Our Research Research divisions Breast Cancer Research Breast Cancer Now Research Centre Director Publications Breast Cancer Research Bioinformatics Group Breast Cancer Systemic Therapy Trials Publications Research overview Breast Surgery Outcome Measures Research overview Research projects Publications Cancer Stem Cell Research overview Publications Cell Death and Immunity Research overview Research projects Publications News from the Cell Death and Immunity laboratory Alumni Drug Target Discovery Publications Endocrine Control Mechanisms Research overview Research projects Functional Genetic Epidemiology Research overview Research projects Publications Functional Genomics Research overview Research projects Publications Gene Function Research overview Research projects Publications Molecular Cell Biology Research overview Research projects Publications Molecular Oncology Research overview Research projects Publications Target Validation and DNA Damage Response Research overview Research projects Publications Cancer Biology Cell Division Research overview Publications Chromatin Biology Publications Development and Cancer Research overview Research projects Publications Dynamical Cell Systems Research overview Research projects Cell Shape and Movement Cellular Response to Stress Cell Cycle and Cell Division Publications Resources Epigenetics and Cancer Epigenetics and Genome Stability Research overview Research projects Publications Functional Proteomics Research overview Research projects Publications Genome Instability and Cancer Research overview Research projects Publications Genome Replication Team Research overview Genome Stability and Innate Immunity Research overview Publications Post-translational Modifications and Cell Proliferation Short Linear Motif Research overview Resources and tools Publications Signalling and Cancer Metabolism Research overview Research projects Publications Structural Biology of Cell Signalling Telomere Biology Research overview Publications Cancer Therapeutics Cancer Biomarkers Clinical Pharmacodynamics Biomarker Group Research overview Research projects Publications Cancer Pharmacology and Stress Response Publications Clinical Pharmacology Adaptive Therapy Group Research overview Research projects Publications Chromosomal Translocations and Intracellular Antibody Therapeutics Research overview The LMO gene and protein family Clinical Pharmacology & Trials (including Drug Metabolism and Pharmacokinetics Group) Research overview Computational Biology and Chemogenomics Publications Head of Biology & Leader of Cell Cycle Control Research overview Research projects PKB (AKT) Kinase Cell Cycle Checkpoint Kinases CHK1 and CHK2 Publications Hit Discovery & Structural Design Research overview Research projects Assay Development and Screening Fragment-based lead discovery Structure-based drug design of cancer drugs Publications Medicinal Chemistry 1 Medicinal Chemistry 2 Research overview Research projects Discovery and Development of Anticancer Drugs Fragment-based Inhibitor Discovery New Screening Libraries for Anticancer Drug Discovery Publications Medicinal Chemistry 3 Research overview Publications Medicinal Chemistry 4 (including Structural Chemistry) Research overview Research projects Publications Medicine (de Bono) Drug Development Unit Myeloma Biology and Therapeutics Publications PET Radiochemistry Signal Transduction and Molecular Pharmacology Research overview Publications Structure-Based Drug Design Target Biology and Genomic Instability Target Evaluation and Molecular Therapeutics Research Overview Publications Thoracic Oncology Immunotherapy Group Systems Chemical Biology Publications Clinical Studies Cancer Biomarkers Research overview Publications ICR-CTSU Integrative Genomic Analysis in Clinical Trials Research overview Research projects Publications Gynaecological Cancers (Systemic Therapy and Clinical Trials) Research overview Research projects Publications Gynaecological Oncology Surgery Research overview ICR-CTSU Breast and Rare Cancers Trials Research overview Research projects Breast Cancer Clinical Trials Head & Neck Cancer Clinical Trials Melanoma Clinical Trials Other Cancer Clinical Trials Urological Cancer Clinical Trials Radiotherapy Clinical Trials Chemotherapy Clinical Trials Hormone Therapy Clinical Trials Surgical Treatment Clinical Trials Clinical Trials of Other Treatments Combination Therapy Clinical Trials Publications ICR-CTSU Early Phase and Adaptive Trials Publications Professional activities Health Informatics ICR-CTSU Radiotherapy, Urology and Head and Neck Cancers Trials Research overview Research projects Urological Cancer Clinical Trials Head and Neck Cancer Clinical Trials Publications The Adult Drug Development Unit at the ICR and the RM Research overview Our team Our facilities Collaboration Training programmes Testimonials Melanoma and Kidney Cancer Team Research overview Research projects Dr James Larkin's publications Dr Samra Turajlic's publications Paediatric & Adolescent Neuro-Oncology and Drug Development (Carceller) Paediatric Solid Tumour Biology and Therapeutics Research overview Research projects Publications Prostate Cancer Targeted Therapy Group Research overview Publications Sarcoma Clinical Trials in Children and Young People Research overview Publications Sarcoma Clinical Trials and Translational Research Research overview Thoracic Oncology Publications Translational Therapeutics Research overview Publications Professional activities Genetics and Epidemiology Aetiological Epidemiology Publications Cancer Genomics Research overview Publications Myeloma Group Oncogenetics Research overview Research projects Research overview UK Genetic Prostate Cancer Study Research overview Getting involved as a patient Information for UKGPCS collaborators Guidelines and study forms for collaborators UKGPCS publications Getting involved as a collaborator Ethics history IMPACT PROFILE GENPET BARCODE 1 BARCODE 2 GENPROS The UK Genetic Prostate Cancer Study (UKGPCS) Publications Translational Genetics Research overview Research projects Publications Molecular Pathology Acute Leukaemia Team Research overview Publications Biology of Childhood Leukaemia Research overview Research projects Publications Chronic Lymphoid malignancies: Clinical Trials and Translational Research (El-Sharkawi) Computational Pathology and Integrative Genomics Research overview Research projects Publications Evolutionary Genomics and Modelling Research overview Publications Gastrointestinal Cancer Biology and Genomics Team Research overview Research projects Publications Glioma Team Research overview Research projects Genomic and epigenomic profiling Model development and preclinical screening Intratumoral heterogeneity and subclonal co-operation Publications Integrated Pathology Research overview LRF CLL4 trial Lymphoma biology and imaging Research overview Medicine (Brown Epigenetic Therapy) Research overview Research projects Molecular and Systems Oncology Team Research overview Research projects Publications Myeloma Molecular Therapy Research overview Publications Paediatric Solid Tumour Biology and Therapeutics Preclinical Modelling of Paediatric Cancer Evolution Research overview Publications Sarcoma Molecular Pathology Research overview Research projects Publications Systems and Precision Cancer Medicine Team Research overview Research projects Publications Translational Oncogenomics Research overview Publications Tumour Functional Heterogeneity Publications Translational Epigenetics Genomics and Evolutionary Dynamics Radiotherapy and Imaging Breast Cancer Radiotherapy Research overview Research projects Publications Clinical Academic Radiotherapy Team (Huddart) Research overview Publications Clinical Academic Radiotherapy Team (Yarnold) Research overview Research projects Publications Functional Imaging Team Research overview Research projects Imaging for Radiotherapy Adaptation Team Research overview Publications Research Projects Quantification of Radiation-Induced Tissue Fibrosis using Ultrasound Imaging Development of ultrasound motion estimation techniques to optimise radiation therapy delivery Development of ultrasound guided radiotherapy of the cervix and kidneys 3D ultrasound contrast imaging biomarkers for assessment of tumour response to radiotherapy Multi-parametric ultrasound imaging for assessment of tumour response to radiotherapy Magnetic Resonance Research overview Research projects Magnetic Resonance Imaging in Radiotherapy Research overview Oncogenetics Preclinical Molecular Imaging Research overview Research projects Publications Pre-Clinical MRI Research overview Publications Prostate and Bladder Cancer Research Research overview The Lancet Commission on Prostate Cancer Quantitative Biomedical Imaging Publications Radioisotope Physics Research overview Radiotherapy Physics Imaging Research overview Publications Radiotherapy Physics Modelling Research overview Publications Radiation-enhanced Immunotherapy Research overview Publications Sarcoma and Melanoma Surgery Research overview Research projects Stereotactic and Precision Radiotherapy Research overview Publications Targeted Therapy Team Research overview Research projects Publications Therapeutic Ultrasound Team Research overview Research projects Publications Translational Breast Radiobiology Research overview Publications Translational Immunotherapy Research overview Research projects Publications Translational Sarcoma, Melanoma and Rare Tumour Surgery Research overview Translational Therapeutic Radiography Research overview Research projects Publications Ultrasound and Optical Imaging Research overview Research projects High Frequency Transducers and Arrays Breast Imaging Neurosurgical Guidance Hybrid 3D Strain Image Acquisition Technique Quantitative elasticity imaging – slip elastography Porosity and Permeability Lateral Displacement and Strain Measurement High resolution and microscopic elastography Organ Motion Tracking Clinical Freehand Reflection-Mode Photoacoustic Imaging Illumination Optimisation for Freehand Reflection-Mode Photoacoustic Imaging Photoacoustic Absorption Spectroscopy and Gold Nanorods for Nolecular Imaging Photoacoustic Imaging and Emission Spectroscopy of Tumour Vascularisation Dynamic Contrast-Enhanced Ultrasound (DCE-US) for Tumour Response Acoustically Activated Nanoparticle Agents for Molecular Imaging Multimodality Imaging of Apoptosis Publications Uro-oncology clinical trials Research overview Research projects Publications Structural Biology Hit Discovery and Structural Design Macromolecular Structure Group Publications Mechanisms and Regulation of pre-mRNA Splicing Research overview Publications Molecular Mechanisms of Cell Cycle Regulation Research overview Structural Biology of Cell Signalling Research overview Research projects Publications Structural Biology of DNA Repair Complexes Research overview Publications Structural Electron Microscopy Research overview Research projects Structural Electron Microscopy Ubiquitin-proteasome System Publications Vannini Group Research overview Research projects Architecture of the RNA Pol III pre-initiation complex RNA polymerase III regulation by tumour suppressors and oncogenes Maf1-dependent regulation of RNA pol III activity by chromatin associated kinases Publications Researchers and teams Professor Alessandro Vannini Research overview Research projects Professional activities Publications Professor Chris Jones Research overview Research projects Professional activities Publications Professor Clare Turnbull Research overview Professional activities Publications Professor Emma Hall Research overview Research projects Professional activities Publications Dr Emma Harris Research overview Research projects Professional activities Publications Dr Marco Gerlinger Research overview Professional activities Publications Professor Nicola Valeri Research overview Research projects Professional activities Publications Dr Rob van Montfort Research overview Research projects Professional activities Publications Dr Sebastian Guettler Research overview Research projects Professional activities Publications Professor Rosalind Eeles Research overview Research projects Professional activities Publications Professor Richard Houlston Research overview Databases and studies National Study of Colorectal Cancer Genetics (NSCCG) FCLL study National Brain Tumour (NBT) study TRANSORCE study PICS database SNPLINK database Professional activities Publications Professor Sue Eccles Research overview Research projects Professor Chris Nutting Dr Andreas Wetscherek Research Overview Publications Dr Glenn Flux Research Overview Dr Fernando Carceller Professor Michael Hubank Dr Claudio Alfieri Research overview Publications Professor Mary O'Brien Dr Fiona McDonald Dr Alistair Ring Dr Naureen Starling Dr Mirco Meniconi Dr Astero Klampatsa Dr Gary Newton Research overview Publications Dr Alejandra Bruna Research overview Publications Dr Basil Greber Research overview Publications Professor Axel Behrens Research overview Publications Professor Manuel Salto-Tellez Research overview Publications Professor James O'Connor Publications Dr Christian Zierhut Research overview Publications Dr Erik Wennerberg Research overview Publications Professor Cathrin Brisken Research overview Research projects Publications Dr Marco Bezzi Publications Dr Charlotte Pawlyn Publications Dr Jörg Mansfeld Publications Dr Adam Sharp Research overview Publications Professional activities Dr Andrew Feber Professor Kristian Helin Dr Anna Minchom Publications Dr Alex Radzisheuskaya Publications Professor Trevor Graham About our research Our research strategy Our research excellence Genetics and cancer risk Cancer biology Drug discovery and therapeutic innovation Clinical trials Cancer evolution and precision medicine Imaging and radiotherapy Informatics at the ICR Departments and teams Tools and resources Careers in informatics Animal research at the ICR How we use animals Using mice to mimic childhood cancers The legislative landscape, ethics and welfare The 3Rs Concordat on Openness on Animal Research Position statement on animals in research The legislative landscape, ethics and welfare The 3Rs Concordat on Openness on Animal Research Position statement on animals in research Research themes Artificial intelligence Cancer evolution Clinical trials Chemical probes Genomics Immunotherapy BRCA gene mutations Research by cancer type Centres and collaborations Centres at the ICR Breast Cancer Now Toby Robins Research Centre Cancer Research UK Cancer Therapeutics Unit Research themes Teams and team leaders Where our new drug targets come from Centre for Cancer Imaging Centre for Evolution and Cancer Scientific aims Team Leaders The Darwin Cancer Blog The Darwin Cancer Blog Authors Background Clinical Trials and Statistics Unit Clinical trials HYBRID HYBRID trial documents (password required) RIO RIO trial documents (password required) UNIRAD UNIRAD trial documents (password required) A-PREDICT A-PREDICT trial documents (password required) VinCaP VinCaP trial documents (password required) BIG4-11 APHINITY PROMPTS TOPARP TOPARP trial documents (password required) BIG2-06 ALTTO MA32 AZURE RAIDER RAIDER trial documents (password required) RE-AKT RE-AKT trial documents (password required) PALLET PALLET trial documents (password required) DARS DARS trial documents (password required) REASURE AURORA CORE CORE trial documents (password required) InPACT InPACT trial documents (password required) PYTHIA PACE PACE trial documents PENELOPE-B plasmaMATCH plasmaMATCH trial documents (password required) PRIMETIME PRIMETIME trial documents (password required) HALT HALT trial documents (password required) RE-ARM RE-ARM trial documents (password protected) PEARLS PEARLS trial documents (password protected) HER2-RADiCAL HER2 -RADiCALtrial documents (password protected) SPRUCE PARABLE PARABLE trial documents (password protected) Other research Contact the ICR-CTSU team Collaborators Transparency Data sharing Patients and public Meetings Department of Data Science Partnerships with The Royal Marsden Biomedical Research Centre Centre for Global Oncology External research activities Centre for Molecular Pathology Centre for Translational Immunotherapy Scientific aims and themes Drug Development Unit ICR-ECMC Network Immunohistochemistry workshop Joint Department of Physics Joint Integrated Pathology Unit Scientific strategy Joint Sarcoma Research Centre Scientific aims and themes Sarcoma Accelerator Consortium Investigators Paediatric Oncology Experimental Medicine Scientific aims Strategic collaborations Cancer Research Centre of Excellence London Cancer Hub Movember Centre of Excellence Scientific aims Projects and collaborations Leadership profiles Professor Johann de Bono key publications Professor Rosalind Eeles key publications Professor Chris Parker key publications Success stories Abiraterone Cabazitaxel Enzalutamide Radium-223 Olaparib Convergence Science Centre The Cancer Epidemiology and Prevention Research Unit (CEPRU) CRUK Children’s Brain Tumour Centre of Excellence Cancer types Bladder cancer Blood cancers Bone cancer Bowel cancer Brain cancer Breast cancer Cervical cancer Childhood cancers Gastrointestinal cancers Head and neck cancer Kidney cancer Lung cancer Melanoma Ovarian cancer Pancreatic cancer Prostate cancer Sarcoma Our strategic partners The Royal Marsden NHS Foundation Trust Cancer Research UK Breast Cancer Now Publications repository Facilities Breast Cancer Now Nina Barough pathology core facility Cell culture facility Cell imaging facility Electron microscopy facility Flow cytometry facility Mechanical workshop Proteomics Core Facility Scientific computing service Tumour Profiling Unit X-ray crystallography facility Studying and Training PhDs for science graduates PhD projects 2021/22 How to apply for your PhD Course essentials ICR and Imperial Convergence Science PhD programme Location and resources Entry requirements Fees and costs Contact us Opportunities for clinicians MSc in Oncology Course essentials Course modules Location and resources Entry requirements Fees and costs How to apply Contact us and FAQs PhD and MD(Res) for clinicians PhD research programmes for Clinicians Course essentials Funding options for clinical research degrees Clinical PhD Fellowships Location and resources Entry requirements Fees and costs How to apply Contact us and FAQs NIHR academic training Radiotherapy and imaging training courses Magnetic resonance imaging (MRI) and spectroscopy course Physics of medical imaging course Image Guided and Adaptive Radiotherapy in Clinical Practice Radiation protection training course Practical and theoretical radiotherapy physics course Nuclear medicine and PET imaging course Radioactive Waste Advisers Training Course Magnetic Resonance Image Guided Radiotherapy (MRIgRT) Survey shows almost all ICR clinical alumni stay research active Postgraduate life Sites and facilities Student benefits International Students Visas and Immigration Opening a bank account in the UK Student life in London Healthcare Registering with the police Accommodation and transport Student committee Student profiles Careers and destinations Alumni profiles Learning and teaching strategy Resources and support Tuition fees Education policies and strategies Quality assurance Learning and teaching strategy E-learning Training and development Library and information service Career support Employability statement Welfare and disability support Disabilities Student charter Academic support Resources for current students WiFi for visitors Contact the Registry Undergraduate Vacation Scholarship Scheme How to apply FAQs Careers Working at the ICR Professional career development Staff benefits Equality policies Our sites and facilities Overseas applicants Committees and societies Training and Development Current vacancies Team Leader vacancies Opportunities at the ICR Postdocs Early-career researchers Career development faculty Career faculty Opportunities for clinicians Employee profiles Dr Giulio Caravagna Elicia Fyle Andy Carr Dr Fabienne Beuron Daisy Henesy Jess Barnes Dr Becky Cook Research division contacts Working with Industry About the Business and Innovation Office Our philosophy for working with industry Business Development Entering into an agreement Clinical Trials Contracts Working with us Opportunities Our researchers Video: Developing therapeutic ultrasound Video: Technology development at the cutting edge of fundamental biology Video: Work with the world’s leading academic centre for drug discovery in oncology Video: Better experimental models to help drugs succeed in clinical trials Video: First-in-human phase I trials in collaboration with industry Video: Industry partnerships in breast cancer research Video: Drug development and clinical trials for immunotherapy and radiosensitising drugs Video: Access to state-of-the-art sequencing for industry partners Video: Working with pharmaceutical companies Video: New partnerships in cancer epigenetics Video: Sharing experience with industry partners Video: Collaborating with commercial partners Video: Exploring new opportunities for collaborative working Video: The benefits of partnering with industry Meet our entrepreneurs-in-residence Our successes Our industrial collaborators Case studies Spin Out Companies Contact the Business and Innovation Office Enterprise events Connections newsletter Connections blog Support Us Our appeals Prostate cancer appeal Bowel cancer appeal Immunotherapy appeal Revolutionising cancer treatment Monthly gift for cancer patients Philanthropy How philanthropy supports our research Centre for Cancer Drug Discovery Cancer's last note Discovery verses Pipette painting marks pioneering cancer research Finished symphony marks a new era of cancer drug discovery The Discovery Club Improving outcomes for women with hormone receptor positive breast cancer Training the next generation Discovery verses Lab coat art Get involved Sports and challenges Cycle London to Paris Cycle Ride RideLondon–Essex 100 Vietnam to Cambodia Cycle Ride Euro City Cycle Ride Run Trek Endurance challenges Run Virtual TCS London Marathon 2022 TCS London Marathon 2022 Royal Parks Half Marathon Edinburgh Marathon Festival Berlin Marathon Great North Run London Landmarks Half Marathon Vitality London 10,000 Cycle Trek Endurance challenges Trek Great Wall of China Trek Peru Inca Trail Ben Nevis Trek London 2 Brighton Challenge Cycle Run Endurance challenges Endurance challenges Fundraise for the ICR Cheering team volunteers Meet our supporters Donor stories The Bob Champion Cancer Trust Dr Sally Gold The Oracle Cancer Trust Masonic Charitable Foundation CRIS Cancer Foundation Rosetrees Trust One More City Legacy supporters The importance of a Will Will for Free programme members Supporter stories Royal Mail worker runs half marathon in father's memory Go-karting enthusiast organises 10th anniversary race in honour of his friend Team ICR steps up to help Carina ICR research hub named in honour of Artemis Wood Manchester father releases EP to fundraise in son’s honour Suffolk farmer flies 7,750 miles in home-built plane to raise money for charity Librarian closes chapter on another charity challenge Inspirational young woman smashes target of raising £21K for the ICR before 21st birthday Marathon runner dedicates each mile to someone who had died from cancer Breast cancer survivor keeps running as a legacy to her father Abbie’s Army join #teamICR for the London Marathon Runner inspired by friend takes her place in #teamICR Fast friends run half marathon around London’s greatest landmarks Great North Run 2018 And I would run 500 miles… for cancer research Matt rode 250km across Norway and Sweden on a husky sled to live by his late grandfather’s mantra Marika set to run three marathons in a month for The ICR despite her incurable breast cancer Caroline trains for the London Marathon to regain her fitness following cancer treatment Joining #teamICR has motivated James through his training for the London Marathon Make John Proud – raising money for male breast cancer research Sian Baker: the reason I cycled 100 miles Family charity partners Abbie’s Army Abbie's Fund Alice's Arc Aoife's Bubbles The Chris Lucas Trust Christopher’s Smile The Kelly Turner Foundation The Little Princess Trust Lucas’ Legacy The Ollie Young Foundation Rob's ARTTT The Rudy A Menon Foundation TeamLuke Foundation The Tom Bowdidge Foundation Our Trusts Fundraising Manager Share your story Share your story – form Leave a legacy Will for Free Supporter FAQs Solicitor FAQs Legacy supporters Giving in memory Our newsletter Search Contact the Development Office Make a donation Gift Aid Gift aid – thank you Payroll giving Blackbaud response About Us Our mission Our research strategy Unravelling cancer’s complexity Innovative approaches Smarter, kinder treatments Making it count Foundations Learning and teaching strategy Our values Responsibility Protecting the environment and sustainability at the ICR HR Excellence in Research Freedom of information Technician Commitment Good research practice Research evaluation Equality and diversity Women in science Athena SWAN charter Celebrating Women in Science Our women in science initiatives Leadership development for women Support for parents and parents-to-be Mentoring programmes REACH Forum LGBT+ Network Our achievements Scientific discoveries Carcinogens in cigarette smoke Discovering early chemotherapy drugs DNA damage and cancer The function of the thymus How cells become cancerous Identifying a breast cancer gene – BRCA2 Advanced radiotherapy techniques Transforming prostate cancer treatment – abiraterone Characterising the BRAF gene Targeting Hsp90 Practice-changing clinical trials in radiotherapy and imaging Identifying cancer predisposition genes Applying evolutionary biology to cancer Applying genetic principles to treatment of BRCA-mutant cancers Discovering and developing a leading PI3K inhibitor Transforming treatment for the most common type of breast cancer Developing the Pharmacological Audit Trail Academic excellence Commercialisation successes Annual research highlights Our history Policy and engagement Position statements Progress towards cancer cures Early-stage clinical trials of cancer drugs for children Clinical trials – regulation and transparency Patenting genetic information Research using animals The use of patient data in research The impact of the vote to leave the EU Big Data Collaboration with industry Innovation in cancer drug discovery and development Drug Evaluation Drug Pricing Early access to medicines Immunotherapy Radiotherapy Improving drug access Cancer Drug Manifesto Consensus statements Factsheets Your career in cancer research Public engagement Public engagement strategy Public events Resources for schools Creating cancer treatments Improving access to cancer clinical trials How we are funded Annual reports Income and expenditure How we are structured Our leadership team Board of Trustees Executive Board Corporate governance List of Trustees with associated charities ICR committees Research projects