Close-up of an the ICR logo on a research centre

Centre for In Vivo Modelling

The Centre for In Vivo Modelling is a newly established research centre within the Division of Cancer Biology at the ICR. Our scientists and clinical researchers use state-of-the-art in vivo models to address fundamental questions in cancer biology, with the ultimate aim of identifying curative treatments. We also serve as a collaborative hub across the ICR and The Royal Marsden, providing cutting-edge expertise in advanced mouse genetics and humanised in vivo models of cancer.

Professor Kamil R Kranc, Chair of Haemato-Oncology, serves as the Centre's Director, while Fabiana Muzzonigro is the Centre Administrator.

 

How we conduct research at this centre

Solid tumours and blood cancers are highly complex ecosystems, with many composed of varying cell types including rare cancer stem cells at the apex of a hierarchical organisation, more differentiated malignant progeny, and a dynamic microenvironment that nurtures tumour growth and survival. At our Centre, we seek to elucidate the fundamental principles that govern this malignant ecosystem. We employ advanced mouse genetics (including barcoding and lineage tracing) and PDX models to dissect how tumour cells function, evolve under selective pressures, evade therapy, and engage with their microenvironment to sustain disease progression. By decoding these intricate cellular and molecular interactions, we aim to identify transformative therapeutic strategies capable of eradicating cancer at its origin - achieving durable remission while preserving normal tissue integrity.

A particular strength of our Centre lies in the generation and application of in vivo models, which are essential for uncovering novel aspects of cancer biology and evaluating emerging therapies. We work in close collaboration with ICR researchers and clinicians at The Royal Marsden to develop patient-derived xenograft (PDX) models of leukaemias and solid tumours by transplanting human cancer tissue into immunocompromised mice. In parallel, we generate and utilise genetically engineered mouse models (GEMMs) to interrogate cancer biology in a physiologically relevant context. By leveraging these sophisticated in vivo systems, the Centre aims to:

  • Uncover new facets of cancer biology in a complex in vivo ecosystem
  • Discover and validate novel therapeutic targets allowing for elimination of cancer stem cells and their malignant progeny in blood cancers and solid tumours
  • Collaborate closely with drug discovery teams at the ICR to develop inhibitors of these targets
  • Evaluate new anti-cancer drugs in pre-clinical in vivo models, paving the way for clinical trials.

In addition to our academic focus, CIVM serves as a collaborative hub across the ICR and The Royal Marsden, providing the ICR community with cutting-edge expertise in advanced mouse genetics and humanised mouse models of cancer.

Join us

We are recruiting two exceptional Group Leaders to join the Division of Cancer Biology and the Centre for In Vivo Modelling (CIVM). This is a unique opportunity to shape the future of cancer biology research, lead innovative programmes, and make discoveries that transform patient outcomes.

These new Group Leaders will investigate fundamental mechanisms of tumour initiation, progression, and treatment resistance, and develop cutting-edge preclinical models to advance understanding of cancer biology. Working in close collaboration across the ICR and The Royal Marsden Hospital, the postholders will translate discovery science into new therapeutic opportunities, contributing to the ICR’s mission to make the discoveries that defeat cancer.

Find out more about the vacancies

Members of this Centre

Pipettes and well plates

In Vivo Modelling core

We provide cutting-edge expertise in advanced mouse genetics and humanized mouse models of cancer.

CIVM Service Core

Other staff:

Driving discovery through collaboration 

At CIVM, our collaborative spirit drives our mission to advance cancer cures. We actively partner with basic science, translational, and clinical research groups across the ICR and The Royal Marsden. Our collaborations also extend beyond, working closely with distinguished academic teams at the Universities of Oxford, Cambridge, Edinburgh, Cardiff, London, Glasgow, and the Francis Crick Institute.

 

News from the Centre

We are recruiting a Group Leader in In Vivo Cancer Modelling. We welcome applications at both the Career Development Faculty and Career Faculty levels. Competitive start up package is available. For further particulars please contact [email protected].

 

 

Current vacancies

There are currently no vacancies available in this group or area.

News from the ICR

06/02/26

Dr Michelle Harrison – an international business leader with three decades of experience advising clients in global public policy, public affairs and brand building – has joined the Board of Trustees of The Institute of Cancer Research, London.

The Board of Trustees, which is principally made up of volunteers who bring expertise from outside of the organisation, has responsibility for the governance of The Institute of Cancer Research (ICR).

Business leader and innovator

Dr Harrison has an impressive career – with a wealth of executive board level experience gained in FTSE-listed and private equity backed businesses, including 17 years as a Chief Executive. She is the President and was Founding CEO of the Verian Group, the largest independent specialist public policy consulting business outside the US; prior to that, she was the Founding CEO of the Government and Public Sector Practice of the WPP Group.

She is recognised as an entrepreneurial leader, strategist and innovator with international experience in corporate divestment, acquisition and integration. Michelle is also known as an expert on social trends and geopolitics, and is a media commentator and platform speaker, including at Davos. Earlier in her career she was a book author and published academic.

Extensive experience in charity governance

Michelle has held charity board positions for more than twenty years. She is currently serving as a Trustee of Big Win Philanthropy, an organisation working to improve lives directly and build demographic dividends for equitable economic growth, peace and security across Africa. She was also, until last year, a Trustee to the Board of Social Finance UK.

Previously Michelle has served on the Boards of Nesta UK and Involve. She was a member of the advisory board of The Discovery Decade, a programme run by the Campaign for Science and Engineering (CaSE); and is a founding member of the Advisory Board of the Reykjavik Global Forum, an advocacy group promoting global gender equality.

Professor Dame Julia Buckingham, Chair of the Board of Trustees at The Institute of Cancer Research, London, said:

"I am delighted to welcome Dr Michelle Harrison to the ICR’s Board of Trustees. She has outstanding professional experience of creating new businesses, and of leading and growing them. Michelle’s policy and public affairs expertise will be a helpful addition to the capabilities we have on the Board. I have no doubt that her contributions will help drive an even stronger future for the ICR."

Dr Michelle Harrison said:

"The Institute of Cancer Research has an extraordinarily inspiring history of delivering key discoveries in their mission to defeat cancer. It will be an honour to work alongside the ICR’s staff and students, and my fellow Trustees, towards our shared mission. I’m delighted to have this opportunity to contribute."