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Mechanisms and Regulation of pre-mRNA Splicing

Professor Vlad Pena's team focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions.

Team leader

Professor Vlad Pena

Professor Vlad Pena

Professor Vlad Pena uses biochemistry, electron cryo-microscopy and X-ray crystallography to understand splicing regulation and the connections between splicing and other gene expression processes. He is a Professor of Structural Biology and Gene Expression at the ICR.

ORCID 0000-0002-7013-5504

Team members

 Negar Goodarzi
Negar Goodarzi
PhD Student

I joined the ICR in 2019. My PhD project is focused on investigating important functional links between splicing and other fundamental events in the cell at the molecular level using biochemical tools and Cryo-EM.

 Csaba Kibedi
Csaba Kibedi
PhD Student

I have a keen interest in structural biology and in particular in Cryo-Electron Microscopy (Cryo-EM). The focus of my PhD is to decipher the mechanism of action of complex ribonucleoprotein assemblies using single particle Cryo-EM.

 Ioana Maruntel
Ioana Maruntel
PhD Student

I am a PhD student in the Division of Structural Biology and my aim is to get a better understanding of pre-mRNA splicing regulation through Cryo-EM analysis.

 Elena-Luiza Mihalachi
Elena-Luiza Mihalachi
PhD Student ORCID 0000-0002-3975-5932

I am a PhD student and I’m interested in understanding the functions and structure of the splicing molecular machinery and capture its linking to other close related events in gene expression.

 Judit Galicza
Judit Galicza
Higher Scientific Officer