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Journal Articles

Ruiz, E.J. Diefenbacher, M.E. Nelson, J.K. Sancho, R. Pucci, F. Chakraborty, A. Moreno, P. Annibaldi, A. Liccardi, G. Encheva, V. Mitter, R. Rosenfeldt, M. Snijders, A.P. Meier, P. Calzado, M.A. Behrens, A. (2019). LUBAC determines chemotherapy resistance in squamous cell lung cancer. Journal of experimental medicine, Vol.216 (2), pp. 450-465.  show abstract

Messal, H.A. Alt, S. Ferreira, R.M. Gribben, C. Wang, V.M. Cotoi, C.G. Salbreux, G. Behrens, A. (2019). Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature, Vol.566 (7742), pp. 126-130.

Wang, V.M. Ferreira, R.M. Almagro, J. Evan, T. Legrave, N. Zaw Thin, M. Frith, D. Carvalho, J. Barry, D.J. Snijders, A.P. Herbert, E. Nye, E.L. MacRae, J.I. Behrens, A. (2019). CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth. Nature cell biology, Vol.21 (11), pp. 1425-1435.

Foster, H. Ruiz, E.J. Moore, C. Stamp, G.W. Nye, E.L. Li, N. Pan, Y. He, Y. Downward, J. Behrens, A. (2019). ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma. Cancer research, Vol.79 (20), pp. 5159-5166.

Khan, O.M. Carvalho, J. Spencer-Dene, B. Mitter, R. Frith, D. Snijders, A.P. Wood, S.A. Behrens, A. (2018). The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. Journal of clinical investigation, Vol.128 (4), pp. 1326-1337.

Ferreira, R.M. Sancho, R. Messal, H.A. Nye, E. Spencer-Dene, B. Stone, R.K. Stamp, G. Rosewell, I. Quaglia, A. Behrens, A. (2017). Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression. Cell reports, Vol.21 (4), pp. 966-978.

Cremona, C.A. Sancho, R. Diefenbacher, M.E. Behrens, A. (2016). Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance. Seminars in cancer biology, Vol.36, pp. 52-61.

Gruber, R. Panayiotou, R. Nye, E. Spencer-Dene, B. Stamp, G. Behrens, A. (2016). YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling. Gastroenterology, Vol.151 (3), pp. 526-539.

Blaas, L. Pucci, F. Messal, H.A. Andersson, A.B. Josue Ruiz, E. Gerling, M. Douagi, I. Spencer-Dene, B. Musch, A. Mitter, R. Bhaw, L. Stone, R. Bornhorst, D. Sesay, A.K. Jonkers, J. Stamp, G. Malanchi, I. Toftgård, R. Behrens, A. (2016). Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours. Nature cell biology, Vol.18 (12), pp. 1346-1356.

Anjos-Afonso, F. Loizou, J.I. Bradburn, A. Kanu, N. Purewal, S. Da Costa, C. Bonnet, D. Behrens, A. (2016). Perturbed hematopoiesis in mice lacking ATMIN. Blood, Vol.128 (16), pp. 2017-2021.  show abstract

Kanu, N. Zhang, T. Burrell, R.A. Chakraborty, A. Cronshaw, J. DaCosta, C. Grönroos, E. Pemberton, H.N. Anderton, E. Gonzalez, L. Sabbioneda, S. Ulrich, H.D. Swanton, C. Behrens, A. (2016). RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene, Vol.35 (30), pp. 4009-4019.

Diefenbacher, M.E. Chakraborty, A. Blake, S.M. Mitter, R. Popov, N. Eilers, M. Behrens, A. (2015). Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer. Cancer research, Vol.75 (7), pp. 1181-1186.

Sancho, R. Cremona, C.A. Behrens, A. (2015). Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease. Embo reports, Vol.16 (5), pp. 571-581.

Chakraborty, A. Diefenbacher, M.E. Mylona, A. Kassel, O. Behrens, A. (2015). The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nature communications, Vol.6 (1).

Diefenbacher, M.E. Popov, N. Blake, S.M. Schülein-Völk, C. Nye, E. Spencer-Dene, B. Jaenicke, L.A. Eilers, M. Behrens, A. (2014). The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. Journal of clinical investigation, Vol.124 (8), pp. 3407-3418.

Penicud, K. Behrens, A. (2014). DMAP1 is an essential regulator of ATM activity and function. Oncogene, Vol.33 (4), pp. 525-531.

Behrens, A. van Deursen, J.M. Rudolph, K.L. Schumacher, B. (2014). Impact of genomic damage and ageing on stem cell function. Nature cell biology, Vol.16 (3), pp. 201-207.

Sancho, R. Gruber, R. Gu, G. Behrens, A. (2014). Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells. Cell stem cell, Vol.15 (2), pp. 139-153.

Zhang, T. Cronshaw, J. Kanu, N. Snijders, A.P. Behrens, A. (2014). UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. Proceedings of the national academy of sciences, Vol.111 (33), pp. 12091-12096.

Davies, C.C. Chakraborty, A. Diefenbacher, M.E. Skehel, M. Behrens, A. (2013). Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. Embo j, Vol.32 (11), pp. 1556-1567.  show abstract

Sancho, R. Blake, S.M. Tendeng, C. Clurman, B.E. Lewis, J. Behrens, A. (2013). Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. Plos biol, Vol.11 (6), p. e1001586.  show abstract

Fontana, X. Hristova, M. Da Costa, C. Patodia, S. Thei, L. Makwana, M. Spencer-Dene, B. Latouche, M. Mirsky, R. Jessen, K.R. Klein, R. Raivich, G. Behrens, A. (2012). c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. Journal of cell biology, Vol.198 (1), pp. 127-141.  show abstract

Zhang, T. Penicud, K. Bruhn, C. Loizou, J.I. Kanu, N. Wang, Z.-. Behrens, A. (2012). Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice. Cell reports, Vol.2 (6), pp. 1498-1504.

Aguilera, C. Nakagawa, K. Sancho, R. Chakraborty, A. Hendrich, B. Behrens, A. (2011). c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Nature, Vol.469 (7329), pp. 231-235.

Loizou, J.I. Sancho, R. Kanu, N. Bolland, D.J. Yang, F. Rada, C. Corcoran, A.E. Behrens, A. (2011). ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma. Cancer cell, Vol.19 (5), pp. 587-600.

Jandke, A. Da Costa, C. Sancho, R. Nye, E. Spencer-Dene, B. Behrens, A. (2011). The F-box protein Fbw7 is required for cerebellar development. Developmental biology, Vol.358 (1), pp. 201-212.

Da Costa, C.R. Villadiego, J. Sancho, R. Fontana, X. Packham, G. Nateri, A.S. Behrens, A. (2010). Bag1-L Is a Phosphorylation-Dependent Coactivator of c-Jun during Neuronal Apoptosis. Molecular and cellular biology, Vol.30 (15), pp. 3842-3852.  show abstract

Sancho, R. Jandke, A. Davis, H. Diefenbacher, M.E. Tomlinson, I. Behrens, A. (2010). F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor. Gastroenterology, Vol.139 (3), pp. 929-941.

Davies, C.C. Chakraborty, A. Cipriani, F. Haigh, K. Haigh, J.J. Behrens, A. (2010). Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. Nature cell biology, Vol.12 (10), pp. 963-972.

Hoeck, J.D. Jandke, A. Blake, S.M. Nye, E. Spencer-Dene, B. Brandner, S. Behrens, A. (2010). Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nature neuroscience, Vol.13 (11), pp. 1365-1372.

Kanu, N. Penicud, K. Hristova, M. Wong, B. Irvine, E. Plattner, F. Raivich, G. Behrens, A. (2010). The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain*. Journal of biological chemistry, Vol.285 (49), pp. 38534-38542.

Blake, S.M. Stricker, S.H. Halavach, H. Poetsch, A.R. Cresswell, G. Kelly, G. Kanu, N. Marino, S. Luscombe, N.M. Pollard, S.M. Behrens, A. Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation. Elife, Vol.5.  show abstract

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