Macromolecular Structural Biology Group

Professor Pearl's group seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways.

Research, projects and publications in this group

Professor Laurence Pearl

Group Leader:

Macromolecular Structural Biology Laurence Pearl (Profile)

Professor Pearl seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways. These basic studies provide the means for discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.

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Researchers in this group

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Email: [email protected]

Location: Chelsea

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Professor Laurence Pearl's group have written 219 publications

Most recent new publication 11/2025

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News and discoveries

New understanding of enzyme regulating gene expression could inform future cancer therapies

12/05/26

Scientists have uncovered how an important cellular enzyme is regulated, revealing new insights into the fundamental biological processes controlling gene expression and opening up potential avenues for future cancer drug development.
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New structural insights reveal how key DNA repair enzymes are recruited and controlled

05/02/26

Researchers have uncovered how a key DNA repair enzyme is recruited and activated inside cells, answering long-standing questions about how cells protect and repair their DNA and providing the structural groundwork that could support the refinement of existing cancer therapies.
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New structural insights reveal molecular details of a key step in cell cycle control

18/12/25

In a major advance for molecular biology and cancer research, scientists have uncovered the molecular mechanisms that control a key step during the activation of cyclin-dependent kinases (CDKs) – the master regulators of cell division.
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