Paediatric Solid Tumour Biology and Therapeutics Group

Professor Louis Chesler’s group is investigating the genetic causes for the childhood cancers, neuroblastoma, medulloblastoma and rhabdomyosarcoma. 

Research, projects and publications in this group

Our group's aim is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma.

The goal of our laboratory is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma, three paediatric solid tumours in which high-risk patient cohorts can be defined by alterations in a single oncogene. We focus on the role of the MYCN oncogene, since aberrant expression of MYCNis very significantly associated with high-risk in all three diseases and implies that they may have a common cell-of-origin.

Elucidating the molecular signalling pathways that control expression of the MYCN oncoprotein and targeting these pathways with novel therapeutics is a major goal of the laboratory. We use a variety of innovative preclinical drug development platforms for this purpose.

Technologically, we focus on genetically engineered cancer models incorporating novel imaging (optical and fluorescent) modalities that can be used as markers to monitor disease progression and therapeutic response.

Our group has several key objectives:

  • Mechanistically dissect the role of the MYCN oncogene, and other key oncogenic driver genes in poor-outcome paediatric solid tumours (neuroblastoma, medulloblastoma, rhabdomyosarcoma).
  • Develop novel therapeutics targeting MYCN oncoproteins and other key oncogenic drivers
  • Develop improved genetic cancer models dually useful for studies of oncogenesis and preclinical development of novel therapeutics.
  • Use such models to develop and functionally validate optical imaging modalities useful as surrogate markers of tumour progression in paediatric cancer.

Professor Louis Chesler

Clinical Senior Lecturer/Group Leader:

Paediatric Solid Tumour Biology and Therapeutics Professor Louis Chesler (Profile pic)

Professor Louis Chesler is working to understand the biology of children’s cancers and use that information to discover and develop new personalised approaches to cancer treatment. His work focuses on improving the understanding of the role of the MYCN oncogene.

Researchers in this group

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6124

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Email: [email protected]

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Phone: +44 20 3437 6118

Email: [email protected]

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Location: Sutton

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OrcID: 0000-0003-3977-7020

Phone: +44 20 3437 6109

Email: [email protected]

Location: Sutton

I obtained an MSci in Biochemistry from the University of Glasgow in 2018. In October 2018 I joined the labs of Dr Michael Hubank and Professor Andrea Sottoriva to investigate the use of liquid biopsy to monitor clonal frequency and emergence of resistance mutations in paediatric cancers.

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Email: [email protected]

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

Professor Louis Chesler's group have written 113 publications

Most recent new publication 4/2025

See all their publications

Vacancies in this group

Working in this group

Senior Technician - in vivo biology

  • Sutton
  • Research Services
  • Permanent

About you The ICR is one of the world's leading cancer research institutes, aiming to defeat cancer. As a Senior Laboratory Technician you will contribute directly to this mission by supporting vital in vivo research. We are looking for a highly motivated, detail-oriented individual, committed to high-quality work. Key requirements include: Education and Knowledge BSc in Life Sciences or IAT Level 3 (Essential) Home Office Personal Licence (PILA, B, C) or equivalent (Essential) Understanding of tumour biology and pre-clinical models (Desirable) Skills Skilled in dissection, surgery, dosing of agents and sampling techniques (Essential) Strong organisational, communication and interpersonal skills (Essential) Ability to work independently and in a team with other scientists and BSU staff (Essential) Computer proficiency and willingness to pursue professional development (Essential) Experience Proven experience in in vivo oncology and PDX models (Essential) Strong foundation in animal (rodent) husbandry and behaviour (Essential) Experience in stereotaxic surgery, imaging techniques and sample preparation (Desirable) What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension Department/Directorate Information We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Bishani Wickrama via email on: [email protected].

Business Development Manager

  • Sutton
  • Business & Innovation Office
  • £61,275 - £74,175
  • Permanent

About the Role We are seeking a Business Development Manager to join The Institute of Cancer Research’s (ICR’s) Business and Innovation Office and contribute to to support a portfolio of academics by protecting and commercialising their research, supporting them in securing translational funding and to highlight to them the benefits of working with industry. The successful candidate will play a key role in strategic project evaluation, stakeholder engagement, IP protection, commercial deal-making (collaborations and licensing), and translational funding support. Key Responsibilities Identify and assess commercially viable research Protect IP and manage confidentiality agreements Draft and negotiate licensing and collaboration contracts Support translational funding applications Drive spinout opportunity management About You We are looking for a proactive, detail-oriented team player. PhD, MBA or equivalent in a relevant field Experience in business development or technology transfer Direct experience of negotiating and closing deals with external partners Strong communication, negotiation, and organizational skills What We Offer • Supportive, collaborative environment • Career development opportunities • Competitive salary and pension Department/Directorate Information The Business and Innovation Office drives commercialisation and strategic partnerships to maximise patient benefit. For more details, please refer to the job pack. For an informal discussion regarding the role, please contact Dr. Amritha Nair via Email on [email protected]

Industrial partnership opportunities with this group

Opportunity: A novel test for predicting future cancer risk in patients with inflammatory bowel disease

Commissioner: Professor Trevor Graham

Recent discoveries from this group

09/10/25

Two new oncology companies have been secured as tenants at the Innovation Gateway, a leading life sciences incubator at the heart of the London Cancer Hub.

Kindling Bio, a start-up focused on developing cancer gene therapies for children, and Beckman Coulter, a leading developer of cancer diagnostics, will base research teams at the Innovation Gateway occupying self-contained lab spaces on a flexible basis. They will join other fast-growing companies including CuResponse, a pioneer in personalised cancer treatments and Vesynta, a spin-out from UCL focused on data-guided precision treatment dosing. The incubator, which provides 3,500 sq ft of lab space over two floors, is now at 85 per cent capacity.

Aviva Capital Partners (ACP), Aviva’s in-house capital unit that invests in regeneration and infrastructure, and place-management specialist Populate, manage the Innovation Gateway.

Opened in in 2021 by Sutton Council, the Innovation Gateway provides flexible lab space for fast-growing companies adjacent to The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, on their shared Sutton campus.

The Innovation Gateway forms part of the London Cancer Hub where plans have been submitted by ACP and Socius for a circa 1 million square foot development of lab and research and development facilities that will enable life-sciences companies to work alongside and collaborate with some of the world’s leading cancer researchers and clinicians.

Works are already underway to enhance the existing infrastructure and public realm. A new pocket park has been introduced to provide a green space for staff, students, patients and visitors to relax and four padel courts, operated by Social Sports Society, are being installed as part of a wellbeing-focused amenity offer to help attract and retain leading companies and talent.

Dr Jon Wilkinson, Director of Business and Innovation at The Institute of Cancer Research, London, said:

"It’s fantastic to see these new arrivals at the Innovation Gateway and the continuing development of the community of smaller, innovative life-sciences companies at The London Cancer Hub. We’re very excited about further expanding our engagement with this growing community."

Sophie White, Head of Regeneration at Aviva Capital Partners said:

"The Innovation Gateway, which provides space for fast-growing oncology companies to collaborate and grow, is a microcosm of what can be achieved at scale at the London Cancer Hub. Our vision is to help the UK get ready for the future by delivering best-in-class lab and R&D space of all sizes that will enable life sciences companies to work closely with The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, and unlock further innovation in cancer treatment."

Olaide Oboh, Managing Director at Populate, added:

"The Innovation Gateway is at the heart of the ecosystem at London Cancer Hub and we are proud to be working with Aviva Capital Partners to provide a launchpad for fast-growing businesses in the oncology space. The workspace is vital but we are equally focused on the spaces between the buildings, and how we can create a more connected and inclusive district where people want to work, meet, socialise and share ideas."

Jeff Drew, Co-Founder at Kindling Bio, said:

"The Innovation Gateway provides the perfect environment for us to advance our research programme, offering flexible and affordable lab space as well as the opportunity to access specialist equipment and collaborate with researchers and clinicians at The Institute of Cancer Research and The Royal Marsden. We are excited to be part of a dynamic and growing research cluster at the London Cancer Hub."

For more information on the London Cancer Hub, please visit CancerHub.London