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Fearon, D., Westwood, I.M., van Montfort, R.L., Bayliss, R., Jones, K. & Bavetsias, V. (2018). Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorg med chem, Vol.26 (11), pp. 3021-3029.  show abstract

van Montfort, R.L. & Workman, P. (2017). Structure-based drug design: aiming for a perfect fit. Essays biochem, Vol.61 (5), pp. 431-437.  show abstract

Cheeseman, M.D., Chessum, N.E., Rye, C.S., Pasqua, A.E., Tucker, M.J., Wilding, B., Evans, L.E., Lepri, S., Richards, M., Sharp, S.Y., et al. (2017). Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J med chem, Vol.60 (1), pp. 180-201.  show abstract

McGrath, S., Tortorici, M., Drouin, L., Solanki, S., Vidler, L., Westwood, I., Gimeson, P., Van Montfort, R. & Hoelder, S. (2017). Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1. Chemistry, Vol.23 (40), pp. 9577-9584.  show abstract

Pettinger, J., Le Bihan, Y.-., Widya, M., van Montfort, R.L., Jones, K. & Cheeseman, M.D. (2017). An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew chem int ed engl, Vol.56 (13), pp. 3536-3540.  show abstract

Pettinger, J., Le Bihan, Y.-., Widya, M., van Montfort, R.L., Jones, K. & Cheeseman, M.D. (2017). An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angewandte chemie-international edition, Vol.56 (13), pp. 3536-3540.

Faisal, A., Mak, G.W., Gurden, M.D., Xavier, C.P., Anderhub, S.J., Innocenti, P., Westwood, I.M., Naud, S., Hayes, A., Box, G., et al. (2017). Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. Br j cancer, Vol.116 (9), pp. 1166-1176.  show abstract

Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., et al. (2016). A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci rep, Vol.6, p. 34701.  show abstract

Rankin, S.S., Caldwell, J.J., Cronin, N.B., van Montfort, R.L. & Collins, I. (2016). Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction. European j org chem, Vol.2016 (26), pp. 4496-4507.  show abstract

Tisi, D., Chiarparin, E., Tamanini, E., Pathuri, P., Coyle, J.E., Hold, A., Holding, F.P., Amin, N., Martin, A.C., Rich, S.J., et al. (2016). Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. Acs chem biol, Vol.11 (11), pp. 3093-3105.  show abstract

Bavetsias, V., Lanigan, R.M., Ruda, G.F., Atrash, B., McLaughlin, M.G., Tumber, A., Mok, N.Y., Le Bihan, Y.-., Dempster, S., Boxall, K.J., et al. (2016). 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J med chem, Vol.59 (4), pp. 1388-1409.  show abstract

Cheeseman, M.D., Westwood, I.M., Barbeau, O., Rowlands, M., Dobson, S., Jones, A.M., Jeganathan, F., Burke, R., Kadi, N., Workman, P., et al. (2016). Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. J med chem, Vol.59 (10), pp. 4625-4636.  show abstract

Innocenti, P., Woodward, H.L., Solanki, S., Naud, S., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., et al. (2016). Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. J med chem, Vol.59 (8), pp. 3671-3688.  show abstract

Loveday, C., Tatton-Brown, K., Clarke, M., Westwood, I., Renwick, A., Ramsay, E., Nemeth, A., Campbell, J., Joss, S., Gardner, M., et al. (2015). Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth. Hum mol genet, Vol.24 (17), pp. 4775-4779.  show abstract

Gurden, M.D., Westwood, I.M., Faisal, A., Naud, S., Cheung, K.-., McAndrew, C., Wood, A., Schmitt, J., Boxall, K., Mak, G., et al. (2015). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer res, Vol.75 (16), pp. 3340-3354.  show abstract

Cheeseman, M.D., Faisal, A., Rayter, S., Barbeau, O.R., Kalusa, A., Westlake, M., Burke, R., Swan, M., van Montfort, R., Linardopoulos, S., et al. (2014). Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg med chem lett, Vol.24 (15), pp. 3469-3474.  show abstract

Tatton-Brown, K., Seal, S., Ruark, E., Harmer, J., Ramsay, E., Del Vecchio Duarte, S., Zachariou, A., Hanks, S., O'Brien, E., Aksglaede, L., et al. (2014). Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability. Nat genet, Vol.46 (4), pp. 385-388.  show abstract

Tatton-Brown, K., Seal, S., Ruark, E., Harmer, J., Ramsay, E., Duarte, S.D., Zachariou, A., Hanks, S., O'Brien, E., Aksglaede, L., et al. (2014). Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability (vol 46, pg 385, 2014). Nature genetics, Vol.46 (6), pp. 657-657.

Workman, P. & van Montfort, R. (2014). EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence. Cancer discov, Vol.4 (6), pp. 642-645.  show abstract

Tatton-Brown, K., Seal, S., Ruark, E., Harmer, J., Ramsay, E., Del Vecchio Duarte, S., Zachariou, A., Hanks, S., O'Brien, E., Aksglaede, L., et al. (2014). Corrigendum: Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability. Nat genet, Vol.46 (6), p. 657.

Newbatt, Y., Hardcastle, A., McAndrew, P.C., Strover, J.A., Mirza, A., Morgan, G.J., Burke, R., Davies, F.E., Collins, I. & van Montfort, R.L., et al. (2013). Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay. J biomol screen, Vol.18 (3), pp. 298-308.  show abstract

Allen, C.E., Chow, C.L., Caldwell, J.J., Westwood, I.M., van Montfort, R.L. & Collins, I. (2013). Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg med chem, Vol.21 (18), pp. 5707-5724.  show abstract

Langdon, S.R., Westwood, I.M., van Montfort, R.L., Brown, N. & Blagg, J. (2013). Scaffold-focused virtual screening: prospective application to the discovery of TTK inhibitors. J chem inf model, Vol.53 (5), pp. 1100-1112.  show abstract

Couty, S., Westwood, I.M., Kalusa, A., Cano, C., Travers, J., Boxall, K., Chow, C.L., Burns, S., Schmitt, J., Pickard, L., et al. (2013). The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, Vol.4, pp. 1-15.  show abstract

Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Cheung, K.M., Liu, M., Hayes, A., Schmitt, J., et al. (2013). Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of the mitotic kinase monopolar spindle 1 (MPS1). J med chem, Vol.56, pp. 10045-10065.

Newbatt, Y., Hardcastle, A., McAndrew, P.C., Strover, J.A., Mirza, A., Morgan, G.J., Burke, R., Davies, F.E., Collins, I. & van Montfort, R.L., et al. (2013). Identification of Autophosphorylation Inhibitors of the Inositol-Requiring Enzyme 1 Alpha (IRE1 alpha) by High-Throughput Screening Using a DELFIA Assay. Journal of biomolecular screening, Vol.18 (3), pp. 298-308.

Silva-Santisteban, M.C., Westwood, I.M., Boxall, K., Brown, N., Peacock, S., McAndrew, C., Barrie, E., Richards, M., Mirza, A., Oliver, A.W., et al. (2013). Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. Plos one, Vol.8 (6), p. e65689.  show abstract

Faisal, A., Naud, S., Schmitt, J., Westwood, I., Hayes, A., Gurden, M., Bavetsias, V., Berry, T., Mak, G., Innocenti, P., et al. (2012). Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor. Cancer research, Vol.72.

Matijssen, C., Silva-Santisteban, M.C., Westwood, I.M., Siddique, S., Choi, V., Sheldrake, P., van Montfort, R.L. & Blagg, J. (2012). Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography. Bioorg med chem, Vol.20 (22), pp. 6630-6639.  show abstract

Barillari, C., Duncan, A.L., Westwood, I.M., Blagg, J. & van Montfort, R.L. (2011). Analysis of water patterns in protein kinase binding sites. Proteins, Vol.79 (7), pp. 2109-2121.  show abstract

Reader, J.C., Matthews, T.P., Klair, S., Cheung, K.-., Scanlon, J., Proisy, N., Addison, G., Ellard, J., Piton, N., Taylor, S., et al. (2011). Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J med chem, Vol.54 (24), pp. 8328-8342.  show abstract

Solanki, S., Innocenti, P., Mas-Droux, C., Boxall, K., Barillari, C., van Montfort, R.L., Aherne, G.W., Bayliss, R. & Hoelder, S. (2011). Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship. J med chem, Vol.54 (6), pp. 1626-1639.  show abstract

Workman, P. & van Montfort, R.L. (2010). PI(3) KINASES Revealing the delta lady. Nat chem biol, Vol.6 (2), pp. 82-83.

Workman, P. & van Montfort, R.L. (2010). Revealing the delta lady (vol 6, pg 82, 2010). Nat chem biol, Vol.6 (4), pp. 306-306.

Whelligan, D.K., Solanki, S., Taylor, D., Thomson, D.W., Cheung, K.-., Boxall, K., Mas-Droux, C., Barillari, C., Burns, S., Grummitt, C.G., et al. (2010). Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J med chem, Vol.53 (21), pp. 7682-7698.  show abstract

Powers, M.V., Jones, K., Barillari, C., Westwood, I., van Montfort, R.L. & Workman, P. (2010). Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?. Cell cycle, Vol.9 (8).  show abstract

Workman, P., Clarke, P.A., Raynaud, F.I. & van Montfort, R.L. (2010). Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer res, Vol.70 (6), pp. 2146-2157.  show abstract

Matthews, T.P., McHardy, T., Klair, S., Boxall, K., Fisher, M., Cherry, M., Allen, C.E., Addison, G.J., Ellard, J., Aherne, G.W., et al. (2010). Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorg med chem lett, Vol.20 (14), pp. 4045-4049.  show abstract

Workman, P. & van Montfort, R.L. (2010). Unveiling the secrets of the ancestral PI3 kinase Vps34. Cancer cell, Vol.17 (5), pp. 421-423.  show abstract

van Montfort, R.L. & Workman, P. (2009). Structure-based design of molecular cancer therapeutics. Trends biotechnol, Vol.27 (5), pp. 315-328.  show abstract

van Montfort, R.L. & Collins, I. (2009). Fragment-Based Methods in Drug Discovery: It's the Small Things that Matter. Curr top med chem, Vol.9 (18), pp. 1676-1677.

Matthews, T.P., Klair, S., Burns, S., Boxall, K., Cherry, M., Fisher, M., Westwood, I.M., Walton, M.I., McHardy, T., Cheung, K.-., et al. (2009). Identification of inhibitors of checkpoint kinase 1 through template screening. J med chem, Vol.52 (15), pp. 4810-4819.  show abstract

Westwood, I., Cheary, D.-., Baxter, J.E., Richards, M.W., van Montfort, R.L., Fry, A.M. & Bayliss, R. (2009). Insights into the conformational variability and regulation of human Nek2 kinase. J mol biol, Vol.386 (2), pp. 476-485.  show abstract

Howard, N., Abell, C., Blakemore, W., Chessari, G., Congreve, M., Howard, S., Jhoti, H., Murray, C.W., Seavers, L.C. & van Montfort, R.L., et al. (2006). Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J med chem, Vol.49 (4), pp. 1346-1355.  show abstract

Van Montfort, R.L., Bateman, O.A., Lubsen, N.H. & Slingsby, C. (2003). Crystal structure of truncated human beta B1-crystallin. Protein sci, Vol.12 (11), pp. 2606-2612.  show abstract

van Montfort, R.L., Congreve, M., Tisi, D., Carr, R. & Jhoti, H. (2003). Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature, Vol.423 (6941), pp. 773-777.  show abstract

Bateman, O.A., Purkiss, A.G., van Montfort, R., Slingsby, C., Graham, C. & Wistow, G. (2003). Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry, Vol.42 (15), pp. 4349-4356.  show abstract

van Montfort, R.L., Basha, E., Friedrich, K.L., Slingsby, C. & Vierling, E. (2001). Crystal structure and assembly of a eukaryotic small heat shock protein. Nat struct biol, Vol.8 (12), pp. 1025-1030.

Van Montfort, R., Slingsby, C. & Vierling, E. (2001). Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones. Adv protein chem, Vol.59, pp. 105-156.

Van Montfort, R.L. & Dijkstra, B.W. (1998). The functional importance of structural differences between the mannitol-specific IIA(mannitol) and the regulatory IIA(nitrogen). Protein sci, Vol.7 (10), pp. 2210-2216.  show abstract

van Montfort, R.L., Pijning, T., Kalk, K.H., Hangyi, I., Kouwijzer, M.L., Robillard, G.T. & Dijkstra, B.W. (1998). The structure of the Escherichia coli phosphotransferase IIA(mannitol) reveals a novel fold with two conformations of the active site. Structure, Vol.6 (3), pp. 377-388.  show abstract

vanMontfort, R.L., Pijning, T., Kalk, K.H., Reizer, J., Saier, M.H., Thunnissen, M.M., Robillard, G.T. & Dijkstra, B.W. (1997). The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases. Structure, Vol.5 (2), pp. 217-225.  show abstract

Dijkstra, B.W. & vanMontfort, R.L. (1996). Structure and function of PEP-dependent sugar transport systems. Prog biophys mol bio, Vol.65, pp. SA103-SA103.

VANMONTFORT, R., PIJNING, T., KALK, K., SCHUURMANWOLTERS, G., REIZER, J., SAIER, M., ROBILLARD, G. & DIJKSTRA, B. (1994). CRYSTALLIZATION OF ENZYME IIB OF THE CELLOBIOSE-SPECIFIC PHOSPHOTRANSFERASE SYSTEM OF ESCHERICHIA-COLI. J mol biol, Vol.239 (4), pp. 588-590.

Lawson, C.L., van Montfort, R., Strokopytov, B., Rozeboom, H.J., Kalk, K.H., de Vries, G.E., Penninga, D., Dijkhuizen, L. & Dijkstra, B.W. (1994). Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form. J mol biol, Vol.236 (2), pp. 590-600.  show abstract

Osborne, J.D., Matthews, T.P., McHardy, T., Proisy, N., Cheung, K.-., Lainchbury, M., Brown, N., Walton, M.I., Eve, P.D., Boxall, K.J., et al. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J med chem, Vol.59 (11), pp. 5221-5237.  show abstract


Conferences

Pettinger, J., Cheeseman, M., Le Bihan, Y.-., Widya, M., van Montfort, R. & Jones, K. (2017). Design and synthesis of lysine-56 targeting covalent inhibitors of HSP72, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.253.

Gurden, M.D., Westwood, I., Faisal, A., Naud, S., Cheung, J., McAndrew, C., Wood, A., Schmitt, J., Boxall, K., Mak, G., et al. (2015). Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance, CANCER RESEARCH, Vol.75.

Innocenti, P., Woodward, H., Cheung, K.-., Naud, S., Solanki, S., Westwood, I.M., Faisal, A., Hayes, A., Schmitt, J., Baker, R., et al. (2015). Structure enabled design of inhibitors of the mitotic kinase MPS1, CANCER RESEARCH, Vol.75.

Clarke, P.A., Roe, T., Swabey, K., McAndrew, C., Boxall, K., Westwood, I., van Montfort, R., Al-Lazikhani, B. & Workman, P. (2015). Resistance to ERK inhibitors as a result of an acquired novel P-loop mutation of ERK2, CANCER RESEARCH, Vol.75.

Faisal, A., Innocenti, P., Westwood, I., Naud, S., Schmitt, J., Hayes, A., Mak, G., Gurden, M., Bavetsias, V., Cheung, J., et al. (2013). CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor., CANCER RESEARCH, Vol.73 (8).

Congreve, M.S., Chessari, G., Davis, D.J., Howard, S., Van Montfort, R.L., Murray, C.W., Howard, N. & Abell, C. (2004). Development of potent inhibitors of thrombin derived by linking of fragments detected by screening using X-ray crystallography., Presented at 228th National Meeting of the American-Chemical-Society, Philadelphia, PA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.228, p.U954.

LAWSON, C.L., VANMONTFORT, R., STROKOPYTOV, B., ROZEBOOM, H.J., KALK, K.H., PENNINGA, D., DEVRIES, G., DIJKHUIZEN, L. & DIJKSTRA, B.W. (1992). PROTEIN ENGINEERING OF CYCLODEXTRIN GLYCOSYL TRANSFERASE (CGTASE) FROM BACILLUS-CIRCULANS STRAIN-251, Presented at 6TH INTERNATIONAL SYMP ON CYCLODEXTRINS, CHICAGO, IL. MINUTES OF THE SIXTH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS, , pp.53-58.

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