomas. You will use these and commercially available antibodies in state‑of‑the‑art multiplexed immunofluorescent analyses of patient-derived sarcoma tissues and experimental models. The role will also include tissue organisation, tissue culture, and general laboratory management tasks essential to the smooth running of the research group. This is an excellent opportunity to be part of a dynamic, collaborative team and contribute to impactful translational cancer research. About you The successful candidate must have: An undergraduate degree (or higher) in a biological or related discipline Strong attention to detail and ability to perform complex laboratory techniques with accuracy Competence in using laboratory software and adhering to laboratory procedures and regulatory standards Ability to build trusted working relationships with peers and senior researchers A team-focused approach, combined with the ability to work independently Ideally, you will also have: Experience contributing to scientific research projects and discussing results with researchers Previous experience using similar laboratory or molecular pathology techniques Enthusiasm and motivation to contribute scientifically to the group’s research objectives Department/Directorate Information The ICR's Division of Cancer Biology is comprehensively characterising the molecular features of cancer, and through strong links with other colleagues elsewhere in The Institute of Cancer Research, London, and at The Royal Marsden NHS Foundation Trust, aims to establish new molecular diagnostics and novel molecular therapeutic targets in cancer. The Sarcoma Molecular Pathology Group is primarily focused on high-risk rhabdomyosarcomas and desmoplastic small round cell tumours that and includes understanding aspects of genetic and epigenetic regulation of differentiation/cell transitioning and the DNA damage response that may be targeted and incorporated into the treatment of these and other sarcomas. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact [email protected]

Under the guidance of Professor Montserrat Garcia-Closas, Group Leader Integrative Cancer Epidemiology, Division of Genetics & Epidemiology, we are seeking to recruit a motivated and organised Scientific Officer to support a range of molecular epidemiology activities within the Generations Study and related projects. This post offers an excellent opportunity, ideally for a recent graduate, however this is not essential. This role offers a great first step into postgraduate study or a career in epidemiology, or population health, to gain broad, hands-on experience in epidemiological research within a multidisciplinary environment. The successful candidate will gain experience across multiple components including laboratory-based activities (e.g. coordination of biobanking and pathology collections), data-driven research and contributions to scientific communications. About you The successful candidate will work closely with epidemiologists and laboratory teams, contributing to high-impact research on cancer risk and prevention and must have: Undergraduate degree in biomedical or biological sciences, population sciences, or a related field General computer literacy (e.g. Word, Excel, databases) Interest in cancer epidemiology or population health research Some experience working with research or health-related data and familiarity with statistical or programming tools (e.g. R, Python) is also desirable. Department/Directorate Information The Integrative Epidemiology Team at The Institute of Cancer Research led by Professor Garcia-Closas is located at the ICR Sutton Campus. The team forms part of the Cancer Epidemiology and Prevention Research Unit (CEPRU), a joint initiative between the ICR and Imperial College London focused on advancing cancer epidemiology through interdisciplinary research and training. The team uses large-scale population data to investigate the causes of cancer, understand carcinogenic processes, and improve risk prediction for precision prevention. A central resource for the team is the Breast Cancer Now Generations Study, a national cohort of over 110,000 women in the UK followed since 2004. Research in the team combines epidemiology and biostatistics with emerging approaches in data science, including analyses of mammography and pathology images and integration of multi-modal data. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Montserrat Garcia-Closas via [email protected]

We have an opportunity for a talented and motivated Postdoctoral Training Fellow to join the Division of Cancer Therapeutics. The team has a role to accelerate the translation of ICR research into drug discovery programmes. The team delivers bespoke, hypothesis-driven data packages to support decision-making for launch of drug discovery projects. The teams dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the team work closely with the Centre for Target Validation to validate and streamline robust, targets into drug discovery programmes in the ICR’s Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners. Also, working with the Centre for Protein Degradation Scientists exploit emerging technology and protein degradation tools for robust target validation experiments. The successful candidate will contribute to the development of new drug targets by expanding our understanding of target biology and drug discovery. Working in close collaboration with other groups within the ICR, the candidate will develop our understanding of the therapeutic relevance of specific targets using genetic and pharmacologic approaches. The successful candidate will be a part of a highly collaborative team that is embedded in the Centre for Cancer Drug Discovery. They will have the opportunity to direct their own research towards target identification, validation and drug discovery. About you Applicants must have a PhD in cell biology, cancer biology, genetics, or similar. Experience in drug discovery and modern cell and molecular biology techniques is essential. Experience with -omics level profiling and handling of large datasets is desired. Excellent organisational and communication skills are also required. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Department/Directorate Information About our organisation We are one of the world’s most influential cancer research institutes with an outstanding record of achievement dating back more than 100 years. We are world leaders in identifying cancer genes, discovering cancer drugs and developing precision radiotherapy. Together with our hospital partner The Royal Marsden, we are rated in the top four centres for cancer research and treatment worldwide. As well as being a world-class institute, we are a college of the University of London. We came top in the league table of university research quality compiled from the Research Excellence Framework in 2014 and second in 2021. We have charitable status and rely on support from partner organisations, charities, donors and the general public. We have more than 1000 staff and postgraduate students across three sites – in Chelsea and Sutton. About our Centre The Centre for Cancer Drug Discovery (CCDD), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality drug candidates for validated biological targets and to progress these candidates to clinical trial. All the scientific disciplines are in place to make this possible. Our world-class biologists, chemists and drug metabolism specialists work together focusing on new molecular targets emerging from human genome and ground-breaking cell biology research. This is an exciting and fast-moving area of cancer research and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment. Group information Our group focus is to build robust target validation data packages against potential cancer targets identified by the ICR's researchers across Divisions. This is to increase confidence in the launch of drug discovery projects against those targets. Our scientists collaborate with ICR researchers to expand on the target biology validation and build a strong therapeutic hypothesis for a target. Tractability of targets is assessed and the most appropriate therapeutic mode of action for a target will be defined. Research at the Centre for Target Validation is focused on applying best practice in target validation and implementing innovative technology to robustly validate targets for drug discovery. Scientists in the CTV will form collaborations with ICR researchers who have identified potential therapeutic targets to: Provide access to resources and core facilities to answer hypothesis-testing questions Generate the key decision-making data required for target to enter drug discovery The Centre for Target Validation therefore links the Centre for Cancer Drug Discovery within the Division of Cancer Therapeutics with partner Divisions that identify potential drug targets. The Centre is also in collaboration with the Division of Breast Cancer Research to validate targets relevant in breast cancer in the context of the Breast Cancer Now (BCN) Toby Robins Research Centre. The CTV is supported and funded by the ICR as part of the ICR research strategy: Defeating Cancer to transform the lives of cancer patients. Group Leader: Joanna Loizou What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Joanna Loizou via [email protected].

Under the guidance of Dr Matthew Blackledge, we are seeking to recruit a Postdoctoral Training Fellow to contribute to deliver treatment-integrated, multimodal agentic AI to drive a step-change in clinical radiotherapy by i) improving patient outcomes for cancers of unmet clinical need; and ii) increasing the efficiency of RT by enabling safe ultra-hypofractionated treatments. The successful candidate will play a key role in developing vision-language models (VLMs) to combine imaging data with human gestures (including eye gaze and voice-dictated prompts) for robust tumour delineation, and innovating Bayesian-enhanced AI to propagate uncertainties through the agentic workflow. The role will include attendance at relevant conferences and workshops, in addition to regular consultation with medical experts and publication of research in high-impact journals. About you The successful candidate must have: A PhD in computational science, artificial intelligence and/or image processing Practical experience with Python programming. Experience with medical datasets, including imaging, clinical reports and/or radtiotherapy. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs at The ICR, more information can be found here. Department/Directorate Information Computational Imaging Group The Blackledge Lab is based at the Institute of Cancer Research (ICR) in London, England. The lab was founded in 2019 with a focus on understanding the interface between medical imaging and computational science in oncology. In particular they aim to develop techniques that monitor imaging changes that inform on patient response and toxicity following radiotherapy. Our enthusiastic team of scientists are passionate to translate their research into clinically practical solutions in order to ensure that patients can benefit from emerging computational techniques. We actively engage with commercial partners to transfer our research into clinical tools. The Division of Radiotherapy and Imaging The Division of Radiotherapy and Imaging is investigating new imaging methods to diagnose cancer, and ways in which advances in technology and molecular biology can improve radiation treatment. It is also increasingly concerned with the use of imaging to evaluate the response to treatment in vivo, through techniques measuring aspects of tumour biology. The ICR’s leading role in the development of intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) has helped to change the way that radiotherapy is provided in the UK and worldwide. Researchers in the division are also interested in developing ways of increasing the effectiveness of radiotherapy by combining it with other treatments – including targeted drugs or viral therapies. A major research focus is the development of multimodality imaging for evaluating response to treatment in vivo. Novel imaging techniques can provide non-invasive assessments of various facets of tumour biology such as tumour angiogenesis, cell proliferation and hypoxia. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Blackledge via Email on [email protected].