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Molecular and Systems Oncology Team

Dr Paul Huang’s team aims to understand how networks of signalling-proteins control tumour progression and drug resistance in cancer.

Team leader

Dr Paul Huang

Dr Paul Huang

Team Leader

Dr Paul Huang uses systems biology and molecular pathology to study drug resistance in sarcomas and lung cancer. He trained at Imperial College London and Massachusetts Institute of Technology, and was awarded a Sir Henry Wellcome Fellowship in 2009 and a Cancer Research UK Career Establishment Award in 2015.

ORCID 0000-0003-3972-5087

Team members

Dr Amani Arthur
Dr Amani Arthur
Clinical Training Fellow

I am currently working on utilising radiogenomics to understand heterogeneity and therapy response in soft tissue sarcoma, and whether combining imaging and molecular data can improve patient outcomes.

Jess Burns
Jess Burns
PhD Student

I am working to understand how drug resistance in soft tissue sarcomas develops, by using mass spectrometry to generate proteomic profiles in tumour specimens.

Madhumeeta Chadha
Madhumeeta Chadha
PhD Student

I am a first year PhD student and my work will be focussed on analysing post translational modifications, particularly phosphoproteomics by mass spectrometry in soft tissue sarcomas.

Beverley Coughlan
Beverley Coughlan
Administrative Assistant

I am an administrative assistant within the Division of Molecular Pathology. I have a keen interest in the world of oncology and am enthusiastic about supporting those who are making a real difference in their work.

Mark Elms
Mark Elms
PhD Student

I am currently a PhD student researching the mechanisms of resistance in soft tissue sarcoma to the tyrosine kinase inhibitors.

Nafia Guljar
Nafia Guljar
Higher Scientific Officer

I am working to validate a molecular signature developed in the lab, which identifies patient subgroups with distinct therapy outcomes, in advanced soft tissue sarcoma.

Dr Andrew Jenks
Dr Andrew Jenks
Higher Scientific Officer

I began my postdoctoral career at the ICR in 2015. Initially working for the Signal Transduction Team (Barbara Tanos) and subsequently joining the Molecular and Systems Oncology Team in 2018. My current research is focused on understanding sub-clonal interactions and tumour heterogeneity driving EGFR inhibitor resistance in lung cancer.

Will Kerrison
Will Kerrison
PhD Student

I am a PhD student and my research focuses on understanding kinase inhibitor resistance mechanisms in soft tissue sarcomas and lung cancers. To do this I am also working to develop better 2D and 3D sarcoma and lung models which are more similar to tumours in the body.

Tsin Koay
Tsin Koay
Scientific Officer

I am a Scientific Officer in the lab, working on tackling EGFR Exon 20 mutations in lung cancer.

Dr Lukas Krasny
Dr Lukas Krasny
Postdoctoral Training Fellow

I am interested in the proteomics of the extracellular matrix during breast cancer progression and in SWATH mass spectrometry development for clinical proteomics.

Dr Laura Pacini
Dr Laura Pacini
Postdoctoral Training Fellow

I am a Postdoctoral training fellow working on the evolution of acquired resistance to targeted EGFR therapy in non-small-cell lung cancer.

Valeriya Pankova
Valeriya Pankova
PhD Student

I am a 1st year PhD student and I’ll be using proteomics to better understand mechanisms of chemoresistance in soft tissue sarcoma (STS), characterising extracellular proteins and associated proteins (matrisome) to do this.

Emma Perkins
Emma Perkins
Honorary Appointment

Previous to working in the Huang lab, I worked for the GI unit as a Specimen Co-ordinator. Now, my role as Tissue Manager involves collecting and banking tissue samples of rare sarcoma subtypes to facilitate current and future research projects for the Huang lab.

Yuen Bun Tam
Yuen Bun Tam
PhD Student

I am a PhD student working to understand the mechanisms of response and resistance in alveolar soft part sarcoma to the TKI cediranib, with the aims of identifying new biomarkers and therapeutic strategies to improve patient outcome.

Amy Vanni
Amy Vanni
PhD student

I am a PhD student working on an integrative bioinformatics analysis to identify and evaluate transcriptional and proteomic signatures in soft tissue sarcoma, with the aim of predicting targeted therapy response and improving patient outcomes.

Dr Simon Vyse
Dr Simon Vyse
Postdoctoral Training Fellow

I have recently, successfully completed a PhD in the Huang Lab at the ICR and now continue my work as a postdoctoral training fellow to identify novel strategies to overcome de novo resistance to EGFR inhibitors in lung cancer.

Chris Wilding
Chris Wilding
Clinical Research Fellow

I left the major trauma centre in Coventry to join the ICR in 2018 as a clinical PhD fellow. My research is focused on identifying biomarkers for response to tyrosine kinase inhibitors, in soft tissue sarcomas, through characterisation of the immune microenvironment.