Paediatric Solid Tumour Biology and Therapeutics Group

Professor Louis Chesler’s group is investigating the genetic causes for the childhood cancers, neuroblastoma, medulloblastoma and rhabdomyosarcoma. 

Research, projects and publications in this group

Our group's aim is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma.

The goal of our laboratory is to improve the treatment and survival of children with neuroblastoma, medulloblastoma and rhabdomyosarcoma, three paediatric solid tumours in which high-risk patient cohorts can be defined by alterations in a single oncogene. We focus on the role of the MYCN oncogene, since aberrant expression of MYCNis very significantly associated with high-risk in all three diseases and implies that they may have a common cell-of-origin.

Elucidating the molecular signalling pathways that control expression of the MYCN oncoprotein and targeting these pathways with novel therapeutics is a major goal of the laboratory. We use a variety of innovative preclinical drug development platforms for this purpose.

Technologically, we focus on genetically engineered cancer models incorporating novel imaging (optical and fluorescent) modalities that can be used as markers to monitor disease progression and therapeutic response.

Our group has several key objectives:

  • Mechanistically dissect the role of the MYCN oncogene, and other key oncogenic driver genes in poor-outcome paediatric solid tumours (neuroblastoma, medulloblastoma, rhabdomyosarcoma).
  • Develop novel therapeutics targeting MYCN oncoproteins and other key oncogenic drivers
  • Develop improved genetic cancer models dually useful for studies of oncogenesis and preclinical development of novel therapeutics.
  • Use such models to develop and functionally validate optical imaging modalities useful as surrogate markers of tumour progression in paediatric cancer.

Professor Louis Chesler

Clinical Senior Lecturer/Group Leader:

Paediatric Solid Tumour Biology and Therapeutics Professor Louis Chesler (Profile pic)

Professor Louis Chesler is working to understand the biology of children’s cancers and use that information to discover and develop new personalised approaches to cancer treatment. His work focuses on improving the understanding of the role of the MYCN oncogene.

Researchers in this group

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6124

Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 3617

Email: [email protected]

Location: Sutton

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Phone: +44 20 8722 4186

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 3501

Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Phone: +44 20 8722 4361

Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6118

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6021

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6196

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6258

Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6121

Email: [email protected]

Location: Sutton

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Phone: +44 20 8722 4527

Email: [email protected]

Location: Sutton

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OrcID: 0000-0003-3977-7020

Phone: +44 20 3437 6109

Email: [email protected]

Location: Sutton

I obtained an MSci in Biochemistry from the University of Glasgow in 2018. In October 2018 I joined the labs of Dr Michael Hubank and Professor Andrea Sottoriva to investigate the use of liquid biopsy to monitor clonal frequency and emergence of resistance mutations in paediatric cancers.

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Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6358

Email: [email protected]

Location: Sutton

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Phone: +44 20 3437 6131

Email: [email protected]

Location: Sutton

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Email: [email protected]

Location: Sutton

Professor Louis Chesler's group have written 113 publications

Most recent new publication 4/2025

See all their publications

Vacancies in this group

Working in this group

Postdoctoral Training Fellow

  • Chelsea
  • Structural Biology
  • Salary Range: £45,600 - £55,000 per annum
  • Fixed term

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

Head of Biology, Cancer Drug Discovery (Group Leader)

  • Sutton
  • Cancer Therapeutics
  • Competitive
  • Permanent

The ICR is seeking an established research leader in cancer drug discovery biology with a track record in discovering innovative drugs to be the Head of Biology in the Centre for Cancer Drug Discovery (CCDD). The appointee will provide scientific leadership for the CCDD biology discipline, champion scientific excellence and work closely with senior team leaders in the CCDD to provide a strategic vision for the research and drug discovery portfolio. Key Requirements The role requires excellence in cancer biology, coupled with significant experience across the target identification to candidate selection stages of drug discovery. We envisage that applicants will have either significant commercial experience of successful drug discovery or have a strong academic track record in cancer biology and small molecule drug discovery; or will have a combination of both backgrounds. As part of your online application you will be required to upload your full CV which will pre-populate your application form. Department/Directorate Information: We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Abby Cook via Email on [email protected]

Industrial partnership opportunities with this group

Opportunity: A novel test for predicting future cancer risk in patients with inflammatory bowel disease

Commissioner: Professor Trevor Graham

Recent discoveries from this group

11/03/25

​Professor Peter Garland CBE, who served as Chief Executive of the ICR from 1989 to 1999, passed away on 5 March.

Before becoming the ICR's Chief Executive, Professor Garland was the founding Head of the Biochemistry Department at the University of Dundee, Principal Scientist at Unilever Research, and Director of Research at Amersham International plc.

A lasting legacy at the ICR

Alongside his scientific achievements, Professor Garland has left a lasting legacy at the ICR. Under his leadership the ICR first received funding from the Higher Education Funding Council for England (HEFCE). This crucial funding from the Government continues to this day from an equivalent body called Research England. Under his leadership, the ICR was also able to increase staff numbers by around 40 per cent and he led the extension of the ICR's Chester Beatty Laboratories (CBL) in Chelsea and the expansion of the ICR's presence on the Sutton campus, which commenced in 1999.

Professor Garland's policy of innovative recruitment saw him bring on board Professor Laurence Pearl and Professor David Barford to jointly head the newly formed Division of Structural Biology, housed in the renovated CBL. This also incorporated the Biomolecular Structure Unit. Peter also appointed Professor Paul Workman, Harrap Professor of Pharmacology and Therapeutics, to lead drug discovery at the ICR. This resulted in the discovery of multiple personalised medicines. Professor Workman, following in Professor Garland's footsteps, later became Chief Executive of the ICR.

Professor Garland also supported Professor Sir Mike Stratton (now at the Wellcome Sanger Institute and a former Director of that institution) in his work in cancer gene discovery. In 1994, this resulted in funding from the ICR to set up a Cancer Gene Cloning Laboratory led by Professor Sir Mike and Professor Colin Cooper and enabled the discovery of the BRCA2 tumour susceptibility gene.

Extremely supportive and extraordinarily influential

He also played an important role as the Chair of Cambridge Antibody Technology (CAT) for many years. One of the UK's most important biotechnology companies, CAT developed the drug Humira that has had a major impact on the treatment of rheumatoid arthritis and Crohn's disease.

Professor Garland was recognised in the 1999 Queen's Birthday Honours with a Commander of the British Empire (CBE) for his services to cancer research and biotechnology.

Speaking about Professor Garland, Professor Paul Workman said:

"Like myself, Peter was trained in biochemistry and had spent some time in industry. I'm hugely grateful that Peter recruited me to the ICR in 1997 from Zeneca Pharmaceuticals to take over the then relatively small drug discovery group at Sutton. He was extremely supportive of my efforts to modernise and build up what is now the Centre for Cancer Drug Discovery and to switch the focus to precision medicines. He also encouraged the productive interaction between my cancer therapeutics centre and Chris Marshall's centre for cell and molecular biology."

Professor David Barford added:

"I'm grateful to Peter for recruiting me and Laurence Pearl to establish a new Section of Structural Biology at the refurbished Chester Beatty Laboratories. The generous support provided allowed us to take on challenging research projects and to collaborate on drug discovery projects with Paul Workman, Chris Marshall and Richard Marais and others. Peter's scientific vision and bold and persuasive recruitment style resulted in far-reaching scientific and medical advances, and positively influenced the careers of many. It is also thanks to Peter's vision as the first Professor of Biochemistry at Dundee University (and Head of Department) in recruiting Philip and Tricia Cohen, that I spent an earlier period of my scientific career in their labs."

Professor Sir Mike Stratton said:

"Peter Garland was an extraordinarily influential Chief Executive of The Institute of Cancer Research. With remarkable shrewdness, foresight, wisdom and determination he reshaped the Institute’s scientific portfolio, setting it on a path of success for decades to come. He was universally respected, and extremely important to me personally in his support and encouragement. I owe him a huge debt of gratitude and will never forget his quiet, but indomitable spirit and vision."