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TOxicity Reduction using Proton bEam therapy for Oropharyngeal cancer

A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer

Disease site: Head and neck cancer

Treatment modality: Other: Proton beam therapy

Status: Open to recruitment

Trial details

TORPEdO is a phase III, multicentre, randomised trial to assess whether intensity modulated proton therapy (IMPT) compared with intensity modulated radiotherapy treatment (IMRT) reduces toxicity in oropharyngeal squamous cell carcinoma.

183 patients will be recruited from UK sites over a 3.5 year period, with patients randomised to IMPT being treated at either The Christie NHS Foundation Trust or University College London Hospitals NHS Foundation Trust. Patients will receive treatment for 6.5 weeks, and will be followed up for a further 5 years.

Further information for potential participants

Patient Information Sheet

Further information for healthcare professionals


Further information 

Clinical trials

Division of Clinical Studies

The division carries out or coordinates high-quality trials and translational research at both an early phase – typically to test new targeted drugs – and a later stage.