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PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost

Disease site: Prostate cancer

Treatment modality: Radiotherapy

Status: Open to recruitment

Trial details

PIVOTALboost is a multicentre four-arm phase III randomised controlled trial. The trial is open to patients receiving radical radiotherapy for localised, node negative prostate cancer. The treatments being compared are radiotherapy to the prostate and pelvis versus prostate alone, with or without a prostate boost.

1952 patients will be recruited from UK sites over a 4.5 year period. Patients will receive radiotherapy treatment and will be followed up for at least 10 years.

Further information

Chief Investigator: Dr Isabel Syndikus, Clatterbridge Cancer Centre, Wirral

ICR-CTSU Scientific Lead: Prof Emma Hall 

Trial management contact: [email protected]

ISRCTN: ISRCTN80146950

Sponsor: The Institute of Cancer Research

Funding:  CRUK (CRUK/16/018)

View PIVOTALboost on the National Institute for Health Research website: NIHR - Be Part Of Research

A lay summary in plain English is available from Cancer Research UK

Current protocol: PIVOTALboost Protocol Version 5.0 24/05/2019

Publications and presentations

There have been no presentations or publications to date.

Clinical trials

Division of Clinical Studies

The division carries out or coordinates high-quality trials and translational research at both an early phase – typically to test new targeted drugs – and a later stage.