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Darby, J.F. Vidler, L.R. Simpson, P.J. Al-Lazikani, B. Matthews, S.J. Sharp, S.Y. Pearl, L.H. Hoelder, S. Workman, P. (2020). Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches. Scientific reports, Vol.10 (1), pp. 16000-?.  show abstract

Polo, L.M. Xu, Y. Hornyak, P. Garces, F. Zeng, Z. Hailstone, R. Matthews, S.J. Caldecott, K.W. Oliver, A.W. Pearl, L.H. (2019). Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1. Cell reports, Vol.26 (3), pp. 573-581.e5.

Leimbacher, P.-. Jones, S.E. Shorrocks, A.-. de Marco Zompit, M. Day, M. Blaauwendraad, J. Bundschuh, D. Bonham, S. Fischer, R. Fink, D. Kessler, B.M. Oliver, A.W. Pearl, L.H. Blackford, A.N. Stucki, M. (2019). MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis. Molecular cell, Vol.74 (3), pp. 571-583.e8.  show abstract

Bigot, N. Day, M. Baldock, R.A. Watts, F.Z. Oliver, A.W. Pearl, L.H. (2019). Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, Vol.8.  show abstract

Day, M. Rappas, M. Ptasinska, K. Boos, D. Oliver, A.W. Pearl, L.H. (2018). BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. Elife, Vol.7.

Martino, F. Pal, M. Muñoz-Hernández, H. Rodríguez, C.F. Núñez-Ramírez, R. Gil-Carton, D. Degliesposti, G. Skehel, J.M. Roe, S.M. Prodromou, C. Pearl, L.H. Llorca, O. (2018). RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature communications, Vol.9 (1), pp. 1501-?.  show abstract

Alt, A. Dang, H.Q. Wells, O.S. Polo, L.M. Smith, M.A. McGregor, G.A. Welte, T. Lehmann, A.R. Pearl, L.H. Murray, J.M. Oliver, A.W. (2017). Specialized interfaces of Smc5/6 control hinge stability and DNA association. Nature communications, Vol.8 (1).

Li, Z. Zhou, L. Prodromou, C. Savic, V. Pearl, L.H. (2017). HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients. Cell reports, Vol.19 (12), pp. 2515-2528.

Jeggo, P.A. Pearl, L.H. Carr, A.M. (2016). DNA repair, genome stability and cancer: a historical perspective. Nature reviews cancer, Vol.16 (1), pp. 35-42.

Densham, R.M. Garvin, A.J. Stone, H.R. Strachan, J. Baldock, R.A. Daza-Martin, M. Fletcher, A. Blair-Reid, S. Beesley, J. Johal, B. Pearl, L.H. Neely, R. Keep, N.H. Watts, F.Z. Morris, J.R. (2016). Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection. Nature structural & molecular biology, Vol.23 (7), pp. 647-655.

Schulze, A. Beliu, G. Helmerich, D.A. Schubert, J. Pearl, L.H. Prodromou, C. Neuweiler, H. (2016). Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. Nature chemical biology, Vol.12 (8), pp. 628-635.

Pearl, L.H. (2016). Review: The HSP90 molecular chaperone—an enigmatic ATPase. Biopolymers, Vol.105 (8), pp. 594-607.

Grundy, G.J. Rulten, S.L. Arribas-Bosacoma, R. Davidson, K. Kozik, Z. Oliver, A.W. Pearl, L.H. Caldecott, K.W. (2016). The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature communications, Vol.7, pp. 11242-?.  show abstract

Grundy, G.J. Polo, L.M. Zeng, Z. Rulten, S.L. Hoch, N.C. Paomephan, P. Xu, Y. Sweet, S.M. Thorne, A.W. Oliver, A.W. Matthews, S.J. Pearl, L.H. Caldecott, K.W. (2016). PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature communications, Vol.7, pp. 12404-?.  show abstract

Smith, J.R. de Billy, E. Hobbs, S. Powers, M. Prodromou, C. Pearl, L. Clarke, P.A. Workman, P. (2015). Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. Oncogene, Vol.34 (1), pp. 15-26.  show abstract

Morgan, R.M. Pal, M. Roe, S.M. Pearl, L.H. Prodromou, C. (2015). Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta crystallographica section d biological crystallography, Vol.71 (5), pp. 1197-1206.  show abstract

Pearl, L.H. Schierz, A.C. Ward, S.E. Al-Lazikani, B. Pearl, F.M. (2015). Therapeutic opportunities within the DNA damage response. Nature reviews cancer, Vol.15 (3), pp. 166-180.

Baldock, R.A. Day, M. Wilkinson, O.J. Cloney, R. Jeggo, P.A. Oliver, A.W. Watts, F.Z. Pearl, L.H. (2015). ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX. Cell reports, Vol.13 (10), pp. 2081-2089.  show abstract

Walker, S. Meisenberg, C. Bibby, R.A. Askwith, T. Williams, G. Rininsland, F.H. Pearl, L.H. Oliver, A.W. El-Khamisy, S. Ward, S. Atack, J.R. (2014). Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical biochemistry, Vol.454, pp. 17-22.

Pal, M. Morgan, M. Phelps, S.E. Roe, S.M. Parry-Morris, S. Downs, J.A. Polier, S. Pearl, L.H. Prodromou, C. (2014). Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, Vol.22 (6), pp. 805-818.

Qu, M. Rappas, M. Wardlaw, C.P. Garcia, V. Ren, J.-. Day, M. Carr, A.M. Oliver, A.W. Du, L.-. Pearl, L.H. (2013). Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1. Molecular cell, Vol.51 (6), pp. 723-736.

Fugel, W. Oberholzer, A.E. Gschloessl, B. Dzikowski, R. Pressburger, N. Preu, L. Pearl, L.H. Baratte, B. Ratin, M. Okun, I. Doerig, C. Kruggel, S. Lemcke, T. Meijer, L. Kunick, C. (2013). 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase-3. Journal of medicinal chemistry, Vol.56 (1), pp. 264-275.

Chambers, A.L. Pearl, L.H. Oliver, A.W. Downs, J.A. (2013). The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic acids research, Vol.41 (19), pp. 9168-9182.

Meier, C. Brookings, D.C. Ceska, T.A. Doyle, C. Gong, H. McMillan, D. Saville, G.P. Mushtaq, A. Knight, D. Reich, S. Pearl, L.H. Powell, K.A. Savva, R. Allen, R.A. (2012). Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. Journal of structural biology, Vol.177 (2), pp. 329-334.

Spagnolo, L. Barbeau, J. Curtin, N.J. Morris, E.P. Pearl, L.H. (2012). Visualization of a DNA-PK/PARP1 complex. Nucleic acids research, Vol.40 (9), pp. 4168-4177.

Ali, A.A. Timinszky, G. Arribas-Bosacoma, R. Kozlowski, M. Hassa, P.O. Hassler, M. Ladurner, A.G. Pearl, L.H. Oliver, A.W. (2012). The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature structural & molecular biology, Vol.19 (7), pp. 685-692.

Tahtouh, T. Elkins, J.M. Filippakopoulos, P. Soundararajan, M. Burgy, G. Durieu, E. Cochet, C. Schmid, R.S. Lo, D.C. Delhommel, F. Oberholzer, A.E. Pearl, L.H. Carreaux, F. Bazureau, J.-. Knapp, S. Meijer, L. (2012). Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. Journal of medicinal chemistry, Vol.55 (21), pp. 9312-9330.

Rappas, M. Oliver, A.W. Pearl, L.H. (2011). Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic acids research, Vol.39 (1), pp. 313-324.

Cuomo, M.E. Platt, G.M. Pearl, L.H. Mittnacht, S. (2011). Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition. Journal of biological chemistry, Vol.286 (11), pp. 9713-9725.

Mollapour, M. Tsutsumi, S. Truman, A.W. Xu, W. Vaughan, C.K. Beebe, K. Konstantinova, A. Vourganti, S. Panaretou, B. Piper, P.W. Trepel, J.B. Prodromou, C. Pearl, L.H. Neckers, L. (2011). Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity. Molecular cell, Vol.41 (6), pp. 672-681.

Maclagan, K. Tommasi, R. Laurine, E. Prodromou, C. Driscoll, P.C. Pearl, L.H. Reich, S. Savva, R. (2011). A combinatorial method to enable detailed investigation of protein–protein interactions. Future medicinal chemistry, Vol.3 (3), pp. 271-282.  show abstract

Morris, E.P. Rivera-Calzada, A. da Fonseca, P.C. Llorca, O. Pearl, L.H. Spagnolo, L. (2011). Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic acids research, Vol.39 (13), pp. 5757-5767.

Kumar, S. Hinks, J.A. Maman, J. Ravirajan, C.T. Pearl, L.H. Isenberg, D.A. (2011). p185, an Immunodominant Epitope, Is an Autoantigen Mimotope. Journal of biological chemistry, Vol.286 (29), pp. 26220-26227.

Boos, D. Sanchez-Pulido, L. Rappas, M. Pearl, L.H. Oliver, A.W. Ponting, C.P. Diffley, J.F. (2011). Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans. Current biology, Vol.21 (13), pp. 1152-1157.

Ali, M.M. Collins, I. Bagratuni, T. Davenport, E.L. Nowak, P.R. Silva-Santisteban, M.C. Hardcastle, A. McAndrews, C. Rowlands, M.G. Morgan, G.J. Aherne, W. Collins, I. Davies, F.E. Pearl, L.H. (2011). Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. Embo j, Vol.30 (5), pp. 894-905.  show abstract

Millson, S.H. Chua, C. Roe, S.M. Polier, S. Solovieva, S. Pearl, L.H. Sim, T. Prodromou, C. Piper, P.W. (2011). Features of theStreptomyces hygroscopicusHtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. The faseb journal, Vol.25 (11), pp. 3828-3837.

Garces, F. Pearl, L.H. Oliver, A.W. (2011). The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ Phosphatase. Molecular cell, Vol.44 (3), pp. 385-396.

Anderson, V.E. Walton, M.I. Eve, P.D. Boxall, K.J. Antoni, L. Caldwell, J.J. Aherne, W. Pearl, L.H. Oliver, A.W. Collins, I. Garrett, M.D. (2011). CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer res, Vol.71 (2), pp. 463-472.  show abstract

Day, J.E. Sharp, S.Y. Rowlands, M.G. Aherne, W. Hayes, A. Raynaud, F.I. Lewis, W. Roe, S.M. Prodromou, C. Pearl, L.H. Workman, P. Moody, C.J. (2011). Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams Synthesis, Structural, Binding, and Cellular Studies. Acs chemical biology, Vol.6 (12), pp. 1339-1347.

Caldwell, J.J. Welsh, E.J. Matijssen, C. Anderson, V.E. Antoni, L. Boxall, K. Urban, F. Hayes, A. Raynaud, F.I. Rigoreau, L.J. Raynham, T. Aherne, G.W. Pearl, L.H. Oliver, A.W. Garrett, M.D. Collins, I. (2011). Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J med chem, Vol.54 (2), pp. 580-590.  show abstract

Mollapour, M. Tsutsumi, S. Donnelly, A.C. Beebe, K. Tokita, M.J. Lee, M.-. Lee, S. Morra, G. Bourboulia, D. Scroggins, B.T. Colombo, G. Blagg, B.S. Panaretou, B. Stetler-Stevenson, W.G. Trepel, J.B. Piper, P.W. Prodromou, C. Pearl, L.H. Neckers, L. (2010). Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function. Molecular cell, Vol.37 (3), pp. 333-343.

Rowlands, M. McAndrew, C. Prodromou, C. Pearl, L. Kalusa, A. Jones, K. Workman, P. Aherne, W. (2010). Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. J biomol screen, Vol.15 (3), pp. 279-286.  show abstract

Woodbine, L. Grigoriadou, S. Goodarzi, A.A. Riballo, E. Tape, C. Oliver, A.W. van Zelm, M.C. Buckland, M.S. Davies, E.G. Pearl, L.H. (2010). An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. Dna repair, Vol.9 (9), pp. 1003-1010.

Zhang, M. Kadota, Y. Prodromou, C. Shirasu, K. Pearl, L.H. (2010). Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors. Molecular cell, Vol.39 (2), pp. 269-281.

Day, J.E. Sharp, S.Y. Rowlands, M.G. Aherne, W. Lewis, W. Roe, S.M. Prodromou, C. Pearl, L.H. Workman, P. Moody, C.J. (2010). Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies. Chemistry - a european journal, Vol.16 (34), pp. 10366-10372.

Hilton, S. Naud, S. Caldwell, J.J. Boxall, K. Burns, S. Anderson, V.E. Antoni, L. Allen, C.E. Pearl, L.H. Oliver, A.W. Wynne Aherne, G. Garrett, M.D. Collins, I. (2010). Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorg med chem, Vol.18 (2), pp. 707-718.  show abstract

Richardson, C.J. Gao, Q. Mitsopoulous, C. Zvelebil, M. Pearl, L.H. Pearl, F.M. (2009). MoKCa database--mutations of kinases in cancer. Nucleic acids research, Vol.37 (Database issue), pp. D824-D831.  show abstract

Vaughan, C.K. Piper, P.W. Pearl, L.H. Prodromou, C. (2009). A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. Febs journal, Vol.276 (1), pp. 199-209.

Bunney, T.D. Opaleye, O. Roe, S.M. Vatter, P. Baxendale, R.W. Walliser, C. Everett, K.L. Josephs, M.B. Christow, C. Rodrigues-Lima, F. Gierschik, P. Pearl, L.H. Katan, M. (2009). Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Molecular cell, Vol.34 (2), pp. 223-233.

Ali, A.A. Jukes, R.M. Pearl, L.H. Oliver, A.W. (2009). Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. Nucleic acids research, Vol.37 (5), pp. 1701-1712.

Doré, A.S. Kilkenny, M.L. Rzechorzek, N.J. Pearl, L.H. (2009). Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation. Molecular cell, Vol.34 (6), pp. 735-745.

Oliver, A.W. Swift, S. Lord, C.J. Ashworth, A. Pearl, L.H. (2009). Structural basis for recruitment of BRCA2 by PALB2. Embo reports, Vol.10 (9), pp. 990-996.

Nilapwar, S. Williams, E. Fu, C. Prodromou, C. Pearl, L.H. Williams, M.A. Ladbury, J.E. (2009). Structural–Thermodynamic Relationships of Interactions in the N-Terminal ATP-Binding Domain of Hsp90. Journal of molecular biology, Vol.392 (4), pp. 923-936.

Recuero-Checa, M.A. Doré, A.S. Arias-Palomo, E. Rivera-Calzada, A. Scheres, S.H. Maman, J.D. Pearl, L.H. Llorca, O. (2009). Electron microscopy of Xrcc4 and the DNA ligase IV–Xrcc4 DNA repair complex. Dna repair, Vol.8 (12), pp. 1380-1389.

Prodromou, C. Nuttall, J.M. Millson, S.H. Roe, S.M. Sim, T.S. Tan, D. Workman, P. Pearl, L.H. Piper, P.W. (2009). Structural basis of the radicicol resistance displayed by a fungal hsp90. Acs chem biol, Vol.4 (4), pp. 289-297.  show abstract

Kilkenny, M.L. Doré, A.S. Roe, S.M. Nestoras, K. Ho, J.C. Watts, F.Z. Pearl, L.H. (2008). Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes & development, Vol.22 (15), pp. 2034-2047.  show abstract

Martin, C.J. Gaisser, S. Challis, I.R. Carletti, I. Wilkinson, B. Gregory, M. Prodromou, C. Roe, S.M. Pearl, L.H. Boyd, S.M. Zhang, M.-. (2008). Molecular Characterization of Macbecin as an Hsp90 Inhibitor. Journal of medicinal chemistry, Vol.51 (9), pp. 2853-2857.

Pearl, L.H. Prodromou, C. Workman, P. (2008). The Hsp90 molecular chaperone: an open and shut case for treatment. Biochemical journal, Vol.410 (3), pp. 439-453.  show abstract

Eccles, S.A. Massey, A. Raynaud, F.I. Sharp, S.Y. Box, G. Valenti, M. Patterson, L. de Haven Brandon, A. Gowan, S. Boxall, F. Aherne, W. Rowlands, M. Hayes, A. Martins, V. Urban, F. Boxall, K. Prodromou, C. Pearl, L. James, K. Matthews, T.P. Cheung, K.M. Kalusa, A. Jones, K. McDonald, E. Barril, X. Brough, P.A. Cansfield, J.E. Dymock, B. Drysdale, M.J. Finch, H. Howes, R. Hubbard, R.E. Surgenor, A. Webb, P. Wood, M. Wright, L. Workman, P. (2008). NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer res, Vol.68 (8), pp. 2850-2860.  show abstract

Millson, S.H. Vaughan, C.K. Zhai, C. Ali, M.M. Panaretou, B. Piper, P.W. Pearl, L.H. Prodromou, C. (2008). Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochemical journal, Vol.413 (2), pp. 261-268.  show abstract

Hawkins, T.A. Haramis, A.-. Etard, C. Prodromou, C. Vaughan, C.K. Ashworth, R. Ray, S. Behra, M. Holder, N. Talbot, W.S. Pearl, L.H. Strähle, U. Wilson, S.W. (2008). The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development, Vol.135 (6), pp. 1147-1156.  show abstract

Pike, A.C. Rellos, P. Niesen, F.H. Turnbull, A. Oliver, A.W. Parker, S.A. Turk, B.E. Pearl, L.H. Knapp, S. (2008). Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. The embo journal, Vol.27 (4), pp. 704-714.

Zhang, M. Botër, M. Li, K. Kadota, Y. Panaretou, B. Prodromou, C. Shirasu, K. Pearl, L.H. (2008). Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. The embo journal, Vol.27 (20), pp. 2789-2798.

Brough, P.A. Aherne, W. Barril, X. Borgognoni, J. Boxall, K. Cansfield, J.E. Cheung, K.M. Collins, I. Davies, N.G. Drysdale, M.J. Dymock, B. Eccles, S.A. Finch, H. Fink, A. Hayes, A. Howes, R. Hubbard, R.E. James, K. Jordan, A.M. Lockie, A. Martins, V. Massey, A. Matthews, T.P. McDonald, E. Northfield, C.J. Pearl, L.H. Prodromou, C. Ray, S. Raynaud, F.I. Roughley, S.D. Sharp, S.Y. Surgenor, A. Walmsley, D.L. Webb, P. Wood, M. Workman, P. Wright, L. (2008). 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J med chem, Vol.51 (2), pp. 196-218.  show abstract

Zhang, M.-. Gaisser, S. Nur-E-Alam, M. Sheehan, L.S. Vousden, W.A. Gaitatzis, N. Peck, G. Coates, N.J. Moss, S.J. Radzom, M. Foster, T.A. Sheridan, R.M. Gregory, M.A. Roe, S.M. Prodromou, C. Pearl, L. Boyd, S.M. Wilkinson, B. Martin, C.J. (2008). Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors. Journal of medicinal chemistry, Vol.51 (18), pp. 5494-5497.

Vaughan, C.K. Mollapour, M. Smith, J.R. Truman, A. Hu, B. Good, V.M. Panaretou, B. Neckers, L. Clarke, P.A. Workman, P. Piper, P.W. Prodromou, C. Pearl, L.H. (2008). Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol cell, Vol.31 (6), pp. 886-895.  show abstract

Sharp, S.Y. Boxall, K. Rowlands, M. Prodromou, C. Roe, S.M. Maloney, A. Powers, M. Clarke, P.A. Box, G. Sanderson, S. Patterson, L. Matthews, T.P. Cheung, K.M. Ball, K. Hayes, A. Raynaud, F. Marais, R. Pearl, L. Eccles, S. Aherne, W. McDonald, E. Workman, P. (2007). In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer res, Vol.67 (5), pp. 2206-2216.  show abstract

Rivera‐Calzada, A. Spagnolo, L. Pearl, L.H. Llorca, O. (2007). Structural model of full‐length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA‐PKcs. Embo reports, Vol.8 (1), pp. 56-62.

Sharp, S.Y. Prodromou, C. Boxall, K. Powers, M.V. Holmes, J.L. Box, G. Matthews, T.P. Cheung, K.M. Kalusa, A. James, K. Hayes, A. Hardcastle, A. Dymock, B. Brough, P.A. Barril, X. Cansfield, J.E. Wright, L. Surgenor, A. Foloppe, N. Hubbard, R.E. Aherne, W. Pearl, L. Jones, K. McDonald, E. Raynaud, F. Eccles, S. Drysdale, M. Workman, P. (2007). Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol cancer ther, Vol.6 (4), pp. 1198-1211.  show abstract

Oliver, A.W. Knapp, S. Pearl, L.H. (2007). Activation segment exchange: a common mechanism of kinase autophosphorylation?. Trends in biochemical sciences, Vol.32 (8), pp. 351-356.

Hassler, M. Singh, S. Yue, W.W. Luczynski, M. Lakbir, R. Sanchez-Sanchez, F. Bader, T. Pearl, L.H. Mittnacht, S. (2007). Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture. Molecular cell, Vol.28 (3), pp. 371-385.

Yue, W.W. Hassler, M. Roe, S.M. Thompson-Vale, V. Pearl, L.H. (2007). Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. The embo journal, Vol.26 (20), pp. 4402-4412.

Bunney, T.D. Harris, R. Gandarillas, N.L. Josephs, M.B. Roe, S.M. Sorli, S.C. Paterson, H.F. Rodrigues-Lima, F. Esposito, D. Ponting, C.P. Gierschik, P. Pearl, L.H. Driscoll, P.C. Katan, M. (2006). Structural and Mechanistic Insights into Ras Association Domains of Phospholipase C Epsilon. Molecular cell, Vol.21 (4), pp. 495-507.

Spagnolo, L. Rivera-Calzada, A. Pearl, L.H. Llorca, O. (2006). Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair. Molecular cell, Vol.22 (4), pp. 511-519.

Jennings, B.H. Pickles, L.M. Wainwright, S.M. Roe, S.M. Pearl, L.H. Ish-Horowicz, D. (2006). Molecular Recognition of Transcriptional Repressor Motifs by the WD Domain of the Groucho/TLE Corepressor. Molecular cell, Vol.22 (5), pp. 645-655.

Doré, A.S. Kilkenny, M.L. Jones, S.A. Oliver, A.W. Roe, S.M. Bell, S.D. Pearl, L.H. (2006). Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic acids research, Vol.34 (16), pp. 4515-4526.

Vaughan, C.K. Gohlke, U. Sobott, F. Good, V.M. Ali, M.M. Prodromou, C. Robinson, C.V. Saibil, H.R. Pearl, L.H. (2006). Structure of an Hsp90-Cdc37-Cdk4 Complex. Molecular cell, Vol.23 (5), pp. 697-707.

Reich, S. Puckey, L.H. Cheetham, C.L. Harris, R. Ali, A.A. Bhattacharyya, U. Maclagan, K. Powell, K.A. Prodromou, C. Pearl, L.H. Driscoll, P.C. Savva, R. (2006). Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications. Protein science, Vol.15 (10), pp. 2356-2365.

Proisy, N. Sharp, S.Y. Boxall, K. Connelly, S. Roe, S.M. Prodromou, C. Slawin, A.M. Pearl, L.H. Workman, P. Moody, C.J. (2006). Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem biol, Vol.13 (11), pp. 1203-1215.  show abstract

Truman, A.W. Millson, S.H. Nuttall, J.M. King, V. Mollapour, M. Prodromou, C. Pearl, L.H. Piper, P.W. (2006). Expressed in the Yeast Saccharomyces cerevisiae , Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase. Eukaryotic cell, Vol.5 (11), pp. 1914-1924.  show abstract

Oliver, A.W. Paul, A. Boxall, K.J. Barrie, S.E. Aherne, G.W. Garrett, M.D. Mittnacht, S. Pearl, L.H. (2006). Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. The embo journal, Vol.25 (13), pp. 3179-3190.

Ioannou, Y. Giles, I. Lambrianides, A. Richardson, C. Pearl, L.H. Latchman, D.S. Isenberg, D.A. Rahman, A. (2006). A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. Bmc biotechnology, Vol.6 (1).  show abstract

Ali, M.M. Roe, S.M. Vaughan, C.K. Meyer, P. Panaretou, B. Piper, P.W. Prodromou, C. Pearl, L.H. (2006). Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex. Nature, Vol.440 (7087), pp. 1013-1017.

Kumar, S. Nagl, S. Kalsi, J.K. Ravirajan, C.T. Athwal, D. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2005). Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. Molecular immunology, Vol.42 (1), pp. 39-48.

Pearl, L.H. (2005). Hsp90 and Cdc37 – a chaperone cancer conspiracy. Current opinion in genetics & development, Vol.15 (1), pp. 55-61.

Rivera-Calzada, A. Maman, J.P. Spagnolo, L. Pearl, L.H. Llorca, O. (2005). Three-Dimensional Structure and Regulation of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs). Structure, Vol.13 (2), pp. 243-255.

Kumar, S. Bunting, K.A. Kalsi, J. Hinks, J.A. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2005). Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV. Immunology, Vol.114 (3), pp. 418-427.

Hu, B. Liao, C. Millson, S.H. Mollapour, M. Prodromou, C. Pearl, L.H. Piper, P.W. Panaretou, B. (2005). Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Molecular microbiology, Vol.55 (6), pp. 1735-1750.

Millson, S.H. Truman, A.W. King, V. Prodromou, C. Pearl, L.H. Piper, P.W. (2005). A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p). Eukaryotic cell, Vol.4 (5), pp. 849-860.  show abstract

Oliver, A.W. Jones, S.A. Roe, S.M. Matthews, S. Goodwin, G.H. Pearl, L.H. (2005). Crystal structure of the proximal BAH domain of the polybromo protein. The biochemical journal, Vol.389 (Pt 3), pp. 657-664.  show abstract

Zhang, M. Windheim, M. Roe, S.M. Peggie, M. Cohen, P. Prodromou, C. Pearl, L.H. (2005). Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex. Molecular cell, Vol.20 (4), pp. 525-538.

Cheung, K.M. Matthews, T.P. James, K. Rowlands, M.G. Boxall, K.J. Sharp, S.Y. Maloney, A. Roe, S.M. Prodromou, C. Pearl, L.H. Aherne, G.W. McDonald, E. Workman, P. (2005). The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg med chem lett, Vol.15 (14), pp. 3338-3343.  show abstract

Polychronopoulos, P. Magiatis, P. Skaltsounis, A.-. Myrianthopoulos, V. Mikros, E. Tarricone, A. Musacchio, A. Roe, S.M. Pearl, L. Leost, M. Greengard, P. Meijer, L. (2004). Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases. Journal of medicinal chemistry, Vol.47 (4), pp. 935-946.

Harris, R. Esposito, D. Sankar, A. Maman, J.D. Hinks, J.A. Pearl, L.H. Driscoll, P.C. (2004). The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR). Journal of molecular biology, Vol.335 (2), pp. 573-582.

Roe, S.M. Ali, M.M. Meyer, P. Vaughan, C.K. Panaretou, B. Piper, P.W. Prodromou, C. Pearl, L.H. (2004). The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37. Cell, Vol.116 (1), pp. 87-98.

Kumar, S. Kalsi, J. Bunting, K. Ravirajan, C.T. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2004). Fine binding characteristics of human autoantibodies—partial molecular characterization. Molecular immunology, Vol.41 (5), pp. 495-510.

Meyer, P. Prodromou, C. Liao, C. Hu, B. Mark Roe, S. Vaughan, C.K. Vlasic, I. Panaretou, B. Piper, P.W. Pearl, L.H. (2004). Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. The embo journal, Vol.23 (3), pp. 511-519.

Llorca, O. Pearl, L.H. (2004). Electron microscopy studies on DNA recognition by DNA-PK. Micron, Vol.35 (8), pp. 625-633.

Siligardi, G. Hu, B. Panaretou, B. Piper, P.W. Pearl, L.H. Prodromou, C. (2004). Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle. Journal of biological chemistry, Vol.279 (50), pp. 51989-51998.

Rowlands, M.G. Newbatt, Y.M. Prodromou, C. Pearl, L.H. Workman, P. Aherne, W. (2004). High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal biochem, Vol.327 (2), pp. 176-183.  show abstract

Oliver, A.W. (2004). Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic acids research, Vol.32 (2), pp. 456-464.

Millson, S.H. Truman, A.W. Wolfram, F. King, V. Panaretou, B. Prodromou, C. Pearl, L.H. Piper, P.W. (2004). Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell stress & chaperones, Vol.9 (4), pp. 359-359.

Hinks, J.A. Roe, M. Ho, J.C. Watts, F.Z. Phelan, J. McAllister, M. Pearl, L.H. (2003). Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta crystallographica section d biological crystallography, Vol.59 (7), pp. 1230-1233.

Prodromou, C. Pearl, L. (2003). Structure and Functional Relationships of Hsp90. Current cancer drug targets, Vol.3 (5), pp. 301-323.

Piper, P.W. Panaretou, B. Millson, S.H. Trumana, A. Mollapour, M. Pearl, L.H. Prodromou, C. (2003). Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90β, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene, Vol.302 (1-2), pp. 165-170.

Bunting, K.A. (2003). Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the  -clamp. The embo journal, Vol.22 (21), pp. 5883-5892.

Dajani, R. (2003). Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. The embo journal, Vol.22 (3), pp. 494-501.

Boskovic, J. (2003). Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs. The embo journal, Vol.22 (21), pp. 5875-5882.

Meyer, P. Prodromou, C. Hu, B. Vaughan, C. Roe, S.M. Panaretou, B. Piper, P.W. Pearl, L.H. (2003). Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions. Molecular cell, Vol.11 (3), pp. 647-658.

Wibley, J.E. Waters, T.R. Haushalter, K. Verdine, G.L. Pearl, L.H. (2003). Structure and Specificity of the Vertebrate Anti-Mutator Uracil-DNA Glycosylase SMUG1. Molecular cell, Vol.11 (6), pp. 1647-1659.

Zhang, X. Mark Roe, S. Hou, Y. Bartlam, M. Rao, Z. Pearl, L.H. Danpure, C.J. (2003). Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship Between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1. Journal of molecular biology, Vol.331 (3), pp. 643-652.

Kumar, S. Nagl, S. Kalsi, J.K. Ravirajan, C.T. Athwal, D. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2003). Anti-cardiolipin/β-2 glycoprotein activities co-exist on human anti-DNA antibody light chains. Molecular immunology, Vol.40 (8), pp. 517-530.

Meijer, L. Skaltsounis, A.-. Magiatis, P. Polychronopoulos, P. Knockaert, M. Leost, M. Ryan, X.P. Vonica, C.A. Brivanlou, A. Dajani, R. Crovace, C. Tarricone, C. Musacchio, A. Roe, S.M. Pearl, L. Greengard, P. (2003). GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins. Chemistry & biology, Vol.10 (12), pp. 1255-1266.

Bunting, K.A. (2003). Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. Nucleic acids research, Vol.31 (6), pp. 1633-1639.

Pearl, L. (2002). Regulation of protein kinases in insulin, growth factor and Wnt signalling. Current opinion in structural biology, Vol.12 (6), pp. 761-767.

Fraser, E. Young, N. Dajani, R. Franca-Koh, J. Ryves, J. Williams, R.S. Yeo, M. Webster, M.-. Richardson, C. Smalley, M.J. Pearl, L.H. Harwood, A. Dale, T.C. (2002). Identification of the Axin and Frat Binding Region of Glycogen Synthase Kinase-3. Journal of biological chemistry, Vol.277 (3), pp. 2176-2185.

Ryves, W.J. Dajani, R. Pearl, L. Harwood, A.J. (2002). Glycogen Synthase Kinase-3 Inhibition by Lithium and Beryllium Suggests the Presence of Two Magnesium Binding Sites. Biochemical and biophysical research communications, Vol.290 (3), pp. 967-972.

Bjørås, M. Seeberg, E. Luna, L. Pearl, L.H. Barrett, T.E. (2002). Reciprocal “flipping” underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. Journal of molecular biology, Vol.317 (2), pp. 171-177.

Hinks, J.A. Evans, M.C. de Miguel, Y. Sartori, A.A. Jiricny, J. Pearl, L.H. (2002). An Iron-Sulfur Cluster in the Family 4 Uracil-DNA Glycosylases. Journal of biological chemistry, Vol.277 (19), pp. 16936-16940.

Pappenberger, G. Wilsher, J.A. Mark Roe, S. Counsell, D.J. Willison, K.R. Pearl, L.H. (2002). Crystal Structure of the CCTγ Apical Domain: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin. Journal of molecular biology, Vol.318 (5), pp. 1367-1379.

Siligardi, G. Panaretou, B. Meyer, P. Singh, S. Woolfson, D.N. Piper, P.W. Pearl, L.H. Prodromou, C. (2002). Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50. Journal of biological chemistry, Vol.277 (23), pp. 20151-20159.

Pickles, L.M. Roe, S.M. Hemingway, E.J. Stifani, S. Pearl, L.H. (2002). Crystal Structure of the C-Terminal WD40 Repeat Domain of the Human Groucho/TLE1 Transcriptional Corepressor. Structure, Vol.10 (6), pp. 751-761.

Panaretou, B. Siligardi, G. Meyer, P. Maloney, A. Sullivan, J.K. Singh, S. Millson, S.H. Clarke, P.A. Naaby-Hansen, S. Stein, R. Cramer, R. Mollapour, M. Workman, P. Piper, P.W. Pearl, L.H. Prodromou, C. (2002). Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol cell, Vol.10 (6), pp. 1307-1318.  show abstract

Fogg, M.J. Pearl, L.H. Connolly, B.A. (2002). Structural basis for uracil recognition by archaeal family B DNA polymerases. Nature structural biology, Vol.9 (12), pp. 922-927.

Kumar, S. Kalsi, J.K. Ravirajan, C.T. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2002). Molecular expression systems for anti-DNA antibodies—2. Lupus, Vol.11 (12), pp. 833-842.  show abstract

Harris, R. Maman, J.D. Hinks, J.A. Sankar, A. Pearl, L.H. Driscoll, P.C. (2002). . Journal of biomolecular nmr, Vol.22 (4), pp. 373-374.

Salek, R.M. Williams, M.A. Prodromou, C. Pearl, L.H. Ladbury, J.E. (2002). . Journal of biomolecular nmr, Vol.23 (4), pp. 327-328.

Zhang, X. Roe, S.M. Pearl, L.H. Danpure, C.J. (2001). Crystallization and preliminary crystallographic analysis of human alanine:glyoxylate aminotransferase and its polymorphic variants. Acta crystallographica section d biological crystallography, Vol.57 (12), pp. 1936-1937.

Ceschini, S. (2001). Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2. The embo journal, Vol.20 (23), pp. 6601-6611.

Kumar, S. Kalsi, J. Latchman, D.S. Pearl, L.H. Isenberg, D.A. (2001). Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity. Journal of molecular biology, Vol.308 (3), pp. 527-539.

Dajani, R. Fraser, E. Roe, S.M. Young, N. Good, V. Dale, T.C. Pearl, L.H. (2001). Crystal Structure of Glycogen Synthase Kinase 3β. Cell, Vol.105 (6), pp. 721-732.

TAN, T.H. EDGERTON, S.A. KUMARI, R. McALISTER, M.S. ROWE, S.M. NAGL, S. PEARL, L.H. SELKIRK, M.E. BIANCO, A.E. TOTTY, N.F. ENGWERDA, C. GRAY, C.A. J. MEYER, D. (2001). Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. Biochemical journal, Vol.357 (2), pp. 373-373.

Evans, S.J. (2000). Improving dideoxynucleotide-triphosphate utilisation by the hyper-thermophilic DNA polymerase from the archaeon Pyrococcus furiosus. Nucleic acids research, Vol.28 (5), pp. 1059-1066.

Pearl, L.H. Prodromou, C. (2000). Structure and in vivo function of Hsp90. Current opinion in structural biology, Vol.10 (1), pp. 46-51.

O'Hara, B.P. Wilson, S.A. Lee, A.W. Roe, S.M. Siligardi, G. Drew, R.E. Pearl, L.H. (2000). Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, AmiC. Protein engineering, design and selection, Vol.13 (2), pp. 129-132.

Pearl, L.H. (2000). Structure and function in the uracil-DNA glycosylase superfamily. Mutation research/dna repair, Vol.460 (3-4), pp. 165-181.

Norman, R.A. Poh, C.L. Pearl, L.H. O'Hara, B.P. Drew, R.E. (2000). Steric Hindrance Regulation of the Pseudomonas aeruginosa Amidase Operon. Journal of biological chemistry, Vol.275 (39), pp. 30660-30667.

Rösler, A. Panayotou, G. Hornby, D.P. Barlow, T. Brown, T. Pearl, L.H. Savva, R. Blackburn, G.M. (2000). The Mechanism of Dna Repair by Uracil-Dna Glycosylase: Studies Using Nucleotide Analogues. Nucleosides, nucleotides and nucleic acids, Vol.19 (10-12), pp. 1505-1516.

Kumar, S. Kalsi, J. Ravirajan, C.T. Rahman, A. Athwal, D. Latchman, D.S. Isenberg, D.A. Pearl, L.H. (2000). Molecular Cloning and Expression of the Fabs of Human Autoantibodies in Escherichia coli. Journal of biological chemistry, Vol.275 (45), pp. 35129-35136.

Prodromou, C. (2000). The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains. The embo journal, Vol.19 (16), pp. 4383-4392.

O'Hara, B.P. (1999). Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex. The embo journal, Vol.18 (19), pp. 5175-5186.

Barrett, T.E. (1999). Crystal structure of a thwarted mismatch glycosylase DNA repair complex. The embo journal, Vol.18 (23), pp. 6599-6609.

Panaretou, B. Sinclair, K. Prodromou, C. Johal, J. Pearl, L. Piper, P.W. (1999). The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C albicans infections. Microbiology, Vol.145 (12), pp. 3455-3463.

Prodromou, C. (1999). Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. The embo journal, Vol.18 (3), pp. 754-762.

Roe, S.M. Prodromou, C. O'Brien, R. Ladbury, J.E. Piper, P.W. Pearl, L.H. (1999). Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin. Journal of medicinal chemistry, Vol.42 (2), pp. 260-266.

Greagg, M.A. Fogg, M.J. Panayotou, G. Evans, S.J. Connolly, B.A. Pearl, L.H. (1999). A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil. Proceedings of the national academy of sciences, Vol.96 (16), pp. 9045-9050.  show abstract

Barrett, T.E. Savva, R. Panayotou, G. Barlow, T. Brown, T. Jiricny, J. Pearl, L.H. (1998). Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase. Cell, Vol.92 (1), pp. 117-129.

Panayotou, G. Brown, T. Barlow, T. Pearl, L.H. Savva, R. (1998). Direct Measurement of the Substrate Preference of Uracil-DNA Glycosylase. Journal of biological chemistry, Vol.273 (1), pp. 45-50.

Barrett, T.E. Savva, R. Barlow, T. Brown, T. Jiricny, J. Pearl, L.H. (1998). Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct. Nature structural & molecular biology, Vol.5 (8), pp. 697-701.

Roe, S.M. Barlow, T. Brown, T. Oram, M. Keeley, A. Tsaneva, I.R. Pearl, L.H. (1998). Crystal Structure of an Octameric RuvA–Holliday Junction Complex. Molecular cell, Vol.2 (3), pp. 361-372.

Panaretou, B. (1998). ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo. The embo journal, Vol.17 (16), pp. 4829-4836.

Chamberlain, D. O'Hara, B.P. Wilson, S.A. Pearl, L.H. Perkins, S.J. (1997). Oligomerization of the Amide Sensor Protein AmiC by X-ray and Neutron Scattering and Molecular Modeling. Biochemistry, Vol.36 (26), pp. 8020-8029.

Prodromou, C. Roe, S.M. Piper, P.W. Pearl, L.H. (1997). A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature structural biology, Vol.4 (6), pp. 477-482.

Prodromou, C. Roe, S.M. O'Brien, R. Ladbury, J.E. Piper, P.W. Pearl, L.H. (1997). Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone. Cell, Vol.90 (1), pp. 65-75.

Aguilar, C.F. Sanderson, I. Moracci, M. Ciaramella, M. Nucci, R. Rossi, M. Pearl, L.H. (1997). Crystal structure of the β-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability. Journal of molecular biology, Vol.271 (5), pp. 789-802.

Wheeler, V.C. Prodromou, C. Pearl, L.H. Williamson, R. Coutelle, C. (1996). Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect. Gene, Vol.169 (2), pp. 251-255.

Jones, D.T. Moody, C.M. Uppenbrink, J. Viles, J.H. Doyle, P.M. Harris, C.J. Pearl, L.H. Sadler, P.J. Thornton, J.M. (1996). Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin-43, an α-helical protein with over 50% sequence identity to an all-β protein. Proteins: structure, function, and genetics, Vol.24 (4), pp. 502-513.

Pearl, L.H. Savva, R. (1996). The problem with pyrimidines. Nature structural & molecular biology, Vol.3 (6), pp. 485-487.

Prodromou, C. Piper, P.W. Pearl, L.H. (1996). Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x-ray diffraction studies of the amino-terminal domain. Proteins: structure, function, and genetics, Vol.25 (4), pp. 517-522.

Koulis, A. Cowan, D.A. Pearl, L.H. Savva, R. (1996). Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. Fems microbiology letters, Vol.143 (2-3), pp. 267-271.

Wilson, S.A. Wachira, S.J. Norman, R.A. Pearl, L.H. Drew, R.E. (1996). Transcription antitermination regulation of the Pseudomonas aeruginosa amidase operon. The embo journal, Vol.15 (21), pp. 5907-5916.

Danson, M.J. Hough, D.W. Russell, R.J. Taylor, G.L. Pearl, L. (1996). Enzyme thermostability and thermoactivity. "protein engineering, design and selection", Vol.9 (8), pp. 629-630.

Savva, R. McAuley-Hecht, K. Brown, T. Pearl, L. (1995). The structural basis of specific base-excision repair by uracil–DNA glycosylase. Nature, Vol.373 (6514), pp. 487-493.

Savva, R. Pearl, L.H. (1995). Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex. Proteins: structure, function, and genetics, Vol.22 (3), pp. 287-289.

Wilson, S.A. Williams, R.J. Pearl, L.H. Drew, R.E. (1995). Identification of Two New Genes in the Pseudomonasaeruginosa Amidase Operon, Encoding an ATPase (AmiB) and a Putative Integral Membrane Protein (AmiS). Journal of biological chemistry, Vol.270 (32), pp. 18818-18824.

Savva, R. Pearl, L.H. (1995). Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase–uracil glycosylase inhibitor protein complex. Nature structural & molecular biology, Vol.2 (9), pp. 752-757.

Pearl, L.H. Savva, R. (1995). DNA repair in three dimensions. Trends in biochemical sciences, Vol.20 (10), pp. 421-426.

O'Hara, B.P. Hemmings, A.M. Buttle, D.J. Pearl, L.H. (1995). Crystal Structure of Glycyl Endopeptidase from Carica papaya: A Cysteine Endopeptidase of Unusual Substrate Specificity. Biochemistry, Vol.34 (40), pp. 13190-13195.

Pearl, L. O'Hara, B. Drew, R. Wilson, S. (1994). Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. The embo journal, Vol.13 (24), pp. 5810-5817.

Pearl, L.H. Hemmings, A.M. Nucci, R. Rossi, M. (1993). Crystallization and Preliminary X-ray Analysis of the β-Galactosidase from the Extreme Thermophilic Archaebacterium Sulfolobus solfataricus. Journal of molecular biology, Vol.229 (2), pp. 561-563.

Pearl, L.H. Demasi, D. Hemmings, A.M. Sica, F. Mazzarella, L. Raia, C.A. D' Auria, S. Rossi, M. (1993). Crystallization and Preliminary X-ray Analysis of an NAD+ -dependent Alcohol Dehydrogenase from the Extreme Thermophilic Archaebacterium Sulfolobus solfataricus. Journal of molecular biology, Vol.229 (3), pp. 782-784.

Pearl, L. (1993). Similarity of active-site structures. Nature, Vol.362 (6415), pp. 24-24.

Wilson, S.A. Wachira, S.J. Drew, R.E. Jones, D. Pearl, L.H. (1993). Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide-binding protein. The embo journal, Vol.12 (9), pp. 3637-3642.

Savva, R. Pearl, L.H. (1993). Crystallization and Preliminary X-ray Analysis of the Uracil-DNA Glycosylase DNA Repair Enzyme from Herpes Simplex Virus Type 1. Journal of molecular biology, Vol.234 (3), pp. 910-912.

Swindells, M.B. Orengo, C.A. Jones, D.T. Pearl, L.H. Thornton, J.M. (1993). Recurrence of a binding motif?. Nature, Vol.362 (6418), pp. 299-299.

RAWLINGS, N.D. PEARL, L.H. BUTTLE, D.J. (1992). The BaculovirusAutographa californicaNuclear Polyhedrosis Virus Genome Includes a Papain-Like Sequence. Biological chemistry hoppe-seyler, Vol.373 (2), pp. 1211-1216.

Prodromou, C. Pearl, L.H. (1992). Recursive PCR: a novel technique for total gene synthesis. "protein engineering, design and selection", Vol.5 (8), pp. 827-829.

Cruzeiro-Hansson, L. Swann, P.F. Pearl, L. Goodfellow, J.M. (1992). Molecular dynamics of alkylated DNA. Carcinogenesis, Vol.13 (11), pp. 2067-2073.

Wilson, S.A. Chayen, N.E. Hemmings, A.M. Drew, R.E. Pearl, L.H. (1991). Crystallization of and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. Journal of molecular biology, Vol.222 (4), pp. 869-871.

Blundell, T.L. Jenkins, J.A. Sewell, B.T. Pearl, L.H. Cooper, J.B. Tickle, I.J. Veerapandian, B. Wood, S.P. (1990). X-ray analyses of aspartic proteinases. Journal of molecular biology, Vol.211 (4), pp. 919-941.

Moelling, K. Schulze, T. Knoop, M.-. Kay, J. Jupp, R. Nicolaou, G. Pearl, L.H. (1990). In vitro inhibition of HIV-1 proteinase by cerulenin. Febs letters, Vol.261 (2), pp. 373-377.

Buttle, D.J. Ritonja, A. Pearl, L.H. Turk, V. Barrett, A.J. (1990). Selective cleavage of glycyl bonds by papaya proteinase IV. Febs letters, Vol.260 (2), pp. 195-197.

Blundell, T. Pearl, L. (1989). A second front against AIDS. Nature, Vol.337 (6208), pp. 596-597.

McKeating, J.A. Gow, J. Goudsmit, J. Pearl, L.H. Mulder, C. Weiss, R.A. (1989). Characterization of HIV-1 neutralization escape mutants. Aids, Vol.3 (12), pp. 777-784.

Neidle, S. Pearl, L.H. Herzyk, P. Berman, H.M. (1988). A molecular model for proflavine--DNA intercalation. Nucleic acids research, Vol.16 (18), pp. 8999-9016.

Neidle, S. Pearl, L.H. Skelly, J.V. (1987). DNA structure and perturbation by drug binding. Biochemical journal, Vol.243 (1), pp. 1-13.

Foundling, S.I. Cooper, J. Watson, F.E. Cleasby, A. Pearl, L.H. Sibanda, B.L. Hemmings, A. Wood, S.P. Blundell, T.L. Valler, M.J. Norey, C.G. Kay, J. Boger, J. Dunn, B.M. Leckie, B.J. Jone, D.M. Atrash, B. Hallett, A. Szelke, M. (1987). High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature, Vol.327 (6120), pp. 349-352.

Pearl, L.H. (1987). The catalytic mechanism of aspartic proteinases. Febs letters, Vol.214 (1), pp. 8-12.

PEAR, L.H. TAYLO, W.R. (1987). Sequence specificity of retroviral proteases. Nature, Vol.328 (6130), pp. 482-482.

Pearl, L.H. Taylor, W.R. (1987). A structural model for the retroviral proteases. Nature, Vol.329 (6137), pp. 351-354.

Foundling, S.I. Cooper, J. Watson, F.E. Pearl, L.H. Hemmings, A. Wood, S.P. Blundell, T. Hallett, A. Jones, D.M. Sueiras, J. Atrash, B. Szelke, M. (1987). Crystallographic Studies of Reduced Bond Inhibitors Complexed with an Aspartic Proteinase. Journal of cardiovascular pharmacology, Vol.10, pp. 59-68.

Ford, K.G. Pearl, L.H. Neidle, S. (1987). Molecular modelling of the interactions of tetra-(4-N-methyIpyridyI) porphin with TA and CG sites on DNA. Nucleic acids research, Vol.15 (16), pp. 6553-6562.

Pearl, L.H. Skelly, J.V. Hudson, B.D. Neidle, S. (1987). The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes. Nucleic acids research, Vol.15 (8), pp. 3469-3478.

Pearl, L.H. Neidle, S. (1986). Origins of stereospecificity in DNA damage by anti -benzo[a ]pyrene diol-epoxides. Febs letters, Vol.209 (2), pp. 269-276.

HEMMINGS, A.M. FOUNDLING, S.I. SIBANDA, B.L. WOOD, S.P. PEARL, L.H. BLUNDELL, T.O. (1985). Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142. Biochemical society transactions, Vol.13 (6), pp. 1036-1041.

Pearl, L. Blundell, T. (1984). The active site of aspartic proteinases. Febs letters, Vol.174 (1), pp. 96-101.

Blundell, T. Sibanda, B.L. Pearl, L. (1983). Three-dimensional structure, specificity and catalytic mechanism of renin. Nature, Vol.304 (5923), pp. 273-275.

Dekker, C. Roe, S.M. McCormack, E.A. Beuron, F. Pearl, L.H. Willison, K.R. The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. The embo journal, Vol.30 (15), pp. 3078-3090.

Polier, S. Samant, R.S. Clarke, P.A. Workman, P. Prodromou, C. Pearl, L.H. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nat chem biol., Vol.9, pp. 307-312.  show abstract

Hallett, S.T. Pastok, M.W. Morgan, R.M. Wittner, A. Blundell, K.L. Felletar, I. Wedge, S.R. Prodromou, C. Noble, M.E. Pearl, L.H. Endicott, J.A. Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System. Cell reports, Vol.21 (5), pp. 1386-1398.

Aherne, W. Maloney, A. Prodromou, C. Rowlands, M.G. Hardcastle, A. Boxall, K. Clarke, P. Walton, M.I. Pearl, L. Assays for HSP90 and Inhibitors. , , pp. 149-162.

Peters, N.E. Ferguson, B.J. Mazzon, M. Fahy, A.S. Krysztofinska, E. Arribas-Bosacoma, R. Pearl, L.H. Ren, H. Smith, G.L. A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus. Plos pathogens, Vol.9 (10), pp. e1003649-e1003649.

Piper, P.W. Millson, S.H. Mollapour, M. Panaretou, B. Siligardi, G. Pearl, L.H. Prodromou, C. Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. European journal of biochemistry, Vol.270 (23), pp. 4689-4695.

Elliott, R.J. Jarvis, A. Rajasekaran, M.B. Menon, M. Bowers, L. Boffey, R. Bayford, M. Firth-Clark, S. Key, R. Aqil, R. Kirton, S.B. Niculescu-Duvaz, D. Fish, L. Lopes, F. McLeary, R. Trindade, I. Vendrell, E. Munkonge, F. Porter, R. Perrior, T. Springer, C. Oliver, A.W. Pearl, L.H. Ashworth, A. Lord, C.J. Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors. Medchemcomm, Vol.6 (9), pp. 1687-1692.  show abstract

Chen, X. Ali, Y.I. Fisher, C.E. Arribas-Bosacoma, R. Rajasekaran, M.B. Williams, G. Walker, S. Booth, J.R. Hudson, J.J. Roe, S.M. Pearl, L.H. Ward, S.E. Pearl, F.M. Oliver, A.W. Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Elife, Vol.10.  show abstract

Day, M. Oliver, A.W. Pearl, L.H. Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. Dna repair, Vol.108, pp. 103232-?.  show abstract

Book Chapters

Pearl, L.H. Prodromou, C. (2006). Structure and Mechanism of the Hsp90 Molecular Chaperone Machinery. . (pp. 271-294). Annual Reviews.

Pearl, L.H. Prodromou, C. (2002). Structure, function, and mechanism of the Hsp90 molecular chaperone. . (pp. 157-186). ACADEMIC PRESS INC.


Schulze, A.Beliu, G.Prodromou, C.Pearl, L.Neuweiler, H. (2015). Local motions within the Hsp90 molecular chaperone machinery observed by fluorescence quenching, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol.44, p.S209.

Polo, L.M.Grundy, G.Rulten, S.Xu, Y.Matthews, S.Caldecot, K.Oliver, A.Pearl, L. (2015). New structural insights into PARP3 function, FEBS JOURNAL, Vol.282, p.397.

Morgan, R.M.Pal, M.Phelps, S.Downs, J.Pearl, L.Prodromou, C. (2014). Structural basis for the phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1, FEBS JOURNAL, Vol.281, p.724.

Droucheau, E.Primot, A.Thomas, V.Mattei, D.Knockaert, M.Richardson, C.Sallicandro, P.Alano, P.Jafarshad, A.Baratte, B.Kunick, C.Parzy, D.Pearl, L.Doerig, C.Meijer, L. (2004). Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol.1697 (1-2), pp.181-196.

Sica, F.Demasi, D.Mazzarella, L.Zagari, A.Capasso, S.Pearl, L.H.D'Auria, S.Raia, C.A.Rossi, M. (1994). Elimination of twinning in crystals of Sulfolobus sofataricus alcohol dehydrogenase holo-enzyme by growth in agarose gels, Acta Crystallographica Section D Biological Crystallography, Vol.50 (4), pp.508-511.

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