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Journal Articles

Bajrami, I., Marlow, R., van de Ven, M., Brough, R., Pemberton, H., Frankum, J., Song, F., Raquif, R., Konde, A., Krastev, D., et al. (2018). E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer. Cancer discovery, Vol.8(4), pp. 498-515.  show abstract

Gurden, M.D., Anderhub, S.J., Faisal, A. & Linardopoulos, S. (2018). Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. Oncotarget, Vol.9(28), pp. 19525-19542.  show abstract

Nirmesh, P., Weekes, D., Drosopoulos, K., Gazinska, P., Noel, E., Rashid, M., Mirza, H., Quist, J., Brasó-Maristany, F., Sumi, M., et al. (2018). Integrated genomics and functional validation identifies malignant cell specific dependencies in Triple Negative Breast Cancer. Nature communications, Vol.9(1), p. 1044.  show abstract

morris, J., koo, C., gianomini, C., reyes-corral, M., olmos, Y., tavares, I., marson, C., linardopoulos, S. & tutt, A. (2017). Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells. Molecular cancer therapeutics, Vol.16(11), pp. 2410-2421.  show abstract

Faisal, A., Mak, G.W., Gurden, M.D., Xavier, C.P., Anderhub, S.J., Innocenti, P., Westwood, I.M., Naud, S., Hayes, A., Box, G., et al. (2017). Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. British journal of cancer, Vol.116(9), pp. 1166-1176.  show abstract

Linardopoulos, S., dolly, S., gurden, M., drosopoulos, K., clarke, P., bono, J., kaye, S. & workman, P. (2017). RNAi screen reveals synthetic lethality between Cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses. British journal of cancer, Vol.117(7), pp. 954-964.  show abstract

Gurden, M.D., Anderhub, S.J., Faisal, A. & Linardopoulos, S. (2016). Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis. Oncotarget, .  show abstract

Innocenti, P., Woodward, H.L., Solanki, S., Naud, S., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., et al. (2016). Rapid Discovery of Pyrido[3,4- d ]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. Journal of medicinal chemistry, Vol.59(8), pp. 3671-3688.  show abstract

Morra, F., Luise, C., Visconti, R., Staibano, S., Merolla, F., Ilardi, G., Guggino, G., Paladino, S., Sarnataro, D., Franco, R., et al. (2015). New therapeutic perspectives in CCDC6 deficient lung cancer cells. International journal of cancer, Vol.136(9), pp. 2146-2157.  show abstract

Linardopoulos, S. & Blagg, J. (2015). Aurora Kinase Inhibition: A New Light in the Sky?. Journal of medicinal chemistry, Vol.58(13), pp. 5186-5188.  show abstract

Bavetsias, V., Pérez-Fuertes, Y., McIntyre, P.J., Atrash, B., Kosmopoulou, M., O’Fee, L., Burke, R., Sun, C., Faisal, A., Bush, K., et al. (2015). 7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent. Bioorganic & medicinal chemistry letters, Vol.25(19), pp. 4203-4209.  show abstract  full text

Gurden, M.D., Westwood, I.M., Faisal, A., Naud, S., Cheung, K.-., McAndrew, C., Wood, A., Schmitt, J., Boxall, K., Mak, G., et al. (2015). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer research, Vol.75(16), pp. 3340-3354.  show abstract

Bavetsias, V. & Linardopoulos, S. (2015). Aurora Kinase Inhibitors: Current Status and Outlook. Frontiers in oncology, Vol.5, p. 278.  show abstract  full text

Cheeseman, M.D., Faisal, A., Rayter, S., Barbeau, O.R., Kalusa, A., Westlake, M., Burke, R., Swan, M., van Montfort, R., Linardopoulos, S., et al. (2014). Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorganic & medicinal chemistry letters, Vol.24(15), pp. 3469-3474.  show abstract

Drosopoulos, K., Tang, C., Chao, W.C. & Linardopoulos, S. (2014). APC/C is an essential regulator of centrosome clustering. Nature communications, Vol.5, p. 3686.  show abstract

Drosopoulos, K. & Linardopoulos, S. (2013). Integration of RNAi and small molecule screens to identify targets for drug development. Methods in molecular biology (clifton, n.j.), Vol.986, pp. 97-104.  show abstract

Regan, J., Sourisseau, T., Soady, K., Kendrick, H., McCarthy, A., Tang, C., Brennan, K., Linardopoulos, S., White, D. & Smalley, M., et al. (2013). Aurora A Kinase Regulates Mammary Epithelial Cell Fate by Determining Mitotic Spindle Orientation in a Notch-Dependent Manner. Cell reports, Vol.4(1), pp. 110-123.  show abstract

Aarts, M., Linardopoulos, S. & Turner, N.C. (2013). Tumour selective targeting of cell cycle kinases for cancer treatment. Current opinion in pharmacology, Vol.13(4), pp. 529-535.  show abstract

Couty, S., Westwood, I.M., Kalusa, A., Cano, C., Travers, J., Boxall, K., Chow, C.L., Burns, S., Schmitt, J., Pickard, L., et al. (2013). The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, Vol.4(10), pp. 1647-1661.  show abstract  full text

Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P., Bavetsias, V., Atrash, B., Cheung, K.-., Liu, M., Hayes, A., Schmitt, J., et al. (2013). Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1). Journal of medicinal chemistry, Vol.56(24), pp. 10045-10065.  show abstract  full text

Bavetsias, V., Faisal, A., Crumpler, S., Brown, N., Kosmopoulou, M., Joshi, A., Atrash, B., Pérez-Fuertes, Y., Schmitt, J.A., Boxall, K.J., et al. (2013). Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5- b ]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells. Journal of medicinal chemistry, Vol.56(22), pp. 9122-9135.  show abstract  full text

Pintzas, A., Zhivotovsky, B., Workman, P., Clarke, P.A., Linardopoulos, S., Martinou, J.-., Lacal, J.C., Robine, S., Nasioulas, G. & Andera, L., et al. (2012). Sensitization of (colon) cancer cells to death receptor related therapies. Cancer biology & therapy, Vol.13(7), pp. 458-466.  show abstract

Faisal, A., Naud, S., Schmitt, J., Westwood, I., Hayes, A., Gurden, M., Bavetsias, V., Berry, T., Mak, G., Innocenti, P., et al. (2012). Abstract 1817: Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor. Cancer research, Vol.72(8 Supplement), pp. 1817-1817.

Drosopoulos, K., Scott, C., Tang, C. & Linardopoulos, S. (2012). Abstract 889: Integration of centrosome-associated and kinase-related screens to identify centrosome amplification-related synthetic lethal interactions. Cancer research, Vol.72(8 Supplement), pp. 889-889.

Bavetsias, V., Crumpler, S., Sun, C., Avery, S., Atrash, B., Faisal, A., Moore, A.S., Kosmopoulou, M., Brown, N., Sheldrake, P.W., et al. (2012). Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia. Journal of medicinal chemistry, Vol.55(20), pp. 8721-8734.  show abstract  full text

Moore, A.S., Faisal, A., Gonzalez de Castro, D., Bavetsias, V., Sun, C., Atrash, B., Valenti, M., de Haven Brandon, A., Avery, S., Mair, D., et al. (2012). Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns. Leukemia, Vol.26(7), pp. 1462-1470.  show abstract  full text

Brough, R., Frankum, J.R., Sims, D., Mackay, A., Mendes-Pereira, A.M., Bajrami, I., Costa-Cabral, S., Rafiq, R., Ahmad, A.S., Cerone, M.A., et al. (2011). Functional Viability Profiles of Breast Cancer. Cancer discov, Vol.1(3), pp. 260-273.  show abstract

Podesta, J.E., Sugar, R., Squires, M., Linardopoulos, S., Pearson, A.D. & Moore, A.S. (2011). Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia. Leukemia res, Vol.35(9), pp. 1273-1275.  show abstract

Faisal, A., Vaughan, L., Bavetsias, V., Sun, C.B., Atrash, B., Avery, S., Jamin, Y., Robinson, S.P., Workman, P., Blagg, J., et al. (2011). The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo. Mol cancer ther, Vol.10(11), pp. 2115-2123.  show abstract

Moore, A.S., Faisal, A., Bavetsias, V., Sun, C., Atrash, B., Valenti, M., de Haven Brandon, A., Avery, S., de Castro, D.G., Raynaud, F.I., et al. (2011). Abstract 3554: CCT137690, a dual inhibitor of Aurora and FLT3 kinases, sensitizes FLT3-ITD positive acute myeloid leukemia and overcomes resistance to selective FLT3-inhibition. Cancer research, Vol.71(8 Supplement), pp. 3554-3554.

Sourisseau, T., Maniotis, D., McCarthy, A., Tang, C., Lord, C.J., Ashworth, A. & Linardopoulos, S. (2010). Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. Embo mol med, Vol.2(4), pp. 130-142.  show abstract  full text

Moore, A.S., Blagg, J., Linardopoulos, S. & Pearson, A.D. (2010). Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia, Vol.24(4), pp. 671-678.  show abstract

Lambros, M.B., Natrajan, R., Geyer, F.C., Lopez-Garcia, M.A., Dedes, K.J., Savage, K., Lacroix-Triki, M., Jones, R.L., Lord, C.J., Linardopoulos, S., et al. (2010). PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study. Modern pathol, Vol.23(10), pp. 1334-1345.  show abstract

Bouloc, N., Large, J.M., Kosmopoulou, M., Sun, C.B., Faisal, A., Matteucci, M., Reynisson, J., Brown, N., Atrash, B., Blagg, J., et al. (2010). Structure-based design of imidazo[1,2-a] pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg med chem lett, Vol.20(20), pp. 5988-5993.  show abstract

Bavetsias, V., Large, J.M., Sun, C.B., Bouloc, N., Kosmopoulou, M., Matteucci, M., Wilsher, N.E., Martins, V., Reynisson, J., Atrash, B., et al. (2010). Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidates. J med chem, Vol.53(14), pp. 5213-5228.  show abstract

Bibby, R.A., Tang, C., Faisal, A., Drosopoulos, K., Lubbe, S., Houlston, R., Bayliss, R. & Linardopoulos, S. (2009). A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2. J biol chem, Vol.284(48), pp. 33177-33184.  show abstract

Rayter, S., Elliott, R., Travers, J., Rowlands, M.G., Richardson, T.B., Boxall, K., Jones, K., Linardopoulos, S., Workman, P., Aherne, W., et al. (2008). A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene, Vol.27(8), pp. 1036-1044.  show abstract

Bavetsias, V., Sun, C., Bouloc, N., Reynisson, J., Workman, P., Linardopoulos, S. & McDonald, E. (2007). Hit generation and exploration: Imidazo[4,5-b] pyridine derivatives as inhibitors of Aurora kinases. Bioorg med chem lett, Vol.17(23), pp. 6567-6571.  show abstract

Sun, C.B., Chan, F., Briassouli, P. & Linardopoulos, S. (2007). Aurora kinase inhibition downregulates NF-kappa B and sensitises tumour cells to chemotherapeutic agents. Biochem bioph res co, Vol.352(1), pp. 220-225.  show abstract

Linardopoulos, S. (2007). Aurora-A kinase regulates NF-kB activity: lessons from combination studies. Journal of buon, Vol.12, pp. S67-S70.  show abstract

Chan, F., Sun, C., Perumal, M., Nguyen, Q.D., Bavetsias, V., McDonald, E., Martins, V., Wilsher, N.E., Raynaud, F.I., Valenti, M., et al. (2007). Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol cancer ther, Vol.6(12), pp. 3147-3157.  show abstract

Whittaker, S.R., Poele, R.H., Chan, F., Linardopoulos, S., Walton, M.I., Garrett, M.D. & Workman, P. (2007). The cyclin-dependent kinase inhibitor seliciclib (Rroscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. Cell cycle, Vol.6(24), pp. 3114-3131.  show abstract

Briassouli, P., Chan, F., Savage, K., Reis, J.S. & Linardopoulos, S. (2007). Aurora-A regulation of nuclear factor-kappa B signaling by phosphorylation of I kappa B alpha. Cancer res, Vol.67(4), pp. 1689-1695.  show abstract

Briassouli, P., Chan, F. & Linardopoulos, S. (2006). The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I kappa B alpha. Hum mol genet, Vol.15(22), pp. 3343-3350.  show abstract

Chieffi, P., Cozzolino, L., Kisslinger, A., Libertini, S., Staibano, S., Mansueto, G., De Rosa, G., Villacci, A., Vitale, M., Linardopoulos, S., et al. (2006). Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation. Prostate, Vol.66(3), pp. 326-333.  show abstract

Sorrentino, R., Libertini, S., Pallante, P.L., Troncone, G., Palombini, L., Bavetsias, V., Spalletti-Cernia, D., Laccetti, P., Linardopoulos, S., Chieffi, P., et al. (2005). Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J clin endocr metab, Vol.90(2), pp. 928-935.  show abstract

Chieffi, P., Troncone, G., Caleo, A., Libertini, S., Linardopoulos, S., Tramontano, D. & Portella, G. (2004). Aurora B expression in normal testis and seminomas. J endocrinol, Vol.181(2), pp. 263-270.  show abstract

Sun, C.B., Newbatt, Y., Douglas, L., Workman, P., Aherne, W. & Linardopoulos, S. (2004). High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase. J biomol screen, Vol.9(5), pp. 391-397.  show abstract

Ewart-Toland, A., Briassouli, P., de Koning, J.P., Mao, J.H., Yuan, J.W., Chan, F., MacCarthy-Morrogh, L., Ponder, B.A., Nagase, H., Burn, J., et al. (2003). Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat genet, Vol.34(4), pp. 403-412.  show abstract

Linardopoulos, S., Silva, S., Klein, G. & Balmain, A. (2000). Allele-specific loss or imbalance of chromosomes 9, 15, and 16 in B-cell tumors from interspecific F1 hybrid mice carrying E mu-C-myc or N-myc transgenes. Int j cancer, Vol.88(6), pp. 920-927.  show abstract

Zoumpourlis, V., Papassava, P., Linardopoulos, S., Gillespie, D., Balmain, A. & Pintzas, A. (2000). High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model. Oncogene, Vol.19(35), pp. 4011-4021.  show abstract

Frame, S., Crombie, R., Liddell, J., Stuart, D., Linardopoulos, S., Nagase, H., Portella, G., Brown, K., Street, A., Akhurst, R., et al. (1998). Epithelial carcinogenesis in the mouse: correlating the genetics and the biology. Philos t roy soc b, Vol.353(1370), pp. 839-845.  show abstract

Tsopanomichalou, M., Ergazaki, M., Linardopoulos, S., Kouroumalis, E. & Spandidos, D.A. (1997). Detection of hepatitis C virus in sera and genotyping according to the 5' non-coding region. Oncology reports, Vol.4(6), pp. 1171-1174.  show abstract

KARACHRISTOS, A., LINARDOPOULOS, S., ERGAZAKI, M. & SPANDIDOS, D.A. (1995). DETECTION AND ANALYSIS OF HEPATITIS-C VIRUS BY A COMBINED RT-PCR METHOD - VARIATION IN THE 5' NONCODING REGION OF THE VIRAL GENOME. J med microbiol, Vol.42(5), pp. 367-371.  show abstract

LINARDOPOULOS, S., STREET, A.J., QUELLE, D.E., PARRY, D., PETERS, G., SHERR, C.J. & BALMAIN, A. (1995). DELETION AND ALTERED REGULATION OF P16(INK4A) AND P15(INK4B) IN UNDIFFERENTIATED MOUSE SKIN TUMORS. Cancer res, Vol.55(22), pp. 5168-5172.  show abstract

LINARDOPOULOS, S. & SPANDIDOS, D.A. (1994). REGULATION OF THE RB GENE BY NORMAL AND MUTATED RAS, TPA AND EGF. Oncology reports, Vol.1(3), pp. 533-536.  show abstract

LINARDOPOULOS, S., PAPADAKIS, E., DELAKAS, D., THEODOSIOU, V., CRANIDIS, A. & SPANDIDOS, D.A. (1993). HUMAN LUNG AND BLADDER-CARCINOMA TUMORS AS COMPARED TO THEIR ADJACENT NORMAL TISSUE HAVE ELEVATED AP-1 ACTIVITY ASSOCIATED WITH THE RETINOBLASTOMA GENE PROMOTER. Anticancer res, Vol.13(1), pp. 257-262.  show abstract

LINARDOPOULOS, S., GONOS, E.S. & SPANDIDOS, D.A. (1993). ABNORMALITIES OF RETINOBLASTOMA GENE STRUCTURE IN HUMAN LUNG-TUMORS. Cancer lett, Vol.71(1-3), pp. 67-74.  show abstract

Spandidos, D.A., Karaiossifidi, H., Malliri, A., Linardopoulos, S., Vassilaros, S., Tsikkinis, A. & Field, J.K. (1992). Expression of ras Rb1 and p53 proteins in human breast cancer. Anticancer research, Vol.12(1), pp. 81-89.  show abstract

PAPADAKIS, E., MALLIRI, A., LINARDOPOULOS, S., KARAIOSSIFIDI, H., FIELD, J.K. & SPANDIDOS, D.A. (1992). RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS. International journal of oncology, Vol.1(4), pp. 403-413.  show abstract

LINARDOPOULOS, S., CORRIGALL, V. & PANAYI, G.S. (1992). ACTIVATION OF HLA-DR AND INTERLEUKIN-6 GENE-TRANSCRIPTION IN RESTING T-CELLS VIA THE CD2 MOLECULE - RELEVANCE TO CHRONIC IMMUNE-MEDIATED INFLAMMATION. Scand j immunol, Vol.36(3), pp. 469-477.  show abstract

SYMONDS, R.P., HABESHAW, T., PAUL, J., KERR, D.J., DARLING, A., BURNETT, R.A., SOTSIOU, F., LINARDOPOULOS, S. & SPANDIDOS, D.A. (1992). NO CORRELATION BETWEEN RAS, C-MYC AND C-JUN PROTOONCOGENE EXPRESSION AND PROGNOSIS IN ADVANCED-CARCINOMA OF CERVIX. Eur j cancer, Vol.28A(10), pp. 1615-1617.  show abstract

TOSCA, A., LINARDOPOULOS, S., MALLIRI, A., HATZIOLOU, E., NICOLAIDOU, A. & SPANDIDOS, D.A. (1991). IMPLICATION OF THE RAS AND MYC ONCOPROTEINS IN THE PATHOGENESIS OF MYCOSIS-FUNGOIDES. Anticancer res, Vol.11(4), pp. 1433-1438.  show abstract

Arvanitis, D., Malliri, A., Antoniou, D., Linardopoulos, S., Field, J.K. & Spandidos, D.A. (1991). Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. In vivo (athens, greece), Vol.5(4), pp. 317-321.  show abstract

LINARDOPOULOS, S., MALLIRI, A., PINTZAS, A., VASSILAROS, S., TSIKKINIS, A. & SPANDIDOS, D.A. (1990). ELEVATED EXPRESSION OF AP-1 ACTIVITY IN HUMAN BREAST-TUMORS AS COMPARED TO NORMAL ADJACENT TISSUE. Anticancer res, Vol.10(6), pp. 1711-1713.  show abstract


Patents and patent applications

Linardopoulos, S., Bavetsias, V. & McDonald, E. Enzyme inhibitors.WO 2007/072017 A2.

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