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Research Projects

Professor Rosalind Eeles, Oncogenetics Team

The Oncogenetics Team aims to translate laboratory findings about genetic risk factors for cancer into the clinic. Our focus is primarily on predisposition to prostate cancer. The laboratory component of the research programme involves the search for prostate cancer predisposition genes and studies of their mutation spectra, risks and interactions with environmental factors.

The clinical component of the research includes risk profiling, targeted screening, prevention and the application of cancer genetics to cancer management. There is close interaction with The Royal Marsden NHS Foundation Trust and, in addition to studies in the management of individuals with a predisposition to prostate cancer, there is a research programme in genetic counselling and integration of cancer genetics into the cancer care pathway extending all the way from primary to tertiary care. We have established collaborations with primary care to effect studies in the community.

We have established a uro-genetics clinic to investigate the application of genetic research in prostate cancer predisposition to the clinic. This is in addition to specialised prostate cancer predisposition risk clinic for the translational research into and management of men with mutations in the genes BRCA1, BRCA2 and Lynch Syndrome.  The prostate cancer risk clinic will shortly be expanded to include new studies in genetic panel testing and its application.

The team also coordinates a number of psychosocial studies evaluating the impact of genetics and screening on men at high risk of prostate cancer.


An evaluation of integrating germline genetic testing into the management of men at risk of / living with prostate cancer.

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The Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium was established in September 2008. It is formed by a collaborative group of researchers interested in inherited risk of prostate cancer with the goal of identifying genes that may be related to the risk of prostate cancer.

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The UK Genetic Prostate Cancer Study (UKGPCS)

This study is looking into genetic predisposition to prostate cancer. Find out more about how a family history of the disease can increase a man’s risk of prostate cancer.

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This study aims to look at early methods of detection of prostate cancer in men who have inherited a higher-risk gene thought to increase their risk of developing this disease .

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A study to investigate the role of targeted prostate cancer screening in men with a family history of the disease.

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This study observes the outcomes after prostate cancer diagnosis and treatment in carriers of rare germline mutations in cancer predisposition genes.

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An observation study for men affected with a BRCA gene mutation who have developed prostate cancer.

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Investigates the role of genetic profiling for risk of prostate cancer in men from the general population - targeting population screening.

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A single arm treatment study for men with prostate cancer. This study investigates how having genetic changes in DNA repair genes can affect response to treatment.

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The Institute of Cancer Research in collaboration with The Royal Marsden NHS Foundation Trust.

With funding from: