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Fearon, D., Westwood, I.M., van Montfort, R.L., Bayliss, R., Jones, K. & Bavetsias, V. (2018). Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorganic & medicinal chemistry, Vol.26 (11), pp. 3021-3029.

Stork, G., Yamashita, A., Hanson, R.M., Phan, L., Phillips, E., Dubé, D., Bos, P.H., Clark, A.J., Gough, M., Greenlee, M.L., et al. (2017). Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine. Organic letters, Vol.19 (19), pp. 5150-5153.

Pettinger, J., Le Bihan, Y.-., Widya, M., van Montfort, R.L., Jones, K. & Cheeseman, M.D. (2017). An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angewandte chemie-international edition, Vol.56 (13), pp. 3536-3540.

Pettinger, J., Jones, K. & Cheeseman, M.D. (2017). Auf Lysin zielende, kovalente Inhibitoren. Angewandte chemie, Vol.129 (48), pp. 15398-15408.

Jones, A.M., Westwood, I.M., Osborne, J.D., Matthews, T.P., Cheeseman, M.D., Rowlands, M.G., Jeganathan, F., Burke, R., Lee, D., Kadi, N., et al. (2016). A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Scientific reports, Vol.6 (1).

Cheeseman, M.D., Westwood, I.M., Barbeau, O., Rowlands, M., Dobson, S., Jones, A.M., Jeganathan, F., Burke, R., Kadi, N., Workman, P., et al. (2016). Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. J med chem, Vol.59 (10), pp. 4625-4636.  show abstract

Andrikopoulos, P., Kieswich, J., Harwood, S.M., Baba, A., Matsuda, T., Barbeau, O., Jones, K., Eccles, S.A. & Yaqoob, M.M. (2015). Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+Influx through the Na+/Ca2+Exchanger. Journal of biological chemistry, Vol.290 (30), pp. 18412-18428.

Cheeseman, M.D., Faisal, A., Rayter, S., Barbeau, O.R., Kalusa, A., Westlake, M., Burke, R., Swan, M., van Montfort, R., Linardopoulos, S., et al. (2014). Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg med chem lett, Vol.24 (15), pp. 3469-3474.  show abstract

Hickin, J.A., Ahmed, A., Fucke, K., Ashcroft, M. & Jones, K. (2014). The synthesis and structure revision of NSC-134754. Chem commun (camb), Vol.50 (10), pp. 1238-1240.  show abstract

Couty, S., Westwood, I.M., Kalusa, A., Cano, C., Travers, J., Boxall, K., Chow, C.L., Burns, S., Schmitt, J., Pickard, L., et al. (2013). The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, Vol.4, pp. 1-15.  show abstract

Silva-Santisteban, M.C., Westwood, I.M., Boxall, K., Brown, N., Peacock, S., McAndrew, C., Barrie, E., Richards, M., Mirza, A., Oliver, A.W., et al. (2013). Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. Plos one, Vol.8 (6), p. e65689.  show abstract

Evans, L.E., Cheeseman, M.D. & Jones, K. (2012). N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines. Org lett, Vol.14 (13), pp. 3546-3549.  show abstract

Francis, N.-., Rowlands, M., Workman, P., Jones, K. & Aherne, W. (2012). Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen. J biomol screen, Vol.17 (8), pp. 1102-1109.  show abstract

Rowlands, M., McAndrew, C., Prodromou, C., Pearl, L., Kalusa, A., Jones, K., Workman, P. & Aherne, W. (2010). Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. J biomol screen, Vol.15 (3), pp. 279-286.  show abstract

Jones, K. & McHardy, T. (2010). Cancer Drug Discovery 2010: from molecules to medicine. Expert rev clin pharmacol, Vol.3 (5), pp. 613-615.  show abstract

Powers, M.V., Jones, K., Barillari, C., Westwood, I., van Montfort, R.L. & Workman, P. (2010). Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?. Cell cycle, Vol.9 (8), pp. 1542-1550.  show abstract

Ahmad, N.M. & Jones, K. (2010). An efficient synthesis of thiazolo[3,2-a]pyrimidinones. Tetrahedron lett, Vol.51 (25), pp. 3263-3265.  show abstract

Mirizzi, D., Hilton, S.T. & Jones, K. (2010). Heteroaryl Radicals Review. Adv heterocycl chem, Vol.100, pp. 101-143.

Kalusa, A., Chessum, N. & Jones, K. (2008). An efficient synthesis of 2,3-diaryl (3H)-quinazolin-4-ones via imidoyl chlorides. Tetrahedron lett, Vol.49 (41), pp. 5840-5842.  show abstract

Rayter, S., Elliott, R., Travers, J., Rowlands, M.G., Richardson, T.B., Boxall, K., Jones, K., Linardopoulos, S., Workman, P., Aherne, W., et al. (2008). A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene, Vol.27 (8), pp. 1036-1044.  show abstract

Eccles, S.A., Massey, A., Raynaud, F.I., Sharp, S.Y., Box, G., Valenti, M., Patterson, L., de Haven Brandon, A., Gowan, S., Boxall, F., et al. (2008). NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer res, Vol.68 (8), pp. 2850-2860.  show abstract

Hardcastle, A., Tomlin, P., Norris, C., Richards, J., Cordwell, M., Boxall, K., Rowlands, M., Jones, K., Collins, I., McDonald, E., et al. (2007). A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation. Mol cancer ther, Vol.6 (3), pp. 1112-1122.  show abstract

Sharp, S.Y., Prodromou, C., Boxall, K., Powers, M.V., Holmes, J.L., Box, G., Matthews, T.P., Cheung, K.-., Kalusa, A., James, K., et al. (2007). Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol cancer ther, Vol.6 (4), pp. 1198-1211.  show abstract

Eccles, S.A., Sharp, S.Y., Raynaud, F.I., Valenti, M., Patterson, L., Gowan, S., Boxall, K., Aherne, W., Rowlands, M., Hayes, A., et al. (2007). NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts. Mol cancer ther, Vol.6 (12), pp. 3522S-3523S.

Raynaud, F.I., Hayes, A., Martins, V., Smith, N.F., Sharp, S.Y., Valenti, M., Henley, A., Matthews, T.P., Cheung, K.M., Kalusa, A., et al. (2007). Cassette dosing in tumor bearing animals for the discovery of NVP-AUY922, a novel HSP90 inhibitor. Mol cancer ther, Vol.6 (12), pp. 3524S-3524S.

Hilton, S.T. & Jones, K. (2007). The tandem radical route to indole alkaloids: an unusual rearrangement reaction. Arkivoc, , pp. 120-128.

Francis, N.J., Rowlands, M., Travers, J., Reynissen, J., Hardcastle, A., Stimson, L., Gamblin, S., Jones, K., Workman, P. & Aherne, W., et al. (2006). A high throughput screen and secondary assays for the identification and evaluation of histone methyltransferase inhibitors. Ejc suppl, Vol.4 (12), pp. 130-130.

McDonald, E., Workman, P. & Jones, K. (2006). Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer. Curr top med chem, Vol.6 (11), pp. 1091-1107.  show abstract

McDonald, E., Jones, K., Brough, P.A., Drysdale, M.J. & Workman, P. (2006). Discovery and development of pyrazole-scaffold Hsp90 inhibitors. Curr top med chem, Vol.6 (11), pp. 1193-1203.  show abstract

Rossiter, S., Peron, J.M., Whitfield, P.J. & Jones, K. (2005). Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes. Bioorg med chem lett, Vol.15 (21), pp. 4806-4808.  show abstract

Tyrrell, E., Allen, J., Jones, K. & Beauchet, R. (2005). Asymmetric 1,3-Dipolar Cycloaddition Reactions of Nitrones with (S)-(-)-4-Benzyl-N-methacryloyl-2-oxazolidinone. Synthesis, (14), pp. 2393-2399.

Gravett, E.C., Hilton, P.J., Jones, K. & Peron, J.M. (2003). A new route to 5-aryl and 5-heteroaryl-2-pyrones via Suzuki coupling of a 2-pyrone-5-boronate ester. Synlett, (2), pp. 253-255.

Jones, K., Roset, X., Rossiter, S. & Whitfield, P. (2003). Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine. Organic & biomolecular chemistry, Vol.1 (24), pp. 4380-4380.

Escolano, C. & Jones, K. (2002). Aryl radical cyclisation onto pyrroles. Tetrahedron, Vol.58 (7), pp. 1453-1464.

Escolano, C., Vallverdú, L. & Jones, K. (2002). Reaction of indolin-2-ones with cerium(IV) ammonium nitrate. Tetrahedron, Vol.58 (47), pp. 9541-9545.

Jones, K. & Toutounji, T. (2001). A short protocol for the synthesis of spirocyclic tetrahydrofurans via intramolecular O–H insertion. Tetrahedron, Vol.57 (12), pp. 2427-2431.

Ong, Q., Hameyer, H., Handa, S. & Jones, K. (2001). Synthetic studies on morphine-based analgesics: an approach to angular substitution in 4a-aryldecahydroisoquinolines via dienolate chemistry. Tetrahedron letters, Vol.42 (44), pp. 7879-7882.

Gravett, E.C., Hilton, P.J., Jones, K. & Romero, F. (2001). A Suzuki coupling approach to bufadienolides. Tetrahedron letters, Vol.42 (51), pp. 9081-9084.

Hilton, S.T., Jones, K., Ho, T.C., Pljevaljcic, G. & Schulte, M. (2001). A tandem radical approach to the ABCE-rings of the Aspidosperma and Strychnos alkaloids. Chemical communications, (2), pp. 209-210.

Jones, K., Fiumana, A. & Escudero-Hernandez, M.L. (2000). Pyridine Radicals in Synthesis Part 3: Cyclopentannulation of Pyridine via the 3-Pyridyl Radical and a Formal Synthesis of (±)-Oxerine. Tetrahedron, Vol.56 (3), pp. 397-406.

Fiumana, A. & Jones, K. (2000). Annulation of indole via indole radicals: addition of the 2-indolyl radical to aromatic rings. Tetrahedron letters, Vol.41 (21), pp. 4209-4211.

Ashraf, M.A., Jones, K. & Handa, S. (2000). Biomimetic ligands for transition metals: catechol-containing peptides. Bioorganic & medicinal chemistry letters, Vol.10 (14), pp. 1617-1620.

Hilton, S.T., Ho, T.C., Pljevaljcic, G. & Jones, K. (2000). A New Route to Spirooxindoles. Organic letters, Vol.2 (17), pp. 2639-2641.

Escolano, C. & Jones, K. (2000). Aryl radical cyclisation onto pyrroles: a divergent synthesis of spiropyrrolidinyloxindoles and pyrroloquinolines. Tetrahedron letters, Vol.41 (46), pp. 8951-8955.

Brunton, S.A. & Jones, K. (2000). The synthesis of 3-methyleneindol-2(3H )-ones related to mitomycins via 5-exo-dig aryl radical cyclisation. Journal of the chemical society, perkin transactions 1, (5), pp. 763-768.

Jones, K. & Storey, J.M. (2000). Intramolecular organolithium addition to indol-2(3H )-ones; an approach to the synthesis of pyrrolo[1,2-a]indoles and pyrido[1,2-a]indoles. Journal of the chemical society, perkin transactions 1, (5), pp. 769-774.

Jones, K. (1999). Glowing jellyfish, luminescence and a molecule called coelenterazine. Trends in biotechnology, Vol.17 (12), pp. 477-481.

Jones, K., Brunton, S.A. & Gosain, R. (1999). The aryl radical route to oxindoles: dependence on temperature and tin hydride concentration. Tetrahedron letters, Vol.40 (50), pp. 8935-8938.

Fiumana, A. & Jones, K. (1999). Intermolecular reactions of indol-2-yl radicals: a new route to 2-substituted indoles. Chemical communications, (17), pp. 1761-1762.

Dobbs, A.P., Jones, K. & Veal, K.T. (1998). Heteroaryl radicals in synthesis: Radical cyclisation reactions of 2-bromoindoles. Tetrahedron, Vol.54 (10), pp. 2149-2160.

Jones, K. & Escudero-Hernandez, M.L. (1998). A short synthesis of (±)-actinidine. Tetrahedron, Vol.54 (10), pp. 2275-2280.

Ho, T.C. & Jones, K. (1997). A synthesis of the tricyclic pyrroloquinoline core of martinelline. Tetrahedron, Vol.53 (24), pp. 8287-8294.

Dobbs, A.P., Jones, K. & Veal, K.T. (1997). Radical cyclisation reactions of 7-bromoindoles. Tetrahedron letters, Vol.38 (30), pp. 5379-5382.

Jones, K., Newton, R.F. & Yarnold, C.J. (1996). Synthetic studies on the ceveratrum alkaloid skeleton. Tetrahedron, Vol.52 (11), pp. 4133-4140.

Houghton, P., Osibogun, I., Woldemariam, T. & Jones, K. (1995). Heteronuclear NMR Studies of the Chromone Alkaloids and Revision of the Structure of Some Piperidino-Chromone Alkaloids. Planta medica, Vol.61 (02), pp. 154-157.

Jones, K. (1995). Aryl Radical Cyclisation on to a Pyrrole Nucleus. Tetrahedron letters, Vol.36 (3), pp. 6743-6744.

Jones, K. & Storey, J.M. (1993). A route to the pyrrolo[1,2-a]indolenine ring system via intermolecular organolithium addition to an oxindole. Tetrahedron, Vol.49 (22), pp. 4901-4906.

Jones, K. & Storey, J.M. (1993). Aryl radical cyclisation approach to highly substituted oxindoles related to mitomycins. Tetrahedron letters, Vol.34 (48), pp. 7797-7798.

Clark, A.J. & Jones, K. (1992). Cobalt-mediated aryl radical cyclisations: A formal synthesis of physovenine. Tetrahedron, Vol.48 (33), pp. 6875-6882.

López-Tudanca, P.L., Jones, K. & Brownbridge, P. (1991). Substituent control in the synthesis of tetrahydropyrans, oxepanes and oxocanes by episulphonium ion-mediated cyclisation. Tetrahedron letters, Vol.32 (20), pp. 2261-2264.

Jones, K. & Woo, K.-. (1991). A total synthesis of (−)-ruspolinone. Tetrahedron, Vol.47 (34), pp. 7179-7184.

Woo, K.-. & Jones, K. (1991). Asymmetric synthesis from α-amino acids; some reactions of (S)-pyroglutamate. Tetrahedron letters, Vol.32 (47), pp. 6949-6952.

Storey, J.M., McCarthy, C. & Jones, K. (1991). Intramolecular alkyllithium additions to lactams; a synthesis of 2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indoles (pyrrolo[1,2-a]indolemnes) related to mitomycins. Journal of the chemical society, chemical communications, (13), pp. 892-892.

Jones, K. & Wood, W.W. (1988). A synthesis of (2S,6S)-2-hydroxymethyl-6-methoxytetrahydropyran; a useful chiral intermediate. Journal of the chemical society, perkin transactions 1, (5), pp. 999-999.

Wright, C., Shulkind, M., Jones, K. & Thompson, M. (1987). A formal total synthesis of geneserine. Tetrahedron letters, Vol.28 (50), pp. 6389-6390.

Jones, K. & Wood, W.W. (1986). The preparation and attempted alkylation of some 6-cyano-carbohydrates. Carbohydrate research, Vol.155, pp. 217-222.

Battersby, A.R., Jones, K. & Snow, R.J. (1983). Novel Methods for Demetalating Tetrapyrrolic Metallo-Macrocycles. Angewandte chemie international edition in english, Vol.22 (9), pp. 734-735.

Montforts, F.-., Ofner, S., Rasetti, V., Eschenmoser, A., Woggon, W.-., Jones, K. & Battersby, A.R. (1979). A Synthetic Approach to the Isobacteriochlorin Macrocycle. Angewandte chemie international edition in english, Vol.18 (9), pp. 675-677.

Battersby, A.R., Jones, K., McDonald, E., Robinson, J.A. & Morris, H.R. (1977). The structures and chemistrty of isobacteriochlorins from. Tetrahedron letters, Vol.18 (25), pp. 2213-2216.

Robinson, C.W., Rye, C.S., Chessum, N.E. & Jones, K. A model β-sheet interaction and thermodynamic analysis of β-strand mimetics. Organic & biomolecular chemistry, Vol.13 (27), pp. 7402-7407.  show abstract

Evans, L.E., Cheeseman, M.D., Yahya, N. & Jones, K. Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition. Plos one, Vol.10 (10), pp. e0140006-e0140006.

Rye, C.S., Chessum, N.E., Lamont, S., Pike, K.G., Faulder, P., Demeritt, J., Kemmitt, P., Tucker, J., Zani, L., Cheeseman, M.D., et al. Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. Medchemcomm, Vol.7 (8), pp. 1580-1586.  show abstract

Rye, C.S., Chessum, N.E., Lamont, S., Pike, K.G., Faulder, P., Demeritt, J., Kemmitt, P., Tucker, J., Zani, L., Cheeseman, M.D., et al. Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 See DOI: 10 1039/c6md00159a. Medchemcomm, Vol.7 (9), pp. 1870-1870.  show abstract

Cheeseman, M., Chessum, , Rye, , Pasqua, , Tucker, , Wilding, , Evans, , Richards, , Sharp, , Ali, , et al. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of medicinal chemistry, .  show abstract

Cheeseman, M., Le Bihan, Y., Pettinger, J., Widya, M., van Montfort, R. & Jones, K. An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angewandte chemie international edition, .  show abstract

Cheeseman, M., Evans, L. & Jones, K. Targeting Secondary Protein Complexes in Drug Discovery: Studying the Druggability and Chemical Biology of the HSP70/BAG1 Complex. Chemical communications, .  show abstract

Cheeseman, M., Pettinger, J. & Jones, K. Lysine-Targeting Covalent Inhibitors. Angewandte chemie, .  show abstract

Fok, J.H., Hedayat, S., Zhang, L., Aronson, L.I., Mirabella, F., Pawlyn, C., Bright, M.D., Wardell, C.P., Keats, J.J., de Billy, E., et al. HSF1: Essential for Myeloma Cell Survival and a Promising Therapeutic Target. Clinical cancer research, .

Cheeseman, M., Chessum, N., Sharp, S., Caldwell, J., Pasqua, E., Wilding, B., Colombano, G., Collins, I., Ozer, B., Richards, M., et al. Demonstrating In-Cell Target Engagement using a Pirin Protein Degradation Probe (CCT367766). Journal of medicinal chemistry, .  show abstract

Jones, K. & Wood, W.W. An approach to the total synthesis of the Prelog–Djerassi lactone. J. chem. soc., perkin trans. 1, (0), pp. 537-545.

Jones, K., Thompson, M. & Wright, C. An efficient synthesis of spiro[cyclohexane-1,3′-indol-2′(3′H)-ones]via radical cyclisation. J. chem. soc., chem. commun., (2), pp. 115-116.

Handa, S., Jones, K., Newton, C.G. & Williams, D.J. A short, stereospecific synthesis of a morphine fragment via an intramolecular Diels–Alder reaction. J. chem. soc., chem. commun., (19), pp. 1362-1363.

Handa, S., Jones, K. & Newton, C.G. An unusual solvent effect in an intramolecular Diels–Alder reaction. J. chem. soc., chem. commun., (24), pp. 1797-1799.

Cheeseman, M., Meyers, J., Chessum, N., Ali, S., Mok, Y., Wilding, B., Pasqua, E., Rowlands, M., Tucker, M., Evans, L., et al. Privileged Structures and Polypharmacology within and between Protein Families. Acs medicinal chemistry letters, .  show abstract


Conferences

Pettinger, J., Cheeseman, M., Le Bihan, Y.-., Widya, M., van Montfort, R. & Jones, K. (2017). Design and synthesis of lysine-56 targeting covalent inhibitors of HSP72, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.253.

Billy, E.D., Chessum, N., Poele, R.T., Smith, J., Zani, L., Sharp, S., Stubbs, M., Aherne, W., Jones, K. & Workman, P., et al. (2014). Abstract 1775: Identification of small molecule inhibitors of HSF1 stress pathway activation in cancer cells, Presented at Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA, Experimental and Molecular Therapeutics, .

Evans, L.E., Cheeseman, M.D., Jones, K. & Workman, P. (2014). Alternative strategies for targeting HSP70, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.248.

Robinson, C.W., Rye, C., Chessum, N. & Jones, K. (2014). Small molecule probes for protein-protein interactions: Mimicking beta-sheet motifs, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.248.

Sharp, S.Y., Prodromou, C., Cheung, K.-., Roe, M., Lynch, C., Pearl, L., Collins, I., McDonald, E., Jones, K. & Workman, P., et al. (2012). Abstract 4749: Insights into the molecular mechanism of HSP90 binding of methoxy-substituted resorcinylic isoxazole amide inhibitors reveal different isoform selectivity profiles, Presented at Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL, Cancer Chemistry, .

Fearon, D., Jones, K., Bayliss, R. & Bavetsias, V. (2012). New structural templates for kinase inhibition, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol.243.

HILTON, P., MCKINNON, W., JONES, K., PERON, J., GRAVETT, E. & LORD, G. (2005). Differential inhibition of Na-K ATPases by synthetic 14β bufadienolides, American Journal of Hypertension, Vol.18 (5), p.A166.