Clinical Pharmacology Adaptive Therapy Group

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

Under the guidance of Professor Trevor Graham, we are seeking to recruit a Data Scientist to support Data Science research across the ICR. The successful candidate will particularly work on the analysis of spatial data including multiplex immunohistochemistry, H&Es and spatial transcriptomics. About you The successful candidate must have: A PhD in quantitative subject, or likely to be awarded PhD in the near future. Research experience equivalent to PhD level will be considered. Undergraduate degree, or Masters or equivalent in a quantitative subject. Skills in bioinformatics computing coding, in languages including R, Python and other scripting languages as is appropriate. Experience of using high performance computing (HPC) systems for scientific computing. Experience of computational biology research methodologies pertinent to the role. Department/Directorate Information The Data Science Committee is chaired by Professor Trevor Graham, providing academic leadership of data science at the ICR to maximise the impact of our cancer research, by applying innovative data science and computation tools (in addition to our traditional areas of strength) to tackle the important cancer questions and ensuring infrastructure is considered to enable this. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof Trevor Graham [email protected].