Paediatric Solid Tumour Biology and Therapeutics Group

Professor Louis Chesler’s group is investigating the genetic causes for the childhood cancers, neuroblastoma, medulloblastoma and rhabdomyosarcoma. 

Research, projects and publications in this group

Our group's aim is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma.

The goal of our laboratory is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma, three paediatric solid tumours in which high-risk patient cohorts can be defined by alterations in a single oncogene. We focus on the role of the MYCN oncogene, since aberrant expression of MYCNis very significantly associated with high-risk in all three diseases and implies that they may have a common cell-of-origin.

Elucidating the molecular signalling pathways that control expression of the MYCN oncoprotein and targeting these pathways with novel therapeutics is a major goal of the laboratory. We use a variety of innovative preclinical drug development platforms for this purpose.

Technologically, we focus on genetically engineered cancer models incorporating novel imaging (optical and fluorescent) modalities that can be used as markers to monitor disease progression and therapeutic response.

Our group has several key objectives:

  • Mechanistically dissect the role of the MYCN oncogene, and other key oncogenic driver genes in poor-outcome paediatric solid tumours (neuroblastoma, medulloblastoma, rhabdomyosarcoma).
  • Develop novel therapeutics targeting MYCN oncoproteins and other key oncogenic drivers
  • Develop improved genetic cancer models dually useful for studies of oncogenesis and preclinical development of novel therapeutics.
  • Use such models to develop and functionally validate optical imaging modalities useful as surrogate markers of tumour progression in paediatric cancer.

Professor Louis Chesler

Clinical Senior Lecturer/Group Leader:

Paediatric Solid Tumour Biology and Therapeutics Professor Louis Chesler (Profile pic)

Professor Louis Chesler is working to understand the biology of children’s cancers and use that information to discover and develop new personalised approaches to cancer treatment. His work focuses on improving the understanding of the role of the MYCN oncogene.

Researchers in this group

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6124

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Phone: +44 20 8722 4361

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6118

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6021

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6196

Email: [email protected]

Location: Sutton

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Email: [email protected]

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Location: Sutton

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OrcID: 0000-0003-3977-7020

Phone: +44 20 3437 6109

Email: [email protected]

Location: Sutton

I obtained an MSci in Biochemistry from the University of Glasgow in 2018. In October 2018 I joined the labs of Dr Michael Hubank and Professor Andrea Sottoriva to investigate the use of liquid biopsy to monitor clonal frequency and emergence of resistance mutations in paediatric cancers.

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

Professor Louis Chesler's group have written 113 publications

Most recent new publication 4/2025

See all their publications

Vacancies in this group

Working in this group

HR Business Partner

  • Chelsea
  • Human Resources
  • £64,500 per annum
  • Permanent

Summary of Role We currently have an exciting opportunity for a self-motivated and experienced HR Business Partner to join our HR Operations team. You will build strong partnerships with client departments, acting as a strategic advisor to align HR initiatives with broader business goals. In addition to leading on strategic HR matters, you will manage an HR Adviser and administrative support to ensure the delivery of a high-quality, consistent HR service across both the Professional Services and Scientific Research Divisions. Your role will involve working closely with operational teams across the ICR to provide a proactive, professional, and customer-focused generalist HR service throughout the employee lifecycle, in accordance with HR policies, procedures, and agreed service standards. Key requirements: Fully qualified Member of the Chartered Institute of Personnel and Development (CIPD), ideally at Chartered Member (MCIPD) level Demonstrated experience in handling a wide range of employee relations issues, including disciplinary and grievance procedures, absence and performance management, TUPE, redundancy, and redeployment Proficiency in using the Agresso Integrated HR/Payroll system, with the flexibility to adapt to Oracle as part of upcoming system changes (desirable) Comprehensive and current understanding of UK employment legislation and HR best practice Department/Directorate Information We know that talented, brilliant, passionate people lie at the heart of the ICR. The Human Resources Directorate provides both strategic and operational advice and support across the ICR to attract and acquire, develop, retain and empower our people to achieve their full potential. This is an exciting and transformative time for the HR Directorate as we begin to implement a new People Strategy and an ERP system to better support the ICR in achieving its mission of making the discoveries that defeat cancer.

Data Engineer/Wrangler (CD3)

  • Sutton
  • Integrative Cancer Epidemiology
  • £39,805 - £41900
  • Fixed term

We are seeking to appoint an experienced Data Engineer/Wrangler to work within the Cancer Data Driven (CD3) Programme, to join our dynamic and forefront research group using epidemiological cohort data approaches to understand the causes of cancer and how to prevent it. Under the leadership of Professor's Montserrat Garcia-Closas this is an exciting opportunity to join our dynamic and forefront research multidisciplinary team, using epidemiological and real-world data-driven approaches to understand the causes of cancer and how to prevent it. In this role you will help develop the study's infrastructure and operational systems, ensuring efficient processing of multi-source data and contributing to the stability and performance of key systems. As a Data Engineer/Wrangler you will clean, transform and integrate complex, multi-source data from large-scale epidemiological and real-word data. Your work will ensure data readiness for research, in collaboration with a multidisciplinary team of epidemiologists, statisticians, data scientists and data managers. This is an exciting opportunity to play a crucial role in the creation of end-to-end data management and processing solutions, according to FAIR (Findable, Accessible, Interoperable and Re-usable) principles to support efficient and secure research data re-use to advance science. About the Cancer Data Driven Detection (CD3) Programme The Data Engineer/Wrangler will work within the Cancer Data Driven (CD3) Programme. CD3 is a new, multidisciplinary and multi-institutional strategic national research programme dedicated to using data to transform our understanding of cancer risk and enable early interception of cancers. It represents a major, multi-million-pound flagship investment funded through a strategic programme award by Cancer Research UK, the National Institute for Health and Care Research (NIHR) and the Engineering and Physical Sciences Research Council (EPSRC); and the Peter Sowerby Foundation; in partnership with Health Data Research UK (HDR UK) and the Economic and Social Research Council’s Administrative Data Research UK programme (ADR UK). The successful candidate will work under the supervision of Professor Montserrat Garcia-Closas at the Integrative Epidemiology Team at The ICR and the Cancer Epidemiology and Prevention Research Unit (CEPRU), a research partnership between The ICR and Imperial College London. About you The successful candidate must have a Master’s degree in computer science, biostatistics, data science or epidemiology and preferably hold a PhD degree in epidemiology, biostatistics, or data science, who will enjoy working as part of a multidisciplinary team interacting with epidemiologists, biologists, statisticians, data scientists and operational managers. The post will be situated within the Division of Genetics & Epidemiology on the ICRs Sutton campus. Department/Directorate Information The Data Engineer/Wrangler will work with the Integrative Cancer Epidemiology Team (led by Professor Montserrat Garcia- Closas) and Clinical Epidemiology Team (led by Professor Amy Berrington) at the ICR Division of Genetics and Epidemiology. The Division is internationally renowned for its pioneering work in understanding the underlying genetic and environmental causes of cancer risk. High-quality laboratory, epidemiological and clinical research within the division is driven by energetic, innovative leadership and complemented by participation in national and international research consortiums, clinical collaborations, and technological partnerships. At the Integrative Cancer Epidemiology Team we use integrative analyses of large-scale data in epidemiological studies to investigate the causes of cancer, understand carcinogenic processes and improve risk assessment for precision prevention. At the Clinical Epidemiology Team we use real world data to investigate the late-effects of cancer treatments, cancer survival and cancer risks from other medications. Our work informs prevention and public health strategies at both the population and individual levels to reduce the burden of cancer. We have a program of research based on the ongoing Generations Study, a national study of over 110,000 women from the UK. Women in the study have provided blood samples and detailed questionnaire information at recruitment, and in repeat follow-up questionnaires. Data includes self- reported risk factor information, hormone levels, genetics, and artificial intelligence (AI) analyses of tissue images from breast tumours, benign breast disease and mammography images. We also access their medical records to collect information on cancer screening and treatments. The scientific staff comprise epidemiologists, statisticians and data scientist who collaborate with researchers around the world. We are part of the newly formed Cancer Epidemiology and Prevention Research Unit, a research partnership between The ICR and Imperial College London to establish collaborations in research, training and knowledge dissemination in cancer epidemiology and prevention. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Montserrat Garcia-Closas via Email at: [email protected]

Industrial partnership opportunities with this group

Opportunity: A novel test for predicting future cancer risk in patients with inflammatory bowel disease

Commissioner: Professor Trevor Graham

Recent discoveries from this group

30/10/25 - by

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The Institute of Cancer Research has ranked among the top UK universities for research partnerships and commercialisation.

We were one of only two UK higher education institutions to gain the highest grades in all measures of both research partnerships and commercialisation in the latest Knowledge Exchange Framework.

We also gained the top grade for public and community engagement.

The Knowledge Exchange Framework – also known by its acronym, ‘the KEF’ – is a yearly assessment of how well UK universities work with external partners, local communities and the public.

It’s run by UK Research and Innovation (UKRI), which funds research at UK universities on behalf of the Government. 

Research partnership

This year the ICR performed very well in both the two measures of research partnership. These metrics look at the proportion of universities’ academic papers that are published with non-academic co-authors, and at the proportion of their research funding that supports collaborative research.

We gained the top possible grade in these metrics due to our strong partnerships with industry and other academic institutions. Only five other higher education institutions gained the same grade.

Intellectual property and commercialisation

We also achieved the top grade in all three measures in the ‘intellectual property and commercialisation category’, alongside six other higher education institutions. These measure the proportion of universities’ income from licensing intellectual property to partners, and the turnover of, and investment in, their mature spinout companies.

Only the ICR and the University of Cambridge gained the top grade in all measures in both categories.

Other highlights of our KEF assessment included gaining the highest possible grade for public and community engagement, and an improvement in a score based on our income from Innovate UK. Innovate UK is part of UKRI and funds collaborative research between academic researchers and companies.

Industry partnerships

The ICR works in collaboration with around 100 industry partners at any one time, across areas from early-stage discovery science to early- and late-stage clinical trials of new cancer treatments.

Last year we made around 20 new industry collaboration agreements relating to joint research, as well as hundreds of other agreements with external partners – including around 250 commercial agreements, 150 clinical trial agreements and 400 non-commercial agreements.

We also signed dozens of licence agreements and filed several new patents.

New collaborations

This year, we won a major award for our work in collaboration with industry from life-sciences sector membership organisation One Nucleus.

Recent new collaborations include a partnership between our Centre for Immunotherapy of Cancer and the company QBiotics, and an Innovate UK-funded partnership between ICR childhood cancer researchers and the Bath University company Revolver Therapeutics.

Meanwhile, recent outcomes to emerge from our commercial collaborations have included regulatory approvals for Roche’s inavolisib in breast cancer, and Verastem Oncology’s avutometinib-defactinib drug combination in ovarian cancer.

We are also a leading research institution in collaboration with other universities – across the UK and internationally. 

One highlight of the past few years is our involvement in the MR-Linac consortium – a group of universities and hospitals from across Europe and the US working with the company Elekta to develop their Unity device.

The Unity combines radiation treatment and Magnetic Resonance Imaging (MRI), enabling simultaneous imaging and treatment.

Spinout companies

ICR spinout companies include Monte Rosa Therapeutics – a leading company in the development of molecular glues, an innovative type of cancer drug.

Other recent ICR spinouts include Kodiform Therapeutics and AI-focused Sentinal4D. We recently changed our spinout policy to encourage even more of our scientists to found companies.

Public engagement

The ICR has gained the highest grade for public engagement in all five KEF assessments so far. Our public engagement team works with our researchers to support and inspire their efforts to inform the public about their science – including through community events and visits.

Our public engagement team also runs a programme of engagement events and activities, including showpiece careers evenings for local schools.

We work closely with our partners at The London Cancer Hub in Sutton, south London – including the Borough of Sutton and site developers Socius – to engage the local community in our science.

Dr Jon Wilkinson, Director of Business and Innovation at the ICR, said, 

“We’re very proud of our strong track record in partnership – partnership with universities, and partnership with companies from across the wide landscape in oncology, from smaller and mid-size biotech to major pharma companies.

“It’s only by working together across different organisations and sectors that we’re able to make sure that our discoveries are translated into new, impactful treatments for cancer patients. Our collaborations also generate other major benefits to society, including stimulating economic growth.”