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Proteomics and Metabolomics Core Facility

The ICR’s proteomics and metabolomics core facility is among the most sophisticated in the UK – providing a highly-skilled specialist service within the institute.rap mass spectrometer for high sensitivity analysis of simple protein mixtures (1–100 proteins).

Our cutting-edge instrumentation enables quantitative analysis of mixtures measuring 10,000 proteins and post-translational modifications per sample. And we build on these platform technologies with experimental and computational tools developed by our expert team.

Working as a valued research partner, the service supports projects from experimental design through to bespoke bioinformatic analysis of results. Recent projects have included whole-proteome analysis to study the impact of mutations on cellular processes, proteomic post-translational profiling to monitor dynamic remodelling of tumours, and identification of protein interactions to reveal characteristics of proteomes.

The service uses an Agilent 1200 Nano liquid chromatography machine coupled to a Velos Orbitrap mass spectrometer for high sensitivity analysis of simple protein mixtures (1–100 proteins).

Almost every analysis is tailored to the individual experiment. Employees within the Proteomics and Metabolomics Core Facility will discuss a researcher’s requirements and help to design the experiments, before performing the proteomic chemistries, mass spectrometry and data analysis. Finally, the facility will describe the final results to publication standards in a formal report.

“The ICR has invested to develop a world class proteomics facility that enables research teams to exploit the full potential of the technology.”

Dr Jyoti Choudhary
Head of Proteomics 

For more information, contact the facility at [email protected]