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Epigenetics and Genome Stability Team

Professor Jessica Downs’s team investigates how DNA packaging influences the stability of genetic information, studying how this packaging and its regulation can influence the development and progression of cancer.

Team leader

Professor Jessica Downs

Professor Jessica Downs

Professor Jessica Downs is Deputy Head of the Division of Cancer Biology. She is investigating the interplay between epigenetics and genome stability. The goal of this research is to understand how the packaging and organisation of DNA in cells helps to maintain its integrity and prevent tumourigenesis.

ORCID 0000-0002-6600-849X

Team members

Dr Alison Harrod
Dr Alison Harrod
Postdoctoral Training Fellow +44 20 7153 5037

Alison obtained her BSc in Biomedical Science at the University of Sheffield. She then completed her MSc degree in Molecular Medicine and her PhD in the Department of Surgery and Cancer at the Imperial College London. In April 2019, she joined Professor Down’s team at the ICR and her research is focusing on chromatin modifiers in cancer, working jointly with Professor Raj Chopra.

Dr Karen Lane
Dr Karen Lane
Postdoctoral Training Fellow +44 20 3437 7459

Karen completed her undergraduate BSc degree in Pharmacology and an MSc in Biomedical Science at the National University of Ireland, Galway. She graduated from the Centre for Chromosome Biology in Galway with a PhD in Biochemistry in 2017. Karen started in Professor Downs' lab in 2018, where she is investigating synthetic lethal drug candidates in cancers which have mutations in the SWI/SNF chromatin remodelling complexes.

Dr Susana Sousa
Dr Susana Sousa
Postdoctoral Training Fellow

Susana completed her BSc degree in Applied Biology at the University of Minho, and her MSc degree in Oncology at the University of Porto, both in Portugal. She then obtained her PhD in Cancer Sciences at The University of Manchester. In January 2019, she joined Professor Downs’ lab at the ICR and is investigating the contribution of chromatin dynamics to DNA damage responses and genome stability.

Dr Chris Bassi
Postdoctoral Training Fellow T +44 20 7153 5197
Katie Begg
Postdoctoral Training Fellow T +44 20 7153 5397
Hugang Feng
Postdoctoral Training Fellow T +44 20 7153 5589