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Structural Biology of Cell Signalling Team

Dr Sebastian Guettler’s team is researching the ways in which certain enzymes, known as ADP-ribosyltransferases (ARTs), control cell function.

Team leader

Dr Sebastian Guettler

Dr Sebastian Guettler

Team Leader

Dr Sebastian Guettler studies the precise molecular mechanisms of signalling processes central to cancer stem cell function, with a particular interest in ADP-ribosylation in signal transduction. His previous work on tankyrase, a poly(ADP-ribose)polymerase (PARP), helped to explain how the rare human disease cherubism is caused.

T +44 (0)207 153 5122

Team members

Iona Black

PhD student

Sam Hibbs

PhD student

Dr Michael Ranes

Postdoctoral Fellow

Dr Peter Saiu

Postdoctoral Fellow

Yexin Xie

Graduate Student

Dr Mariola Zaleska

Higher Scientific Officer T +442071535180