Close-up of an the ICR logo on a research centre

Centre for In Vivo Modelling

The Centre for In Vivo Modelling is a newly established research centre within the Division of Cancer Biology at the ICR. Our scientists and clinical researchers use state-of-the-art in vivo models to address fundamental questions in cancer biology, with the ultimate aim of identifying curative treatments. We also serve as a collaborative hub across the ICR and The Royal Marsden, providing cutting-edge expertise in advanced mouse genetics and humanised in vivo models of cancer.

Professor Kamil R Kranc, Chair of Haemato-Oncology, serves as the Centre's Director, while Fabiana Muzzonigro is the Centre Administrator.

 

How we conduct research at this centre

Solid tumours and blood cancers are highly complex ecosystems, with many composed of varying cell types including rare cancer stem cells at the apex of a hierarchical organisation, more differentiated malignant progeny, and a dynamic microenvironment that nurtures tumour growth and survival. At our Centre, we seek to elucidate the fundamental principles that govern this malignant ecosystem. We employ advanced mouse genetics (including barcoding and lineage tracing) and PDX models to dissect how tumour cells function, evolve under selective pressures, evade therapy, and engage with their microenvironment to sustain disease progression. By decoding these intricate cellular and molecular interactions, we aim to identify transformative therapeutic strategies capable of eradicating cancer at its origin - achieving durable remission while preserving normal tissue integrity.

A particular strength of our Centre lies in the generation and application of in vivo models, which are essential for uncovering novel aspects of cancer biology and evaluating emerging therapies. We work in close collaboration with ICR researchers and clinicians at The Royal Marsden to develop patient-derived xenograft (PDX) models of leukaemias and solid tumours by transplanting human cancer tissue into immunocompromised mice. In parallel, we generate and utilise genetically engineered mouse models (GEMMs) to interrogate cancer biology in a physiologically relevant context. By leveraging these sophisticated in vivo systems, the Centre aims to:

  • Uncover new facets of cancer biology in a complex in vivo ecosystem
  • Discover and validate novel therapeutic targets allowing for elimination of cancer stem cells and their malignant progeny in blood cancers and solid tumours
  • Collaborate closely with drug discovery teams at the ICR to develop inhibitors of these targets
  • Evaluate new anti-cancer drugs in pre-clinical in vivo models, paving the way for clinical trials.

In addition to our academic focus, CIVM serves as a collaborative hub across the ICR and The Royal Marsden, providing the ICR community with cutting-edge expertise in advanced mouse genetics and humanised mouse models of cancer.

Members of this Centre

Pipettes and well plates

In Vivo Modelling core

We provide cutting-edge expertise in advanced mouse genetics and humanized mouse models of cancer.

CIVM Service Core

Other staff:

Driving discovery through collaboration 

At CIVM, our collaborative spirit drives our mission to advance cancer cures. We actively partner with basic science, translational, and clinical research groups across the ICR and The Royal Marsden. Our collaborations also extend beyond, working closely with distinguished academic teams at the Universities of Oxford, Cambridge, Edinburgh, Cardiff, London, Glasgow, and the Francis Crick Institute.

 

News from the Centre

We are recruiting a Group Leader in In Vivo Cancer Modelling. We welcome applications at both the Career Development Faculty and Career Faculty levels. Competitive start up package is available. For further particulars please contact [email protected].

 

 

News from the ICR

30/10/25 - by

sir-richard-doll-building-sutton-945x532

The Institute of Cancer Research has ranked among the top UK universities for research partnerships and commercialisation.

We were one of only two UK higher education institutions to gain the highest grades in all measures of both research partnerships and commercialisation in the latest Knowledge Exchange Framework.

We also gained the top grade for public and community engagement.

The Knowledge Exchange Framework – also known by its acronym, ‘the KEF’ – is a yearly assessment of how well UK universities work with external partners, local communities and the public.

It’s run by UK Research and Innovation (UKRI), which funds research at UK universities on behalf of the Government. 

Research partnership

This year the ICR performed very well in both the two measures of research partnership. These metrics look at the proportion of universities’ academic papers that are published with non-academic co-authors, and at the proportion of their research funding that supports collaborative research.

We gained the top possible grade in these metrics due to our strong partnerships with industry and other academic institutions. Only five other higher education institutions gained the same grade.

Intellectual property and commercialisation

We also achieved the top grade in all three measures in the ‘intellectual property and commercialisation category’, alongside six other higher education institutions. These measure the proportion of universities’ income from licensing intellectual property to partners, and the turnover of, and investment in, their mature spinout companies.

Only the ICR and the University of Cambridge gained the top grade in all measures in both categories.

Other highlights of our KEF assessment included gaining the highest possible grade for public and community engagement, and an improvement in a score based on our income from Innovate UK. Innovate UK is part of UKRI and funds collaborative research between academic researchers and companies.

Industry partnerships

The ICR works in collaboration with around 100 industry partners at any one time, across areas from early-stage discovery science to early- and late-stage clinical trials of new cancer treatments.

Last year we made around 20 new industry collaboration agreements relating to joint research, as well as hundreds of other agreements with external partners – including around 250 commercial agreements, 150 clinical trial agreements and 400 non-commercial agreements.

We also signed dozens of licence agreements and filed several new patents.

New collaborations

This year, we won a major award for our work in collaboration with industry from life-sciences sector membership organisation One Nucleus.

Recent new collaborations include a partnership between our Centre for Immunotherapy of Cancer and the company QBiotics, and an Innovate UK-funded partnership between ICR childhood cancer researchers and the Bath University company Revolver Therapeutics.

Meanwhile, recent outcomes to emerge from our commercial collaborations have included regulatory approvals for Roche’s inavolisib in breast cancer, and Verastem Oncology’s avutometinib-defactinib drug combination in ovarian cancer.

We are also a leading research institution in collaboration with other universities – across the UK and internationally. 

One highlight of the past few years is our involvement in the MR-Linac consortium – a group of universities and hospitals from across Europe and the US working with the company Elekta to develop their Unity device.

The Unity combines radiation treatment and Magnetic Resonance Imaging (MRI), enabling simultaneous imaging and treatment.

Spinout companies

ICR spinout companies include Monte Rosa Therapeutics – a leading company in the development of molecular glues, an innovative type of cancer drug.

Other recent ICR spinouts include Kodiform Therapeutics and AI-focused Sentinal4D. We recently changed our spinout policy to encourage even more of our scientists to found companies.

Public engagement

The ICR has gained the highest grade for public engagement in all five KEF assessments so far. Our public engagement team works with our researchers to support and inspire their efforts to inform the public about their science – including through community events and visits.

Our public engagement team also runs a programme of engagement events and activities, including showpiece careers evenings for local schools.

We work closely with our partners at The London Cancer Hub in Sutton, south London – including the Borough of Sutton and site developers Socius – to engage the local community in our science.

Dr Jon Wilkinson, Director of Business and Innovation at the ICR, said:

“We’re very proud of our strong track record in partnership – partnership with universities, and partnership with companies from across the wide landscape in oncology, from smaller and mid-size biotech to major pharma companies.

“It’s only by working together across different organisations and sectors that we’re able to make sure that our discoveries are translated into new, impactful treatments for cancer patients. Our collaborations also generate other major benefits to society, including stimulating economic growth.”

Dr Mariana Campos, Public Engagement Manager at the ICR, said:

“We’re thrilled to see our continued success in public and community engagement recognised once again in the latest KEF.

"This reflects the creativity and commitment of our researchers and professional services staff, who give their time to share their science, inspire young people and build strong connections with our local communities. Engagement is at the heart of how we work – it’s about openness, collaboration and making sure our research benefits people far beyond the lab.”