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Bland, P. Saville, H. Wai, P.T. Curnow, L. Muirhead, G. Nieminuszczy, J. Ravindran, N. John, M.B. Hedayat, S. Barker, H.E. Wright, J. Yu, L. Mavrommati, I. Read, A. Peck, B. Allen, M. Gazinska, P. Pemberton, H.N. Gulati, A. Nash, S. Noor, F. Guppy, N. Roxanis, I. Pratt, G. Oldreive, C. Stankovic, T. Barlow, S. Kalirai, H. Coupland, S.E. Broderick, R. Alsafadi, S. Houy, A. Stern, M.-. Pettit, S. Choudhary, J.S. Haider, S. Niedzwiedz, W. Lord, C.J. Natrajan, R. (2023). SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. Nat genet, Vol.55 (8), pp. 1311-1323.  show abstract

Thakur, S. Haider, S. Natrajan, R. (2023). Implications of tumour heterogeneity on cancer evolution and therapy resistance: lessons from breast cancer. J pathol, Vol.260 (5), pp. 621-636.  show abstract

Mansur, M.B. deSouza, N.M. Natrajan, R. Abegglen, L.M. Schiffman, J.D. Greaves, M. (2023). Evolutionary determinants of curability in cancer. Nat ecol evol, Vol.7 (11), pp. 1761-1770.  show abstract

Alexander, J. Mariani, O. Meaudre, C. Fuhrmann, L. Xiao, H. Naidoo, K. Gillespie, A. Roxanis, I. Vincent-Salomon, A. Haider, S. Natrajan, R. (2022). Assessment of the Molecular Heterogeneity of E-Cadherin Expression in Invasive Lobular Breast Cancer. Cancers (basel), Vol.14 (2).  show abstract

Khalique, S. Nash, S. Natrajan, R. (2022). Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis-related ovarian cancers‡. J pathol, Vol.258 (1), pp. 1-3.  show abstract

Gómez-Cuadrado, L. Bullock, E. Mabruk, Z. Zhao, H. Souleimanova, M. Noer, P.R. Turnbull, A.K. Oxvig, C. Bertos, N. Byron, A. Dixon, J.M. Park, M. Haider, S. Natrajan, R. Sims, A.H. Brunton, V.G. (2022). Characterisation of the Stromal Microenvironment in Lobular Breast Cancer. Cancers (basel), Vol.14 (4).  show abstract

Stevenson, J. Barrow-McGee, R. Yu, L. Paul, A. Mansfield, D. Owen, J. Woodman, N. Natrajan, R. Haider, S. Gillett, C. Tutt, A. Pinder, S.E. Choudary, J. Naidoo, K. (2021). Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment. Npj breast cancer, Vol.7 (1), p. 24.  show abstract

Banerjee, S. Stewart, J. Porta, N. Toms, C. Leary, A. Lheureux, S. Khalique, S. Tai, J. Attygalle, A. Vroobel, K. Lord, C.J. Natrajan, R. Bliss, J. (2021). ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI). Int j gynecol cancer, Vol.31 (11), pp. 1471-1475.  show abstract

Peck, B. Bland, P. Mavrommati, I. Muirhead, G. Cottom, H. Wai, P.T. Maguire, S.L. Barker, H.E. Morrison, E. Kriplani, D. Yu, L. Gibson, A. Falgari, G. Brennan, K. Farnie, G. Buus, R. Marlow, R. Novo, D. Knight, E. Guppy, N. Kolarevic, D. Susnjar, S. Milijic, N.M. Naidoo, K. Gazinska, P. Roxanis, I. Pancholi, S. Martin, L.-. Holgersen, E.M. Cheang, M.C. Noor, F. Postel-Vinay, S. Quinn, G. McDade, S. Krasny, L. Huang, P. Daley, F. Wallberg, F. Choudhary, J.S. Haider, S. Tutt, A.N. Natrajan, R. (2021). 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer. Cancer res, Vol.81 (4), pp. 847-859.  show abstract

Mavrommati, I. Johnson, F. Echeverria, G.V. Natrajan, R. (2021). Subclonal heterogeneity and evolution in breast cancer. Npj breast cancer, Vol.7 (1), p. 155.  show abstract

Khalique, S. Nash, S. Mansfield, D. Wampfler, J. Attygale, A. Vroobel, K. Kemp, H. Buus, R. Cottom, H. Roxanis, I. Jones, T. von Loga, K. Begum, D. Guppy, N. Ramagiri, P. Fenwick, K. Matthews, N. Hubank, M.J. Lord, C.J. Haider, S. Melcher, A. Banerjee, S. Natrajan, R. (2021). Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma. Cancers (basel), Vol.13 (15).  show abstract

Khalique, S. Pettitt, S.J. Kelly, G. Tunariu, N. Natrajan, R. Banerjee, S. Lord, C.J. (2020). Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR. J pathol clin res, Vol.6 (1), pp. 3-11.  show abstract

Nagarajan, S. Rao, S.V. Sutton, J. Cheeseman, D. Dunn, S. Papachristou, E.K. Prada, J.-. Couturier, D.-. Kumar, S. Kishore, K. Chilamakuri, C.S. Glont, S.-. Archer Goode, E. Brodie, C. Guppy, N. Natrajan, R. Bruna, A. Caldas, C. Russell, A. Siersbæk, R. Yusa, K. Chernukhin, I. Carroll, J.S. (2020). ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat genet, Vol.52 (2), pp. 187-197.  show abstract

Barrow-McGee, R. Procter, J. Owen, J. Woodman, N. Lombardelli, C. Kothari, A. Kovacs, T. Douek, M. George, S. Barry, P.A. Ramsey, K. Gibson, A. Buus, R. Holgersen, E. Natrajan, R. Haider, S. Shattock, M.J. Gillett, C. Tutt, A.N. Pinder, S.E. Naidoo, K. (2020). Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study. J pathol, Vol.250 (3), pp. 262-274.  show abstract

Khalique, S. Lord, C.J. Banerjee, S. Natrajan, R. (2020). Translational genomics of ovarian clear cell carcinoma. Semin cancer biol, Vol.61, pp. 121-131.  show abstract

Clarke, M. Mackay, A. Ismer, B. Pickles, J.C. Tatevossian, R.G. Newman, S. Bale, T.A. Stoler, I. Izquierdo, E. Temelso, S. Carvalho, D.M. Molinari, V. Burford, A. Howell, L. Virasami, A. Fairchild, A.R. Avery, A. Chalker, J. Kristiansen, M. Haupfear, K. Dalton, J.D. Orisme, W. Wen, J. Hubank, M. Kurian, K.M. Rowe, C. Maybury, M. Crosier, S. Knipstein, J. Schüller, U. Kordes, U. Kram, D.E. Snuderl, M. Bridges, L. Martin, A.J. Doey, L.J. Al-Sarraj, S. Chandler, C. Zebian, B. Cairns, C. Natrajan, R. Boult, J.K. Robinson, S.P. Sill, M. Dunkel, I.J. Gilheeney, S.W. Rosenblum, M.K. Hughes, D. Proszek, P.Z. Macdonald, T.J. Preusser, M. Haberler, C. Slavc, I. Packer, R. Ng, H.-. Caspi, S. Popović, M. Faganel Kotnik, B. Wood, M.D. Baird, L. Davare, M.A. Solomon, D.A. Olsen, T.K. Brandal, P. Farrell, M. Cryan, J.B. Capra, M. Karremann, M. Schittenhelm, J. Schuhmann, M.U. Ebinger, M. Dinjens, W.N. Kerl, K. Hettmer, S. Pietsch, T. Andreiuolo, F. Driever, P.H. Korshunov, A. Hiddingh, L. Worst, B.C. Sturm, D. Zuckermann, M. Witt, O. Bloom, T. Mitchell, C. Miele, E. Colafati, G.S. Diomedi-Camassei, F. Bailey, S. Moore, A.S. Hassall, T.E. Lowis, S.P. Tsoli, M. Cowley, M.J. Ziegler, D.S. Karajannis, M.A. Aquilina, K. Hargrave, D.R. Carceller, F. Marshall, L.V. von Deimling, A. Kramm, C.M. Pfister, S.M. Sahm, F. Baker, S.J. Mastronuzzi, A. Carai, A. Vinci, M. Capper, D. Popov, S. Ellison, D.W. Jacques, T.S. Jones, D.T. Jones, C. (2020). Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes. Cancer discov, Vol.10 (7), pp. 942-963.  show abstract

Krasny, L. Bland, P. Burns, J. Lima, N.C. Harrison, P.T. Pacini, L. Elms, M.L. Ning, J. Martinez, V.G. Yu, Y.-. Acton, S.E. Ho, P.-. Calvo, F. Swain, A. Howard, B.A. Natrajan, R.C. Huang, P.H. (2020). A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts. Dis model mech, Vol.13 (7).  show abstract

Yap, T.A. O'Carrigan, B. Penney, M.S. Lim, J.S. Brown, J.S. de Miguel Luken, M.J. Tunariu, N. Perez-Lopez, R. Rodrigues, D.N. Riisnaes, R. Figueiredo, I. Carreira, S. Hare, B. McDermott, K. Khalique, S. Williamson, C.T. Natrajan, R. Pettitt, S.J. Lord, C.J. Banerji, U. Pollard, J. Lopez, J. de Bono, J.S. (2020). Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors. J clin oncol, Vol.38 (27), pp. 3195-3204.  show abstract

Dalton, W.B. Helmenstine, E. Walsh, N. Gondek, L.P. Kelkar, D.S. Read, A. Natrajan, R. Christenson, E.S. Roman, B. Das, S. Zhao, L. Leone, R.D. Shinn, D. Groginski, T. Madugundu, A.K. Patil, A. Zabransky, D.J. Medford, A. Lee, J. Cole, A.J. Rosen, M. Thakar, M. Ambinder, A. Donaldson, J. DeZern, A.E. Cravero, K. Chu, D. Madero-Marroquin, R. Pandey, A. Hurley, P.J. Lauring, J. Park, B.H. (2019). Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. J clin invest, Vol.129 (11), pp. 4708-4723.  show abstract

Naidoo, K. Wai, P.T. Maguire, S.L. Daley, F. Haider, S. Kriplani, D. Campbell, J. Mirza, H. Grigoriadis, A. Tutt, A. Moseley, P.M. Abdel-Fatah, T.M. Chan, S.Y. Madhusudan, S. Rhaka, E.A. Ellis, I.O. Lord, C.J. Yuan, Y. Green, A.R. Natrajan, R. (2018). Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer. Mol cancer ther, Vol.17 (1), pp. 306-315.  show abstract

Barry, P. Vatsiou, A. Spiteri, I. Nichol, D. Cresswell, G.D. Acar, A. Trahearn, N. Hrebien, S. Garcia-Murillas, I. Chkhaidze, K. Ermini, L. Huntingford, I.S. Cottom, H. Zabaglo, L. Koelble, K. Khalique, S. Rusby, J.E. Muscara, F. Dowsett, M. Maley, C.C. Natrajan, R. Yuan, Y. Schiavon, G. Turner, N. Sottoriva, A. (2018). The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer. Clin cancer res, Vol.24 (19), pp. 4763-4770.  show abstract

Bajrami, I. Marlow, R. van de Ven, M. Brough, R. Pemberton, H.N. Frankum, J. Song, F. Rafiq, R. Konde, A. Krastev, D.B. Menon, M. Campbell, J. Gulati, A. Kumar, R. Pettitt, S.J. Gurden, M.D. Cardenosa, M.L. Chong, I. Gazinska, P. Wallberg, F. Sawyer, E.J. Martin, L.-. Dowsett, M. Linardopoulos, S. Natrajan, R. Ryan, C.J. Derksen, P.W. Jonkers, J. Tutt, A.N. Ashworth, A. Lord, C.J. (2018). E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer. Cancer discov, Vol.8 (4), pp. 498-515.  show abstract

Khalique, S. Naidoo, K. Attygalle, A.D. Kriplani, D. Daley, F. Lowe, A. Campbell, J. Jones, T. Hubank, M. Fenwick, K. Matthews, N. Rust, A.G. Lord, C.J. Banerjee, S. Natrajan, R. (2018). Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers. J pathol clin res, Vol.4 (3), pp. 154-166.  show abstract

Krasny, L. Bland, P. Kogata, N. Wai, P. Howard, B.A. Natrajan, R.C. Huang, P.H. (2018). SWATH mass spectrometry as a tool for quantitative profiling of the matrisome. J proteomics, Vol.189, pp. 11-22.  show abstract

Ng, C.K. Piscuoglio, S. Geyer, F.C. Burke, K.A. Pareja, F. Eberle, C.A. Lim, R.S. Natrajan, R. Riaz, N. Mariani, O. Norton, L. Vincent-Salomon, A. Wen, Y.H. Weigelt, B. Reis-Filho, J.S. (2017). The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas. Clin cancer res, Vol.23 (14), pp. 3859-3870.  show abstract

Wilkerson, P.M. Dedes, K.J. Samartzis, E.P. Dedes, I. Lambros, M.B. Natrajan, R. Gauthier, A. Piscuoglio, S. Töpfer, C. Vukovic, V. Daley, F. Weigelt, B. Reis-Filho, J.S. (2017). Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. Oncotarget, Vol.8 (4), pp. 6057-6066.  show abstract

Piscuoglio, S. Ng, C.K. Geyer, F.C. Burke, K.A. Cowell, C.F. Martelotto, L.G. Natrajan, R. Popova, T. Maher, C.A. Lim, R.S. Bruijn, I.D. Mariani, O. Norton, L. Vincent-Salomon, A. Weigelt, B. Reis-Filho, J.S. (2017). Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast. Npj breast cancer, Vol.3, p. 48.  show abstract

Krasny, L. Paul, A. Wai, P. Howard, B.A. Natrajan, R.C. Huang, P.H. (2016). Comparative proteomic assessment of matrisome enrichment methodologies. Biochem j, Vol.473 (21), pp. 3979-3995.  show abstract

Showeil, R. Romano, C. Valganon, M. Lambros, M. Trivedi, P. Van Noorden, S. Sriraksa, R. El-Kaffash, D. El-Etreby, N. Natrajan, R. Foroni, L. Osborne, R. El-Bahrawy, M. (2016). The status of epidermal growth factor receptor in borderline ovarian tumours. Oncotarget, Vol.7 (9), pp. 10568-10577.  show abstract

Natrajan, R. Sailem, H. Mardakheh, F.K. Arias Garcia, M. Tape, C.J. Dowsett, M. Bakal, C. Yuan, Y. (2016). Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis. Plos med, Vol.13 (2), p. e1001961.  show abstract

Miller, R.E. Brough, R. Bajrami, I. Williamson, C.T. McDade, S. Campbell, J. Kigozi, A. Rafiq, R. Pemberton, H. Natrajan, R. Joel, J. Astley, H. Mahoney, C. Moore, J.D. Torrance, C. Gordan, J.D. Webber, J.T. Levin, R.S. Shokat, K.M. Bandyopadhyay, S. Lord, C.J. Ashworth, A. (2016). Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Mol cancer ther, Vol.15 (7), pp. 1472-1484.  show abstract

Natrajan, R. Weigelt, B. (2016). Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All?. J natl cancer inst, Vol.108 (9).

Maguire, S.L. Peck, B. Wai, P.T. Campbell, J. Barker, H. Gulati, A. Daley, F. Vyse, S. Huang, P. Lord, C.J. Farnie, G. Brennan, K. Natrajan, R. (2016). Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model. J pathol, Vol.240 (3), pp. 315-328.  show abstract

Campbell, J. Ryan, C.J. Brough, R. Bajrami, I. Pemberton, H.N. Chong, I.Y. Costa-Cabral, S. Frankum, J. Gulati, A. Holme, H. Miller, R. Postel-Vinay, S. Rafiq, R. Wei, W. Williamson, C.T. Quigley, D.A. Tym, J. Al-Lazikani, B. Fenton, T. Natrajan, R. Strauss, S.J. Ashworth, A. Lord, C.J. (2016). Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. Cell rep, Vol.14 (10), pp. 2490-2501.  show abstract

Wong, J.P. Todd, J.R. Finetti, M.A. McCarthy, F. Broncel, M. Vyse, S. Luczynski, M.T. Crosier, S. Ryall, K.A. Holmes, K. Payne, L.S. Daley, F. Wai, P. Jenks, A. Tanos, B. Tan, A.-. Natrajan, R.C. Williamson, D. Huang, P.H. (2016). Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors. Cell rep, Vol.17 (5), pp. 1265-1275.  show abstract

Morrison, E. Wai, P. Leonidou, A. Bland, P. Khalique, S. Farnie, G. Daley, F. Peck, B. Natrajan, R. (2016). Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures. J vis exp, (118).  show abstract

Todd, J.R. Ryall, K.A. Vyse, S. Wong, J.P. Natrajan, R.C. Yuan, Y. Tan, A.-. Huang, P.H. (2016). Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer. Oncotarget, Vol.7 (39), pp. 62939-62953.  show abstract

Carvalho, D. Taylor, K. Burford, A. Nowak, I. Mackay, A. Vinci, M. Bjerke, L. Molinari, V. Nandhabalan, M. Ingram, W. Jury, A. Natrajan, R. Jones, D. Pfister, S. Shats, L. Moore, A. Jacques, T. Popov, S. Jones, C. (2015). HG-09 * INFANTILE GLIOBLASTOMA WITH SARCOMATOUS HISTOLOGY DRIVEN BY ETV6:NTRK3 FUSIONS ARE SENSITIVE TO TRK INHIBITION BY PHA-848125. Neuro-oncology, Vol.17 (suppl 3), pp. iii12-iii12.

Maguire, S.L. Leonidou, A. Wai, P. Marchiò, C. Ng, C.K. Sapino, A. Salomon, A.-. Reis-Filho, J.S. Weigelt, B. Natrajan, R.C. (2015). SF3B1 mutations constitute a novel therapeutic target in breast cancer. J pathol, Vol.235 (4), pp. 571-580.  show abstract

Weigelt, B. Ng, C.K. Shen, R. Popova, T. Schizas, M. Natrajan, R. Mariani, O. Stern, M.-. Norton, L. Vincent-Salomon, A. Reis-Filho, J.S. (2015). Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. Mod pathol, Vol.28 (3), pp. 340-351.  show abstract

Schouten, P.C. Grigoriadis, A. Kuilman, T. Mirza, H. Watkins, J.A. Cooke, S.A. van Dyk, E. Severson, T.M. Rueda, O.M. Hoogstraat, M. Verhagen, C.V. Natrajan, R. Chin, S.-. Lips, E.H. Kruizinga, J. Velds, A. Nieuwland, M. Kerkhoven, R.M. Krijgsman, O. Vens, C. Peeper, D. Nederlof, P.M. Caldas, C. Tutt, A.N. Wessels, L.F. Linn, S.C. (2015). Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms. Mol oncol, Vol.9 (7), pp. 1274-1286.  show abstract

Natrajan, R.C. (2015). Breast cancer heterogeneity: parallel evolution or conscious uncoupling?. J pathol, Vol.237 (1), pp. 1-3.  show abstract

Martelotto, L.G. De Filippo, M.R. Ng, C.K. Natrajan, R. Fuhrmann, L. Cyrta, J. Piscuoglio, S. Wen, H.-. Lim, R.S. Shen, R. Schultheis, A.M. Wen, Y.H. Edelweiss, M. Mariani, O. Stenman, G. Chan, T.A. Colombo, P.-. Norton, L. Vincent-Salomon, A. Reis-Filho, J.S. Weigelt, B. (2015). Genomic landscape of adenoid cystic carcinoma of the breast. J pathol, Vol.237 (2), pp. 179-189.  show abstract

Maley, C.C. Koelble, K. Natrajan, R. Aktipis, A. Yuan, Y. (2015). An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer. Breast cancer res, Vol.17 (1), p. 131.  show abstract

Ng, C.K. Martelotto, L.G. Gauthier, A. Wen, H.-. Piscuoglio, S. Lim, R.S. Cowell, C.F. Wilkerson, P.M. Wai, P. Rodrigues, D.N. Arnould, L. Geyer, F.C. Bromberg, S.E. Lacroix-Triki, M. Penault-Llorca, F. Giard, S. Sastre-Garau, X. Natrajan, R. Norton, L. Cottu, P.H. Weigelt, B. Vincent-Salomon, A. Reis-Filho, J.S. (2015). Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome biol, Vol.16 (1), p. 107.  show abstract

Bajrami, I. Frankum, J.R. Konde, A. Miller, R.E. Rehman, F.L. Brough, R. Campbell, J. Sims, D. Rafiq, R. Hooper, S. Chen, L. Kozarewa, I. Assiotis, I. Fenwick, K. Natrajan, R. Lord, C.J. Ashworth, A. (2014). Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer res, Vol.74 (1), pp. 287-297.  show abstract

Natrajan, R. Wilkerson, P.M. Marchiò, C. Piscuoglio, S. Ng, C.K. Wai, P. Lambros, M.B. Samartzis, E.P. Dedes, K.J. Frankum, J. Bajrami, I. Kopec, A. Mackay, A. A'hern, R. Fenwick, K. Kozarewa, I. Hakas, J. Mitsopoulos, C. Hardisson, D. Lord, C.J. Kumar-Sinha, C. Ashworth, A. Weigelt, B. Sapino, A. Chinnaiyan, A.M. Maher, C.A. Reis-Filho, J.S. (2014). Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. J pathol, Vol.232 (5), pp. 553-565.  show abstract

Garcia-Murillas, I. Sharpe, R. Pearson, A. Campbell, J. Natrajan, R. Ashworth, A. Turner, N.C. (2014). An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene, Vol.33 (19), pp. 2478-2486.  show abstract

Dryden, N.H. Broome, L.R. Dudbridge, F. Johnson, N. Orr, N. Schoenfelder, S. Nagano, T. Andrews, S. Wingett, S. Kozarewa, I. Assiotis, I. Fenwick, K. Maguire, S.L. Campbell, J. Natrajan, R. Lambros, M. Perrakis, E. Ashworth, A. Fraser, P. Fletcher, O. (2014). Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C. Genome res, Vol.24 (11), pp. 1854-1868.  show abstract

Piscuoglio, S. Ng, C.K. Martelotto, L.G. Eberle, C.A. Cowell, C.F. Natrajan, R. Bidard, F.-. De Mattos-Arruda, L. Wilkerson, P.M. Mariani, O. Vincent-Salomon, A. Weigelt, B. Reis-Filho, J.S. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular oncology, Vol.8 (8), pp. 1588-1602.

Shiu, K.-. Wetterskog, D. Mackay, A. Natrajan, R. Lambros, M. Sims, D. Bajrami, I. Brough, R. Frankum, J. Sharpe, R. Marchio, C. Horlings, H. Reyal, F. van der Vijver, M. Turner, N. Reis-Filho, J.S. Lord, C.J. Ashworth, A. (2014). Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies. Oncogene, Vol.33 (5), pp. 619-631.  show abstract

Eccles, S.A. Aboagye, E.O. Ali, S. Anderson, A.S. Armes, J. Berditchevski, F. Blaydes, J.P. Brennan, K. Brown, N.J. Bryant, H.E. Bundred, N.J. Burchell, J.M. Campbell, A.M. Carroll, J.S. Clarke, R.B. Coles, C.E. Cook, G.J. Cox, A. Curtin, N.J. Dekker, L.V. Silva, I.D. Duffy, S.W. Easton, D.F. Eccles, D.M. Edwards, D.R. Edwards, J. Evans, D. Fenlon, D.F. Flanagan, J.M. Foster, C. Gallagher, W.M. Garcia-Closas, M. Gee, J.M. Gescher, A.J. Goh, V. Groves, A.M. Harvey, A.J. Harvie, M. Hennessy, B.T. Hiscox, S. Holen, I. Howell, S.J. Howell, A. Hubbard, G. Hulbert-Williams, N. Hunter, M.S. Jasani, B. Jones, L.J. Key, T.J. Kirwan, C.C. Kong, A. Kunkler, I.H. Langdon, S.P. Leach, M.O. Mann, D.J. Marshall, J.F. Martin, L. Martin, S.G. Macdougall, J.E. Miles, D.W. Miller, W.R. Morris, J.R. Moss, S.M. Mullan, P. Natrajan, R. O'Connor, J.P. O'Connor, R. Palmieri, C. Pharoah, P.D. Rakha, E.A. Reed, E. Robinson, S.P. Sahai, E. Saxton, J.M. Schmid, P. Smalley, M.J. Speirs, V. Stein, R. Stingl, J. Streuli, C.H. Tutt, A.N. Velikova, G. Walker, R.A. Watson, C.J. Williams, K.J. Young, L.S. Thompson, A.M. (2013). Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast cancer res, Vol.15 (5), p. R92.  show abstract

Wetterskog, D. Wilkerson, P.M. Rodrigues, D.N. Lambros, M.B. Fritchie, K. Andersson, M.K. Natrajan, R. Gauthier, A. Di Palma, S. Shousha, S. Gatalica, Z. Toepfer, C. Vukovic, V. A'Hern, R. Weigelt, B. Vincent-Salomon, A. Stenman, G. Rubin, B.P. Reis-Filho, J.S. (2013). Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology, Vol.62 (4), pp. 543-550.

Horlings, H.M. Weigelt, B. Anderson, E.M. Lambros, M.B. Mackay, A. Natrajan, R. Ng, C.K. Geyer, F.C. van de Vijver, M.J. Reis-Filho, J.S. (2013). Genomic profiling of histological special types of breast cancer. Breast cancer research and treatment, Vol.142 (2), pp. 257-269.

Natrajan, R.C. Leonidou, A. Brough, R. Frankum, J. Wai, P.T. Ng, C.K. Reis-Filho, J.S. Lord, C.J. Ashworth, A. (2013). Integrated genomic analyses of members of protein kinase C family identifies subtype specific alterations as novel therapeutic targets. Cancer research, Vol.73.

Natrajan, R. Wilkerson, P. (2013). From Integrative Genomics to Therapeutic Targets. Cancer research, Vol.73 (12), pp. 3483-3488.

Piscuoglio, S. Ng, C.K. Martelotto, L.G. Cowell, C.F. Natrajan, R. Bidard, F.-. Wilkerson, P.M. Mariani, O. Vincent-Salomon, A. Weigelt, B. Reis-Filho, J.S. (2013). Genomic and transcriptomic characterization of papillary carcinomas of the breast. Cancer research, Vol.73.

Patani, N. Lambros, M.B. Natrajan, R. Dedes, K.J. Geyer, F.C. Ward, E. Martin, L.-. Dowsett, M. Reis-Filho, J.S. (2012). Non-existence of caveolin-1 gene mutations in human breast cancer. Breast cancer res treat, Vol.131 (1), pp. 307-310.  show abstract

Wetterskog, D. Angeles Lopez-Garcia, M. Lambros, M.B. A'Hern, R. Geyer, F.C. Milanezi, F. Cabral, M.C. Natrajan, R. Gauthier, A. Shiu, K.-. Orr, N. Shousha, S. Gatalica, Z. Mackay, A. Palacios, J. S Reis-Filho, J. Weigelt, B. (2012). Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers. Journal of pathology, Vol.226 (1), pp. 84-96.

Duprez, R. Wilkerson, P.M. Lacroix-Triki, M. Lambros, M.B. MacKay, A. A'Hern, R. Gauthier, A. Pawar, V. Colombo, P.-. Daley, F. Natrajan, R. Ward, E. MacGrogan, G. Arbion, F. Michenet, P. Weigelt, B. Vincent-Salomon, A. Reis-Filho, J.S. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. J pathol, Vol.226 (3), pp. 427-441.  show abstract

Geyer, F.C. de Biase, D. Lambros, M.B. Ragazzi, M. Lopez-Garcia, M.A. Natrajan, R. Mackay, A. Kurelac, I. Gasparre, G. Ashworth, A. Eusebi, V. Reis-Filho, J.S. Tallini, G. (2012). Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology. Breast cancer res treat, Vol.132 (1), pp. 15-28.  show abstract

Hernandez, L. Wilkerson, P.M. Lambros, M.B. Campion-Flora, A. Rodrigues, D.N. Gauthier, A. Cabral, C. Pawar, V. Mackay, A. A'Hern, R. Marchiò, C. Palacios, J. Natrajan, R. Weigelt, B. Reis-Filho, J.S. (2012). Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection. J pathol, Vol.227 (1), pp. 42-52.  show abstract

Natrajan, R. Mackay, A. Lambros, M.B. Weigelt, B. Wilkerson, P.M. Manie, E. Grigoriadis, A. A'Hern, R. van der Groep, P. Kozarewa, I. Popova, T. Mariani, O. Turaljic, S. Furney, S.J. Marais, R. Rodruigues, D.-. Flora, A.C. Wai, P. Pawar, V. McDade, S. Carroll, J. Stoppa-Lyonnet, D. Green, A.R. Ellis, I.O. Swanton, C. van Diest, P. Delattre, O. Lord, C.J. Foulkes, W.D. Vincent-Salomon, A. Ashworth, A. Stern, M.H. Reis-Filho, J.S. (2012). A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers. J pathol, Vol.227 (1), pp. 29-41.  show abstract

Geyer, F.C. Lacroix-Triki, M. Colombo, P.-. Patani, N. Gauthier, A. Natrajan, R. Lambros, M.B. Khalifeh, I. Albarracin, C. Orru, S. Marchio, C. Sapino, A. Mackay, A. Weigelt, B. Schmitt, F.C. Wesseling, J. Sneige, N. Reis-Filho, J.S. (2012). Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. Histopathology, Vol.60 (6B), pp. E115-E130.

Brough, R. Bajrami, I. Vatcheva, R. Natrajan, R. Reis-Filho, J.S. Lord, C.J. Ashworth, A. (2012). APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. Embo journal, Vol.31 (5), pp. 1160-1176.

Daemen, A. Wolf, D.M. Korkola, J.E. Griffith, O.L. Frankum, J.R. Brough, R. Jakkula, L.R. Wang, N.J. Natrajan, R. Reis-Filho, J.S. Lord, C.J. Ashworth, A. Spellman, P.T. Gray, J.W. van't Veer, L.J. (2012). Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Breast cancer research and treatment, Vol.135 (2), pp. 505-517.

Grigoriadis, A. Mackay, A. Noel, E. Wu, P.J. Natrajan, R. Frankum, J. Reis-Filho, J.S. Tutt, A. (2012). Molecular characterisation of cell line models for triple-negative breast cancers. Bmc genomics, Vol.13.

Mackay, A.G. Natrajan, R. Maher, C. Lambros, M. Weigelt, B. Nava-Rodrigues, D. Wilkerson, P. CampionFlora, A. Kozarewa, I. Fenwick, K. Campbell, J. Chen, L. Lord, C.J. Gauthier, A. Pawar, V. Mariani, O. Vincent-Salomon, A. Reis-Filho, J. (2012). Integrative genomic and transcriptomic analysis of metaplastic carcinomas of the breast. Cancer research, Vol.72.

Ng, C.K. Gauthier, A. Mackay, A. Lambros, M.B. Rodrigues, D.N. Arnoud, L. Lacroix-Triki, M. Penault-Llorca, F. Baranzelli, M.C. Sastre-Garau, X. Lord, C.J. Zvelebil, M. Mitsopoulos, C. Ashworth, A. Natrajan, R. Weigelt, B. Delattre, O. Cottu, P. Reis-Filho, J.S. Vincent-Salomon, A. (2012). Genomic characterisation of invasive breast cancers with heterogeneous HER2 gene amplification. Cancer research, Vol.72.

Gauthier, A. Lambros, M. Rodrigues, D.N. Arnould, L. Lacroix-Tikri, M. Penault-Llorca, F. Baranzelli, M.-. Sastre, X. Natrajan, R. Delattre, O. Cottu, P. Reis-Filho, J.S. Vincent-Salomon, A. (2012). Genomic analyses of heterogeneous HER2 3+invasive ductal carcinomas of the breast. Cancer research, Vol.72.

Natrajan, R. Mackay, A. Wilkerson, P.M. Lambros, M.B. Wetterskog, D. Arnedos, M. Shiu, K.-. Geyer, F.C. Langerød, A. Kreike, B. Reyal, F. Horlings, H.M. van de Vijver, M.J. Palacios, J. Weigelt, B. Reis-Filho, J.S. (2012). Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast cancer res, Vol.14 (2), p. R53.  show abstract

Dedes, K.J. Natrajan, R. Lambros, M.B. Geyer, F.C. Lopez-Garcia, M.A. Savage, K. Jones, R.L. Reis-Filho, J.S. (2011). Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer. Eur j cancer, Vol.47 (1), pp. 138-150.  show abstract

Lambros, M.B. Wilkerson, P.M. Natrajan, R. Patani, N. Pawar, V. Vatcheva, R. Mansour, M. Laschet, M. Oelze, B. Orr, N. Muller, S. Reis-Filho, J.S. (2011). High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform. Laboratory investigation, Vol.91 (10), pp. 1491-11.

Geyer, F.C. Lacroix-Triki, M. Savage, K. Arnedos, M. Lambros, M.B. MacKay, A. Natrajan, R. Reis-Filho, J.S. (2011). β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Mod pathol, Vol.24 (2), pp. 209-231.  show abstract

Natrajan, R. Reis-Filho, J.S. (2011). Next-generation sequencing applied to molecular diagnostics. Expert rev mol diagn, Vol.11 (4), pp. 425-444.  show abstract

Brough, R. Frankum, J.R. Sims, D. Mackay, A. Mendes-Pereira, A.M. Bajrami, I. Costa-Cabral, S. Rafiq, R. Ahmad, A.S. Cerone, M.A. Natrajan, R. Sharpe, R. Shiu, K.-. Wetterskog, D. Dedes, K.J. Lambros, M.B. Rawjee, T. Linardopoulos, S. Reis-Filho, J.S. Turner, N.C. Lord, C.J. Ashworth, A. (2011). Functional viability profiles of breast cancer. Cancer discov, Vol.1 (3), pp. 260-273.  show abstract

Hungermann, D. Schmidt, H. Natrajan, R. Tidow, N. Poos, K. Reis-Filho, J.S. Brandt, B. Buerger, H. Korsching, E. (2011). Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer. J pathol, Vol.224 (4), pp. 517-528.  show abstract

Wilkerson, P.M. Dedes, K.J. Wetterskog, D. Mackay, A. Lambros, M.B. Mansour, M. Frankum, J. Lord, C.J. Natrajan, R. Ashworth, A. Reis-Filho, J.S. (2011). Functional characterization of EMSY gene amplification in human cancers. J pathol, Vol.225 (1), pp. 29-42.  show abstract

Williams, R.D. Al-Saadi, R. Natrajan, R. Mackay, A. Chagtai, T. Little, S. Hing, S.N. Fenwick, K. Ashworth, A. Grundy, P. Anderson, J.R. Dome, J.S. Perlman, E.J. Jones, C. Pritchard-Jones, K. (2011). Molecular Profiling Reveals Frequent Gain of MYCN and Anaplasia-Specific Loss of 4q and 14q in Wilms Tumor. Genes chromosomes & cancer, Vol.50 (12), pp. 982-14.

Robinson, D.R. Kalyana-Sundaram, S. Wu, Y.-. Shankar, S. Cao, X. Ateeq, B. Asangani, I.A. Iyer, M. Maher, C.A. Grasso, C.S. Lonigro, R.J. Quist, M. Siddiqui, J. Mehra, R. Jing, X. Giordano, T.J. Sabel, M.S. Kleer, C.G. Palanisamy, N. Natrajan, R. Lambros, M.B. Reis-Filho, J.S. Kumar-Sinha, C. Chinnaiyan, A.M. (2011). Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature medicine, Vol.17 (12), pp. 1646-U163.

Tan, D.S. Iravani, M. McCluggage, W.G. Lambros, M.B. Milanezi, F. Mackay, A. Gourley, C. Geyer, F.C. Vatcheva, R. Millar, J. Thomas, K. Natrajan, R. Savage, K. Fenwick, K. Williams, A. Jameson, C. El-Bahrawy, M. Gore, M.E. Gabra, H. Kaye, S.B. Ashworth, A. Reis-Filho, J.S. (2011). Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas. Clin cancer res, Vol.17 (6), pp. 1521-1534.  show abstract

Sharpe, R. Pearson, A. Herrera-Abreu, M.T. Johnson, D. Mackay, A. Welti, J.C. Natrajan, R. Reynolds, A.R. Reis-Filho, J.S. Ashworth, A. Turner, N.C. (2011). FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin cancer res, Vol.17 (16), pp. 5275-5286.  show abstract

Daemen, A. Wolf, D.M. Korkola, J.E. Griffith, O.L. Frankum, J.R. Jakkula, L.R. Wang, N.J. Natrajan, R. Reis-Filho, J.S. Lord, C.J. Ashworth, A. Gray, J.W. Spellman, P.T. van't Veer, L. (2011). Identification of Biomarkers in Breast Cancer for Prediction of Response to PARP Inhibitor Olaparib. Cancer research, Vol.71.

Wilkerson, P. Dedes, K.J. Wetterskog, D. Natrajan, R. Lambros, M.B. Mackay, A. Lord, C.J. Ashworth, A. Reis-Filho, J.S. (2011). EMSY amplification and overexpression is not associated with defective homologous recombination and does not predict sensitivity to cisplatin or PARP inhibitors. Cancer research, Vol.71.

Natrajan, R. Maher, C.A. Lambros, M.B. Pawar, V. Wetterskog, D. Marchio, C. Barbashina, V. Geyer, F.C. Fenwick, K. Kozarewa, I. Mackay, A. Hakas, J. Mitsopoulos, K. Hardisson, D. Sapino, A. Vincent-Salomon, A. Lord, C.J. Chinniayan, A. Ashworth, A. Reis-Filho, J.S. (2011). Massively parallel RNA sequencing analysis of micropapillary carcinomas of the breast. Cancer research, Vol.71.

Wetterskog, D. Shiu, K.-. Chong, I. Meijer, T. Natrajan, R. Lord, C.J. Ashworth, A. Reis-Filho, J.S. (2011). Identification of novel genes and pathways involved in resistance to HER2-targeting agents in breast cancer. Cancer research, Vol.71.

Chong, I. Wetterskog, D. Shiu, K.-. Meijer, T. Natrajan, R. Maryou, L. Reis-Filho, J. Lord, L.J. David, C. Ashworth, A. (2011). Identification of a novel biomarker of resistance to lapatinib common to both breast and oesophagogastric cancer. Cancer research, Vol.71.

Mackay, A. Weigelt, B. Grigoriadis, A. Kreike, B. Natrajan, R. A'Hern, R. Tan, D.S. Dowsett, M. Ashworth, A. Reis-Filho, J.S. (2011). Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement. J natl cancer inst, Vol.103 (8), pp. 662-673.  show abstract

Xu, H. Yan, M. Patra, J. Natrajan, R. Yan, Y. Swagemakers, S. Tomaszewski, J.M. Verschoor, S. Millar, E.K. van der Spek, P. Reis-Filho, J.S. Ramsay, R.G. O'Toole, S.A. McNeil, C.M. Sutherland, R.L. McKay, M.J. Fox, S.B. (2011). Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers. Breast cancer res, Vol.13 (1), p. R9.  show abstract

Ha, K.C. Lalonde, E. Li, L. Cavallone, L. Natrajan, R. Lambros, M.B. Mitsopoulos, C. Hakas, J. Kozarewa, I. Fenwick, K. Lord, C.J. Ashworth, A. Vincent-Salomon, A. Basik, M. Reis-Filho, J.S. Majewski, J. Foulkes, W.D. (2011). Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines. Bmc med genomics, Vol.4, p. 75.  show abstract

Tanas, M.R. Sboner, A. Oliveira, A.M. Erickson-Johnson, M.R. Hespelt, J. Hanwright, P.J. Flanagan, J. Luo, Y. Fenwick, K. Natrajan, R. Mitsopoulos, C. Zvelebil, M. Hoch, B.L. Weiss, S.W. Debiec-Rychter, M. Sciot, R. West, R.B. Lazar, A.J. Ashworth, A. Reis-Filho, J.S. Lord, C.J. Gerstein, M.B. Rubin, M.A. Rubin, B.P. (2011). Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Sci transl med, Vol.3 (98), p. 98ra82.  show abstract

Weigelt, B. Geyer, F.C. Natrajan, R. Lopez-Garcia, M.A. Ahmad, A.S. Savage, K. Kreike, B. Reis-Filho, J.S. (2010). The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type. J pathol, Vol.220 (1), pp. 45-57.  show abstract

Weigelt, B. Mackay, A. Natrajan, R. Tan, D.S. Dowsett, M. Ashworth, A. Reis-Filho, J.S. (2010). The importance of gene-centring microarray data Reply. Lancet oncology, Vol.11 (8), pp. 720-2.

Shiu, K.-. Natrajan, R. Geyer, F.C. Ashworth, A. Reis-Filho, J.S. (2010). DNA amplifications in breast cancer: genotypic-phenotypic correlations. Future oncology, Vol.6 (6), pp. 967-18.

Turner, N. Pearson, A. Sharpe, R. Lambros, M. Geyer, F. Lopez-Garcia, M.A. Natrajan, R. Marchio, C. Iorns, E. Mackay, A. Gillett, C. Grigoriadis, A. Tutt, A. Reis-Filho, J.S. Ashworth, A. (2010). FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer. Cancer research, Vol.70 (5), pp. 2085-10.

Klingbeil, P. Natrajan, R. Everitt, G. Vatcheva, R. Marchio, C. Palacios, J. Buerger, H. Reis-Filho, J.S. Isacke, C.M. (2010). CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification. Breast cancer res treat, Vol.120 (1), pp. 95-109.  show abstract

Molyneux, G. Geyer, F.C. Magnay, F.-. McCarthy, A. Kendrick, H. Natrajan, R. Mackay, A. Grigoriadis, A. Tutt, A. Ashworth, A. Reis-Filho, J.S. Smalley, M.J. (2010). BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell stem cell, Vol.7 (3), pp. 403-417.  show abstract

Geyer, F.C. Weigelt, B. Natrajan, R. Lambros, M.B. de Biase, D. Vatcheva, R. Savage, K. Mackay, A. Ashworth, A. Reis-Filho, J.S. (2010). Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas. J pathol, Vol.220 (5), pp. 562-573.  show abstract

Weigelt, B. Mackay, A. A'hern, R. Natrajan, R. Tan, D.S. Dowsett, M. Ashworth, A. Reis-Filho, J.S. (2010). Breast cancer molecular profiling with single sample predictors: a retrospective analysis. Lancet oncol, Vol.11 (4), pp. 339-349.  show abstract

Natrajan, R. Weigelt, B. Mackay, A. Geyer, F.C. Grigoriadis, A. Tan, D.S. Jones, C. Lord, C.J. Vatcheva, R. Rodriguez-Pinilla, S.M. Palacios, J. Ashworth, A. Reis-Filho, J.S. (2010). An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast cancer res treat, Vol.121 (3), pp. 575-589.  show abstract

Geyer, F.C. Lambros, M.B. Natrajan, R. Mehta, R. Mackay, A. Savage, K. Parry, S. Ashworth, A. Badve, S. Reis-Filho, J.S. (2010). Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast. Mod pathol, Vol.23 (7), pp. 951-960.  show abstract

Turner, N. Lambros, M.B. Horlings, H.M. Pearson, A. Sharpe, R. Natrajan, R. Geyer, F.C. van Kouwenhove, M. Kreike, B. Mackay, A. Ashworth, A. van de Vijver, M.J. Reis-Filho, J.S. (2010). Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene, Vol.29 (14), pp. 2013-2023.  show abstract

Lopez-Garcia, M.A. Geyer, F.C. Natrajan, R. Kreike, B. Mackay, A. Grigoriadis, A. Reis-Filho, J.S. Weigelt, B. (2010). Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas. J pathol, Vol.222 (1), pp. 64-75.  show abstract

Lambros, M.B. Natrajan, R. Geyer, F.C. Lopez-Garcia, M.A. Dedes, K.J. Savage, K. Lacroix-Triki, M. Jones, R.L. Lord, C.J. Linardopoulos, S. Ashworth, A. Reis-Filho, J.S. (2010). PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study. Mod pathol, Vol.23 (10), pp. 1334-1345.  show abstract

Lacroix-Triki, M. Suarez, P.H. MacKay, A. Lambros, M.B. Natrajan, R. Savage, K. Geyer, F.C. Weigelt, B. Ashworth, A. Reis-Filho, J.S. (2010). Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. J pathol, Vol.222 (3), pp. 282-298.  show abstract

Dedes, K.J. Lopez-Garcia, M.-. Geyer, F.C. Lambros, M.B. Savage, K. Vatcheva, R. Wilkerson, P. Wetterskog, D. Lacroix-Triki, M. Natrajan, R. Reis-Filho, J.S. (2010). Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study. Breast cancer res treat, Vol.124 (3), pp. 653-666.  show abstract

Dedes, K.J. Wetterskog, D. Mendes-Pereira, A.M. Natrajan, R. Lambros, M.B. Geyer, F.C. Vatcheva, R. Savage, K. Mackay, A. Lord, C.J. Ashworth, A. Reis-Filho, J.S. (2010). PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. Sci transl med, Vol.2 (53), p. 53ra75.  show abstract

Dedes, K.J. Wetterskog, D. Mendes-Pereira, A.M. Vatcheva, R. Natrajan, R. Lambros, M.B. Lord, C.J. Ashworth, A. Reis-Filho, J.S. (2010). Preclinical evaluation of PARP inhibition as a treatment for endometrioid endometrial carcinomas. Journal of clinical oncology, Vol.28 (15).

Tan, D.S. Lambros, M.B. Rayter, S. Natrajan, R. Vatcheva, R. Gao, Q. Marchiò, C. Geyer, F.C. Savage, K. Parry, S. Fenwick, K. Tamber, N. Mackay, A. Dexter, T. Jameson, C. McCluggage, W.G. Williams, A. Graham, A. Faratian, D. El-Bahrawy, M. Paige, A.J. Gabra, H. Gore, M.E. Zvelebil, M. Lord, C.J. Kaye, S.B. Ashworth, A. Reis-Filho, J.S. (2009). PPM1D is a potential therapeutic target in ovarian clear cell carcinomas. Clin cancer res, Vol.15 (7), pp. 2269-2280.  show abstract

Drake, K.M. Ruteshouser, E.C. Natrajan, R. Harbor, P. Wegert, J. Gessler, M. Pritchard-Jones, K. Grundy, P. Dome, J. Huff, V. Jones, C. Aldred, M.A. (2009). Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562. Clin cancer res, Vol.15 (19), pp. 5985-5992.  show abstract

Marchio, C. Iravan, M. Natrajan, R. Lambros, M.B. Geyer, F.C. Savage, K. Parry, S. Tamber, N. Fenwick, K. Mackay, A. Schmitt, F.C. Bussolati, G. Ellis, I. Ashworth, A. Sapino, A. Reis-Filho, J.S. (2009). Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components. Journal of pathology, Vol.218 (3), pp. 301-15.

Natrajan, R. Lambros, M.B. Geyer, F.C. Marchio, C. Tan, D.S. Vatcheva, R. Shiu, K.-. Hungermann, D. Rodriguez-Pinilla, S.M. Palacios, J. Ashworth, A. Buerger, H. Reis-Filho, J.S. (2009). Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?. Genes chromosomes cancer, Vol.48 (4), pp. 351-365.  show abstract

Marchio, C. Iravani, M. Natrajan, R. Geyer, F. Lambros, M. Savage, K. Mackay, A. Schmitt, F. Bussolati, G. Ellis, I.O. Ashworth, A. Sapino, A. Reis-Filho, J.S. (2009). Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components. Virchows archiv, Vol.455, pp. 40-41.

Geyer, F.C. Kushner, Y.B. Lambros, M.B. Natrajan, R. Mackay, A. Tamber, N. Fenwick, K. Purnell, D. Ashworth, A. Walker, R.A. Reis-Filho, J.S. (2009). Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. Histopathology, Vol.55 (6), pp. 732-12.

Natrajan, R. Lambros, M.B. Maria Rodriguez-Pinilla, S. Moreno-Bueno, G. Tan, D.S. Marchio, C. Vatcheva, R. Rayter, S. Mahler-Araujo, B. Fulford, L.G. Hungermann, D. Mackay, A. Grigoriadis, A. Fenwick, K. Tamber, N. Hardisson, D. Tutt, A. Palacios, J. Lord, C.J. Buerger, H. Ashworth, A. Reis-Filho, J.S. (2009). Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers. Clinical cancer research, Vol.15 (8), pp. 2711-12.

Stephens, P.J. McBride, D.J. Lin, M.-. Varela, I. Pleasance, E.D. Simpson, J.T. Stebbings, L.A. Leroy, C. Edkins, S. Mudie, L.J. Greenman, C.D. Jia, M. Latimer, C. Teague, J.W. Lau, K.W. Burton, J. Quail, M.A. Swerdlow, H. Churcher, C. Natrajan, R. Sieuwerts, A.M. Martens, J.W. Silver, D.P. Langerød, A. Russnes, H.E. Foekens, J.A. Reis-Filho, J.S. van 't Veer, L. Richardson, A.L. Børresen-Dale, A.-. Campbell, P.J. Futreal, P.A. Stratton, M.R. (2009). Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature, Vol.462 (7276), pp. 1005-1010.  show abstract

Iorns, E. Lord, C.J. Grigoriadis, A. McDonald, S. Fenwick, K. Mackay, A. Mein, C.A. Natrajan, R. Savage, K. Tamber, N. Reis-Filho, J.S. Turner, N.C. Ashworth, A. (2009). Integrated functional, gene expression and genomic analysis for the identification of cancer targets. Plos one, Vol.4 (4), p. e5120.  show abstract

Natrajan, R. Warren, W. Messahel, B. Reis-Filho, J.S. Brundler, M.-. Dome, J.S. Grundy, P.E. Vujanic, G. Pritchard-Jones, K. Jones, C. (2008). Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours. J clin pathol, Vol.61 (1), pp. 95-102.  show abstract

Arriola, E. Marchio, C. Tan, D.S. Drury, S.C. Lambros, M.B. Natrajan, R. Rodriguez-Pinilla, S.M. Mackay, A. Tamber, N. Fenwick, K. Jones, C. Dowsett, M. Ashworth, A. Reis-Filho, J.S. (2008). Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines. Lab invest, Vol.88 (5), pp. 491-503.  show abstract

Reis-Filho, J.S. Natrajan, R. Vatcheva, R. Lambros, M.B. Marchió, C. Mahler-Araújo, B. Paish, C. Hodi, Z. Eusebi, V. Ellis, I.O. (2008). Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probes. Histopathology, Vol.52 (7), pp. 840-846.  show abstract

Reis-Filho, J.S. Drury, S. Lambros, M.B. Marchio, C. Johnson, N. Natrajan, R. Salter, J. Levey, P. Fletcher, O. Peto, J. Ashworth, A. Dowsett, M. (2008). ESR1 gene amplification in breast cancer: a common phenomenon?. Nat genet, Vol.40 (7), pp. 809-810.

Marchiò, C. Iravani, M. Natrajan, R. Lambros, M.B. Savage, K. Tamber, N. Fenwick, K. Mackay, A. Senetta, R. Di Palma, S. Schmitt, F.C. Bussolati, G. Ellis, L.O. Ashworth, A. Sapino, A. Reis-Filho, J.S. (2008). Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. J pathol, Vol.215 (4), pp. 398-410.  show abstract

Marchiò, C. Natrajan, R. Shiu, K.K. Lambros, M.B. Rodriguez-Pinilla, S.M. Tan, D.S. Lord, C.J. Hungermann, D. Fenwick, K. Tamber, N. Mackay, A. Palacios, J. Sapino, A. Buerger, H. Ashworth, A. Reis-Filho, J.S. (2008). The genomic profile of HER2-amplified breast cancers: the influence of ER status. J pathol, Vol.216 (4), pp. 399-407.  show abstract

Edwards, S.L. Brough, R. Lord, C.J. Natrajan, R. Vatcheva, R. Levine, D.A. Boyd, J. Reis-Filho, J.S. Ashworth, A. (2008). Resistance to therapy caused by intragenic deletion in BRCA2. Nature, Vol.451 (7182), pp. 1111-1115.  show abstract

Natrajan, R. Little, S.E. Sodha, N. Reis-Filho, J.S. Mackay, A. Fenwick, K. Ashworth, A. Perlman, E.J. Dome, J.S. Grundy, P.E. Pritchard-Jones, K. Jones, C. (2007). Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour. J pathol, Vol.211 (1), pp. 52-59.  show abstract

Little, S.E. Bax, D.A. Rodriguez-Pinilla, M. Natrajan, R. Messahel, B. Pritchard-Jones, K. Vujanic, G.M. Reis-Filho, J.S. Jones, C. (2007). Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. Clin cancer res, Vol.13 (15 Pt 1), pp. 4360-4364.  show abstract

Marchio, C. Iravani, M. Natrajan, R. Lambros, M. James, M. Savage, K. Mackay, A. Fenwick, K. Tamber, N. Schmitt, F.C. Ashworth, A. Ellis, I. Sapino, A. Bussolati, G. Reis-Filho, J.S. (2007). Molecular genetics and immunophenotypical characterization of micropapillary carcinomas of the breast. Virchows archiv, Vol.451 (2), pp. 145-2.

Arriola, E. Lambros, M. Marchio, C. Tan, D. Natrajan, R. Rodriguez-Pinilla, S.M. Tamber, N. Fenwick, K. Mackay, A. Jones, C. Ashworth, A. Reis-Filho, J.S. (2007). Her2/TOP2A amplicon in breast: A microarray-based and chromogenic in situ hybridisation analysis. Virchows archiv, Vol.451 (2), pp. 141-1.

Natrajan, R. Williams, R.D. Grigoriadis, A. Mackay, A. Fenwick, K. Ashworth, A. Dome, J.S. Grundy, P.E. Pritchard-Jones, K. Jones, C. (2007). Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH. Genes chromosomes cancer, Vol.46 (6), pp. 607-615.  show abstract

Lambros, M.B. Natrajan, R. Reis-Filho, J.S. (2007). Chromogenic and fluorescent in situ hybridization in breast cancer. Hum pathol, Vol.38 (8), pp. 1105-1122.  show abstract

Tan, D.S. Lambros, M.B. Natrajan, R. Reis-Filho, J.S. (2007). Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research. Lab invest, Vol.87 (8), pp. 737-754.  show abstract

Natrajan, R. RodriGuez Pinilla, S.M. Marchio, C. Vatcheva, R. Savage, K. Mackay, A. Fenwick, K. Tamber, N. Palacios, J. Ashworth, A. Reis-Filho, J.S. (2007). Near tiling microarray-based CGH identifies CCNE1 amplification in basal-like breast cancer. Virchows archiv, Vol.451 (2), pp. 136-137.

Natrajan, R. Reis-Filho, J.S. Little, S.E. Messahel, B. Brundler, M.-. Dome, J.S. Grundy, P.E. Vujanic, G.M. Pritchard-Jones, K. Jones, C. (2006). Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse. Cancer res, Vol.66 (23), pp. 11148-11155.  show abstract

Little, S.E. Vuononvirta, R. Reis-Filho, J.S. Natrajan, R. Iravani, M. Fenwick, K. Mackay, A. Ashworth, A. Pritchard-Jones, K. Jones, C. (2006). Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA. Genomics, Vol.87 (2), pp. 298-306.  show abstract

Lambros, M.B. Simpson, P.T. Jones, C. Natrajan, R. Westbury, C. Steele, D. Savage, K. Mackay, A. Schmitt, F.C. Ashworth, A. Reis, J.S. (2006). Unlocking pathology archives for molecular genetic studies:: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization. Laboratory investigation, Vol.86 (4), pp. 398-11.

Natrajan, R. Williams, R.D. Hing, S.N. Mackay, A. Reis-Filho, J.S. Fenwick, K. Iravani, M. Valgeirsson, H. Grigoriadis, A. Langford, C.F. Dovey, O. Gregory, S.G. Weber, B.L. Ashworth, A. Grundy, P.E. Pritchard-Jones, K. Jones, C. (2006). Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse. J pathol, Vol.210 (1), pp. 49-58.  show abstract

Natrajan, R. Little, S.E. Reis-Filho, J.S. Hing, L. Messahel, B. Grundy, P.E. Dome, J.S. Schneider, T. Vujanic, G.M. Pritchard-Jones, K. Jones, C. (2006). Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. Clin cancer res, Vol.12 (24), pp. 7284-7293.  show abstract

Williams, R.D. Hing, S.N. Greer, B.T. Whiteford, C.C. Wei, J.S. Natrajan, R. Kelsey, A. Rogers, S. Campbell, C. Pritchard-Jones, K. Khan, J. (2004). Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines. Genes chromosomes cancer, Vol.41 (1), pp. 65-79.  show abstract

Natrajan, R. Louhelainen, J. Williams, S. Laye, J. Knowles, M.A. (2003). High-resolution deletion mapping of 15q13 2-q21 1 in transitional cell carcinoma of the bladder. Cancer res, Vol.63 (22), pp. 7657-7662.  show abstract

Read, A. Natrajan, R. Splicing dysregulation as a driver of breast cancer. Endocrine-related cancer, , pp. ERC-18-0068-ERC-18-0068.


Book Chapters

Leonidou, A. Peck, B. Natrajan, R. (2017). Identification and Validation of Driver Kinases from Next-Generation Sequencing Data. . (pp. 179-195).

Tan, D.S. Natrajan, R. Reis‐Filho, J.S. (2009). Microarray‐Based Comparative Genomic Hybridization. . (pp. 135-161). Wiley, ISBN: 9780470515976.