Researchers at the centre are answering three big questions in cancer medicine: why are humans so vulnerable to cancer; what determines the unpredictable development of cancers in the body over time; and why is drug resistance so frequent?
Computational biologists, geneticists, cell biologists and clinical scientists are working together to explore exciting new avenues of cancer-related evolutionary research. Researchers are identifying the genetic diversity within individual tumours, and exploring the use of genetic profiling of tumours as fingerprints that could predict progression of disease, metastases or drug resistance.
Dr Andrea Sottoriva, Leader of the Evolutionary Genomics and Modelling Team, is currently the Chris Rokos Fellow in Evolution and Cancer at the ICR.
The Centre is supported by a Strategic Award from the Wellcome Trust.