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Journal Articles

Bland, P. Saville, H. Wai, P.T. Curnow, L. Muirhead, G. Nieminuszczy, J. Ravindran, N. John, M.B. Hedayat, S. Barker, H.E. Wright, J. Yu, L. Mavrommati, I. Read, A. Peck, B. Allen, M. Gazinska, P. Pemberton, H.N. Gulati, A. Nash, S. Noor, F. Guppy, N. Roxanis, I. Pratt, G. Oldreive, C. Stankovic, T. Barlow, S. Kalirai, H. Coupland, S.E. Broderick, R. Alsafadi, S. Houy, A. Stern, M.-. Pettit, S. Choudhary, J.S. Haider, S. Niedzwiedz, W. Lord, C.J. Natrajan, R. (2023). SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. , Vol.55 (8), pp. 1311-1323.  show abstract

Nieminuszczy, J. Martin, P.R. Broderick, R. Krwawicz, J. Kanellou, A. Mocanu, C. Bousgouni, V. Smith, C. Wen, K.-. Woodward, B.L. Bakal, C. Shackley, F. Aguilera, A. Stewart, G.S. Vyas, Y.M. Niedzwiedz, W. (2023). Actin nucleators safeguard replication forks by limiting nascent strand degradation. , Vol.51 (12), pp. 6337-6354.  show abstract

Sandoz, J. Cigrang, M. Zachayus, A. Catez, P. Donnio, L.-. Elly, C. Nieminuszczy, J. Berico, P. Braun, C. Alekseev, S. Egly, J.-. Niedzwiedz, W. Giglia-Mari, G. Compe, E. Coin, F. (2023). Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress. , Vol.14 (1), p. 341.  show abstract

Broderick, R. Cherdyntseva, V. Nieminuszczy, J. Dragona, E. Kyriakaki, M. Evmorfopoulou, T. Gagos, S. Niedzwiedz, W. (2023). Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity. , Vol.14 (1), p. 2428.  show abstract

Llorca-Cardenosa, M.J. Aronson, L.I. Krastev, D.B. Nieminuszczy, J. Alexander, J. Song, F. Dylewska, M. Broderick, R. Brough, R. Zimmermann, A. Zenke, F.T. Gurel, B. Riisnaes, R. Ferreira, A. Roumeliotis, T. Choudhary, J. Pettitt, S.J. de Bono, J. Cervantes, A. Haider, S. Niedzwiedz, W. Lord, C.J. Chong, I.Y. (2022). SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance. , Vol.82 (21), pp. 3962-3973.  show abstract

Hodson, C. van Twest, S. Dylewska, M. O'Rourke, J.J. Tan, W. Murphy, V.J. Walia, M. Abbouche, L. Nieminuszczy, J. Dunn, E. Bythell-Douglas, R. Heierhorst, J. Niedzwiedz, W. Deans, A.J. (2022). Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal. , Vol.41 (10), p. 111749.  show abstract

Kalogeropoulou, A. Mougkogianni, M. Iliadou, M. Nikolopoulou, E. Flordelis, S. Kanellou, A. Arbi, M. Nikou, S. Nieminuszczy, J. Niedzwiedz, W. Kardamakis, D. Bravou, V. Lygerou, Z. Taraviras, S. (2022). Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress. Stem cell reports, Vol.17 (6), pp. 1395-1410.

Han, S.-. Wen, K.-. García-Rubio, M.L. Wold, M.S. Aguilera, A. Niedzwiedz, W. Vyas, Y.M. (2022). WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. , Vol.13 (1), p. 3743.  show abstract

Nieminuszczy, J. Broderick, R. Bellani, M.A. Smethurst, E. Schwab, R.A. Cherdyntseva, V. Evmorfopoulou, T. Lin, Y.-. Minczuk, M. Pasero, P. Gagos, S. Seidman, M.M. Niedzwiedz, W. (2019). EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2. Molecular cell, Vol.75 (3), pp. 605-619.e6.  show abstract

Coquel, F. Silva, M.-. Técher, H. Zadorozhny, K. Sharma, S. Nieminuszczy, J. Mettling, C. Dardillac, E. Barthe, A. Schmitz, A.-. Promonet, A. Cribier, A. Sarrazin, A. Niedzwiedz, W. Lopez, B. Costanzo, V. Krejci, L. Chabes, A. Benkirane, M. Lin, Y.-. Pasero, P. (2018). SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature, Vol.557 (7703), pp. 57-61.

Sun, L. Huang, Y. Edwards, R.A. Yang, S. Blackford, A.N. Niedzwiedz, W. Glover, J.N. (2017). Structural Insight into BLM Recognition by TopBP1. Structure, Vol.25 (10), pp. 1582-1588.e3.

Broderick, R. Nieminuszczy, J. Baddock, H.T. Deshpande, R.A. Gileadi, O. Paull, T.T. McHugh, P.J. Niedzwiedz, W. (2016). EXD2 promotes homologous recombination by facilitating DNA end resection. Nature cell biology, Vol.18 (3), pp. 271-280.

Fenwick, A.L. Kliszczak, M. Cooper, F. Murray, J. Sanchez-Pulido, L. Twigg, S.R. Goriely, A. McGowan, S.J. Miller, K.A. Taylor, I.B. Logan, C. Bozdogan, S. Danda, S. Dixon, J. Elsayed, S.M. Elsobky, E. Gardham, A. Hoffer, M.J. Koopmans, M. McDonald-McGinn, D.M. Santen, G.W. Savarirayan, R. de Silva, D. Vanakker, O. Wall, S.A. Wilson, L.C. Yuregir, O.O. Zackai, E.H. Ponting, C.P. Jackson, A.P. Wilkie, A.O. Niedzwiedz, W. Bicknell, L.S. (2016). Mutations in CDC45 , Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis. The american journal of human genetics, Vol.99 (1), pp. 125-138.

Nieminuszczy, J. Broderick, R. Niedzwiedz, W. (2016). EXD2 - a new player joins the DSB resection team. Cell cycle, Vol.15 (12), pp. 1519-1520.

Higgs, M.R. Reynolds, J.J. Winczura, A. Blackford, A.N. Borel, V. Miller, E.S. Zlatanou, A. Nieminuszczy, J. Ryan, E.L. Davies, N.J. Stankovic, T. Boulton, S.J. Niedzwiedz, W. Stewart, G.S. (2015). BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Molecular cell, Vol.59 (3), pp. 462-477.

Schwab, R.A. Nieminuszczy, J. Shah, F. Langton, J. Lopez Martinez, D. Liang, C.-. Cohn, M.A. Gibbons, R.J. Deans, A.J. Niedzwiedz, W. (2015). The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription. Molecular cell, Vol.60 (3), pp. 351-361.

Broderick, R. Nieminuszczy, J. Blackford, A.N. Winczura, A. Niedzwiedz, W. (2015). TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution. Nature communications, Vol.6, pp. 6572-?.  show abstract

Blackford, A.N. Nieminuszczy, J. Schwab, R.A. Galanty, Y. Jackson, S.P. Niedzwiedz, W. (2015). TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Molecular cell, Vol.57 (6), pp. 1133-1141.  show abstract

Lai, X. Broderick, R. Bergoglio, V. Zimmer, J. Badie, S. Niedzwiedz, W. Hoffmann, J.-. Tarsounas, M. MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. Nature communications, Vol.8 (1).  show abstract

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