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Journal Articles

Meisenberg, C., Pinder, S.I., Hopkins, S.R., Wooller, S.K., Benstead-Hume, G., Pearl, F.M., Jeggo, P.A. & Downs, J.A. (2019). Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Molecular cell, Vol.73 (2), pp. 212-223.e7.

Jeggo, P.A., Downs, J.A. & Gasser, S.M. (2017). Chromatin modifiers and remodellers in DNA repair and signalling. Philosophical transactions of the royal society b: biological sciences, Vol.372 (1731), pp. 20160279-20160279.

Hopkins, S.R., McGregor, G.A., Murray, J.M., Downs, J.A. & Savic, V. (2016). Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. Dna repair, Vol.46, pp. 47-54.

Myrianthopoulos, V., Gaboriaud-Kolar, N., Tallant, C., Hall, M.-., Grigoriou, S., Brownlee, P.M., Fedorov, O., Rogers, C., Heidenreich, D., Wanior, M., et al. (2016). Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. Journal of medicinal chemistry, Vol.59 (19), pp. 8787-8803.

Kakarougkas, A., Downs, J.A. & Jeggo, P.A. (2015). The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & cellular oncology, Vol.2 (1), pp. e970072-e970072.

Brownlee, P.M., Meisenberg, C. & Downs, J.A. (2015). The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis. Dna repair, Vol.32, pp. 127-133.

Alatwi, H.E. & Downs, J.A. (2015). Removal of H2A Z by INO 80 promotes homologous recombination. Embo reports, Vol.16 (8), pp. 986-994.

Niimi, A., Hopkins, S.R., Downs, J.A. & Masutani, C. (2015). The BAH domain of BAF180 is required for PCNA ubiquitination. Mutation research/fundamental and molecular mechanisms of mutagenesis, Vol.779, pp. 16-23.

Schalbetter, S.A., Mansoubi, S., Chambers, A.L., Downs, J.A. & Baxter, J. (2015). Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the national academy of sciences, Vol.112 (33), pp. E4565-E4570.

Brownlee, P.M., Chambers, A.L., Cloney, R., Bianchi, A. & Downs, J.A. (2014). BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy. Cell reports, Vol.6 (6), pp. 973-981.

Pal, M., Morgan, M., Phelps, S.E., Roe, S.M., Parry-Morris, S., Downs, J.A., Polier, S., Pearl, L.H. & Prodromou, C. (2014). Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, Vol.22 (6), pp. 805-818.

Kakarougkas, A., Ismail, A., Chambers, A.L., Riballo, E., Herbert, A.D., Künzel, J., Löbrich, M., Jeggo, P.A. & Downs, J.A. (2014). Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin. Molecular cell, Vol.55 (5), pp. 723-732.

Jeggo, P.A. & Downs, J.A. (2014). Roles of chromatin remodellers in DNA double strand break repair. Experimental cell research, Vol.329 (1), pp. 69-77.

López-Perrote, A., Alatwi, H.E., Torreira, E., Ismail, A., Ayora, S., Downs, J.A. & Llorca, O. (2014). Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases. Journal of biological chemistry, Vol.289 (33), pp. 22614-22629.

Chambers, A.L., Pearl, L.H., Oliver, A.W. & Downs, J.A. (2013). The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic acids research, Vol.41 (19), pp. 9168-9182.

Niimi, A., Chambers, A.L., Downs, J.A. & Lehmann, A.R. (2012). A role for chromatin remodellers in replication of damaged DNA. Nucleic acids research, Vol.40 (15), pp. 7393-7403.

Chambers, A.L., Ormerod, G., Durley, S.C., Sing, T.L., Brown, G.W., Kent, N.A. & Downs, J.A. (2012). The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes & development, Vol.26 (23), pp. 2590-2603.

Brownlee, P.M., Chambers, A.L., Oliver, A.W. & Downs, J.A. (2012). Cancer and the bromodomains of BAF180. Biochemical society transactions, Vol.40 (2), pp. 364-369.  show abstract

Chambers, A.L. & Downs, J.A. (2012). The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair. , , pp. 229-261.

Foster, E.R. & Downs, J.A. (2009). Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. The journal of cell biology, Vol.184 (5), pp. 631-638.

Titman, C.M., Downs, J.A., Oliver, S.G., Carmichael, P.L., Scott, A.D. & Griffin, J.L. (2009). A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomycescerevisiae. Molecular biosystems, Vol.5 (12), pp. 1913-1913.

Downs, J.A. (2008). Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. Dna repair, Vol.7 (12), pp. 2020-2024.

Chambers, A.L. & Downs, J.A. (2007). The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses. Biochemical society transactions, Vol.35 (6), pp. 1519-1524.  show abstract

Downs, J.A., Nussenzweig, M.C. & Nussenzweig, A. (2007). Chromatin dynamics and the preservation of genetic information. Nature, Vol.447 (7147), pp. 951-958.

Bilsland, E., Hult, M., Bell, S.D., Sunnerhagen, P. & Downs, J.A. (2007). The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage. Dna repair, Vol.6 (10), pp. 1471-1484.

Downs, J.A. (2007). Chromatin structure and DNA double-strand break responses in cancer progression and therapy. Oncogene, Vol.26 (56), pp. 7765-7772.

Kent, N.A., Chambers, A.L. & Downs, J.A. (2007). Dual Chromatin Remodeling Roles for RSC during DNA Double Strand Break Induction and Repair at the YeastMATLocus. Journal of biological chemistry, Vol.282 (38), pp. 27693-27701.

Bilsland, E. & Downs, J.A. (2005). Tails of histones in DNA double-strand break repair. Mutagenesis, Vol.20 (3), pp. 153-163.

Harvey, A.C., Jackson, S.P. & Downs, J.A. (2005). Saccharomyces cerevisiae Histone H2A Ser122 Facilitates DNA Repair. Genetics, Vol.170 (2), pp. 543-553.

Zaid, O. & Downs, J.A. (2005). Histones as tumour suppressor genes. Cellular and molecular life sciences, Vol.62 (15), pp. 1653-1656.

WARDLEWORTH, B.N. & DOWNS, J.A. (2005). Spotting new DNA damage-responsive chromatin-binding proteins. Biochemical journal, Vol.388 (1).  show abstract

Downs, J.A. & Cote, J. (2005). Dynamics of Chromatin during the Repair of DNA Double-Strand Breaks. Cell cycle, Vol.4 (10), pp. 1373-1376.

Downs, J.A. & Jackson, S.P. (2004). A means to a DNA end: the many roles of Ku. Nature reviews molecular cell biology, Vol.5 (5), pp. 367-378.

Downs, J.A., Allard, S., Jobin-Robitaille, O., Javaheri, A., Auger, A., Bouchard, N., Kron, S.J., Jackson, S.P. & Côté, J. (2004). Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites. Molecular cell, Vol.16 (6), pp. 979-990.

Downs, J.A., Kosmidou, E., Morgan, A. & Jackson, S.P. (2003). Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone. Molecular cell, Vol.11 (6), pp. 1685-1692.

Downs, J.A., Lowndes, N.F. & Jackson, S.P. (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, Vol.408 (6815), pp. 1001-1004.

Downs, J.A. & Jackson, S.P. (1999). Involvement of DNA End-Binding Protein Ku in Ty Element Retrotransposition. Molecular and cellular biology, Vol.19 (9), pp. 6260-6268.  show abstract

Meisenberg, C., Ashour, M.E., El-Shafie, L., Liao, C., Hodgson, A., Pilborough, A., Khurram, S.A., Downs, J.A., Ward, S.E. & El-Khamisy, S.F., et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic acids research, , pp. gkw1026-gkw1026.

Chambers, A.L., Brownlee, P.M., Durley, S.C., Beacham, T., Kent, N.A. & Downs, J.A. The Two Different Isoforms of the RSC Chromatin Remodeling Complex Play Distinct Roles in DNA Damage Responses. Plos one, Vol.7 (2), pp. e32016-e32016.

Foster, E.R. & Downs, J.A. Histone H2A phosphorylation in DNA double-strand break repair. Febs journal, Vol.272 (13), pp. 3231-3240.

Harvey, A.C. & Downs, J.A. What functions do linker histones provide?. Molecular microbiology, Vol.53 (3), pp. 771-775.

Benstead-Hume, G., Chen, X., Hopkins, S.R., Lane, K.A., Downs, J.A. & Pearl, F.M. Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. Plos computational biology, Vol.15 (4), pp. e1006888-e1006888.

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