FAST - Prospective randomised clinical trial testing 5.7 Gy and 6.0 Gy fractions of whole breast radiotherapy in terms of late normal tissue responses and tumour control.
Disease site: Breast cancer
Treatment modality: Radiotherapy
Status: In active follow-up
The FAST trial aims to test 5 fractions of 5.7 Gy and 6.0 Gy against 25 fractions of 2.0 Gy in terms of late normal tissue effects and tumour control in women prescribed whole breast radiotherapy (no boost) after local excision of early breast cancer.
915 patients were recruited into the trial between October 2004 and March 2007. 19 UK centres participated in the trial.
Chief Investigator: Professor John Yarnold, The Institute of Cancer Research & Royal Marsden NHS Foundation Trust
ICR-CTSU Scientific Lead: Professor Judith Bliss
Trial management contact: [email protected]
Sponsor: The Institute of Cancer Research
Funding: Cancer Research UK programme grant funding
Publications and presentations
The FAST Trialists Group. First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015). Radiother. Oncol. 2011;100(1):93-100
Brunt AM, Sydenham M, Bliss J, et al. A 5-fraction regimen of adjuvant radiotherapy for women with early breast cancer: first analysis of the randomised UK FAST Trial (ISRCTN62488883, CRUKE/04/015). European Journal of Cancer Supplements 2009;7(3):2
Tsang YM, Venables K, Sydenham M, on behalf of the FAST Working Party. Interim quality assurance (QA) analysis of treatment plans in the 'Faster Radiotherpay for Breast Cancer patients' (FAST) Trial. NCRI Cancer Conference; 2006.
Sydenham M, Haviland J, Donovan E, Venables K, Bliss JM, Yarnold J, on behalf of the FAST Trial Management Group. Further testing of radiotherapy hypofractionation (fewer, larger fractions) in early breast cancer - The FAST Trial. NCRI Cancer Conference; 2006.
Yarnold J, Bloomfield D, LeVay J, et al. Prospective randomised trial testing 5.7 Gy and 6.0 Gy fractions of whole-breast radiotherapy in women with early breast cancer (FAST Trial). Clin. Oncol. (R. Coll. Radiol). 2004;16(6):S30 #P3.02