Professor Paul Workman’s Team is a key part of the Cancer Research UK Cancer Therapeutics Unit and focuses on the mechanisms of molecular cancer therapies.
Professor Paul Workman is a passionate advocate of personalised molecular medicine, and is an enthusiastic practitioner of multidisciplinary cancer drug discovery and development approaches to ‘drugging the cancer genome’.
I am a cell biologist with experience in tumour biology and signal transduction. My role within our team is to use reverse translational approaches to investigate new candidate targets for drug discovery projects, with a particular focus on oesophageal cancer.
I am interested in identifying new targeted treatments of cancer and understanding the mechanism of anticancer drugs. I set up CRISPR/Cas9 pooled screening technology in the lab, and am looking at EML4-ALK variant-specific synthetic lethal partners of HSP90 inhibitors and the sensitivity of lung cancer cells to cytotoxic NK cells.
As part of a collaboration with a Pharma partner my research focusses on the therapeutic targeting of the regulation of protein synthesis initiation. I will use molecular biochemical and cellular techniques to further define the potential for inhibiting protein synthesis initiation as a therapeutic strategy in cancer.
I have expertise in the genetic manipulation of cells, alongside the use of chemical tools to determine the molecular pharmacology of novel therapeutic agents and the identification of mechanistic and predictive biomarkers. My research focuses on the therapeutic targeting of the cancer cell stress response and included the discovery of the clinically active HSP90 inhibitor luminespib (AUY922).
I am an experienced molecular and cell biologist, supporting the research aims of the team within the Cancer Therapeutics Unit. My research is currently focused on the discovery of inhibitors of RNA processing.
I am helping to identify and develop innovative targeted cancer drugs, and understand their molecular pharmacology and mechanism of action. I was involved in the discovery of HSP90 inhibitors, including luminespib (AUY922), which shows activity in drug-resistant breast and lung cancers. I am currently a member of a collaborative team with a Pharma partner identifying WNT-pathway inhibitors.
I am an experienced cell biologist funded by the Kidani trust to translate our team’s research into ovarian cancer models.
I have been involved in several drug development projects that discovered small molecule inhibitors of PI3K and WNT signalling. I am currently part of the project team developing inhibitors of the cancer cell stress response. My research focusses on gene expression profiling techniques to help understand the mechanism of action of compounds, molecular determinants of sensitivity and markers of drug response.
I am investigating the molecular biology of a new drug discovery target. My role is to uncover the mechanism and highlight the biological function of a target candidate that regulates mRNA processing, including new biomarkers for targeted cancer therapy. I aim to bring novel approaches to discoveries that can translate into highly effective therapeutic technologies.
I am focused on developing ways to overcome drug resistance acquired during cancer treatment. These include evaluating combinatorial therapies and targeting cancer evolution mechanisms with small molecules. I am experienced in drug target identification and verification using high-content screening. I am also developing new next-generation sequencing methodology and data analysis tools.