Main Menu

Centre for Genome Stability at the ICR and The Royal Marsden

Centre for Genome Stability (CGS) is a unique multidisciplinary programme bringing together experts from across the ICR and The Royal Marsden who work on DNA-damage response and genome instability research with clinical experts in the treatment of cancer.

Our world-leading centre of excellence aims to understand genetic, epigenetic and proteomic changes to genomic stability in the development of cancer in order to develop biomarkers and therapeutic targets for improved cancer treatment. This will allow us to apply multidisciplinary approaches to address important research questions, thus accelerating discoveries into the causes of tumorigenesis and delivering major clinical impacts, both nationally and internationally.

A diagram showing fundamental research, clinical research, translation and drug development to bring about improved cancer treatment.

Our vision

We aim to harness the breadth of expertise in genomic stability at the ICR to develop new and better therapies against cancer to make the most meaningful impact in clinics.

Our themes

The Centre's main themes are as follows.

The molecular mechanisms of Genome Stability Maintenance

Investigating how the maintenance of genome stability is accomplished throughout the cell cycle by a complex network of proteins referred to as the DNA-damage response (DDR) pathways. Mutations in DDR factors are associated with elevated cancer predisposition and also underly phenotypes of many aging-related diseases. 

Understanding the replication stress responses

Investigating how cells control DNA replication with the highest possible fidelity in order to prevent catastrophic changes to their genome. We aim to understand how DNA replication and repair machineries function and how these processes differ in cancer cells.  

Integrative Systems Biology of cancer and aging

Developing tools to interrogate large data sets of genetic, genomic and proteomic information to generate hypotheses for experimental analysis, with the ultimate goal of understanding the changes that occur to the genomes and proteomes of cells as they transition to a cancerous or aged state.

Genome instability and cancer therapeutics

Investigating new dependencies within the DDR pathways that may represent targetable vulnerabilities in cancer cells, with a major focus on synthetic-lethal interactions and over-reliance on DDR pathways allowing for selective killing of cancer cells.

Centre resources

The centre will establish a single-domain antibody screening facility to generate DNA-repair related biomarker detection and intracellular antibody protein perturbation tools.

Our researchers

Professor Louis Chesler

Dr Gideon Coster

Professor Johann de Bono

Professor Jessica Downs

Dr Max Douglas

Professor Richard Houlston

Professor Chris Lord

Professor Wojciech Niedzwiedz

Professor Laurence Pearl

Professor Jon Pines

Professor Terence Rabbitts

Dr Olivia Rossanese

Professor Janet Shipley

Professor Andrew Tutt

Professor Paul Workman

Dr Christian Zierhut