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UK scientists create most detailed map yet of mutations that drive cancer
Scientists have created the most comprehensive map to date of the genetic mutations that fuel cancer – opening the door to extending precision treatments to thousands more patients and offering clues as to why bowel cancer rates are rising in younger people.
ICR scientists support promising new immunotherapy trial for advanced ovarian cancer
Scientists at The Institute of Cancer Research, London, are supporting an international clinical trial of a promising new immunotherapy treatment for advanced ovarian cancer.
New study reveals key enzyme as hidden driver of cancer stress responses
An important study has uncovered an unexpected molecular player that helps make cancer cells stress-resilient, thereby promoting the survival, growth and progression of cancer.
Scientists discover new avenue for treating an aggressive form of breast cancer
A gene that is typically active only in reproductive cells may hold the key to new treatments for triple negative breast cancer, according to new research by scientists at The Institute of Cancer Research, London
Immunotherapy uses invisibility cloak to deliver direct hit to prostate cancer
A new immunotherapy drug has shown promise for safely treating prostate cancer, a phase I trial reports.
.jpg?sfvrsn=205a5de0_2 "Castration resistant prostate cancer cells stained for a number of key driver molecules. (Mateus Crespo, Gerhardt Attard and Johann de Bono / the ICR, 2012)")
Targeted radiotherapy injection shrinks treatment-resistant prostate cancer tumours in early clinical trial
A new drug for prostate cancer, which delivers a precisely targeted dose of radiation to cancer cells, can keep cancer at bay, a phase I trial reports.
Researchers overcome major obstacle in targeted protein degradation
In a significant advancement, cancer researchers have found a long-sought way to overcome a critical design barrier in the generation of small-molecule chemical tools and drugs that work by targeted protein degradation.
New study shows promise for more reliable imaging of an important tumour characteristic
A team of scientists at The Institute of Cancer Research, London, has developed a repeatable three-dimensional (3D) imaging technique that could transform preclinical cancer studies.
New strategy targets “undruggable” protein in T-cell leukaemia, triggering cancer cell death
Scientists have unveiled a ground-breaking approach to tackling one of cancer biology’s most elusive targets: the protein LMO2, a key driver of T-cell acute lymphoblastic leukaemia (T-ALL).
Breast cancer blood test can predict treatment response
A blood test can predict how well patients with advanced breast cancer will respond to targeted therapies – before treatment begins, according to new research.
New research uncovers critical DNA repair mechanism during cell division
A major advance in cell biology has revealed how our cells safeguard their genetic material during one of the most vulnerable moments in their life cycle. The study identifies a specific protein complex as a central coordinator of DNA repair during cell division.
Tumour samples from the 1950s could help unlock the mystery of rising bowel cancer cases in the under 50s
Tens of thousands of tumour samples which have been stored in the basement of a London hospital for more than 70 years could be the key to unlocking the mystery of why bowel cancer cases are rising in the under 50s, scientists believe.
Researchers at The Institute of Cancer Research, London, and St Marks Hospital are launching a pioneering study to compare bowel cancer specimens from the 1960s with modern-day cancer samples.