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Macromolecular Structure Group

Professor Pearl's group seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways.

Team leader

Professor Laurence Pearl

Professor Laurence Pearl

Team Leader

Professor Pearl seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways. These basic studies provide the means for discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.

ORCID 0000-0002-6910-1809

Team members

Dr Jasmeen Oberoi

Non-Honorary (DIRECTSB)

Dr Mohinder Pal

Honorary Appointment (DIRECTSB)