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Journal Articles

Meisenberg, C. Pinder, S.I. Hopkins, S.R. Wooller, S.K. Benstead-Hume, G. Pearl, F.M. Jeggo, P.A. Downs, J.A. (2019). Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Molecular cell, Vol.73 (2), pp. 212-223.e7.

Jeggo, P.A. Downs, J.A. Gasser, S.M. (2017). Chromatin modifiers and remodellers in DNA repair and signalling. Philosophical transactions of the royal society b: biological sciences, Vol.372 (1731), pp. 20160279-20160279.

Hopkins, S.R. McGregor, G.A. Murray, J.M. Downs, J.A. Savic, V. (2016). Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. Dna repair, Vol.46, pp. 47-54.

Myrianthopoulos, V. Gaboriaud-Kolar, N. Tallant, C. Hall, M.-. Grigoriou, S. Brownlee, P.M. Fedorov, O. Rogers, C. Heidenreich, D. Wanior, M. Drosos, N. Mexia, N. Savitsky, P. Bagratuni, T. Kastritis, E. Terpos, E. Filippakopoulos, P. Müller, S. Skaltsounis, A.-. Downs, J.A. Knapp, S. Mikros, E. (2016). Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. Journal of medicinal chemistry, Vol.59 (19), pp. 8787-8803.

Kakarougkas, A. Downs, J.A. Jeggo, P.A. (2015). The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & cellular oncology, Vol.2 (1), pp. e970072-e970072.

Alatwi, H.E. Downs, J.A. (2015). Removal of H2A Z by INO 80 promotes homologous recombination. Embo reports, Vol.16 (8), pp. 986-994.

Brownlee, P.M. Meisenberg, C. Downs, J.A. (2015). The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis. Dna repair, Vol.32, pp. 127-133.

Niimi, A. Hopkins, S.R. Downs, J.A. Masutani, C. (2015). The BAH domain of BAF180 is required for PCNA ubiquitination. Mutation research/fundamental and molecular mechanisms of mutagenesis, Vol.779, pp. 16-23.

Schalbetter, S.A. Mansoubi, S. Chambers, A.L. Downs, J.A. Baxter, J. (2015). Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the national academy of sciences, Vol.112 (33), pp. E4565-E4570.  show abstract

Brownlee, P.M. Chambers, A.L. Cloney, R. Bianchi, A. Downs, J.A. (2014). BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy. Cell reports, Vol.6 (6), pp. 973-981.

Pal, M. Morgan, M. Phelps, S.E. Roe, S.M. Parry-Morris, S. Downs, J.A. Polier, S. Pearl, L.H. Prodromou, C. (2014). Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, Vol.22 (6), pp. 805-818.

Kakarougkas, A. Ismail, A. Chambers, A.L. Riballo, E. Herbert, A.D. Künzel, J. Löbrich, M. Jeggo, P.A. Downs, J.A. (2014). Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin. Molecular cell, Vol.55 (5), pp. 723-732.

Jeggo, P.A. Downs, J.A. (2014). Roles of chromatin remodellers in DNA double strand break repair. Experimental cell research, Vol.329 (1), pp. 69-77.

López-Perrote, A. Alatwi, H.E. Torreira, E. Ismail, A. Ayora, S. Downs, J.A. Llorca, O. (2014). Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases. Journal of biological chemistry, Vol.289 (33), pp. 22614-22629.

Chambers, A.L. Pearl, L.H. Oliver, A.W. Downs, J.A. (2013). The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic acids research, Vol.41 (19), pp. 9168-9182.

Niimi, A. Chambers, A.L. Downs, J.A. Lehmann, A.R. (2012). A role for chromatin remodellers in replication of damaged DNA. Nucleic acids research, Vol.40 (15), pp. 7393-7403.

Brownlee, P.M. Chambers, A.L. Oliver, A.W. Downs, J.A. (2012). Cancer and the bromodomains of BAF180. Biochemical society transactions, Vol.40 (2), pp. 364-369.  show abstract

Chambers, A.L. Ormerod, G. Durley, S.C. Sing, T.L. Brown, G.W. Kent, N.A. Downs, J.A. (2012). The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes & development, Vol.26 (23), pp. 2590-2603.

Chambers, A.L. Downs, J.A. (2012). The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair. , , pp. 229-261.

Foster, E.R. Downs, J.A. (2009). Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. Journal of cell biology, Vol.184 (5), pp. 631-638.  show abstract

Titman, C.M. Downs, J.A. Oliver, S.G. Carmichael, P.L. Scott, A.D. Griffin, J.L. (2009). A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomycescerevisiae. Molecular biosystems, Vol.5 (12), pp. 1913-1913.

Downs, J.A. (2008). Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. Dna repair, Vol.7 (12), pp. 2020-2024.

Chambers, A.L. Downs, J.A. (2007). The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses. Biochemical society transactions, Vol.35 (6), pp. 1519-1524.  show abstract

Downs, J.A. Nussenzweig, M.C. Nussenzweig, A. (2007). Chromatin dynamics and the preservation of genetic information. Nature, Vol.447 (7147), pp. 951-958.

Bilsland, E. Hult, M. Bell, S.D. Sunnerhagen, P. Downs, J.A. (2007). The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage. Dna repair, Vol.6 (10), pp. 1471-1484.

Downs, J.A. (2007). Chromatin structure and DNA double-strand break responses in cancer progression and therapy. Oncogene, Vol.26 (56), pp. 7765-7772.

Kent, N.A. Chambers, A.L. Downs, J.A. (2007). Dual Chromatin Remodeling Roles for RSC during DNA Double Strand Break Induction and Repair at the YeastMATLocus. Journal of biological chemistry, Vol.282 (38), pp. 27693-27701.

Bilsland, E. Downs, J.A. (2005). Tails of histones in DNA double-strand break repair. Mutagenesis, Vol.20 (3), pp. 153-163.

Harvey, A.C. Jackson, S.P. Downs, J.A. (2005). Saccharomyces cerevisiae Histone H2A Ser122 Facilitates DNA Repair. Genetics, Vol.170 (2), pp. 543-553.

Zaid, O. Downs, J.A. (2005). Histones as tumour suppressor genes. Cellular and molecular life sciences, Vol.62 (15), pp. 1653-1656.

WARDLEWORTH, B.N. DOWNS, J.A. (2005). Spotting new DNA damage-responsive chromatin-binding proteins. Biochemical journal, Vol.388 (1).  show abstract

Downs, J.A. Cote, J. (2005). Dynamics of Chromatin during the Repair of DNA Double-Strand Breaks. Cell cycle, Vol.4 (10), pp. 1373-1376.

Downs, J.A. Jackson, S.P. (2004). A means to a DNA end: the many roles of Ku. Nature reviews molecular cell biology, Vol.5 (5), pp. 367-378.

Downs, J.A. Allard, S. Jobin-Robitaille, O. Javaheri, A. Auger, A. Bouchard, N. Kron, S.J. Jackson, S.P. Côté, J. (2004). Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites. Molecular cell, Vol.16 (6), pp. 979-990.

Downs, J.A. Kosmidou, E. Morgan, A. Jackson, S.P. (2003). Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone. Molecular cell, Vol.11 (6), pp. 1685-1692.

Downs, J.A. Lowndes, N.F. Jackson, S.P. (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, Vol.408 (6815), pp. 1001-1004.

Downs, J.A. Jackson, S.P. (1999). Involvement of DNA End-Binding Protein Ku in Ty Element Retrotransposition. Molecular and cellular biology, Vol.19 (9), pp. 6260-6268.  show abstract

Meisenberg, C. Ashour, M.E. El-Shafie, L. Liao, C. Hodgson, A. Pilborough, A. Khurram, S.A. Downs, J.A. Ward, S.E. El-Khamisy, S.F. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic acids research, , pp. gkw1026-gkw1026.

Benstead-Hume, G. Chen, X. Hopkins, S.R. Lane, K.A. Downs, J.A. Pearl, F.M. Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. Plos computational biology, Vol.15 (4), pp. e1006888-e1006888.

Foster, E.R. Downs, J.A. Histone H2A phosphorylation in DNA double-strand break repair. Febs journal, Vol.272 (13), pp. 3231-3240.

Harvey, A.C. Downs, J.A. What functions do linker histones provide?. Molecular microbiology, Vol.53 (3), pp. 771-775.

Chambers, A.L. Brownlee, P.M. Durley, S.C. Beacham, T. Kent, N.A. Downs, J.A. The Two Different Isoforms of the RSC Chromatin Remodeling Complex Play Distinct Roles in DNA Damage Responses. Plos one, Vol.7 (2), pp. e32016-e32016.

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