Clinical Pharmacology Adaptive Therapy Group

Professor Banerji's group aims to study re-wiring of signal transduction to understand and overcome mechanisms of drug resistance and, in addition, to understand exploit cancer evolution using pharmacological tools.

We are focused on the re-wiring of signal transduction using established cell lines to control mechanisms of drug resistance and comprehend the evolution of cancer.  

Rewiring of signal transduction

This group is working on the set-up and validation of a highly sensitive antibody-based assay on the Nanostring platform which will allow quantification of 50 - 100 phosphoproteins/proteins. It plans to digest tumour tissue obtained during surgery or from biopsies and expose them to a matrix of 20 - 30 anticancer drugs before obtaining phosphoproteomic data.

It also aims to use organoids and patient-derived xenografts to take this forward. The proteomic data will be modelled with the Computational Biology and Chemogenomics Team led by Professor Bissan Al-Lazikani. The group also supports PhD students studying the re-wiring of signal transduction in colon cancer and the role of stroma in influencing signal transduction.

The group also currently works with Professor Andrea Sottoriva at the Centre for Evolution and Cancer at the ICR to look at barcoding of cancer cells and the study of evolutionary trajectories of clones under experimental conditions. It is also studying mechanisms of resistance, collateral drug sensitivity and resistance of these emergent clones.


The primary area of this group is focused on the re-wiring of signal transduction using established cell lines as well as fresh cancer cells derived and isolated from patients and then exposing them to novel anticancer drugs. Pre- and post-proteomic profiling provides insights into mechanisms of drug resistance and how to overcome this with combination therapies. The initial work was carried out using cancer cells isolated from ascites and pleural effusions; the group in now developing expertise in organoid and patient-derived xenograft tissue.

The group develops its own antibody-based proteomic platforms and collaborates with teams involved in mass spectroscopic methods, led by Jyoti Choudhary. The group generates significant amounts of data and collaborates with the ICR's Computational Biology and Chemogenomics Team led by Professor Bissan Al-Lazikani to develop and decipher the data.

The secondary focus of this lab is the study of the pharmacological effects on cancer evolution in experimental models and methods to quantify this and herd cancer cells to a vulnerable state.

Professor Banerji works with Professor Andrea Sottoriva in the Centre for Evolution and Cancer at the ICR and plans to translate these concepts in to the clinic.

Vacancies at the ICR

Working at the ICR

Pensions Manager

  • Chelsea
  • Human Resources
  • Salary: £61,275 - £74,175 pro rata
  • Permanent

About the Role We are seeking a Pensions Manager to join our Human Resources Directorate, where you will deliver a high-quality, professional and customer-focused pensions service across the employee lifecycle. This role has a significant impact on the organisation by ensuring the effective administration and governance of all pension schemes, supporting our staff and Trustees, and enabling the ICR to recruit, retain and develop exceptional people. You will be responsible for ensuring that pension contributions and data are processed accurately, that scheme rules and deadlines are met, and that colleagues receive clear and timely guidance on a wide range of pension matters. Key Responsibilities Oversee the administration of all ICR pension schemes, ensuring accurate and timely contributions, reporting and financial records, while working closely with payroll and internal teams to maintain correct system configuration and resolve issues. Provide expert guidance on complex pension matters, including retirement, redundancy, ill-health and death-in-service, and prepare complex calculations, manage sensitive casework and deliver training on scheme changes and legislation. Act as Scheme Secretary for the closed ICR Pension Scheme, supporting Trustees, managing governance processes, coordinating meetings, maintaining scheme documentation and ensuring compliance with regulatory requirements. Lead and support the Pensions Officer and Pensions Contribution Officer through effective line management, promoting high performance, service improvement and professional development. About You We are seeking a proactive, detail-focused pensions professional with strong communication and stakeholder-management skills. You will have solid knowledge of pension law, experience with USS and/or NHS Pension Schemes, and a background working with both defined benefit and defined contribution arrangements. You will be confident managing complex pension cases, interpreting legislation and working effectively with scheme providers and advisers. You should be comfortable handling large data sets, using HR/Payroll systems and meeting tight deadlines, while building credibility through clear, authoritative guidance to staff, managers and Trustees. Strong interpersonal skills, accuracy, conflict-resolution ability and experience supervising others are essential. Professional qualifications such as PMI or CIPD membership, or a relevant degree, would be beneficial. What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information The Human Resources Directorate provides the policies, systems and infrastructure that support the ICR’s talented and diverse workforce. The directorate is made up of HR Operations, Learning and Organisational Development, Pensions, and Reward, Information and Systems. Together, these teams ensure the organisation has the workforce capacity and capability to achieve its mission: to make the discoveries that defeat cancer. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Mohammad Rehmman via email on [email protected]

Group Leader in In Vivo Cancer Modelling

  • Sutton
  • Cancer Biology
  • From £66,092 per annum
  • Fixed term

The Institute of Cancer Research (ICR) in London seeks to appoint a Group Leader in In Vivo Cancer Modelling to play a pivotal role in advancing our cutting-edge cancer research. The position is based at the newly established Centre for In Vivo Modelling (CIVM), part of the Division of Cancer Biology. We welcome applications at both the Career Development Faculty and Career Faculty levels. Key Requirements The successful candidate will generate and employ state-of-the-art genetic and humanised mouse models of cancer to tackle fundamental and translational questions in haemato-oncology and/or solid tumour oncology. In addition to leading a successful research group, they will expand the CIVM's research capabilities and foster productive collaborations with other groups and centres at the ICR, thus promoting in vivo modelling by integrating it into multidisciplinary projects and initiatives. Applicants must have an internationally recognised track record of leading research in in vivo modelling and advanced mouse genetics, demonstrated by high-quality publications and significant funding success. For more junior candidates, an outstanding track record in cancer research, coupled with a compelling research vision leveraging advanced genetic mouse models and clear potential to secure competitive external funding, is essential. As part of your online application you will be required to upload your full CV which will pre-populate your application form, you will also be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: Lists of major publications, achievements, research grants, distinctions. Research plan (five to six pages outlining your current research interests and research programme for the next 5 years) A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity You must also complete the personal statement section of the application form in the format of a covering letter including the names and contact details of three academic referees Department/Directorate Information: The ICR is one of the world’s most influential cancer research institutions, with an outstanding track record of achievement dating back more than 100 years. In addition to being one of the UK’s leading higher education institutions for research quality and impact, the ICR is consistently ranked among the world’s most successful for industry collaboration. As a member institution of the University of London, we also provide postgraduate higher education of international distinction. One of the ICR’s key research strategies is to defeat cancer by viewing it as a dynamic ecosystem. We aim to solidify our expertise in state-of-the-art in vivo cancer models to probe these complex cancer ecosystems, discover their underlying biology, and identify new therapeutic targets. The postholder will significantly contribute to driving these strategic priorities. We encourage all applicants to access the job pack attached for more detailed information regarding this role. If you would like to informally discuss this position, please contact Professor Kamil R. Kranc ([email protected]), Director of the Centre for In Vivo Modelling, or Professor Chris Jones ([email protected]), Head of the Division of Cancer Biology at the ICR.

Industrial partnership opportunities with this group

Opportunity: A potent, orally bioavailable clinical-stage inhibitor of MPS1 with potential as a treatment for a range of cancer types including triple negative breast cancer

Commissioner: Swen Hoelder

Recent discoveries from this group