Research scientists and scientific support

Under the guidance of Alexis De Haven Brandon, we are seeking to recruit a Higher Scientific Officer. We seek an experienced and dedicated in vivo scientist. The central aim of this position is to undertake in vivo technical work, playing a key role in supporting a variety of in vivo experiments and laboratory approaches. You will be a highly skilled in vivo scientist with sound knowledge and experience in in vivo approaches in a research setting. You will possess a Home Office Personal Licence. Your responsibilities will include planning and performing animal procedures, maintaining detailed records, and performing some routine laboratory tasks. This position offers an excellent opportunity for a highly skilled in vivo scientist with a passion for in vivo science, and animal welfare. There will occasionally be the need for out of hours work to ensure Home Office compliance, and the needs of the projects are met. The successful candidate will be a motivated individual with a strong background in in vivo techniques. We highly value diversity and encourage candidates from all backgrounds to apply. About you The successful candidate must have: Personal Home Office Licence PIL A,B,C BSc in life sciences or equivalent Proven experience in a technical in vivo research setting - to include techniques such as dosing, surgical and sampling Ability to plan and execute complex in vivo studies, to the highest ethical standards Ability to work independently and collaboratively Department/Directorate Information The In Vivo Pharmacology team (IVP) provides in vivo support for all projects within the Centre for Cancer Drug Discovery (CCDD). The team carries out critical proof-of principle intervention studies and provides the essential pharmacological assays required to guide target validation in addition to the optimisation and selection of new drug candidates. Importantly, these experiments include the demonstration of drug effects in vivo, biomarker discovery and therapy studies, all of which underpin the drug discovery programs across the portfolio. The IVP works across a wide range of tumour models, including human tumour xenografts models (both cell line- and patient-derived xenografts), genetically engineered mouse models, organoid-based models and preclinical metastatic models. The team has specialised skills to develop and implement novel models, and supporting the design and implementation of studies, whilst complying with increasingly complex Home Office regulations. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Alexis De Haven Brandon: [email protected].

About the role Under the guidance of Alexis De Haven Brandon, We seek a dedicated early career in vivo scientist. The central aim of this position is to assist in the undertaking of in vivo technical work, playing a key role in supporting a variety of in vivo experiments and laboratory approaches. You will be an in vivo scientist with a basic knowledge and experience of in vivo techniques. Your responsibilities will include monitoring animal welfare, carrying out animal procedures, maintaining detailed records. This position offers an excellent opportunity for an early career in vivo scientist with a passion for in vivo science, and animal welfare. We offer full training to gain a home office PIL, for more technical procedures to the right candidate. There will occasionally be the need for out of hours work to ensure Home office compliance, and the needs of the projects are met. The successful candidate will be a motivated individual with a strong background in animal welfare and husbandry in a research setting. We highly value diversity and encourage candidates from all backgrounds to apply. About you The successful candidate must have: Broad-based knowledge of animal welfare within a research setting At least a year in an in vivo research setting with rodents. Proven experience in husbandry, welfare monitoring and animal handling. Ability to work both independently and as part of a team. BSc in life sciences/or related degree High degree of integrity and understanding of the need for confidentiality surrounding drug discovery programmes. Willingness to occasionally work out of hours. About our team Under UK law, animals can only be used for research if there is no appropriate alternative. All our research proposals are thoroughly assessed before approval to ensure that there is no alternative to the use of animals, and that the studies will provide valuable information that will ultimately help cancer patients. The ICR is strongly committed to the highest standards of animal welfare in all research studies, and has led the development of best practice in this area. We also support the principles of the 3Rs – replacement, refinement and reduction of use of animals for research – and are working to develop alternative experimental techniques. The In Vivo Pharmacology team provides in vivo support for all projects within the Centre for Cancer Drug Discovery. The team carries out critical proof-of-principle intervention studies and provides the essential pharmacological assays required to guide target validation in addition to the optimisation and selection of new drug candidates. Importantly, these experiments include the demonstration of drug effects in vivo, biomarker discovery and therapy studies all of which underpin the drug discovery programs across the portfolio. The team works across a wide range of tumour models, including human tumour xenografts models (both cell line- and patient-derived xenografts), genetically engineered mouse models and organoid based models. The team is also highly experienced in preclinical metastatic models. The team has specialised skills to develop and implement novel models, and supporting the design and implementation of studies, all whilst complying with increasingly complex Home Office regulations. Department/Directorate Information About our organisation We are one of the world’s most influential cancer research institutes with an outstanding record of achievement dating back more than 100 years. We are world leaders in identifying cancer genes, discovering cancer drugs and developing precision radiotherapy. Together with our hospital partner The Royal Marsden, we are rated in the top four centres for cancer research and treatment worldwide. As well as being a world-class institute, we are a college of the University of London. We are consistently in the top performing universities in the league table of university research quality complied from Research Excellence Framework (REF 2014 &2021). We have charitable status and rely on support from partner organisations, charities, donors and the general public. We have more than 1000 staff and postgraduate students across three sites – in Chelsea and Sutton. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact [email protected]

Under the guidance of Dr Fiona Dziegiel, we are seeking to recruit a Scientific Writer to produce clear, accurate and engaging scientific content to showcase the innovative research of the Centres for Protein Degradation and Cancer Drug Discovery to enhance external visibility. About you The successful candidate must have: PhD in life sciences, health sciences, or related field Excellent writing skills with the ability to translate complex scientific concepts into clear and engaging content Experience writing manuscripts and social media content Excellent organisational skills, flexibility and the ability to manage changing priorities Ability to work independently and collaboratively The postholder will support the development, editing and management of scientific documents including manuscripts, reports, presentations and material for grant applications. They will coordinate data collection, maintain organised information systems, and manage online and social media content to strengthen the Centres’ visibility. Working closely with scientists, project managers, and the professional services teams, the Scientific Writer will ensure timely, effective communication of research activities and key developments, helping to advance the Centres’ missions to discover and develop innovative cancer therapeutics. Department Information The Centre for Protein Degradation The ICR established the Centre for Protein Degradation (CPD) in 2022 to accelerate targeted protein degradation-based drug discovery – an innovative approach utilising drug-induced degradation of harmful proteins via the cell’s endogenous protein disposal system. Our aim is to discover novel molecular glue degraders and PROTACs for the treatment of the most challenging cancers. Based at the ICR’s Centre for Cancer Drug Discovery, the CPD benefits from state-of-the-art drug discovery platforms – biology, medicinal and in silico chemistry, biophysics, structural biology, proteomics, bioinformatics, as well as strong cancer biology and clinical expertise within the wider ICR and the Royal Marsden Hospital. We also have established collaborations with biotechnology companies and the pharmaceutical industry. The Centre for Cancer Drug Discovery The Division of Cancer Therapeutics has an unrivalled track record at discovering novel cancer treatments for the personalised treatment of cancer. Within the Division, the Centre for Cancer Drug Discovery (CCDD) is a multidisciplinary 'bench to bedside' centre, comprising 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. We are one of the largest academic cancer drug discovery groups in the world and, together with our collaborators, have discovered 21 preclinical development candidates, 13 of which have been progressed to clinical evaluation, many with our partners in the ICR/Royal Marsden Drug Development Unit. Our drug abiraterone (Zytiga) has been approved in the US, Canada and Europe for late-stage prostate cancer. The CCDD’s mission is to develop personalised medicines by translating information from the cancer genome and cancer biology into drugs for patient benefit. We implement innovative drug discovery technologies, discover novel mechanism-based drugs, and develop these as rapidly as possible from the laboratory through to hypothesis-testing early clinical trials. We publish our work extensively and have a large network of collaborations with academia, biotechnology companies, and the pharmaceutical industry. Our teams are dedicated to the discovery of small molecule drug candidates, and to the development of high-quality chemical probes to enable new cancer biology research. The Division of Cancer Therapeutics is based in state-of-the art laboratories in the Centre for Cancer Drug Discovery building, opened in 2020 on the ICR Sutton campus. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For further information, please contact Dr Fiona Dziegiel ([email protected])