Study and Careers

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

The ICR is seeking an established research leader in cancer drug discovery biology with a track record in discovering innovative drugs to be the Head of Biology in the Centre for Cancer Drug Discovery (CCDD). The appointee will provide scientific leadership for the CCDD biology discipline, champion scientific excellence and work closely with senior team leaders in the CCDD to provide a strategic vision for the research and drug discovery portfolio. Key Requirements The role requires excellence in cancer biology, coupled with significant experience across the target identification to candidate selection stages of drug discovery. We envisage that applicants will have either significant commercial experience of successful drug discovery or have a strong academic track record in cancer biology and small molecule drug discovery; or will have a combination of both backgrounds. As part of your online application you will be required to upload your full CV which will pre-populate your application form. Department/Directorate Information: We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Abby Cook via Email on [email protected]

The ICR is seeking an established research leader in cancer biology with a track record in target validation for drug discovery to be the Director of the Centre for Target Validation (CTV). The appointee will provide scientific and strategic leadership of the CTV, ensuring a pipeline of robust, clinically relevant targets for drug discovery programmes within the ICR’s Centre for Cancer Drug Discovery (CCDD). They will collaborate with scientists across the ICR to identify target validation projects with therapeutic potential that are suitable to benefit from the Centre’s dedicated resource and scientific expertise. They will lead, direct, and participate in multidisciplinary projects to define/refine therapeutic hypotheses, examine mechanisms of target modulation, and explore biomarkers and patient selection criteria. Working with the CTV Deputy Director, they will ensure that ICR expertise in drug target identification is effectively translated to drug discovery programmes at ICR and with external partners. Key Requirements The appointee will lead an independent research group contributing to the discovery of novel targets and/or innovative small molecule anticancer therapies, aligned with the strategy and goals of the CTV / CCDD. The role requires expertise in cancer biology and substantial experience in target identification & validation; experience of later drug discovery stages is valued. We envisage that applicants will have either significant commercial experience or have a strong academic track record in cancer biology for target validation; or will have a combination of both backgrounds. As part of your online application you will be required to upload your full CV which will pre-populate your application form. Department/Directorate Information: We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Abby Cook Email on [email protected]

The ICR is seeking a cancer biology research leader to join us in our mission to discovery novel small molecule therapeutics for the treatment of cancer. The appointee will lead an independent cancer biology research group that contributes to the overall strategy and goals of the Centre for Cancer Drug Discovery (CCDD); in particular, progression of innovative small molecule anticancer compounds to proof-of-concept clinical trials. Commitment to translational and drug discovery research is fundamental to this position. The appointee will lead and participate in multidisciplinary drug discovery projects to discover small molecule clinical candidates. Key Requirements The role requires application of molecular pharmacology and cancer biology approaches to 1) support hypothesis-driven target identification and validation; 2) design and implement functional and mechanistic assays to support discovery and progression of small molecule therapeutics; and 3) develop and test hypotheses regarding patient selection strategies and biomarkers. Enthusiasm for working in a collaborative interdisciplinary environment is essential. We envisage that applicants will have either commercial experience of successful drug discovery or have a strong academic track record in cancer drug discovery; or will have a combination of both backgrounds. As part of your online application you will be required to upload your full CV which will pre-populate your application form. Department/Directorate Information: We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Abby Cook via Email on [email protected]