Working life and benefits

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research: Cancer target validation Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders Novel E3 ligase biology and ligand discovery The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterisation of novel molecular glue degraders and PROTACs, but may also contribute to other activities. About you The successful candidate: Will be a strong team player who is technically minded and passionate about science and cancer drug discovery Will hold a first degree, and preferably a PhD, in biological science or biochemistry Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling Experience in targeted protein degradation will be a significant advantage. Department/Directorate Information This position will be based in the ICR's Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signalling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterising their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients. What we offer A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK Access to state-of-the-art facilities and professional development Collaboration with leading drug discovery and oncology scientist Competitive salary and pension To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [email protected].

The Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU) is expanding its statistical and methodology team. We want to hear from you if you: Enjoy the challenge of researching, developing, and implementing efficient trial methodology that would make a difference in patients’ lives. Seek variety in your work and opportunities to apply your statistical knowledge across multiple therapeutic areas in oncology. Thrive on being part of a multi-disciplinary research team with like-minded statisticians. Applications are now open for a Trials Methodologist/Senior Trials Methodologist position to join our team of over 20 statisticians. The post offers an excellent opportunity for an enthusiastic and well-motivated statistician to work in a dynamic and supportive academic environment at a leading cancer clinical trials unit. Key Requirements The successful applicant will be an experienced and highly motivated statistician interested in researching new statistical methods to improve efficiency in clinical trials and eager to apply their statistical knowledge across various therapeutic areas in oncology. The successful applicant will have a post-graduate qualification in statistics. They should demonstrate a solid understanding of clinical trials and experience in applying statistical methods to real-world data. Familiarity with Bayesian statistics is highly desirable. Effective oral and written communication skills, as well as enthusiasm for collaborating with others from diverse disciplines, are essential. Department/Directorate Information ICR-CTSU manages an exciting portfolio of national and international phase II and III clinical trials and an expanding number of early phase I/II cancer trials. You will contribute in shaping the development of methodological innovations and implementing efficient methods in new and ongoing trials, with a specific focus in early phase and adaptive trials. You will work as part of a multi-disciplinary team on trials methodology research and on the statistical development, oversight, and analysis of a number of clinical trials within ICR-CTSU’s portfolio and early phase portfolio in collaboration with external organisation and the Drug Development Unit. We encourage all applicants to access the job pack attached for more detailed information regarding this role. This is an office based role. Requests for hybrid working (splitting time between our Sutton site and home) may be considered following successful completion of key training and if the role allows. Flexible working options may be considered. For informal discussion about the Trial Methodologist/Senior Trial Methodologist post, please contact Professor Christina Yap and Dr Jan Rekowski, email: [email protected] and [email protected]. For general queries about the recruitment process, please contact ICR-CTSU, email: [email protected].

Under the leadership of Dr Stephen-John Sammut, we are seeking a highly motivated and ambitious postdoctoral researcher to apply existing and develop cutting-edge single-cell computational methods for modelling breast tumour evolution during chemotherapy and immunotherapy. Your work will contribute to the development of predictive frameworks that can be deployed in breast clinical trials to guide treatment decisions. This role offers an outstanding opportunity to drive innovation at the interface of computational biology and clinical research, shaping the future of precision oncology. For general information on Post Doc's at The ICR can be found here. The ICR has a workforce agreement stating that there is a maximum duration of employment of 7 years including pre-ICR PDTF experience. Key Requirements The successful candidate must have a PhD in a computational biology or other numerical subject, have extensive programming experience, and possess a basic knowledge of cancer biology. A background in the analysis and interpretation of molecular data is essential. If available, please include a link to your online, publicly-available source code repository in your application. Department/Directorate Information: The Cancer Dynamics Laboratory headed by Dr Stephen John Sammut, focuses on developing computational and experimental frameworks that model changes in breast cancer biology during treatment to develop personalised precision cancer therapies. The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is directed by Clinician Scientist Professor Andrew Tutt. We encourage all applicants to access the job pack attached for more detailed information regarding this role. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role.