Close-up of an the ICR logo on a research centre

Centre for In Vivo Modelling

The Centre for In Vivo Modelling is a newly established research centre within the Division of Cancer Biology at the ICR. Our scientists and clinical researchers use state-of-the-art in vivo models to address fundamental questions in cancer biology, with the ultimate aim of identifying curative treatments. We also serve as a collaborative hub across the ICR and The Royal Marsden, providing cutting-edge expertise in advanced mouse genetics and humanised in vivo models of cancer.

Professor Kamil R Kranc, Chair of Haemato-Oncology, serves as the Centre's Director, while Fabiana Muzzonigro is the Centre Administrator.

 

How we conduct research at this centre

Solid tumours and blood cancers are highly complex ecosystems, with many composed of varying cell types including rare cancer stem cells at the apex of a hierarchical organisation, more differentiated malignant progeny, and a dynamic microenvironment that nurtures tumour growth and survival. At our Centre, we seek to elucidate the fundamental principles that govern this malignant ecosystem. We employ advanced mouse genetics (including barcoding and lineage tracing) and PDX models to dissect how tumour cells function, evolve under selective pressures, evade therapy, and engage with their microenvironment to sustain disease progression. By decoding these intricate cellular and molecular interactions, we aim to identify transformative therapeutic strategies capable of eradicating cancer at its origin - achieving durable remission while preserving normal tissue integrity.

A particular strength of our Centre lies in the generation and application of in vivo models, which are essential for uncovering novel aspects of cancer biology and evaluating emerging therapies. We work in close collaboration with ICR researchers and clinicians at The Royal Marsden to develop patient-derived xenograft (PDX) models of leukaemias and solid tumours by transplanting human cancer tissue into immunocompromised mice. In parallel, we generate and utilise genetically engineered mouse models (GEMMs) to interrogate cancer biology in a physiologically relevant context. By leveraging these sophisticated in vivo systems, the Centre aims to:

  • Uncover new facets of cancer biology in a complex in vivo ecosystem
  • Discover and validate novel therapeutic targets allowing for elimination of cancer stem cells and their malignant progeny in blood cancers and solid tumours
  • Collaborate closely with drug discovery teams at the ICR to develop inhibitors of these targets
  • Evaluate new anti-cancer drugs in pre-clinical in vivo models, paving the way for clinical trials.

In addition to our academic focus, CIVM serves as a collaborative hub across the ICR and The Royal Marsden, providing the ICR community with cutting-edge expertise in advanced mouse genetics and humanised mouse models of cancer.

Members of this Centre

Pipettes and well plates

In Vivo Modelling core

We provide cutting-edge expertise in advanced mouse genetics and humanized mouse models of cancer.

CIVM Service Core

Other staff:

Driving discovery through collaboration 

At CIVM, our collaborative spirit drives our mission to advance cancer cures. We actively partner with basic science, translational, and clinical research groups across the ICR and The Royal Marsden. Our collaborations also extend beyond, working closely with distinguished academic teams at the Universities of Oxford, Cambridge, Edinburgh, Cardiff, London, Glasgow, and the Francis Crick Institute.

 

News from the Centre

We are recruiting a Group Leader in In Vivo Cancer Modelling. We welcome applications at both the Career Development Faculty and Career Faculty levels. Competitive start up package is available. For further particulars please contact [email protected].

 

 

News from the ICR

25/11/25

The Institute of Cancer Research, London, has received the highest national honour in UK further and higher education for its pioneering radiotherapy research.

The Queen Elizabeth Prizes for Higher and Further Education (formerly the Queen’s Anniversary Prize) recognise the radiotherapy research programme at The Institute of Cancer Research (ICR), which has significantly improved patient treatment, and delivered benefits to healthcare systems and economies in the UK and around the world.

The Prizes, first awarded in 1994, reflect the late Her Majesty Queen Elizabeth II’s lifelong dedication to education, and this marks the ICR’s third time receiving the award.

The Queen Elizabeth Prizes acknowledge the significant contribution that the ICR has made in revolutionising cancer care by pioneering advanced radiotherapy techniques and leading clinical trials that have improved patient outcomes, reduced costs, and shaped global treatment standards.

Radiotherapy is the cornerstone of cancer treatment

Radiotherapy is a cornerstone of cancer treatment, contributing to nearly half of all cancer cures and improving quality of life for up to 60 per cent of patients. Scientists at the ICR, working in close partnership with colleagues at The Royal Marsden NHS Foundation Trust, have played a part in some of the most pivotal developments in radiotherapy research by integrating biological and medical physics research with clinical practice. The honour focuses on how these discoveries have improved the lives of people with cancer by:

A recognition of outstanding work

Much of the research recognised by the award was funded by the ICR itself, government funding bodies including the National Institute for Health and Care Research (NIHR) Biomedical Research Centre at The Royal Marsden and The ICR and the charity Cancer Research UK.

The Queen Elizabeth Prizes for Higher and Further Education are granted every two years by The Monarch in recognition of outstanding work by UK colleges and universities.

To qualify, an institution must produce high-quality innovative work that benefits the public in a distinctive way.

Experts, specialists and organisations across the UK are involved in the independent review process, which takes several months. The Awards Council of the Trust considers a shortlist of entries, and The Monarch approves a final list of recommended institutions, on the Prime Minister’s advice.

The ICR was previously recognised with Queen Elizabeth Prizes for Education in 2017 and 2023 for its outstanding contribution to the discovery of new cancer drugs and for innovative work in breast cancer research, including in radiotherapy.

‘This award is a powerful recognition of decades of collaborative laboratory and clinical research’

Professor Kevin Harrington, Head of the Division of Radiotherapy and Imaging at The Institute of Cancer Research, London, said:

"This award is a powerful recognition of the decades of collaborative laboratory and clinical research that have transformed radiotherapy into the highly targeted, personalised treatment that it is today. I’m extremely proud of the role our scientists and clinicians have played in developing techniques and trials that are now improving outcomes for patients across the globe."

Dr Alison Tree, Consultant Clinical Oncologist at The Royal Marsden and Reader in Uro-oncology Clinical Trials at The Institute of Cancer Research, London, said:

"We are delighted that this award recognises not only our research but also the vital role of education in advancing cancer care. The Royal Marsden and the ICR have a unique partnership that combines world-class clinical expertise with academic excellence. With the methodology leadership from the ICR’s Clinical Trials and Statistics Unit we have delivered landmark trials while training and inspiring the next generation of oncologists. It’s wonderful to see the impact of this collaboration celebrated at the highest level."

Professor Kristian Helin, Chief Executive of The Institute of Cancer Research, London, said:

“We are honoured to receive a Queen Elizabeth Prize for Education, which recognises the worldwide impact of our research advances in radiotherapy. This recognition reflects our commitment to innovation, collaboration, and ensuring that scientific discovery delivers real- benefit for patients around the world."

Sir Damon Buffini, Chair of The Royal Anniversary Trust said:

 “The Queen Elizabeth Prizes for Higher and Further Education celebrate the power of education to change the world for the better. This much-loved national honour recognises, at the highest level of state, outstanding work in UK universities and colleges, and the remarkable benefit they bring to our economy, society and the wider world. This year we are delighted to honour 19 institutions whose work offers an inspiring snapshot of the excellent and innovative work going on in universities and colleges across the UK. Congratulations all.”