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Journal Articles

Moore, A.S. Faisal, A. Mak, G.W. Miraki-Moud, F. Bavetsias, V. Valenti, M. Box, G. Hallsworth, A. de Haven Brandon, A. Xavier, C.P. Stronge, R. Pearson, A.D. Blagg, J. Raynaud, F.I. Chopra, R. Eccles, S.A. Taussig, D.C. Linardopoulos, S. (2020). Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736. Blood advances, Vol.4 (7), pp. 1478-1491.  show abstract

Anderhub, S.J. Mak, G.W. Gurden, M.D. Faisal, A. Drosopoulos, K. Walsh, K. Woodward, H.L. Innocenti, P. Westwood, I.M. Naud, S. Hayes, A. Theofani, E. Filosto, S. Saville, H. Burke, R. van Montfort, R.L. Raynaud, F.I. Blagg, J. Hoelder, S. Eccles, S.A. Linardopoulos, S. (2019). High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Molecular cancer therapeutics, Vol.18 (10), pp. 1696-1707.

Faisal, A. Mak, G.W. Gurden, M.D. Xavier, C.P. Anderhub, S.J. Innocenti, P. Westwood, I.M. Naud, S. Hayes, A. Box, G. Valenti, M.R. De Haven Brandon, A.K. O'Fee, L. Schmitt, J. Woodward, H.L. Burke, R. vanMontfort, R.L. Blagg, J. Raynaud, F.I. Eccles, S.A. Hoelder, S. Linardopoulos, S. (2017). Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. British journal of cancer, Vol.116 (9), pp. 1166-1176.

Gurden, M.D. Anderhub, S.J. Faisal, A. Linardopoulos, S. (2016). Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. Oncotarget, .  show abstract

Gurden, M.D. Westwood, I.M. Faisal, A. Naud, S. Cheung, K.-. McAndrew, C. Wood, A. Schmitt, J. Boxall, K. Mak, G. Workman, P. Burke, R. Hoelder, S. Blagg, J. Van Montfort, R.L. Linardopoulos, S. (2015). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer research, Vol.75 (16), pp. 3340-3354.

Drosopoulos, K. Tang, C. Chao, W.C. Linardopoulos, S. (2014). APC/C is an essential regulator of centrosome clustering. Nat commun, Vol.5, p. 3686.  show abstract

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