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Sarcoma Molecular Pathology Team

Professor Janet Shipley’s team is investigating ways to improve the treatment of patients with soft tissue sarcomas associated with poor clinical outcome.

Team leader

Professor Janet Shipley

Professor Janet Shipley

Professor of Cancer Molecular Pathology

Professor Janet Shipley is investigating ways to improve the treatment of patients with sarcomas that have a poor outcome. She is the Head of the Division of Molecular Pathology.

ORCID 0000-0001-6748-8678

Team members

Dr Ewa Aladowicz
Dr Ewa Aladowicz
Higher Scientific Officer

I joined the ICR in 2013. I work on the development and characterisation of 3D and PDX models of paediatric sarcomas. I use these models to study new therapies that combine standard chemotherapy with targeting drugs.

Dr Carolina Bernauer
Dr Carolina Bernauer
Clinical Research Fellow

I am a Clinical Research Fellow interested in understanding the complexities of cancer and bridging the gap between researchers and clinicians. My current project is focused on understanding whether tumour hypoxia can be targeted, and used as a predictive biomarker to improve treatment response, in patients with aggressive forms of rhabdomyosarcoma.

Dr Lucile Delespaul
Dr Lucile Delespaul
Postdoctoral Training Fellow

I am interested in deciphering the oncogenic mechanisms associated with sarcomas genesis and progression through transcriptomic and genetic analysis. My current project focusses on paediatric rhabdomyosarcomas and my research aims to identify molecular characteristics associated with drug resistance leading to tumour relapse, a process observed in one-third of patients.

 Sarah Johnson
Sarah Johnson
Personal Assistant

I am Personal Assistant to Professor Janet Shipley, Head of the Division of Molecular Pathology. I also act as the liaison point for the Divisional Team Leaders and their teams to ensure smooth running of the administration and oversight of the Division.

Dr Anastasia Loktev
Dr Anastasia Loktev
Postdoctoral Training Fellow

My research interests lie within translational cancer research to develop better therapeutic interventions for patients. Currently, I am working on combination treatments for the targeted therapy of rare paediatric sarcomas.

Dr Stella Man
Dr Stella Man
Higher Scientific Officer

I am currently developing three dimensional spheroid models for paediatric soft tissue sarcomas. The in vitro models will serve as invaluable tools for testing novel treatment strategies as well as for understanding the role of the tumour stroma on these rare and often aggressive tumours.

 Antonio Romo-Morales
Antonio Romo-Morales
PhD Student

I’m in the final year of my PhD in Ewing Sarcoma. My research aim is to identify novel therapeutic strategies for this rare cancer through combination strategies using spheroid models and molecular biology techniques.

Dr Olivia Ruhen
Dr Olivia Ruhen
Postdoctoral Training Fellow

I work on rhabdomyosarcoma, an aggressive cancer of the soft tissue which is most common in children and young adults. My project is focused on developing a new circulating tumour DNA-based blood test which will hopefully enable earlier detection of treatment failure and disease recurrence in paediatric rhabdomyosarcoma patients.

 Sami Sandakly
Sami Sandakly
PhD Student

The focus of my PhD project is to identify if and how it would be possible to therapeutically leverage the mutations in the BCOR gene, occurring in a subset of rhabdomyosarcoma patients. To that end I am establishing a model that mimics these mutations to characterise and understand their effect on the cancer cells.

Dr Joanna Selfe
Dr Joanna Selfe
Senior Scientific Officer

I am a Senior Scientific Officer and am involved in several projects looking at rhabdomyosarcoma. These involve trying to improve the prognostication of rhabdomyosarcoma as well as identifying new drug targets and approaches to treating rhabdomyosarcoma to achieve better outcomes while sparing children unnecessary treatment and therefore side effects that can affect them in later life.

 Brenda Summersgill
Brenda Summersgill
Volunteer

I joined the team in 1992 working mainly with rhabdomyosarcoma and testicular germ cell tumours. Since 2014 I have worked on a voluntary basis cataloguing the department's tissue assets.