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Journal Articles

Radzisheuskaya, A. Peña-Rømer, I. Lorenzini, E. Koche, R. Zhan, Y. Shliaha, P.V. Cooper, A.J. Fan, Z. Shlyueva, D. Johansen, J.V. Hendrickson, R.C. Helin, K. (2023). An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions. Embo j, Vol.42 (24), p. e114221.  show abstract

Radzisheuskaya, A. Shliaha, P.V. Grinev, V.V. Shlyueva, D. Damhofer, H. Koche, R. Gorshkov, V. Kovalchuk, S. Zhan, Y. Rodriguez, K.L. Johnstone, A.L. Keogh, M.-. Hendrickson, R.C. Jensen, O.N. Helin, K. (2021). Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. Mol cell, Vol.81 (8), pp. 1749-1765.e8.  show abstract

Damhofer, H. Radzisheuskaya, A. Helin, K. (2021). Generation of locus-specific degradable tag knock-ins in mouse and human cell lines. Star protoc, Vol.2 (2), p. 100575.  show abstract

Tremble, K.C. Stirparo, G.G. Bates, L.E. Maskalenka, K. Stuart, H.T. Jones, K. Andersson-Rolf, A. Radzisheuskaya, A. Koo, B.-. Bertone, P. Silva, J.C. (2021). Sox2 modulation increases naïve pluripotency plasticity. Iscience, Vol.24 (3), p. 102153.  show abstract

Müller, I. Moroni, A.S. Shlyueva, D. Sahadevan, S. Schoof, E.M. Radzisheuskaya, A. Højfeldt, J.W. Tatar, T. Koche, R.P. Huang, C. Helin, K. (2021). MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nat commun, Vol.12 (1), p. 3034.  show abstract

Pastore, F. Bhagwat, N. Pastore, A. Radzisheuskaya, A. Karzai, A. Krishnan, A. Li, B. Bowman, R.L. Xiao, W. Viny, A.D. Zouak, A. Park, Y.C. Cordner, K.B. Braunstein, S. Maag, J.L. Grego, A. Mehta, J. Wang, M. Lin, H. Durham, B.H. Koche, R.P. Rampal, R.K. Helin, K. Scherle, P. Vaddi, K. Levine, R.L. (2020). PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN. Cancer discov, Vol.10 (11), pp. 1742-1757.  show abstract

Stuart, H.T. Stirparo, G.G. Lohoff, T. Bates, L.E. Kinoshita, M. Lim, C.Y. Sousa, E.J. Maskalenka, K. Radzisheuskaya, A. Malcolm, A.A. Alves, M.R. Lloyd, R.L. Nestorowa, S. Humphreys, P. Mansfield, W. Reik, W. Bertone, P. Nichols, J. Göttgens, B. Silva, J.C. (2019). Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell stem cell, Vol.25 (3), pp. 388-406.e8.  show abstract

Radzisheuskaya, A. Shliaha, P.V. Grinev, V. Lorenzini, E. Kovalchuk, S. Shlyueva, D. Gorshkov, V. Hendrickson, R.C. Jensen, O.N. Helin, K. (2019). PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nat struct mol biol, Vol.26 (11), pp. 999-1012.  show abstract

Garland, W. Comet, I. Wu, M. Radzisheuskaya, A. Rib, L. Vitting-Seerup, K. Lloret-Llinares, M. Sandelin, A. Helin, K. Jensen, T.H. (2019). A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell rep, Vol.29 (7), pp. 1800-1811.e6.  show abstract

Radzisheuskaya, A. Shlyueva, D. Müller, I. Helin, K. (2016). Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic acids res, Vol.44 (18), p. e141.  show abstract

Pedersen, M.T. Kooistra, S.M. Radzisheuskaya, A. Laugesen, A. Johansen, J.V. Hayward, D.G. Nilsson, J. Agger, K. Helin, K. (2016). Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. Embo j, Vol.35 (14), pp. 1550-1564.  show abstract

Stuart, H.T. van Oosten, A.L. Radzisheuskaya, A. Martello, G. Miller, A. Dietmann, S. Nichols, J. Silva, J.C. (2014). NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program. Curr biol, Vol.24 (3), pp. 340-346.  show abstract

dos Santos, R.L. Tosti, L. Radzisheuskaya, A. Caballero, I.M. Kaji, K. Hendrich, B. Silva, J.C. (2014). MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner. Cell stem cell, Vol.15 (1), pp. 102-110.  show abstract

Radzisheuskaya, A. Silva, J.C. (2014). Do all roads lead to Oct4? the emerging concepts of induced pluripotency. Trends cell biol, Vol.24 (5), pp. 275-284.  show abstract

Christophorou, M.A. Castelo-Branco, G. Halley-Stott, R.P. Oliveira, C.S. Loos, R. Radzisheuskaya, A. Mowen, K.A. Bertone, P. Silva, J.C. Zernicka-Goetz, M. Nielsen, M.L. Gurdon, J.B. Kouzarides, T. (2014). Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature, Vol.507 (7490), pp. 104-108.  show abstract

Radzisheuskaya, A. Chia, G.L. dos Santos, R.L. Theunissen, T.W. Castro, L.F. Nichols, J. Silva, J.C. (2013). A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nat cell biol, Vol.15 (6), pp. 579-590.  show abstract

Davies, O.R. Lin, C.-. Radzisheuskaya, A. Zhou, X. Taube, J. Blin, G. Waterhouse, A. Smith, A.J. Lowell, S. (2013). Tcf15 primes pluripotent cells for differentiation. Cell rep, Vol.3 (2), pp. 472-484.  show abstract

Pasque, V. Radzisheuskaya, A. Gillich, A. Halley-Stott, R.P. Panamarova, M. Zernicka-Goetz, M. Surani, M.A. Silva, J.C. (2012). Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J cell sci, Vol.125 (Pt 24), pp. 6094-6104.  show abstract

Posrednik, D.V. Ramanouskaya, T.V. Radzisheuskaya, A.A. Khatkevich, A.A. Goncharevich, A.Y. Cherepovich, V.S. Grinev, V.V. (2011). Structural and thermodynamic features of intergenic and intronic human primary microRNAs. Molecular biology, Vol.45 (3), pp. 508-516.

Theunissen, T.W. Costa, Y. Radzisheuskaya, A. van Oosten, A.L. Lavial, F. Pain, B. Castro, L.F. Silva, J.C. (2011). Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development, Vol.138 (22), pp. 4853-4865.  show abstract

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