The Houlston Group has a primary interest in using genetic approaches to understand a genetic background underlying susceptibility and pathogenesis of human malignancies.
The research of the group focuses on the following strands:
- Susceptibility gene identification in cancer using large-scale genetic and genomic approaches. We are involved in the major international efforts exploiting large-scale genome wide association and next-generation sequencing efforts to map variants impacting on cancer predisposition
- Translating gene identification into biological insights and clinical advances. We use complementary approaches involving human, animal models and cellular systems to define the biological and clinical consequences of discoveries.
- Genomic epidemiology. Integrating genetic and other data to advance understanding of basic genomic processes.
- Statistical genetics and bioinformatics. Implementation of new approaches to tackle associated analytical challenges.
- Our recent research has made a major contribution to advances in the understanding of the genetic basis of cancer and our work has featured in over 50 papers published in Nature Genetics, Nature and Science.