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Rose, A.J. Fleming, M.M. Francis, J.C. Ning, J. Patrikeev, A. Chauhan, R. Harrington, K.J. Swain, A. (2024). Cell-type-specific tumour sensitivity identified with a bromodomain targeting PROTAC in adenoid cystic carcinoma. J pathol, Vol.262 (1), pp. 37-49.  show abstract

Neeb, A. Figueiredo, I. Bogdan, D. Cato, L. Stober, J. Jiménez-Vacas, J.M. Gourain, V. Lee, I.I. Seeger, R. Muhle-Goll, C. Gurel, B. Welti, J. Nava Rodrigues, D. Rekowski, J. Qiu, X. Jiang, Y. Di Micco, P. Mateos, B. Bielskutė, S. Riisnaes, R. Ferreira, A. Miranda, S. Crespo, M. Buroni, L. Ning, J. Carreira, S. Bräse, S. Jung, N. Gräßle, S. Swain, A. Salvatella, X. Plymate, S.R. Al-Lazikani, B. Long, H.W. Yuan, W. Brown, M. Cato, A.C. de Bono, J.S. Sharp, A. (2024). Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer. Mol cancer ther, .  show abstract

Kerrison, W.G. Ning, J. Krasny, L. Arthur, A. Guljar, N. Elms, M.L. Swain, A. Jones, R.L. Thway, K. Huang, P.H. (2022). Characterisation of a Novel Cell Line (ICR-SS-1) Established from a Patient-Derived Xenograft of Synovial Sarcoma. Cells, Vol.11 (15).  show abstract  full text

Sowalsky, A.G. Figueiredo, I. Lis, R.T. Coleman, I. Gurel, B. Bogdan, D. Yuan, W. Russo, J.W. Bright, J.R. Whitlock, N.C. Trostel, S.Y. Ku, A.T. Patel, R.A. True, L.D. Welti, J. Jimenez-Vacas, J.M. Rodrigues, D.N. Riisnaes, R. Neeb, A. Sprenger, C.T. Swain, A. Wilkinson, S. Karzai, F. Dahut, W.L. Balk, S.P. Corey, E. Nelson, P.S. Haffner, M.C. Plymate, S.R. de Bono, J.S. Sharp, A. (2022). Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer. Clin cancer res, Vol.28 (16), pp. 3509-3525.  show abstract  full text

Francis, J.C. Gardiner, J.R. Renaud, Y. Chauhan, R. Weinstein, Y. Gomez-Sanchez, C. Lefrançois-Martinez, A.-. Bertherat, J. Val, P. Swain, A. (2021). HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours. Br j cancer, Vol.124 (4), pp. 805-816.  show abstract  full text

Neeb, A. Herranz, N. Arce-Gallego, S. Miranda, S. Buroni, L. Yuan, W. Athie, A. Casals, T. Carmichael, J. Rodrigues, D.N. Gurel, B. Rescigno, P. Rekowski, J. Welti, J. Riisnaes, R. Gil, V. Ning, J. Wagner, V. Casanova-Salas, I. Cordoba, S. Castro, N. Fenor de la Maza, M.D. Seed, G. Chandran, K. Ferreira, A. Figueiredo, I. Bertan, C. Bianchini, D. Aversa, C. Paschalis, A. Gonzalez, M. Morales-Barrera, R. Suarez, C. Carles, J. Swain, A. Sharp, A. Gil, J. Serra, V. Lord, C. Carreira, S. Mateo, J. de Bono, J.S. (2021). Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. Eur urol, Vol.79 (2), pp. 200-211.  show abstract  full text

Welti, J. Sharp, A. Brooks, N. Yuan, W. McNair, C. Chand, S.N. Pal, A. Figueiredo, I. Riisnaes, R. Gurel, B. Rekowski, J. Bogdan, D. West, W. Young, B. Raja, M. Prosser, A. Lane, J. Thomson, S. Worthington, J. Onions, S. Shannon, J. Paoletta, S. Brown, R. Smyth, D. Harbottle, G.W. Gil, V.S. Miranda, S. Crespo, M. Ferreira, A. Pereira, R. Tunariu, N. Carreira, S. Neeb, A.J. Ning, J. Swain, A. Taddei, D. SU2C/PCF International Prostate Cancer Dream Team, Schiewer, M.J. Knudsen, K.E. Pegg, N. de Bono, J.S. (2021). Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer discov, Vol.11 (5), pp. 1118-1137.  show abstract  full text

Gil, V. Miranda, S. Riisnaes, R. Gurel, B. D'Ambrosio, M. Vasciaveo, A. Crespo, M. Ferreira, A. Brina, D. Troiani, M. Sharp, A. Sheehan, B. Christova, R. Seed, G. Figueiredo, I. Lambros, M. Dolling, D. Rekowski, J. Alajati, A. Clarke, M. Pereira, R. Flohr, P. Fowler, G. Boysen, G. Sumanasuriya, S. Bianchini, D. Rescigno, P. Aversa, C. Tunariu, N. Guo, C. Paschalis, A. Bertan, C. Buroni, L. Ning, J. Carreira, S. Workman, P. Swain, A. Califano, A. Shen, M.M. Alimonti, A. Neeb, A. Welti, J. Yuan, W. de Bono, J. PCF/SU2C International Prostate Cancer Dream Team, (2021). HER3 Is an Actionable Target in Advanced Prostate Cancer. Cancer res, Vol.81 (24), pp. 6207-6218.  show abstract  full text

Ermini, L. Francis, J.C. Rosa, G.S. Rose, A.J. Ning, J. Greaves, M. Swain, A. (2021). Evolutionary selection of alleles in the melanophilin gene that impacts on prostate organ function and cancer risk. Evol med public health, Vol.9 (1), pp. 311-321.  show abstract  full text

Krasny, L. Bland, P. Burns, J. Lima, N.C. Harrison, P.T. Pacini, L. Elms, M.L. Ning, J. Garcia Martinez, V. Yu, Y.-. Acton, S.E. Ho, P.-. Calvo, F. Swain, A. Howard, B.A. Natrajan, R.C. Huang, P.H. (2020). A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts. Dis model mech, .  show abstract

Krasny, L. Bland, P. Burns, J. Lima, N.C. Harrison, P.T. Pacini, L. Elms, M.L. Ning, J. Martinez, V.G. Yu, Y.-. Acton, S.E. Ho, P.-. Calvo, F. Swain, A. Howard, B.A. Natrajan, R.C. Huang, P.H. (2020). A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts. Dis model mech, Vol.13 (7).  show abstract  full text

Fletcher, C.E. Sulpice, E. Combe, S. Shibakawa, A. Leach, D.A. Hamilton, M.P. Chrysostomou, S.L. Sharp, A. Welti, J. Yuan, W. Dart, D.A. Knight, E. Ning, J. Francis, J.C. Kounatidou, E.E. Gaughan, L. Swain, A. Lupold, S.E. de Bono, J.S. McGuire, S.E. Gidrol, X. Bevan, C.L. (2019). Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer. Oncogene, Vol.38 (28), pp. 5700-5724.  show abstract  full text

Gonzalez-Exposito, R. Semiannikova, M. Griffiths, B. Khan, K. Barber, L.J. Woolston, A. Spain, G. von Loga, K. Challoner, B. Patel, R. Ranes, M. Swain, A. Thomas, J. Bryant, A. Saffery, C. Fotiadis, N. Guettler, S. Mansfield, D. Melcher, A. Powles, T. Rao, S. Watkins, D. Chau, I. Matthews, N. Wallberg, F. Starling, N. Cunningham, D. Gerlinger, M. (2019). CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. J immunother cancer, Vol.7 (1), p. 101.  show abstract  full text

Welti, J. Sharp, A. Yuan, W. Dolling, D. Nava Rodrigues, D. Figueiredo, I. Gil, V. Neeb, A. Clarke, M. Seed, G. Crespo, M. Sumanasuriya, S. Ning, J. Knight, E. Francis, J.C. Hughes, A. Halsey, W.S. Paschalis, A. Mani, R.S. Raj, G.V. Plymate, S.R. Carreira, S. Boysen, G. Chinnaiyan, A.M. Swain, A. de Bono, J.S. International SU2C/PCF Prostate Cancer Dream Team, (2018). Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC). Clin cancer res, Vol.24 (13), pp. 3149-3162.  show abstract  full text

Francis, J.C. Swain, A. (2018). Prostate Organogenesis. Cold spring harb perspect med, Vol.8 (7).  show abstract

Pettitt, S.J. Krastev, D.B. Brandsma, I. Dréan, A. Song, F. Aleksandrov, R. Harrell, M.I. Menon, M. Brough, R. Campbell, J. Frankum, J. Ranes, M. Pemberton, H.N. Rafiq, R. Fenwick, K. Swain, A. Guettler, S. Lee, J.-. Swisher, E.M. Stoynov, S. Yusa, K. Ashworth, A. Lord, C.J. (2018). Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nat commun, Vol.9 (1), p. 1849.  show abstract  full text

Francis, J.C. Capper, A. Ning, J. Knight, E. de Bono, J. Swain, A. (2018). SOX9 is a driver of aggressive prostate cancer by promoting invasion, cell fate and cytoskeleton alterations and epithelial to mesenchymal transition. Oncotarget, Vol.9 (7), pp. 7604-7615.  show abstract  full text

Pettitt, S.J. Krastev, D.B. Pemberton, H.N. Fontebasso, Y. Frankum, J. Rehman, F.L. Brough, R. Song, F. Bajrami, I. Rafiq, R. Wallberg, F. Kozarewa, I. Fenwick, K. Armisen-Garrido, J. Swain, A. Gulati, A. Campbell, J. Ashworth, A. Lord, C.J. (2017). Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. Sci data, Vol.4, p. 170020.  show abstract  full text

Shenoy, T.R. Boysen, G. Wang, M.Y. Xu, Q.Z. Guo, W. Koh, F.M. Wang, C. Zhang, L.Z. Wang, Y. Gil, V. Aziz, S. Christova, R. Rodrigues, D.N. Crespo, M. Rescigno, P. Tunariu, N. Riisnaes, R. Zafeiriou, Z. Flohr, P. Yuan, W. Knight, E. Swain, A. Ramalho-Santos, M. Xu, D.Y. de Bono, J. Wu, H. (2017). CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair. Ann oncol, Vol.28 (7), pp. 1495-1507.  show abstract  full text

Magness, A.J. Squires, J.A. Griffiths, B. Khan, K. Swain, A. Willison, K.R. Cunningham, D. Gerlinger, M. Klug, D.R. (2017). Multiplexed single cell protein expression analysis in solid tumours using a miniaturised microfluidic assay. Convergent science physical oncology, Vol.3 (2).

Swain, A. (2017). Ductal sex determination. Science, Vol.357 (6352), p. 648.

Pearson, A. Smyth, E. Babina, I.S. Herrera-Abreu, M.T. Tarazona, N. Peckitt, C. Kilgour, E. Smith, N.R. Geh, C. Rooney, C. Cutts, R. Campbell, J. Ning, J. Fenwick, K. Swain, A. Brown, G. Chua, S. Thomas, A. Johnston, S.R. Ajaz, M. Sumpter, K. Gillbanks, A. Watkins, D. Chau, I. Popat, S. Cunningham, D. Turner, N.C. (2016). High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. Cancer discov, Vol.6 (8), pp. 838-851.  show abstract  full text

International Surgical Outcomes Study group, (2016). Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries. Br j anaesth, Vol.117 (5), pp. 601-609.  show abstract

Francis, J.C. Melchor, L. Campbell, J. Kendrick, H. Wei, W. Armisen-Garrido, J. Assiotis, I. Chen, L. Kozarewa, I. Fenwick, K. Swain, A. Smalley, M.J. Lord, C.J. Ashworth, A. (2015). Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours. J pathol, Vol.236 (2), pp. 186-200.  show abstract

Mateo, J. Carreira, S. Sandhu, S. Miranda, S. Mossop, H. Perez-Lopez, R. Nava Rodrigues, D. Robinson, D. Omlin, A. Tunariu, N. Boysen, G. Porta, N. Flohr, P. Gillman, A. Figueiredo, I. Paulding, C. Seed, G. Jain, S. Ralph, C. Protheroe, A. Hussain, S. Jones, R. Elliott, T. McGovern, U. Bianchini, D. Goodall, J. Zafeiriou, Z. Williamson, C.T. Ferraldeschi, R. Riisnaes, R. Ebbs, B. Fowler, G. Roda, D. Yuan, W. Wu, Y.-. Cao, X. Brough, R. Pemberton, H. A'Hern, R. Swain, A. Kunju, L.P. Eeles, R. Attard, G. Lord, C.J. Ashworth, A. Rubin, M.A. Knudsen, K.E. Feng, F.Y. Chinnaiyan, A.M. Hall, E. de Bono, J.S. (2015). DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N engl j med, Vol.373 (18), pp. 1697-1708.  show abstract  full text

Lokody, I.B. Francis, J.C. Gardiner, J.R. Erler, J.T. Swain, A. (2015). Pten Regulates Epithelial Cytodifferentiation during Prostate Development. Plos one, Vol.10 (6), p. e0129470.  show abstract  full text

Bryant, S.L. Francis, J.C. Lokody, I.B. Wang, H. Risbridger, G.P. Loveland, K.L. Swain, A. (2014). Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development. Dev biol, Vol.395 (2), pp. 209-217.  show abstract  full text

Francis, J.C. Thomsen, M.K. Taketo, M.M. Swain, A. (2013). beta-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma. Plos genetics, Vol.9 (1).

Buaas, F.W. Gardiner, J.R. Clayton, S. Val, P. Swain, A. (2012). In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development, Vol.139 (24), pp. 4561-4570.  show abstract

Strochlic, L. Falk, J. Goillot, E. Sigoillot, S. Bourgeois, F. Delers, P. Rouviere, J. Swain, A. Castellani, V. Schaeffer, L. Legay, C. (2012). Wnt4 Participates in the Formation of Vertebrate Neuromuscular Junction. Plos one, Vol.7 (1).

Gardiner, J.R. Shima, Y. Morohashi, K.-. Swain, A. (2012). SF-1 expression during adrenal development and tumourigenesis. Molecular and cellular endocrinology, Vol.351 (1), pp. 12-18.

Tsaousi, A. Williams, H. Lyon, C.A. Taylor, V. Swain, A. Johnson, J.L. George, S.J. (2011). Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening. Circulation research, Vol.108 (4), pp. 427-27.

Thomsen, M.K. Ambroisine, L. Wynn, S. Cheah, K.S. Foster, C.S. Fisher, G. Berney, D.M. Møller, H. Reuter, V.E. Scardino, P. Cuzick, J. Ragavan, N. Singh, P.B. Martin, F.L. Butler, C.M. Cooper, C.S. Swain, A. Transatlantic Prostate Group, (2010). SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer res, Vol.70 (3), pp. 979-987.  show abstract

Francis, J.C. McCarthy, A. Thomsen, M.K. Ashworth, A. Swain, A. (2010). Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis. Plos genetics, Vol.6 (6), p. 9.

Val, P. Swain, A. (2010). Gene dosage effects and transcriptional regulation of early mammalian adrenal cortex development. Molecular and cellular endocrinology, Vol.323 (1), pp. 105-10.

Buaas, F.W. Val, P. Swain, A. (2009). The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum mol genet, Vol.18 (16), pp. 2989-3001.  show abstract

Thomsen, M.K. Francis, J.C. Swain, A. (2008). The role of Sox9 in prostate development. Differentiation, Vol.76 (6), pp. 728-8.

Thomsen, M.K. Butler, C.M. Shen, M.M. Swain, A. (2008). Sox9 is required for prostate development. Dev biol, Vol.316 (2), pp. 302-311.  show abstract

Val, P. Martinez-Barbera, J.-. Swain, A. (2007). Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development, Vol.134 (12), pp. 2349-2358.  show abstract

Val, P. Jeays-Ward, K. Swain, A. (2006). Identification of a novel population of adrenal-like cells in the mammalian testis. Dev biol, Vol.299 (1), pp. 250-256.  show abstract

Swain, A. (2006). Sex determination: time for meiosis? The gonad decides. Curr biol, Vol.16 (13), pp. R507-R509.  show abstract

Val, P. Swain, A. (2005). Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals. Nature clinical practice urology, Vol.2 (12), pp. 616-12.

Yao, H.H. Matzuk, M.M. Jorgez, C.J. Menke, D.B. Page, D.C. Swain, A. Capel, B. (2004). Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Developmental dynamics, Vol.230 (2), pp. 210-6.  full text

Jeays-Ward, K. Dandonneau, M. Swain, A. (2004). Wnt4 is required for proper male as well as female sexual development. Dev biol, Vol.276 (2), pp. 431-440.  show abstract

Mizusaki, H. Kawabe, K. Mukai, T. Ariyoshi, E. Kasahara, M. Yoshioka, H. Swain, A. Morohashi, K. (2003). Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by Wnt4 in the female developing gonad. Molecular endocrinology, Vol.17 (4), pp. 507-13.

Jeays-Ward, K. Hoyle, C. Brennan, J. Dandonneau, M. Alldus, G. Capel, B. Swain, A. (2003). Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development, Vol.130 (16), pp. 3663-3670.  show abstract

Swain, A. (2002). Vertebrate sex determination: a new player in the field. Curr biol, Vol.12 (17), pp. R602-R603.  show abstract

Hoyle, C. Narvaez, V. Alldus, G. Lovell-Badge, R. Swain, A. (2002). Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad. Mol endocrinol, Vol.16 (4), pp. 747-756.  show abstract

De Vries, G.J. Rissman, E.F. Simerly, R.B. Yang, L.Y. Scordalakes, E.M. Auger, C.J. Swain, A. Lovell-Badge, R. Burgoyne, P.S. Arnold, A.P. (2002). A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. Journal of neuroscience, Vol.22 (20), pp. 9005-10.

Jordan, B.K. Mohammed, M. Ching, S.T. Délot, E. Chen, X.-. Dewing, P. Swain, A. Rao, P.N. Elejalde, B.R. Vilain, E. (2001). Up-Regulation of WNT-4 Signaling and Dosage-Sensitive Sex Reversal in Humans. The american journal of human genetics, Vol.68 (5), pp. 1102-1109.

Swain, A. (2000). Molecular mechanisms in sex determination and gonadal development. Biology of reproduction, Vol.62, pp. 83-1.

Swain, A. Lovell-Badge, R. (1999). Mammalian sex determination: a molecular drama. Genes & development, Vol.13 (7), pp. 755-13.

Swain, A. Lovell-Badge, R. (1998). Developmental genetics - Too much sex is bad for males. Nature, Vol.396 (6707), pp. 115-2.

Swain, A. Narvaez, V. Burgoyne, P. Camerino, G. Lovell-Badge, R. (1998). Dax1 antagonizes Sry action in mammalian sex determination. Nature, Vol.391 (6669), pp. 761-767.  show abstract

Swain, A. Lovell-Badge, R. (1997). A molecular approach to sex determination in mammals. Acta paediatr suppl, Vol.423, pp. 46-49.  show abstract

Swain, A. Zanaria, E. Hacker, A. Lovell-Badge, R. Camerino, G. (1996). Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nat genet, Vol.12 (4), pp. 404-409.  show abstract

Morais da Silva, S. Hacker, A. Harley, V. Goodfellow, P. Swain, A. Lovell-Badge, R. (1996). Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat genet, Vol.14 (1), pp. 62-68.  show abstract

Ikeda, Y. Swain, A. Weber, T.J. Hentges, K.E. Zanaria, E. Lalli, E. Tamai, K.T. Sassone-Corsi, P. Lovell-Badge, R. Camerino, G. Parker, K.L. (1996). Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. Molecular endocrinology, Vol.10 (10), pp. 1261-1272.

Ikeda, Y. Swain, A. Weber, T.J. Hentges, K.E. Zanaria, E. Lalli, E. Tamai, K.T. SassoneCorsi, P. LovellBadge, R. Camerino, G. Parker, K.L. (1996). Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development. Molecular endocrinology, Vol.10 (10), pp. 1261-12.

Capel, B. Swain, A. Nicolis, S. Hacker, A. Walter, M. Koopman, P. Goodfellow, P. Lovell-Badge, R. (1993). Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell, Vol.73 (5), pp. 1019-1030.  show abstract