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Mechanisms and Regulation of pre-mRNA Splicing

Professor Vlad Pena's team focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions.

Group leader

Professor Vlad Pena

Professor Vlad Pena

Professor Vlad Pena uses biochemistry, electron cryo-microscopy and X-ray crystallography to understand splicing regulation and the connections between splicing and other gene expression processes. He is a Professor of Structural Biology and Gene Expression at the ICR.

ORCID 0000-0002-7013-5504

Group members

Imogen Andrews
Imogen Andrews
PhD Student

Imogen is a PhD student in the Division of Structural Biology focused on designing small molecule splicing modulators, in collaboration with the Centre for Cancer Drug Discovery.

Dr Tiffany Bergot
Dr Tiffany Bergot
Postdoctoral Training Fellow +44 20 7153 5524

Tiffany is a postdoctoral fellow who works on SF3B functions relevant to cancer.

Judit Galicza
Judit Galicza
Higher Scientific Officer

Judit is a higher scientific officer studying the regulation of RNA processing.

Negar Goodarzi
Negar Goodarzi
PhD Student

Negar is a PhD student working on splicing helicases.

Gus Hyland
PhD Student

Gus explores the modulation of gene expression by oncolytic viruses.

Csaba Kibedi
Csaba Kibedi
Postdoctoral Training Fellow +44 20 7153 5092

Csaba is a postdoctoral fellow working on splicing regulation.

Dr Hyunah Lee
Dr Hyunah Lee
Postdoctoral Training Fellow +44 20 7153 5498

Hyunah is a postdoctoral fellow who studies the regulation of alternative splicing.

Ioana Maruntel
Ioana Maruntel
PhD Student

Ioana is a PhD student focused on splicing mechanisms.

Elena-Luiza Mihalachi
PhD Student ORCID 0000-0002-3975-5932

I am a PhD student and I’m interested in understanding the functions and structure of the splicing molecular machinery and capture its linking to other close related events in gene expression.

Dr Constantin Cretu
Honorary Appointment