OTIS-S

OTIS-S: Investigating a new blood test for monitoring in testicular and ovarian cancer

Status: In set up

What is the study about?

We want to find out if a new blood test can be used to check whether the cancer is returning for people who have had surgery to remove an early stage testicular (seminoma) cancer or a similar type of cancer (dysgerminoma) that normally occurs in the ovaries. Most people have a low risk of their cancer returning after surgery, so they do not need any more treatment and are usually monitored for up to 5 years. Monitoring normally involves check-ups, scans (CT, MRI and/or ultrasound) and blood tests.

OTIS-S will look to see if a new blood test can be used as part of monitoring. Previous research suggests this test might be good at detecting these types of cancer if they are returning. This could reduce or avoid the need for scans which are currently used for this purpose. The blood test may even be able to detect a returning cancer earlier, but this is not yet known.

The study will be conducted in two parts (A and B). Only part A is currently being opened, and this page will be updated once part B is starting.

Who is included in the study?

OTIS-S includes people with early testicular (seminoma) cancer or ovarian (dysgerminoma) cancer. Everyone who joins the trial will have had surgery to remove their cancer and have a low risk of the cancer returning. Up to 260 people will be included in part A from NHS hospitals across the UK.

What does the study involve?

People who join the OTIS-S study in part A will have the new blood test alongside the normal monitoring, which involves check-ups, scans (CT, MRI and/or ultrasounds? and blood tests.

Everyone will have regular check-ups for 5 years to check if the cancer is returning and we will collect information about how they are getting on until the study is completed.

Further information for participants

Participant information sheet - PART A - Adults

Participant information sheet - PART A - Parent and Guardian

Participant information sheet - PART A - Older Children and Younger teenagers

Participant information sheet - PART A - Children

A detailed summary will be available on Cancer Research UK’s website (link to be provided once the record is live)

Our team are unable to offer any medical advice. If you are interested in finding out more about the trial or the tests involved, please talk to your hospital doctor or GP about whether they may be a suitable option for you.