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Structural Biology of Cell Signalling Team

Dr Sebastian Guettler’s team is researching the ways in which certain enzymes, known as ADP-ribosyltransferases (ARTs), control cell function.

Team leader

Dr Sebastian Guettler

Dr Sebastian Guettler

Team Leader

Dr Sebastian Guettler is Deputy Head of the Division of Structural Biology. He studies the precise molecular mechanisms of signalling processes central to cancer stem cell function, with a particular interest in ADP-ribosylation in signal transduction. His previous work on tankyrase, a poly(ADP-ribose)polymerase (PARP), helped to explain how the rare human disease cherubism is caused.

ORCID 0000-0002-3135-1546

Team members

 Iona Black
Iona Black
PhD Student

Iona completed her undergraduate degree in Chemistry with Medicinal Chemistry at the University of Glasgow. At the ICR, in a collaborative project between Dr Sebastian Guettler and Professor Ian Collins, she investigates novel strategies to target the PARP enzyme tankyrase.

Dr Oviya Inian
Dr Oviya Inian
Postdoctoral Training Fellow

Oviya studied Biotechnology during her undergraduate degree at SRM University, India. She then completed her PhD in Professor Sara Sandin's lab at Nanyang Technological University, Singapore. Oviya joined the ICR as a postdoc in 2019 and is currently studying the function of tankyrase at telomeres.

Dr Matthew Jessop
Dr Matthew Jessop
Postdoctoral Training Fellow

I completed my BSc (Hons) in Biology at the University of Auckland, New Zealand, in 2015. I then moved to the Institut de Biologie Structurale in Grenoble, France, for my PhD, working in Dr Irina Gutsche’s group. During my PhD, I used cryo-EM and biochemistry to characterise the bacterial AAA+ ATPase RavA and the Mitochondrial Complex I Assembly Complex. I moved to the Guettler lab in 2020 to work on the cryo-EM characterisation of tankyrase.

Dr Nisha Pillay
Dr Nisha Pillay
Postdoctoral Training Fellow

I studied Natural Sciences at the University of Cambridge majoring in Biochemistry. I then moved on to the University of Manchester to undertake a Wellcome-funded PhD in the lab of Professor Stephen Taylor investigating the poly(ADP-ribose) reversal enzyme poly(ADP-ribose) glycohydrolase (PARG) as a therapeutic target. In 2020, I joined Sebastian’s lab to pursue my interests in ADP-ribosylation biology, investigating ADP-ribosylation of tankyrase targets, with a particular interest in telomeric functions of tankyrase.

Dr Michael Ranes
Dr Michael Ranes
Postdoctoral Training Fellow

Michael received his MSc degree in Medical Biology in 2009 from the Radboud University in the Netherlands. He then moved to the Clare Hall Laboratories at the London Research Institute, where he obtained his PhD in Biochemistry. In 2014, he joined the ICR, working on understanding how the poly(ADP-ribose)polymerase tankyrase regulates the Wnt/β-catenin signalling pathway.

 Lucie  Vyletova
Lucie Vyletova
Higher Scientific Officer

After completing my MRes degree in Molecular Biophysics at King’s College London in 2011, I joined Professor Dale Wigley’s team as a Scientific Officer in the Division of Structural Biology at the ICR. I worked for over five years in the Baculovirus Laboratory, managing the facility for two years. In February 2020, I joined Sebastian’s group as a Higher Scientific Officer, studying the mechanisms of tankyrase regulation.

 Yexin Xie
Yexin Xie
PhD Student

Yexin completed her Bachelor's degree in Medical Sciences at University College London (UK), during which she also explored the therapeutic potential of MEK inhibitors using breast cancer spheroids. In Dr Guettler's lab, Yexin studies various roles of tankyrase at telomeres.

Dr Mariola Zaleska
Dr Mariola Zaleska
Higher Scientific Officer +442071535180

Mariola studied Biotechnology (BSc) at the University of Silesia in Poland and undertook her MSc in Analytical Bioscience at the University of Huddersfield. She then did her PhD in Dr Mark Pfuhl’s lab at King’s College London. Mariola joined Dr Guettler’s lab in July 2017.

Dr Paul Hopkins
Dr Paul Hopkins
Higher Scientific Officer