Professor Pascal Meier grew up in Switzerland, where he obtained his PhD in Molecular Biology from the University of Zürich. He is currently a Professor in the Breast Cancer Now Toby Robins Research Centre at the Institute of Cancer Research, London.
His lab focuses on the complex relationship between cell death and inflammation. In particular, he is investigating how ubiquitin (Ub)- and Ub-like messages are used in a spatial and temporal manner to modulate the cellular response to cell death and inflammation, and how this can be exploited to prevent tumour formation and treatment resistance.
His work has had a major impact on our understanding how Inhibitor of APoptosis (IAP) proteins modulate cell death and inflammatory signalling cascades. He was the first to study IAP-mediated regulation of cell death and inflammation. His group demonstrated that IAPs function as last line of defence from caspase-mediated cell death, and that IAPs act as Ub-E3 ligases and Ub-receptors that regulate caspase-dependent as well as caspase-independent signalling processes.
He made several key contributions, which firmly established that IAPs function at the cross-road of cell death regulation and inflammation, a view point that is currently being exploited in clinical trials with pharmacological inhibitors of IAPs.
He is a member of the Young Investigator Programme (YIP, elected 2003), European Molecular Biology Organisation (EMBO, 2013), and received the Royal Society Wolfson Research Merit Award in 2012.