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Centre for Paediatric Oncology Experimental Medicine 

The Centre for Paediatric Oncology Experimental Medicine, a collaboration between The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, is identifying and studying the molecular changes underlying the development of childhood cancers and targeting them with innovative new treatments. 

We aim to accelerate the discovery and development of innovative new treatments for children with cancer, by expanding research infrastructure and academic training, producing translational research, through designing and implementing mechanistically driven, biomarker-enriched clinical trials.

Movember Centre Members

Through our new state-our-the-art Centre, we want to speed up advances in treatment for children with cancer. Our Centre aims to develop collaborative research projects that will grow and further strengthen links between scientists and clinicians, between the ICR and The Royal Marsden’s Oak Paediatric and Adolescent Drug Development Unit, and with other clinical and research centres.  

We have identified a particular need to train more academic clinicians in paediatric oncology to be able to correctly interpret complex research data and integrate findings into their clinical practice. We see significant potential in being able to cooperate more widely in the acquisition, analysis and interpretation of samples and data from patients. If we can share expertise in interpreting large datasets, it should enable us to identify and drug the key biological changes that cause paediatric cancers. 

We ultimately aim to identify and target the molecular changes that cause childhood cancer development. We aim to deliver first-in-child cancer drugs together with biomarkers capable of guiding their use in patients into innovative clinical trials. All of the resources we develop and make available through our Centre will be focused on this overriding priority - to develop innovative treatments for children with cancer and extend patient survival. 


Professor Louis Chesler

Professor Louis Chesler is Head of the Centre for Paediatric Experimental Medicine.

Professor Louis Chesler

Dr Lynley Marshall

Dr Lynley Marshall, Oak Foundation Consultant in Paediatric and Adolescent Oncology Drug Development, is the clinical lead for the Centre at The Royal Marsden.

Dr Lynley Marshall

Scientific aims

The Centre’s goal is to deliver novel treatments, diagnostic tests and clinical practice change to children with cancer within the context of hypothesis-driven and biomarker-enriched clinical trials.

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