Randomised trial testing intensity modulated and partial organ radiotherapy following breast conservation surgery for early breast cancer.
Disease site: Breast cancer
Treatment modality: Radiotherapy
Status: In active follow-up
IMPORT LOW tests partial breast radiotherapy (RT) in a group of women with early breast cancer who are at a low risk of local tumour recurrence. The trial compares a standard dose of RT delivered to the whole breast in 15 fractions over 3 weeks, with two different test arms delivering less radiotherapy to the whole breast and a standard dose to the partial breast, or no RT to the whole breast and a standard dose to the partial breast. The reduced RT to the whole breast in the test arms reflects the fact that the risk of true local recurrence is highest in the area of the breast close to the site of the original tumour. The trial tests whether this reduction in dose to the whole breast preserves the physical appearance of the breast and reduces the side effects of RT, whilst maintaining cancer cure.
IMPORT LOW opened in May 2007 and entered the first patient in the same month. The trial closed to recruitment on 30 September 2010 with 2,018 patients.
Chief Investigator: Dr Charlotte Coles, University of Cambridge
ICR-CTSU Scientific Lead: Professor Judith Bliss
Trial management contact: Jenny Titley - Trial Manager, [email protected]
Sponsor: The Institute of Cancer Research
Funding: Cancer Research UK (CRUK/06/003) and the Department of Health
Lay summary of primary analysis
Publications and presentations
Charlotte E Coles, Clare L Griffin, Anna M Kirby, Jenny Titley, Rajiv K Agrawal, Abdulla Alhasso, Indrani S Bhattacharya, Adrian M Brunt, Laura Ciurlionis, Charlie Chan, Ellen M Donovan, Marie A Emson, Adrian N Harnett, Joanne S Haviland, Penelope Hopwood, Monica L Jefford, Ronald Kaggwa, Elinor J Sawyer, Isabel Syndikus, Yat M Tsang, Duncan A Wheatley, Maggie Wilcox, John R Yarnold, Judith M Bliss on behalf of the IMPORT Trialists. Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. The Lancet published on-line 2nd August 2017.
C Coles, R Agrawal, ML Ah-See, H Algurafi, A Alhasso, AM Brunt, C Chan, C Griffin, A Harnett, P Hopwood, A Kirby, E Sawyer, I Syndikus, J Titley, Y Tsang, D Wheatley, M Wilcox, J Yarnold, JM Bliss and on behalf of the IMPORT TMG. Partial breast radiotherapy for women with early breast cancer: first results of local recurrence data for IMPORT LOW (CRUK/06/003). Late breaking abstract presentation at EBCC, 09/03/2016, Amsterdam.
Partial breast radiotherapy for women with early breast cancer: first analysis of late cosmesis adverse events from IMPORT LOW (CRUK06/003). On behalf of the IMPORT Trial Management Group. Abstract number EBCC 0454; Oral presentation, EBCC-9, Glasgow, Scotland. 19 – 21 March 2014
Ciurlionis L, Tsang Y, Titley J, Coles CE, Yarnold J, Bliss J, on behalf of the Import Trial Management Group. Interim analysis of treatment plans in the IMPORT LOW Trial. NCRI National Cancer Conference; 2010; Liverpool.
Coles C, Titley J, Bliss JM, Chan C, Ciurlionis L, Haviland J, Sydenham M, Tsang Y, Wishart G, Yarnold J, on behalf of the START Trial Management Group. IMPORT LOW re-visited: How strategic trial management has increased average monthly accrual. NCRI National Cancer Conference; 2009; Birmingham.
Mills J, Haviland J, Bliss J, Hopwood P, on behalf of the IMPORT Low & Start Trial Management Groups. The IMPORT LOW Quality of Life Study: What we have learnt from the START Trial. NCRI National Cancer Conference; 2008 ;Birmingham.
Sydenham M, Bliss J, Coles C, Donovan E, Evans P, Haviland J, Yarnold J, on behalf of the Import Trial Management Group. IMPORT LOW: Changing service delivery to optimise trial recruitment. NCRI National Cancer Conference; 2008; Birmingham.
Tsang Y, on behalf of the Import Trial Working Party. Moving UK breast radiotherapy forward in the IMPORT LOW Trial - enabling safe change of practice through quality assurance (QA). NCRI National Cancer Conference; 2008; Birmingham.