HOT - Randomised phase II trial of hyperbaric oxygen therapy for patients with chronic arm lymphoedema after radiotherapy for early breast cancer.
Disease site: Breast cancer
Treatment modality: Other
Status: In active follow-up
The primary aim of HOT was to test the efficacy of hyperbaric oxygen (HBO) therapy in reducing arm lymphoedema in patients suffering long-term adverse effects of high dose radiotherapy for early breast cancer. A secondary aim was to test mechanisms of tissue reperfusion and healing in response to HB. 58 patients were recruited to this trial.
Chief Investigator: Professor J. Yarnold, Royal Marsden NHS Foundation Trust
ICR-CTSU Scientific Lead: Professor Judith Bliss
Sponsor: The Institute of Cancer Research
Funding: Cancer Research UK and the Department of Health
Patient friendly information on HOT at CancerHelp UK
Publications and presentations
Gothard L, Haviland J, Bryson P, et al. Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiother. Oncol. 2010;97(1):101-07