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Molecular and Systems Oncology Team

Dr Paul Huang’s team aims to understand how networks of signalling-proteins control tumour progression and drug resistance in cancer.

Team leader

Dr Paul Huang

Dr Paul Huang

Team Leader

Dr Paul Huang uses systems biology and molecular pathology to study drug resistance in sarcomas and lung cancer. He trained at Imperial College London and Massachusetts Institute of Technology, and was awarded a Sir Henry Wellcome Fellowship in 2009 and a Cancer Research UK Career Establishment Award in 2015.

ORCID 0000-0003-3972-5087

Team members

Yeasmin Akther
Yeasmin Akther
Higher Scientific Officer +44 20 3437 6659

I am a higher scientific officer. My work involves Nanostring gene expression analysis to establish molecular signatures or biomarkers for targeted therapy response in sarcoma trials.

Sara Arfan
Sara Arfan
PhD Student

I am PhD student focusing on understanding angiosarcomas. My work involves molecular profiling of angiosarcoma patient samples to better understand mechanisms of treatment response and resistance and identify potential biomarkers.

Dr Amani Arthur
Dr Amani Arthur
Clinical Research Fellow

I am currently working on utilising radiogenomics to understand heterogeneity and therapy response in soft tissue sarcoma, and whether combining imaging and molecular data can improve patient outcomes.

Madhumeeta Chadha
Madhumeeta Chadha
PhD Student

I am a PhD student and my work will be focussed on analysing post translational modifications, particularly phosphoproteomics by mass spectrometry in soft tissue sarcomas.

Dr Avirup Chowdhury
Dr Avirup Chowdhury
Clinical Research Fellow +44 20 3437 6680

My research aims to identify candidate biomarkers for improving neoadjuvant therapy in high-risk soft tissue sarcomas. This convergence science project uses an explant-in-chip model developed by the Overby group, our collaborators at Imperial College London.

Beverley Coughlan
Beverley Coughlan
Administrative Assistant

I am an administrative assistant within the Division of Molecular Pathology. I have a keen interest in the world of oncology and am enthusiastic about supporting those who are making a real difference in their work.

Dr Andrew Jenks
Dr Andrew Jenks
Higher Scientific Officer

I began my postdoctoral career at the ICR in 2015. Initially working for the Signal Transduction Team (Barbara Tanos) and subsequently joining the Molecular and Systems Oncology Team in 2018. My current research is focused on understanding sub-clonal interactions and tumour heterogeneity driving EGFR inhibitor resistance in lung cancer.

Pooja Kaur
Pooja Kaur
PhD Student ICR-Imperial

I am a first-year PhD student split between Imperial College London (Ishihara lab) and the Institute of Cancer Research (Huang lab). My research will be focused on the bioengineering and development of immunomodulatory agents designed to target the extracellular matrix as a novel therapeutic strategy to treat sarcoma.

Tsin Koay
Tsin Koay
Scientific Officer

I am a Scientific Officer in the lab, working on tackling EGFR Exon 20 mutations in lung cancer.

Dr Lukas Krasny
Dr Lukas Krasny
Honorary Appointment

I am interested in the proteomics of the extracellular matrix during breast cancer progression and in SWATH mass spectrometry development for clinical proteomics.

Kaan Low
Kaan Low
Higher Scientific Officer +44 20 3437 6918

I am a Higher Scientific Officer currently investigating the drug resistance mechanisms in lung cancer patients with EGFR Exon20 insertion mutations using gene editing approaches such as CRISPR-Cas9.

Valeriya Pankova
Valeriya Pankova
PhD Student

I am a fourth year PhD student and I’ll be using proteomics to better understand mechanisms of chemoresistance in soft tissue sarcoma (STS), characterising extracellular proteins and associated proteins (matrisome) to do this.

Yuen Bun Tam
Yuen Bun Tam
PhD Student

I am a PhD student working to understand the mechanisms of response and resistance in alveolar soft part sarcoma to the TKI cediranib, with the aims of identifying new biomarkers and therapeutic strategies to improve patient outcome.

Isabella Clottey
Engagement Manager T +44 20 3437 7022