Clinical Pharmacology Adaptive Therapy Group
Professor Banerji's group aims to study re-wiring of signal transduction to understand and overcome mechanisms of drug resistance and, in addition, to understand exploit cancer evolution using pharmacological tools.
We are focused on the re-wiring of signal transduction using established cell lines to control mechanisms of drug resistance and comprehend the evolution of cancer.
Rewiring of signal transduction
This group is working on the set-up and validation of a highly sensitive antibody-based assay on the Nanostring platform which will allow quantification of 50 - 100 phosphoproteins/proteins. It plans to digest tumour tissue obtained during surgery or from biopsies and expose them to a matrix of 20 - 30 anticancer drugs before obtaining phosphoproteomic data.
It also aims to use organoids and patient-derived xenografts to take this forward. The proteomic data will be modelled with the Computational Biology and Chemogenomics Team led by Professor Bissan Al-Lazikani. The group also supports PhD students studying the re-wiring of signal transduction in colon cancer and the role of stroma in influencing signal transduction.
The group also currently works with Professor Andrea Sottoriva at the Centre for Evolution and Cancer at the ICR to look at barcoding of cancer cells and the study of evolutionary trajectories of clones under experimental conditions. It is also studying mechanisms of resistance, collateral drug sensitivity and resistance of these emergent clones.
The primary area of this group is focused on the re-wiring of signal transduction using established cell lines as well as fresh cancer cells derived and isolated from patients and then exposing them to novel anticancer drugs. Pre- and post-proteomic profiling provides insights into mechanisms of drug resistance and how to overcome this with combination therapies. The initial work was carried out using cancer cells isolated from ascites and pleural effusions; the group in now developing expertise in organoid and patient-derived xenograft tissue.
The group develops its own antibody-based proteomic platforms and collaborates with teams involved in mass spectroscopic methods, led by Jyoti Choudhary. The group generates significant amounts of data and collaborates with the ICR's Computational Biology and Chemogenomics Team led by Professor Bissan Al-Lazikani to develop and decipher the data.
The secondary focus of this lab is the study of the pharmacological effects on cancer evolution in experimental models and methods to quantify this and herd cancer cells to a vulnerable state.
Professor Banerji works with Professor Andrea Sottoriva in the Centre for Evolution and Cancer at the ICR and plans to translate these concepts in to the clinic.
Vacancies at the ICR
Working at the ICR
Prospect Research Manager
About the Role Our Prospect Research team plays a central role in unlocking new funding opportunities across the ICR's philanthropic income streams. It is responsible for delivering high quality, insightful prospect briefings and fundraising intelligence, which supports the ICR's fundraisers in their efforts to build meaningful relationships with philanthropic high net-worth individuals, trusts, foundations and corporates who have the interest and capacity to support the ICR's vital research. The post holder will play a key role in supporting the Development & Communications directorate to source, assess and validate new funding opportunities, maximise income secured across our philanthropic income streams and fundraising campaign, and grow our incredible donor community. The successful candidate will have experience of devising and successfully implementing targeted prospecting strategies. You will play a lead role in identifying philanthropic HNWIs and corporates with the capacity and inclination to support our work. The post holder will also be responsible for carrying out due diligence research and alerting fundraisers to reputational risks identified in support of the ICR's gift acceptance policy. You will work closely with the Head of Prospect Development to support fundraisers in maximising the success of our senior volunteer network through network mapping and expanding its ranks. In addition, the post holder will manage the Prospect Research Executive, providing development and mentoring support. What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Caroline Porter via telephone on 020 7153 5486 or email at [email protected].
Principal Statistician
Job Details The Cancer Research UK funded Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU) seek an experienced and highly motivated Principal Statistician to join their team of over 20 statisticians. We want to hear from you if you: Enjoy the challenge of designing efficient clinical trials and analysing complex datasets to answer clinical questions that will make a difference in patients’ lives Seek variety in your work and opportunities to apply your statistical knowledge across multiple therapeutic areas in oncology. Thrive on being part of a multi-disciplinary research team with like-minded statisticians. Are looking to develop your career within a dynamic and supportive academic environment at a leading cancer clinical trials unit. Key Requirements The successful applicant will be an experienced and highly motivated medical statistician interested in applying their statistical knowledge to the design and analysis of patient-centred clinical trials. They will have a post-graduate qualification in statistics. They should demonstrate a solid understanding of clinical trials and experience in applying statistical methods to real-world data. Effective oral and written communication skills, as well as enthusiasm for collaborating with others from diverse disciplines, are essential. Department/Directorate Information ICR-CTSU manages an exciting portfolio of national and international phase II and III cancer clinical trials and an expanding number of phase I trials. You will work as part of a multi-disciplinary team on the statistical design and development of new trials. You will conduct and oversee analysis of a number of clinical trials and/ or associated imaging or translational biomarker research studies across our portfolio. In your supporting statement please summarise how your research/managerial experience fits with the role. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion about the role please contact Nuria Porta, email [email protected] This is an office based role. Requests for hybrid working (splitting time between our Sutton site and home) may be considered following successful completion of key training and only if the role allows. Flexible working options may be considered. Informal enquiries may be made by emailing [email protected]
Employee Story
Dr Fatemeh Ahmadi Moughari is a bioinformatician working in the Functional Genomics Team, led by Rachael Natrajan, and the Bioinformatics Team, led by Syed Haider. She joined the ICR from her home country of Iran where she completed her PhD in anti-cancer drug response at Shahid Beheshti University.
"I really enjoy the multidisciplinary atmosphere here and it’s the thing that stood out when I first joined the ICR."
Industrial partnership opportunities with this group
Opportunity: A potent, orally bioavailable clinical-stage inhibitor of MPS1 with potential as a treatment for a range of cancer types including triple negative breast cancer
Commissioner: Swen Hoelder
