Paediatric Solid Tumour Biology and Therapeutics Group

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

Under the leadership of Dr Stephen-John Sammut, we are seeking a highly motivated and ambitious postdoctoral researcher to apply existing and develop cutting-edge single-cell computational methods for modelling breast tumour evolution during chemotherapy and immunotherapy. Your work will contribute to the development of predictive frameworks that can be deployed in breast clinical trials to guide treatment decisions. This role offers an outstanding opportunity to drive innovation at the interface of computational biology and clinical research, shaping the future of precision oncology. For general information on Post Doc's at The ICR can be found here. The ICR has a workforce agreement stating that there is a maximum duration of employment of 7 years including pre-ICR PDTF experience. Key Requirements The successful candidate must have a PhD in a computational biology or other numerical subject, have extensive programming experience, and possess a basic knowledge of cancer biology. A background in the analysis and interpretation of molecular data is essential. If available, please include a link to your online, publicly-available source code repository in your application. Department/Directorate Information: The Cancer Dynamics Laboratory headed by Dr Stephen John Sammut, focuses on developing computational and experimental frameworks that model changes in breast cancer biology during treatment to develop personalised precision cancer therapies. The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is directed by Clinician Scientist Professor Andrew Tutt. We encourage all applicants to access the job pack attached for more detailed information regarding this role. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role.